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Spontaneous conjunctival filtering bleb

MedGen UID:
1693159
Concept ID:
C5209225
Anatomical Abnormality
Synonyms: Conjunctival avascular cysts (filtering blebs); Spontaneous filtering bleb
 
HPO: HP:0020125

Definition

Avascular cystic elevations of the superior conjunctiva not related to ocular surgery or trauma. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSpontaneous conjunctival filtering bleb

Conditions with this feature

Facial dysmorphism-lens dislocation-anterior segment abnormalities-spontaneous filtering blebs syndrome
MedGen UID:
330396
Concept ID:
C1832167
Disease or Syndrome
Traboulsi syndrome is characterized by dislocated crystalline lenses and anterior segment abnormalities in association with a distinctive facies involving flat cheeks and a beaked nose. Some affected individuals develop highly unusual nontraumatic conjunctival cysts (filtering blebs), presumably caused by abnormal thinning of the sclera (Patel et al., 2014).

Professional guidelines

PubMed

Loane ME, Galanopoulos A
Curr Opin Ophthalmol 1999 Apr;10(2):121-5. doi: 10.1097/00055735-199904000-00008. PMID: 10537762
Tomlinson CP, Belcher CD 3rd, Smith PD, Simmons RJ
Ann Ophthalmol 1987 Nov;19(11):405-8, 411. PMID: 3322135
Loewenthal LM
Ann Ophthalmol 1977 Sep;9(9):1179-86. PMID: 900738

Recent clinical studies

Etiology

Sanjuán P, Salvador-Culla B, Canut MI, Barraquer RI
Eur J Ophthalmol 2021 Mar;31(2):NP136-NP140. Epub 2019 Sep 17 doi: 10.1177/1120672119877159. PMID: 31530022
Karimi A, Hopes M, Martin KR, Lindfield D
J Glaucoma 2018 Oct;27(10):864-868. doi: 10.1097/IJG.0000000000001044. PMID: 30095602
Munro M, McWhae J, Romanchuk K, Crichton A, Carter G, Ball A
Cornea 2014 Jul;33(7):752-4. doi: 10.1097/ICO.0000000000000132. PMID: 24831195
Tabet R, Feldman RM, Bell NP, Lee DA
J Glaucoma 2009 Sep;18(7):546-51. doi: 10.1097/IJG.0b013e3181815a06. PMID: 19745670
Budenz DL, Chen PP, Weaver YK
Arch Ophthalmol 1999 Aug;117(8):1014-9. doi: 10.1001/archopht.117.8.1014. PMID: 10448743

Diagnosis

Pathan AHK, Barash A, Tena LB, Finger PT
Eur J Ophthalmol 2018 Jan;28(1):119-122. doi: 10.5301/ejo.5001046. PMID: 28967074
Munro M, McWhae J, Romanchuk K, Crichton A, Carter G, Ball A
Cornea 2014 Jul;33(7):752-4. doi: 10.1097/ICO.0000000000000132. PMID: 24831195
Budenz DL, Chen PP, Weaver YK
Arch Ophthalmol 1999 Aug;117(8):1014-9. doi: 10.1001/archopht.117.8.1014. PMID: 10448743
Wong VA, Beiko G, Pavlin CJ, Rootman DS
Can J Ophthalmol 1995 Dec;30(7):377-9. PMID: 8963941

Therapy

Karimi A, Hopes M, Martin KR, Lindfield D
J Glaucoma 2018 Oct;27(10):864-868. doi: 10.1097/IJG.0000000000001044. PMID: 30095602
Rao A, Chatterjee S
Semin Ophthalmol 2014 Jan;29(1):48-51. Epub 2013 Aug 23 doi: 10.3109/08820538.2013.810281. PMID: 23971715
Anis S, Ritch R, Shihadeh W, Liebmann J
Arch Ophthalmol 2006 Jun;124(6):890-4. doi: 10.1001/archopht.124.6.890. PMID: 16769845
Loane ME, Galanopoulos A
Curr Opin Ophthalmol 1999 Apr;10(2):121-5. doi: 10.1097/00055735-199904000-00008. PMID: 10537762
Budenz DL, Chen PP, Weaver YK
Arch Ophthalmol 1999 Aug;117(8):1014-9. doi: 10.1001/archopht.117.8.1014. PMID: 10448743

Prognosis

Kitagawa K, Yanagisawa S, Watanabe K, Yunoki T, Hayashi A, Okabe M, Nikaido T
Am J Ophthalmol 2009 Sep;148(3):383-9. Epub 2009 May 23 doi: 10.1016/j.ajo.2009.03.030. PMID: 19464670
Hyung SM, Ahn DG
Korean J Ophthalmol 1999 Dec;13(2):85-91. doi: 10.3341/kjo.1999.13.2.85. PMID: 10761403
Budenz DL, Chen PP, Weaver YK
Arch Ophthalmol 1999 Aug;117(8):1014-9. doi: 10.1001/archopht.117.8.1014. PMID: 10448743
Loewenthal LM
Ann Ophthalmol 1977 Sep;9(9):1179-86. PMID: 900738

Clinical prediction guides

Gonçalves Dos Santos Martins T, Fontes de Azevedo Costa AL
Ir J Med Sci 2018 Aug;187(3):815-816. Epub 2018 Jan 18 doi: 10.1007/s11845-018-1740-2. PMID: 29349557
Munro M, McWhae J, Romanchuk K, Crichton A, Carter G, Ball A
Cornea 2014 Jul;33(7):752-4. doi: 10.1097/ICO.0000000000000132. PMID: 24831195
Tomlinson CP, Belcher CD 3rd, Smith PD, Simmons RJ
Ann Ophthalmol 1987 Nov;19(11):405-8, 411. PMID: 3322135
Soong HK, Fitzgerald J, Boruchoff SA, Sugar A, Meyer RF, Gabel MG
Ophthalmology 1986 Mar;93(3):340-3. doi: 10.1016/s0161-6420(86)33737-0. PMID: 3703501

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