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Metastatic Thymic Neuroendocrine Neoplasm

MedGen UID:
1693423
•Concept ID:
C5206573
•
Neoplastic Process

Definition

A thymic neuroendocrine neoplasm that has spread from its original site of growth to another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Thymic Neuroendocrine Neoplasm

Professional guidelines

PubMed

Lymph Node Involvement and the Surgical Treatment of Thymic Epithelial and Neuroendocrine Carcinoma.
Cheufou DH, Valdivia D, Puhlvers S, Fels B, Weinreich G, Taube C, Theegarten D, Stuschke M, Schuler M, Hegedus B, Stamatis G, Aigner C
Ann Thorac Surg 2019 Jun;107(6):1632-1638. Epub 2019 Feb 2 doi: 10.1016/j.athoracsur.2019.01.006. PMID: 30721691
Diagnosis and treatment of multiple endocrine neoplasia type 1 (MEN1).
Gaztambide S, Vazquez F, Castaño L
Minerva Endocrinol 2013 Mar;38(1):17-28. PMID: 23435440
Treatment of early stage thymic tumors: surgery and radiation therapy.
Gielda BT, Peng R, Coleman JL, Thomas CR, Cameron RB
Curr Treat Options Oncol 2008 Dec;9(4-6):259-68. Epub 2009 Jan 24 doi: 10.1007/s11864-008-0080-2. PMID: 19169830

Recent clinical studies

Etiology

Update on C-Cell Neuroendocrine Neoplasm: Prognostic and Predictive Histopathologic and Molecular Features of Medullary Thyroid Carcinoma.
Jung CK, Agarwal S, Hang JF, Lim DJ, Bychkov A, Mete O
Endocr Pathol 2023 Mar;34(1):1-22. Epub 2023 Mar 8 doi: 10.1007/s12022-023-09753-5. PMID: 36890425
Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Radiological features and metastatic patterns of thymic neuroendocrine tumours.
Araki T, Sholl LM, Hatabu H, Nishino M
Clin Radiol 2018 May;73(5):479-484. Epub 2018 Jan 6 doi: 10.1016/j.crad.2017.11.025. PMID: 29310810
Bronchial and Thymic Carcinoid Tumors.
Litvak A, Pietanza MC
Hematol Oncol Clin North Am 2016 Feb;30(1):83-102. doi: 10.1016/j.hoc.2015.09.003. PMID: 26614370
Primary and metastatic parathyroid malignancies: a rare or underdiagnosed condition?
Shifrin A, LiVolsi V, Shifrin-Douglas S, Zheng M, Erler B, Matulewicz T, Davis J
J Clin Endocrinol Metab 2015 Mar;100(3):E478-81. Epub 2014 Dec 9 doi: 10.1210/jc.2014-2760. PMID: 25490272

Diagnosis

Update on C-Cell Neuroendocrine Neoplasm: Prognostic and Predictive Histopathologic and Molecular Features of Medullary Thyroid Carcinoma.
Jung CK, Agarwal S, Hang JF, Lim DJ, Bychkov A, Mete O
Endocr Pathol 2023 Mar;34(1):1-22. Epub 2023 Mar 8 doi: 10.1007/s12022-023-09753-5. PMID: 36890425
PRAME Expression in Cancer. A Systematic Immunohistochemical Study of >5800 Epithelial and Nonepithelial Tumors.
Kaczorowski M, Chłopek M, Kruczak A, Ryś J, Lasota J, Miettinen M
Am J Surg Pathol 2022 Nov 1;46(11):1467-1476. Epub 2022 Aug 16 doi: 10.1097/PAS.0000000000001944. PMID: 35973038Free PMC Article
Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Neuroendocrine Tumors of the Thyroid and Their Mimics.
Livolsi VA
Endocr Pathol 2021 Jun;32(2):211-221. Epub 2021 Mar 9 doi: 10.1007/s12022-021-09672-3. PMID: 33687689
Bronchial and Thymic Carcinoid Tumors.
Litvak A, Pietanza MC
Hematol Oncol Clin North Am 2016 Feb;30(1):83-102. doi: 10.1016/j.hoc.2015.09.003. PMID: 26614370

