U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Resectable Osteosarcoma

MedGen UID:
1693492
•Concept ID:
C5206724
•
Neoplastic Process

Definition

Osteosarcoma that is amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVResectable Osteosarcoma

Professional guidelines

PubMed

Orphan drugs revisited: cost-effectiveness analysis of the addition of mifamurtide to the conventional treatment of osteosarcoma.
Brosa M, García del Muro X, Mora J, Villacampa A, Pozo-Rubio T, Cubells L, Montoto C
Expert Rev Pharmacoecon Outcomes Res 2015 Apr;15(2):331-40. Epub 2014 Oct 29 doi: 10.1586/14737167.2015.972378. PMID: 25354299
Mifamurtide: a review of its use in the treatment of osteosarcoma.
Frampton JE
Paediatr Drugs 2010 Jun;12(3):141-53. doi: 10.2165/11204910-000000000-00000. PMID: 20481644
Intra-arterial infusion of radiosensitizer (BUdR) combined with hypofractionated irradiation and chemotherapy for primary treatment of osteogenic sarcoma.
Martinez A, Goffinet DR, Donaldson SS, Bagshaw MA, Kaplan HS
Int J Radiat Oncol Biol Phys 1985 Jan;11(1):123-8. doi: 10.1016/0360-3016(85)90370-0. PMID: 3855408

Recent clinical studies

Etiology

A longitudinal evaluation on 3-year change of anxiety and depression, and their risk factors among parents of childhood and adolescence patients with resectable osteosarcoma: A cohort study.
Meng J, Wu J, Zhang X, Guo L, Li H
Medicine (Baltimore) 2022 Oct 21;101(42):e30981. doi: 10.1097/MD.0000000000030981. PMID: 36281181Free PMC Article
The addition of the immunomodulator mifamurtide to adjuvant chemotherapy for early osteosarcoma: a retrospective analysis.
Kokkali S, Kotsantis I, Magou E, Sophia T, Kormas T, Diakoumis G, Spathas N, Psyrri A, Ardavanis A
Invest New Drugs 2022 Jun;40(3):668-675. Epub 2022 Mar 21 doi: 10.1007/s10637-022-01225-7. PMID: 35312944
Disease progression in osteosarcoma: a multistate model for the EURAMOS-1 (European and American Osteosarcoma Study) randomised clinical trial.
Hazewinkel AD, Lancia C, Anninga J, van de Sande M, Whelan J, Gelderblom H, Fiocco M
BMJ Open 2022 Mar 4;12(3):e053083. doi: 10.1136/bmjopen-2021-053083. PMID: 35246418Free PMC Article
EURAMOS-1, an international randomised study for osteosarcoma: results from pre-randomisation treatment.
Whelan JS, Bielack SS, Marina N, Smeland S, Jovic G, Hook JM, Krailo M, Anninga J, Butterfass-Bahloul T, Böhling T, Calaminus G, Capra M, Deffenbaugh C, Dhooge C, Eriksson M, Flanagan AM, Gelderblom H, Goorin A, Gorlick R, Gosheger G, Grimer RJ, Hall KS, Helmke K, Hogendoorn PC, Jundt G, Kager L, Kuehne T, Lau CC, Letson GD, Meyer J, Meyers PA, Morris C, Mottl H, Nadel H, Nagarajan R, Randall RL, Schomberg P, Schwarz R, Teot LA, Sydes MR, Bernstein M; EURAMOS collaborators
Ann Oncol 2015 Feb;26(2):407-14. Epub 2014 Nov 24 doi: 10.1093/annonc/mdu526. PMID: 25421877Free PMC Article
Prediction of tumour necrosis fractions using metabolic and volumetric 18F-FDG PET/CT indices, after one course and at the completion of neoadjuvant chemotherapy, in children and young adults with osteosarcoma.
Im HJ, Kim TS, Park SY, Min HS, Kim JH, Kang HG, Park SE, Kwon MM, Yoon JH, Park HJ, Kim SK, Park BK
Eur J Nucl Med Mol Imaging 2012 Jan;39(1):39-49. Epub 2011 Sep 28 doi: 10.1007/s00259-011-1936-4. PMID: 21953008

