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Testicular Diffuse Large B-Cell Lymphoma

MedGen UID:
1693324
Concept ID:
C5206577
Neoplastic Process

Definition

A diffuse large B-cell lymphoma that arises from the testis. It predominantly affects older men. Patients usually present with a unilateral hard painless mass. Bilateral masses have been described in a minority of patients. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTesticular Diffuse Large B-Cell Lymphoma

Professional guidelines

PubMed

Deng L, Xu-Monette ZY, Loghavi S, Manyam GC, Xia Y, Visco C, Huh J, Zhang L, Zhai Q, Wang Y, Qiu L, Dybkær K, Chiu A, Perry AM, Zhang S, Tzankov A, Rao H, Abramson J, Sohani AR, Xu M, Hsi ED, Zhu J, Ponzoni M, Wang S, Li L, Zhang M, Ferreri AJ, Parsons BM, Li Y, Piris MA, Medeiros LJ, Young KH
Leukemia 2016 Feb;30(2):361-72. Epub 2013 Aug 26 doi: 10.1038/leu.2015.237. PMID: 26308769
Zucca E, Gregorini A, Cavalli F
Ther Umsch 2010 Oct;67(10):517-25. doi: 10.1024/0040-5930/a000088. PMID: 20886458

Recent clinical studies

Etiology

Conconi A, Chiappella A, Ferreri AJM, Stathis A, Botto B, Sassone M, Gaidano G, Balzarotti M, Merli F, Tucci A, Vanazzi A, Tani M, Bruna R, Orsucci L, Cabras MG, Celli M, Annibali O, Liberati AM, Zanni M, Ghiggi C, Pisani F, Pinotti G, Dore F, Esposito F, Pirosa MC, Cesaretti M, Bonomini L, Vitolo U, Zucca E
Blood Adv 2024 Mar 26;8(6):1541-1549. doi: 10.1182/bloodadvances.2023011251. PMID: 38181782Free PMC Article
Zhi Y, Bao S, Mao J, Chai G, Liu C, Zhu J
J Int Med Res 2023 Sep;51(9):3000605231197052. doi: 10.1177/03000605231197052. PMID: 37676929Free PMC Article
Ollikainen RK, Kotkaranta PH, Kemppainen J, Teppo HR, Kuitunen H, Pirinen R, Turpeenniemi-Hujanen T, Kuittinen O, Kuusisto MEL
Leuk Lymphoma 2021 Sep;62(9):2151-2160. Epub 2021 Apr 15 doi: 10.1080/10428194.2021.1913150. PMID: 33856274
Kridel R, Telio D, Villa D, Sehn LH, Gerrie AS, Shenkier T, Klasa R, Slack GW, Tan K, Gascoyne RD, Connors JM, Savage KJ
Br J Haematol 2017 Jan;176(2):210-221. Epub 2016 Oct 14 doi: 10.1111/bjh.14392. PMID: 27739058
Vitolo U, Chiappella A, Ferreri AJ, Martelli M, Baldi I, Balzarotti M, Bottelli C, Conconi A, Gomez H, Lopez-Guillermo A, Martinelli G, Merli F, Novero D, Orsucci L, Pavone V, Ricardi U, Storti S, Gospodarowicz MK, Cavalli F, Sarris AH, Zucca E
J Clin Oncol 2011 Jul 10;29(20):2766-72. Epub 2011 Jun 6 doi: 10.1200/JCO.2010.31.4187. PMID: 21646602

Diagnosis

Zhi Y, Bao S, Mao J, Chai G, Liu C, Zhu J
J Int Med Res 2023 Sep;51(9):3000605231197052. doi: 10.1177/03000605231197052. PMID: 37676929Free PMC Article
Sukswai N, Lyapichev K, Khoury JD, Medeiros LJ
Pathology 2020 Jan;52(1):53-67. Epub 2019 Nov 15 doi: 10.1016/j.pathol.2019.08.013. PMID: 31735345
Twa DDW, Mottok A, Savage KJ, Steidl C
Blood Rev 2018 May;32(3):249-255. Epub 2017 Dec 20 doi: 10.1016/j.blre.2017.12.001. PMID: 29289361
Kridel R, Telio D, Villa D, Sehn LH, Gerrie AS, Shenkier T, Klasa R, Slack GW, Tan K, Gascoyne RD, Connors JM, Savage KJ
Br J Haematol 2017 Jan;176(2):210-221. Epub 2016 Oct 14 doi: 10.1111/bjh.14392. PMID: 27739058
Kuper-Hommel MJ, Janssen-Heijnen ML, Vreugdenhil G, Krol AD, Kluin-Nelemans HC, Coebergh JW, van Krieken JH
Leuk Lymphoma 2012 Feb;53(2):242-6. Epub 2011 Sep 19 doi: 10.3109/10428194.2011.607528. PMID: 21787261

