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Testicular Diffuse Large B-Cell Lymphoma

MedGen UID:
1693324
•Concept ID:
C5206577
•
Neoplastic Process

Definition

A diffuse large B-cell lymphoma that arises from the testis. It predominantly affects older men. Patients usually present with a unilateral hard painless mass. Bilateral masses have been described in a minority of patients. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTesticular Diffuse Large B-Cell Lymphoma

Professional guidelines

PubMed

Primary testicular diffuse large B-cell lymphoma displays distinct clinical and biological features for treatment failure in rituximab era: a report from the International PTL Consortium.
Deng L, Xu-Monette ZY, Loghavi S, Manyam GC, Xia Y, Visco C, Huh J, Zhang L, Zhai Q, Wang Y, Qiu L, Dybkær K, Chiu A, Perry AM, Zhang S, Tzankov A, Rao H, Abramson J, Sohani AR, Xu M, Hsi ED, Zhu J, Ponzoni M, Wang S, Li L, Zhang M, Ferreri AJ, Parsons BM, Li Y, Piris MA, Medeiros LJ, Young KH
Leukemia 2016 Feb;30(2):361-72. Epub 2013 Aug 26 doi: 10.1038/leu.2015.237. PMID: 26308769
Management of non-Hodgkin lymphomas arising at extranodal sites.
Zucca E, Gregorini A, Cavalli F
Ther Umsch 2010 Oct;67(10):517-25. doi: 10.1024/0040-5930/a000088. PMID: 20886458

Recent clinical studies

Etiology

Different chemokine profile between systemic and testicular diffuse large B-cell lymphoma.
Ollikainen RK, Kotkaranta PH, Kemppainen J, Teppo HR, Kuitunen H, Pirinen R, Turpeenniemi-Hujanen T, Kuittinen O, Kuusisto MEL
Leuk Lymphoma 2021 Sep;62(9):2151-2160. Epub 2021 Apr 15 doi: 10.1080/10428194.2021.1913150. PMID: 33856274
Intravenous but not intrathecal central nervous system-directed chemotherapy improves survival in patients with testicular diffuse large B-cell lymphoma.
Mannisto S, Vähämurto P, Pollari M, Clausen MR, Jyrkkiö S, Kellokumpu-Lehtinen PL, Kovanen P, Karjalainen-Lindsberg ML, d'Amore F, Leppä S
Eur J Cancer 2019 Jul;115:27-36. Epub 2019 May 10 doi: 10.1016/j.ejca.2019.04.004. PMID: 31082690
Diffuse large B-cell lymphoma with testicular involvement: outcome and risk of CNS relapse in the rituximab era.
Kridel R, Telio D, Villa D, Sehn LH, Gerrie AS, Shenkier T, Klasa R, Slack GW, Tan K, Gascoyne RD, Connors JM, Savage KJ
Br J Haematol 2017 Jan;176(2):210-221. Epub 2016 Oct 14 doi: 10.1111/bjh.14392. PMID: 27739058
Clinical and pathological features of testicular diffuse large B-cell lymphoma: a heterogeneous disease.
Kuper-Hommel MJ, Janssen-Heijnen ML, Vreugdenhil G, Krol AD, Kluin-Nelemans HC, Coebergh JW, van Krieken JH
Leuk Lymphoma 2012 Feb;53(2):242-6. Epub 2011 Sep 19 doi: 10.3109/10428194.2011.607528. PMID: 21787261
First-line treatment for primary testicular diffuse large B-cell lymphoma with rituximab-CHOP, CNS prophylaxis, and contralateral testis irradiation: final results of an international phase II trial.
Vitolo U, Chiappella A, Ferreri AJ, Martelli M, Baldi I, Balzarotti M, Bottelli C, Conconi A, Gomez H, Lopez-Guillermo A, Martinelli G, Merli F, Novero D, Orsucci L, Pavone V, Ricardi U, Storti S, Gospodarowicz MK, Cavalli F, Sarris AH, Zucca E
J Clin Oncol 2011 Jul 10;29(20):2766-72. Epub 2011 Jun 6 doi: 10.1200/JCO.2010.31.4187. PMID: 21646602