Diagnosis

The addition of the immunomodulator mifamurtide to adjuvant chemotherapy for early osteosarcoma: a retrospective analysis.
Kokkali S, Kotsantis I, Magou E, Sophia T, Kormas T, Diakoumis G, Spathas N, Psyrri A, Ardavanis A
Invest New Drugs 2022 Jun;40(3):668-675. Epub 2022 Mar 21 doi: 10.1007/s10637-022-01225-7. PMID: 35312944
Addition of Zoledronate to Chemotherapy in Patients with Osteosarcoma Treated with Limb-Sparing Surgery: A Phase III Clinical Trial.
Li S, Chen P, Pei Y, Zheng K, Wang W, Qiu E, Zhang X
Med Sci Monit 2019 Feb 23;25:1429-1438. doi: 10.12659/MSM.913236. PMID: 30796194Free PMC Article
Prediction of tumour necrosis fractions using metabolic and volumetric 18F-FDG PET/CT indices, after one course and at the completion of neoadjuvant chemotherapy, in children and young adults with osteosarcoma.
Im HJ, Kim TS, Park SY, Min HS, Kim JH, Kang HG, Park SE, Kwon MM, Yoon JH, Park HJ, Kim SK, Park BK
Eur J Nucl Med Mol Imaging 2012 Jan;39(1):39-49. Epub 2011 Sep 28 doi: 10.1007/s00259-011-1936-4. PMID: 21953008
Mifamurtide: a review of its use in the treatment of osteosarcoma.
Frampton JE
Paediatr Drugs 2010 Jun;12(3):141-53. doi: 10.2165/11204910-000000000-00000. PMID: 20481644
Therapy for osteosarcoma: where do we go from here?
Chou AJ, Geller DS, Gorlick R
Paediatr Drugs 2008;10(5):315-27. doi: 10.2165/00148581-200810050-00005. PMID: 18754698

Therapy

Disease progression in osteosarcoma: a multistate model for the EURAMOS-1 (European and American Osteosarcoma Study) randomised clinical trial.
Hazewinkel AD, Lancia C, Anninga J, van de Sande M, Whelan J, Gelderblom H, Fiocco M
BMJ Open 2022 Mar 4;12(3):e053083. doi: 10.1136/bmjopen-2021-053083. PMID: 35246418Free PMC Article
EURAMOS-1, an international randomised study for osteosarcoma: results from pre-randomisation treatment.
Whelan JS, Bielack SS, Marina N, Smeland S, Jovic G, Hook JM, Krailo M, Anninga J, Butterfass-Bahloul T, Böhling T, Calaminus G, Capra M, Deffenbaugh C, Dhooge C, Eriksson M, Flanagan AM, Gelderblom H, Goorin A, Gorlick R, Gosheger G, Grimer RJ, Hall KS, Helmke K, Hogendoorn PC, Jundt G, Kager L, Kuehne T, Lau CC, Letson GD, Meyer J, Meyers PA, Morris C, Mottl H, Nadel H, Nagarajan R, Randall RL, Schomberg P, Schwarz R, Teot LA, Sydes MR, Bernstein M; EURAMOS collaborators
Ann Oncol 2015 Feb;26(2):407-14. Epub 2014 Nov 24 doi: 10.1093/annonc/mdu526. PMID: 25421877Free PMC Article
Mifamurtide: a review of its use in the treatment of osteosarcoma.
Frampton JE
Paediatr Drugs 2010 Jun;12(3):141-53. doi: 10.2165/11204910-000000000-00000. PMID: 20481644
Non-randomized therapy trial to determine the safety and efficacy of heavy ion radiotherapy in patients with non-resectable osteosarcoma.
Blattmann C, Oertel S, Schulz-Ertner D, Rieken S, Haufe S, Ewerbeck V, Unterberg A, Karapanagiotou-Schenkel I, Combs SE, Nikoghosyan A, Bischof M, Jäkel O, Huber P, Kulozik AE, Debus J
BMC Cancer 2010 Mar 12;10:96. doi: 10.1186/1471-2407-10-96. PMID: 20226028Free PMC Article
Therapy for osteosarcoma: where do we go from here?
Chou AJ, Geller DS, Gorlick R
Paediatr Drugs 2008;10(5):315-27. doi: 10.2165/00148581-200810050-00005. PMID: 18754698