Therapy

Conconi A, Chiappella A, Ferreri AJM, Stathis A, Botto B, Sassone M, Gaidano G, Balzarotti M, Merli F, Tucci A, Vanazzi A, Tani M, Bruna R, Orsucci L, Cabras MG, Celli M, Annibali O, Liberati AM, Zanni M, Ghiggi C, Pisani F, Pinotti G, Dore F, Esposito F, Pirosa MC, Cesaretti M, Bonomini L, Vitolo U, Zucca E
Blood Adv 2024 Mar 26;8(6):1541-1549. doi: 10.1182/bloodadvances.2023011251. PMID: 38181782Free PMC Article
Zhi Y, Bao S, Mao J, Chai G, Liu C, Zhu J
J Int Med Res 2023 Sep;51(9):3000605231197052. doi: 10.1177/03000605231197052. PMID: 37676929Free PMC Article
Ho JC, Dabaja BS, Milgrom SA, Smith GL, Reddy JP, Mazloom A, Young KH, Deng L, Medeiros LJ, Dong W, Allen PK, Andraos TY, Fowler NH, Nastoupil LJ, Oki Y, Fayad LE, Turturro F, Neelapu SS, Westin J, Hagemeister FB, Rodriguez MA, Pinnix CC
Leuk Lymphoma 2017 Dec;58(12):2833-2844. Epub 2017 May 9 doi: 10.1080/10428194.2017.1312381. PMID: 28482717Free PMC Article
Kridel R, Telio D, Villa D, Sehn LH, Gerrie AS, Shenkier T, Klasa R, Slack GW, Tan K, Gascoyne RD, Connors JM, Savage KJ
Br J Haematol 2017 Jan;176(2):210-221. Epub 2016 Oct 14 doi: 10.1111/bjh.14392. PMID: 27739058
Vitolo U, Chiappella A, Ferreri AJ, Martelli M, Baldi I, Balzarotti M, Bottelli C, Conconi A, Gomez H, Lopez-Guillermo A, Martinelli G, Merli F, Novero D, Orsucci L, Pavone V, Ricardi U, Storti S, Gospodarowicz MK, Cavalli F, Sarris AH, Zucca E
J Clin Oncol 2011 Jul 10;29(20):2766-72. Epub 2011 Jun 6 doi: 10.1200/JCO.2010.31.4187. PMID: 21646602

Prognosis

Zhi Y, Bao S, Mao J, Chai G, Liu C, Zhu J
J Int Med Res 2023 Sep;51(9):3000605231197052. doi: 10.1177/03000605231197052. PMID: 37676929Free PMC Article
Yang S, Chang W, Zhang B, Shang P
J Cancer Res Clin Oncol 2023 Sep;149(12):10269-10278. Epub 2023 Jun 4 doi: 10.1007/s00432-023-04907-8. PMID: 37270733
Ollikainen RK, Kotkaranta PH, Kemppainen J, Teppo HR, Kuitunen H, Pirinen R, Turpeenniemi-Hujanen T, Kuittinen O, Kuusisto MEL
Leuk Lymphoma 2021 Sep;62(9):2151-2160. Epub 2021 Apr 15 doi: 10.1080/10428194.2021.1913150. PMID: 33856274
Kridel R, Telio D, Villa D, Sehn LH, Gerrie AS, Shenkier T, Klasa R, Slack GW, Tan K, Gascoyne RD, Connors JM, Savage KJ
Br J Haematol 2017 Jan;176(2):210-221. Epub 2016 Oct 14 doi: 10.1111/bjh.14392. PMID: 27739058
Vitolo U, Chiappella A, Ferreri AJ, Martelli M, Baldi I, Balzarotti M, Bottelli C, Conconi A, Gomez H, Lopez-Guillermo A, Martinelli G, Merli F, Novero D, Orsucci L, Pavone V, Ricardi U, Storti S, Gospodarowicz MK, Cavalli F, Sarris AH, Zucca E
J Clin Oncol 2011 Jul 10;29(20):2766-72. Epub 2011 Jun 6 doi: 10.1200/JCO.2010.31.4187. PMID: 21646602

Clinical prediction guides

Yang S, Chang W, Zhang B, Shang P
J Cancer Res Clin Oncol 2023 Sep;149(12):10269-10278. Epub 2023 Jun 4 doi: 10.1007/s00432-023-04907-8. PMID: 37270733
Shen Y, Wang L, Ou J, Wang B, Cen X
Int J Med Sci 2022;19(2):225-232. Epub 2022 Jan 1 doi: 10.7150/ijms.65517. PMID: 35165508Free PMC Article
Pollari M, Pellinen T, Karjalainen-Lindsberg ML, Kellokumpu-Lehtinen PL, Leivonen SK, Leppä S
Eur J Haematol 2020 Dec;105(6):712-721. Epub 2020 Sep 22 doi: 10.1111/ejh.13484. PMID: 32632935
Wang Q, Zheng D, Chai D, Wu S, Wang X, Chen S, Wu L, Cao R, Tao Y
Medicine (Baltimore) 2020 Mar;99(12):e19463. doi: 10.1097/MD.0000000000019463. PMID: 32195944Free PMC Article
Deng L, Xu-Monette ZY, Loghavi S, Manyam GC, Xia Y, Visco C, Huh J, Zhang L, Zhai Q, Wang Y, Qiu L, Dybkær K, Chiu A, Perry AM, Zhang S, Tzankov A, Rao H, Abramson J, Sohani AR, Xu M, Hsi ED, Zhu J, Ponzoni M, Wang S, Li L, Zhang M, Ferreri AJ, Parsons BM, Li Y, Piris MA, Medeiros LJ, Young KH
Leukemia 2016 Feb;30(2):361-72. Epub 2013 Aug 26 doi: 10.1038/leu.2015.237. PMID: 26308769

Supplemental Content

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