Diagnosis

Primary testicular diffuse large B-cell lymphoma: Case series.
Wang Q, Zheng D, Chai D, Wu S, Wang X, Chen S, Wu L, Cao R, Tao Y
Medicine (Baltimore) 2020 Mar;99(12):e19463. doi: 10.1097/MD.0000000000019463. PMID: 32195944Free PMC Article
Diffuse large B-cell lymphoma variants: an update.
Sukswai N, Lyapichev K, Khoury JD, Medeiros LJ
Pathology 2020 Jan;52(1):53-67. Epub 2019 Nov 15 doi: 10.1016/j.pathol.2019.08.013. PMID: 31735345
The pathobiology of primary testicular diffuse large B-cell lymphoma: Implications for novel therapies.
Twa DDW, Mottok A, Savage KJ, Steidl C
Blood Rev 2018 May;32(3):249-255. Epub 2017 Dec 20 doi: 10.1016/j.blre.2017.12.001. PMID: 29289361
Diffuse large B-cell lymphoma with testicular involvement: outcome and risk of CNS relapse in the rituximab era.
Kridel R, Telio D, Villa D, Sehn LH, Gerrie AS, Shenkier T, Klasa R, Slack GW, Tan K, Gascoyne RD, Connors JM, Savage KJ
Br J Haematol 2017 Jan;176(2):210-221. Epub 2016 Oct 14 doi: 10.1111/bjh.14392. PMID: 27739058
Clinical and pathological features of testicular diffuse large B-cell lymphoma: a heterogeneous disease.
Kuper-Hommel MJ, Janssen-Heijnen ML, Vreugdenhil G, Krol AD, Kluin-Nelemans HC, Coebergh JW, van Krieken JH
Leuk Lymphoma 2012 Feb;53(2):242-6. Epub 2011 Sep 19 doi: 10.3109/10428194.2011.607528. PMID: 21787261

Therapy

Intravenous but not intrathecal central nervous system-directed chemotherapy improves survival in patients with testicular diffuse large B-cell lymphoma.
Mannisto S, Vähämurto P, Pollari M, Clausen MR, Jyrkkiö S, Kellokumpu-Lehtinen PL, Kovanen P, Karjalainen-Lindsberg ML, d'Amore F, Leppä S
Eur J Cancer 2019 Jul;115:27-36. Epub 2019 May 10 doi: 10.1016/j.ejca.2019.04.004. PMID: 31082690
Radiation therapy improves survival in patients with testicular diffuse large B-cell lymphoma<sup/>.
Ho JC, Dabaja BS, Milgrom SA, Smith GL, Reddy JP, Mazloom A, Young KH, Deng L, Medeiros LJ, Dong W, Allen PK, Andraos TY, Fowler NH, Nastoupil LJ, Oki Y, Fayad LE, Turturro F, Neelapu SS, Westin J, Hagemeister FB, Rodriguez MA, Pinnix CC
Leuk Lymphoma 2017 Dec;58(12):2833-2844. Epub 2017 May 9 doi: 10.1080/10428194.2017.1312381. PMID: 28482717Free PMC Article
Diffuse large B-cell lymphoma with testicular involvement: outcome and risk of CNS relapse in the rituximab era.
Kridel R, Telio D, Villa D, Sehn LH, Gerrie AS, Shenkier T, Klasa R, Slack GW, Tan K, Gascoyne RD, Connors JM, Savage KJ
Br J Haematol 2017 Jan;176(2):210-221. Epub 2016 Oct 14 doi: 10.1111/bjh.14392. PMID: 27739058
Primary testicular diffuse large B-cell lymphoma displays distinct clinical and biological features for treatment failure in rituximab era: a report from the International PTL Consortium.
Deng L, Xu-Monette ZY, Loghavi S, Manyam GC, Xia Y, Visco C, Huh J, Zhang L, Zhai Q, Wang Y, Qiu L, Dybkær K, Chiu A, Perry AM, Zhang S, Tzankov A, Rao H, Abramson J, Sohani AR, Xu M, Hsi ED, Zhu J, Ponzoni M, Wang S, Li L, Zhang M, Ferreri AJ, Parsons BM, Li Y, Piris MA, Medeiros LJ, Young KH
Leukemia 2016 Feb;30(2):361-72. Epub 2013 Aug 26 doi: 10.1038/leu.2015.237. PMID: 26308769
First-line treatment for primary testicular diffuse large B-cell lymphoma with rituximab-CHOP, CNS prophylaxis, and contralateral testis irradiation: final results of an international phase II trial.
Vitolo U, Chiappella A, Ferreri AJ, Martelli M, Baldi I, Balzarotti M, Bottelli C, Conconi A, Gomez H, Lopez-Guillermo A, Martinelli G, Merli F, Novero D, Orsucci L, Pavone V, Ricardi U, Storti S, Gospodarowicz MK, Cavalli F, Sarris AH, Zucca E
J Clin Oncol 2011 Jul 10;29(20):2766-72. Epub 2011 Jun 6 doi: 10.1200/JCO.2010.31.4187. PMID: 21646602

