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Increased anti-alpha-gal IgE antibody level

MedGen UID:
1692565
•Concept ID:
C5139427
•
Finding
Synonym: Increased anti-galactose-alpha-1, 3 galactose IgE antibody level
 
HPO: HP:0410249

Definition

Increased level of IgE antibody against galactose-alpha-1, 3 galactose (alpha-gal), a carbohydrate found in mammalian meat. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased anti-alpha-gal IgE antibody level

Recent clinical studies

Etiology

Consideration for alpha-gal syndrome in two critically ill persons with group O blood who received group B plasma.
Miller MJ, Lee P, Lee BG, Flegel WA, West-Mitchell K, Conry-Cantilena K, De Giorgi V
Transfusion 2024 May;64(5):949-951. Epub 2024 Apr 3 doi: 10.1111/trf.17811. PMID: 38566573Free PMC Article
Association between lone star tick bites and increased alpha-gal sensitization: evidence from a prospective cohort of outdoor workers.
Mitchell CL, Lin FC, Vaughn M, Apperson CS, Meshnick SR, Commins SP
Parasit Vectors 2020 Sep 14;13(1):470. doi: 10.1186/s13071-020-04343-4. PMID: 32928302Free PMC Article
Clinical gamasoidosis and antibody response in two patients infested with Ornithonyssus bursa (Acari: Gamasida: Macronyssidae).
Lima-Barbero JF, Sánchez MS, Cabezas-Cruz A, Mateos-Hernández L, Contreras M, de Mera IGF, Villar M, de la Fuente J
Exp Appl Acarol 2019 Aug;78(4):555-564. Epub 2019 Jul 31 doi: 10.1007/s10493-019-00408-x. PMID: 31367978
Environmental and Molecular Drivers of the α-Gal Syndrome.
Cabezas-Cruz A, Hodžić A, Román-Carrasco P, Mateos-Hernández L, Duscher GG, Sinha DK, Hemmer W, Swoboda I, Estrada-Peña A, de la Fuente J
Front Immunol 2019;10:1210. Epub 2019 May 31 doi: 10.3389/fimmu.2019.01210. PMID: 31214181Free PMC Article
Salivary Prostaglandin E2: Role in Tick-Induced Allergy to Red Meat.
Cabezas-Cruz A, Mateos-Hernández L, Chmelař J, Villar M, de la Fuente J
Trends Parasitol 2017 Jul;33(7):495-498. Epub 2017 Mar 30 doi: 10.1016/j.pt.2017.03.004. PMID: 28365087

Diagnosis

Characterization of the anti-α-Gal antibody profile in association with Guillain-Barré syndrome, implications for tick-related allergic reactions.
Pacheco I, Fernández de Mera IG, Feo Brito F, Gómez Torrijos E, Villar M, Contreras M, Lima-Barbero JF, Doncel-Pérez E, Cabezas-Cruz A, Gortázar C, de la Fuente J
Ticks Tick Borne Dis 2021 May;12(3):101651. Epub 2021 Jan 11 doi: 10.1016/j.ttbdis.2021.101651. PMID: 33465663
Clinical gamasoidosis and antibody response in two patients infested with Ornithonyssus bursa (Acari: Gamasida: Macronyssidae).
Lima-Barbero JF, Sánchez MS, Cabezas-Cruz A, Mateos-Hernández L, Contreras M, de Mera IGF, Villar M, de la Fuente J
Exp Appl Acarol 2019 Aug;78(4):555-564. Epub 2019 Jul 31 doi: 10.1007/s10493-019-00408-x. PMID: 31367978
Environmental and Molecular Drivers of the α-Gal Syndrome.
Cabezas-Cruz A, Hodžić A, Román-Carrasco P, Mateos-Hernández L, Duscher GG, Sinha DK, Hemmer W, Swoboda I, Estrada-Peña A, de la Fuente J
Front Immunol 2019;10:1210. Epub 2019 May 31 doi: 10.3389/fimmu.2019.01210. PMID: 31214181Free PMC Article

Therapy

Association between lone star tick bites and increased alpha-gal sensitization: evidence from a prospective cohort of outdoor workers.
Mitchell CL, Lin FC, Vaughn M, Apperson CS, Meshnick SR, Commins SP
Parasit Vectors 2020 Sep 14;13(1):470. doi: 10.1186/s13071-020-04343-4. PMID: 32928302Free PMC Article

Clinical prediction guides

Association between lone star tick bites and increased alpha-gal sensitization: evidence from a prospective cohort of outdoor workers.
Mitchell CL, Lin FC, Vaughn M, Apperson CS, Meshnick SR, Commins SP
Parasit Vectors 2020 Sep 14;13(1):470. doi: 10.1186/s13071-020-04343-4. PMID: 32928302Free PMC Article

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