Prognosis

Disease progression in osteosarcoma: a multistate model for the EURAMOS-1 (European and American Osteosarcoma Study) randomised clinical trial.
Hazewinkel AD, Lancia C, Anninga J, van de Sande M, Whelan J, Gelderblom H, Fiocco M
BMJ Open 2022 Mar 4;12(3):e053083. doi: 10.1136/bmjopen-2021-053083. PMID: 35246418Free PMC Article
Addition of Zoledronate to Chemotherapy in Patients with Osteosarcoma Treated with Limb-Sparing Surgery: A Phase III Clinical Trial.
Li S, Chen P, Pei Y, Zheng K, Wang W, Qiu E, Zhang X
Med Sci Monit 2019 Feb 23;25:1429-1438. doi: 10.12659/MSM.913236. PMID: 30796194Free PMC Article
Prediction of tumour necrosis fractions using metabolic and volumetric 18F-FDG PET/CT indices, after one course and at the completion of neoadjuvant chemotherapy, in children and young adults with osteosarcoma.
Im HJ, Kim TS, Park SY, Min HS, Kim JH, Kang HG, Park SE, Kwon MM, Yoon JH, Park HJ, Kim SK, Park BK
Eur J Nucl Med Mol Imaging 2012 Jan;39(1):39-49. Epub 2011 Sep 28 doi: 10.1007/s00259-011-1936-4. PMID: 21953008
Interferon-α/β receptor as a prognostic marker in osteosarcoma.
Kubo T, Shimose S, Matsuo T, Fujimori J, Arihiro K, Ochi M
J Bone Joint Surg Am 2011 Mar 16;93(6):519-26. doi: 10.2106/JBJS.J.00198. PMID: 21411701
Therapy for osteosarcoma: where do we go from here?
Chou AJ, Geller DS, Gorlick R
Paediatr Drugs 2008;10(5):315-27. doi: 10.2165/00148581-200810050-00005. PMID: 18754698

Clinical prediction guides

A longitudinal evaluation on 3-year change of anxiety and depression, and their risk factors among parents of childhood and adolescence patients with resectable osteosarcoma: A cohort study.
Meng J, Wu J, Zhang X, Guo L, Li H
Medicine (Baltimore) 2022 Oct 21;101(42):e30981. doi: 10.1097/MD.0000000000030981. PMID: 36281181Free PMC Article
Disease progression in osteosarcoma: a multistate model for the EURAMOS-1 (European and American Osteosarcoma Study) randomised clinical trial.
Hazewinkel AD, Lancia C, Anninga J, van de Sande M, Whelan J, Gelderblom H, Fiocco M
BMJ Open 2022 Mar 4;12(3):e053083. doi: 10.1136/bmjopen-2021-053083. PMID: 35246418Free PMC Article
Orphan drugs revisited: cost-effectiveness analysis of the addition of mifamurtide to the conventional treatment of osteosarcoma.
Brosa M, García del Muro X, Mora J, Villacampa A, Pozo-Rubio T, Cubells L, Montoto C
Expert Rev Pharmacoecon Outcomes Res 2015 Apr;15(2):331-40. Epub 2014 Oct 29 doi: 10.1586/14737167.2015.972378. PMID: 25354299
Prediction of tumour necrosis fractions using metabolic and volumetric 18F-FDG PET/CT indices, after one course and at the completion of neoadjuvant chemotherapy, in children and young adults with osteosarcoma.
Im HJ, Kim TS, Park SY, Min HS, Kim JH, Kang HG, Park SE, Kwon MM, Yoon JH, Park HJ, Kim SK, Park BK
Eur J Nucl Med Mol Imaging 2012 Jan;39(1):39-49. Epub 2011 Sep 28 doi: 10.1007/s00259-011-1936-4. PMID: 21953008
Interferon-α/β receptor as a prognostic marker in osteosarcoma.
Kubo T, Shimose S, Matsuo T, Fujimori J, Arihiro K, Ochi M
J Bone Joint Surg Am 2011 Mar 16;93(6):519-26. doi: 10.2106/JBJS.J.00198. PMID: 21411701

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...