Therapy

Capecitabine and Celecoxib as a Promising Therapy for Thymic Neoplasms.
Wood K, Byron E, Janisch L, Salgia R, Sharma MR
Am J Clin Oncol 2018 Oct;41(10):963-966. doi: 10.1097/COC.0000000000000400. PMID: 28654574Free PMC Article
Chemotherapy in NETs: When and how.
Angelousi A, Kaltsas G, Koumarianou A, Weickert MO, Grossman A
Rev Endocr Metab Disord 2017 Dec;18(4):485-497. doi: 10.1007/s11154-017-9432-1. PMID: 28890993
Bronchial and Thymic Carcinoid Tumors.
Litvak A, Pietanza MC
Hematol Oncol Clin North Am 2016 Feb;30(1):83-102. doi: 10.1016/j.hoc.2015.09.003. PMID: 26614370
Treatment of early stage thymic tumors: surgery and radiation therapy.
Gielda BT, Peng R, Coleman JL, Thomas CR, Cameron RB
Curr Treat Options Oncol 2008 Dec;9(4-6):259-68. Epub 2009 Jan 24 doi: 10.1007/s11864-008-0080-2. PMID: 19169830
Carcinoid tumor.
Kinova S, Duris I
Bratisl Lek Listy 2001;102(11):495-504. PMID: 11901706

Prognosis

Update on C-Cell Neuroendocrine Neoplasm: Prognostic and Predictive Histopathologic and Molecular Features of Medullary Thyroid Carcinoma.
Jung CK, Agarwal S, Hang JF, Lim DJ, Bychkov A, Mete O
Endocr Pathol 2023 Mar;34(1):1-22. Epub 2023 Mar 8 doi: 10.1007/s12022-023-09753-5. PMID: 36890425
Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Ocular metastases from neuroendocrine tumors: A literature review.
La Salvia A, Persano I, Trevisi E, Parlagreco E, Muratori L, Scagliotti GV, Brizzi MP
Semin Oncol 2020 Apr-Jun;47(2-3):144-147. Epub 2020 May 6 doi: 10.1053/j.seminoncol.2020.04.003. PMID: 32402472
Chemotherapy in NETs: When and how.
Angelousi A, Kaltsas G, Koumarianou A, Weickert MO, Grossman A
Rev Endocr Metab Disord 2017 Dec;18(4):485-497. doi: 10.1007/s11154-017-9432-1. PMID: 28890993
Bronchial and Thymic Carcinoid Tumors.
Litvak A, Pietanza MC
Hematol Oncol Clin North Am 2016 Feb;30(1):83-102. doi: 10.1016/j.hoc.2015.09.003. PMID: 26614370

Clinical prediction guides

Update on C-Cell Neuroendocrine Neoplasm: Prognostic and Predictive Histopathologic and Molecular Features of Medullary Thyroid Carcinoma.
Jung CK, Agarwal S, Hang JF, Lim DJ, Bychkov A, Mete O
Endocr Pathol 2023 Mar;34(1):1-22. Epub 2023 Mar 8 doi: 10.1007/s12022-023-09753-5. PMID: 36890425
PCSK2 expression in neuroendocrine tumors points to a midgut, pulmonary, or pheochromocytoma-paraganglioma origin.
Remes SM, Leijon H, Vesterinen T, Louhimo J, Pulkkinen V, Ezer S, Kere J, Haglund C, Arola J
APMIS 2020 Nov;128(11):563-572. Epub 2020 Sep 28 doi: 10.1111/apm.13071. PMID: 32794589Free PMC Article
The prognosis and management of neuroendocrine neoplasms-related metastatic bone disease: lessons from clinical practice.
Alexandraki KI, Pizanias M, Uri I, Thomas D, Page T, Kolomodi D, Low CS, Adesanya O, Tsoli M, Gross DJ, Randeva H, Srirajaskanthan R, Grozinsky-Glasberg S, Kaltsas G, Weickert MO
Endocrine 2019 Jun;64(3):690-701. Epub 2019 Jan 11 doi: 10.1007/s12020-019-01838-8. PMID: 30635793
Primary lesions that may imitate metastatic tumors histologically: A selective review.
Wick MR
Semin Diagn Pathol 2018 Mar;35(2):123-142. Epub 2017 Nov 17 doi: 10.1053/j.semdp.2017.11.010. PMID: 29174934
Thymic neuroendocrine tumors: a SEER database analysis of 160 patients.
Gaur P, Leary C, Yao JC
Ann Surg 2010 Jun;251(6):1117-21. doi: 10.1097/SLA.0b013e3181dd4ec4. PMID: 20485130

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