Prognosis

Different chemokine profile between systemic and testicular diffuse large B-cell lymphoma.
Ollikainen RK, Kotkaranta PH, Kemppainen J, Teppo HR, Kuitunen H, Pirinen R, Turpeenniemi-Hujanen T, Kuittinen O, Kuusisto MEL
Leuk Lymphoma 2021 Sep;62(9):2151-2160. Epub 2021 Apr 15 doi: 10.1080/10428194.2021.1913150. PMID: 33856274
Intravenous but not intrathecal central nervous system-directed chemotherapy improves survival in patients with testicular diffuse large B-cell lymphoma.
Mannisto S, Vähämurto P, Pollari M, Clausen MR, Jyrkkiö S, Kellokumpu-Lehtinen PL, Kovanen P, Karjalainen-Lindsberg ML, d'Amore F, Leppä S
Eur J Cancer 2019 Jul;115:27-36. Epub 2019 May 10 doi: 10.1016/j.ejca.2019.04.004. PMID: 31082690
Diffuse large B-cell lymphoma with testicular involvement: outcome and risk of CNS relapse in the rituximab era.
Kridel R, Telio D, Villa D, Sehn LH, Gerrie AS, Shenkier T, Klasa R, Slack GW, Tan K, Gascoyne RD, Connors JM, Savage KJ
Br J Haematol 2017 Jan;176(2):210-221. Epub 2016 Oct 14 doi: 10.1111/bjh.14392. PMID: 27739058
Clinical and pathological features of testicular diffuse large B-cell lymphoma: a heterogeneous disease.
Kuper-Hommel MJ, Janssen-Heijnen ML, Vreugdenhil G, Krol AD, Kluin-Nelemans HC, Coebergh JW, van Krieken JH
Leuk Lymphoma 2012 Feb;53(2):242-6. Epub 2011 Sep 19 doi: 10.3109/10428194.2011.607528. PMID: 21787261
First-line treatment for primary testicular diffuse large B-cell lymphoma with rituximab-CHOP, CNS prophylaxis, and contralateral testis irradiation: final results of an international phase II trial.
Vitolo U, Chiappella A, Ferreri AJ, Martelli M, Baldi I, Balzarotti M, Bottelli C, Conconi A, Gomez H, Lopez-Guillermo A, Martinelli G, Merli F, Novero D, Orsucci L, Pavone V, Ricardi U, Storti S, Gospodarowicz MK, Cavalli F, Sarris AH, Zucca E
J Clin Oncol 2011 Jul 10;29(20):2766-72. Epub 2011 Jun 6 doi: 10.1200/JCO.2010.31.4187. PMID: 21646602

Clinical prediction guides

Development and validation of a survival nomogram in patients with primary testicular diffuse large B-cell lymphoma.
Zhi Y, Bao S, Mao J, Chai G, Liu C, Zhu J
J Int Med Res 2023 Sep;51(9):3000605231197052. doi: 10.1177/03000605231197052. PMID: 37676929Free PMC Article
Loss of 5-hydroxymethylcytosine as a Poor Prognostic Factor for Primary Testicular Diffuse Large B-cell Lymphoma.
Shen Y, Wang L, Ou J, Wang B, Cen X
Int J Med Sci 2022;19(2):225-232. Epub 2022 Jan 1 doi: 10.7150/ijms.65517. PMID: 35165508Free PMC Article
Adverse prognostic impact of regulatory T-cells in testicular diffuse large B-cell lymphoma.
Pollari M, Pellinen T, Karjalainen-Lindsberg ML, Kellokumpu-Lehtinen PL, Leivonen SK, Leppä S
Eur J Haematol 2020 Dec;105(6):712-721. Epub 2020 Sep 22 doi: 10.1111/ejh.13484. PMID: 32632935
Primary testicular diffuse large B-cell lymphoma: Case series.
Wang Q, Zheng D, Chai D, Wu S, Wang X, Chen S, Wu L, Cao R, Tao Y
Medicine (Baltimore) 2020 Mar;99(12):e19463. doi: 10.1097/MD.0000000000019463. PMID: 32195944Free PMC Article
Primary testicular diffuse large B-cell lymphoma displays distinct clinical and biological features for treatment failure in rituximab era: a report from the International PTL Consortium.
Deng L, Xu-Monette ZY, Loghavi S, Manyam GC, Xia Y, Visco C, Huh J, Zhang L, Zhai Q, Wang Y, Qiu L, Dybkær K, Chiu A, Perry AM, Zhang S, Tzankov A, Rao H, Abramson J, Sohani AR, Xu M, Hsi ED, Zhu J, Ponzoni M, Wang S, Li L, Zhang M, Ferreri AJ, Parsons BM, Li Y, Piris MA, Medeiros LJ, Young KH
Leukemia 2016 Feb;30(2):361-72. Epub 2013 Aug 26 doi: 10.1038/leu.2015.237. PMID: 26308769

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