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Pigmented Epithelioid Melanocytoma

MedGen UID:
1693568
Concept ID:
C5230531
Neoplastic Process
Synonyms: Epithelioid Blue Nevus; Pigmented epithelioid melanocytoma
SNOMED CT: Pigmented epithelioid melanocytoma (789445008)

Definition

A cutaneous melanocytic neoplasm composed of heavily pigmented epithelioid and dendritic cells, with metastatic potential limited to regional lymph nodes. It can occur as a sporadic lesion or in patients with Carney complex. (WHO 2018) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPigmented Epithelioid Melanocytoma

Professional guidelines

PubMed

de la Fouchardiere A, Blokx W, van Kempen LC, Luzar B, Piperno-Neumann S, Puig S, Alos L, Calonje E, Massi D; ESP Dermatopathology Working Group; EORTC Melanoma Group; EURACAN
Virchows Arch 2021 Jul;479(1):3-11. Epub 2021 Jan 12 doi: 10.1007/s00428-020-03005-1. PMID: 33432480
Aung PP, Mutyambizi KK, Danialan R, Ivan D, Prieto VG
J Clin Pathol 2015 Dec;68(12):963-70. doi: 10.1136/jclinpath-2015-202887. PMID: 26602414

Recent clinical studies

Etiology

de la Fouchardiere A, Tirode F, Castillo C, Buisson A, Boivin F, Macagno N, Pissaloux D
Am J Surg Pathol 2022 Aug 1;46(8):1106-1115. Epub 2022 Mar 22 doi: 10.1097/PAS.0000000000001888. PMID: 35319526
Benton S, Zhao J, Asadbeigi S, Kim D, Zhang B, Gerami P
Surg Pathol Clin 2021 Jun;14(2):285-292. Epub 2021 Apr 28 doi: 10.1016/j.path.2021.01.004. PMID: 34023106
Isales MC, Mohan LS, Quan VL, Garfield EM, Zhang B, Shi K, Arva N, Beaubier N, Yazdan P, White K, Taxter TJ, Gerami P
Am J Surg Pathol 2019 Apr;43(4):480-488. doi: 10.1097/PAS.0000000000001195. PMID: 30475255
Bax MJ, Brown MD, Rothberg PG, Laughlin TS, Scott GA
J Am Acad Dermatol 2017 Aug;77(2):328-332. Epub 2017 Apr 14 doi: 10.1016/j.jaad.2017.01.029. PMID: 28416343
Vyas R, Keller JJ, Honda K, Cooper KD, Gerstenblith MR
J Am Acad Dermatol 2015 Dec;73(6):1031-9. Epub 2015 Sep 26 doi: 10.1016/j.jaad.2015.08.016. PMID: 26412164

Diagnosis

Benton S, Zhao J, Asadbeigi S, Kim D, Zhang B, Gerami P
Surg Pathol Clin 2021 Jun;14(2):285-292. Epub 2021 Apr 28 doi: 10.1016/j.path.2021.01.004. PMID: 34023106
Quan VL, Panah E, Zhang B, Shi K, Mohan LS, Gerami P
J Cutan Pathol 2019 Nov;46(11):878-887. Epub 2019 Jun 20 doi: 10.1111/cup.13521. PMID: 31152596
Cabrera R, Recule F
Am J Clin Dermatol 2018 Nov;19(Suppl 1):15-23. doi: 10.1007/s40257-018-0373-6. PMID: 30374898Free PMC Article
Bax MJ, Brown MD, Rothberg PG, Laughlin TS, Scott GA
J Am Acad Dermatol 2017 Aug;77(2):328-332. Epub 2017 Apr 14 doi: 10.1016/j.jaad.2017.01.029. PMID: 28416343
Aung PP, Mutyambizi KK, Danialan R, Ivan D, Prieto VG
J Clin Pathol 2015 Dec;68(12):963-70. doi: 10.1136/jclinpath-2015-202887. PMID: 26602414

Therapy

Yazdan P, Haghighat Z, Guitart J, Gerami P
Am J Surg Pathol 2013 Jan;37(1):81-8. doi: 10.1097/PAS.0b013e3182608fa5. PMID: 22892599
Vezzoni GM, Martini L, Ricci C
Dermatol Surg 2008 Jan;34(1):105-9; discussion 110. Epub 2007 Dec 5 doi: 10.1111/j.1524-4725.2007.34023.x. PMID: 18053035

Prognosis

Zaaroura H, Cyrenne B, Somers GR, Wong KW, Davidge KM, Propst EJ, Kulkarni AV, Lo W, Villani A, Lara-Corrales I, Levy R
Dermatol Online J 2023 Oct 15;29(5) doi: 10.5070/D329562403. PMID: 38478639
Isales MC, Mohan LS, Quan VL, Garfield EM, Zhang B, Shi K, Arva N, Beaubier N, Yazdan P, White K, Taxter TJ, Gerami P
Am J Surg Pathol 2019 Apr;43(4):480-488. doi: 10.1097/PAS.0000000000001195. PMID: 30475255
Cabrera R, Recule F
Am J Clin Dermatol 2018 Nov;19(Suppl 1):15-23. doi: 10.1007/s40257-018-0373-6. PMID: 30374898Free PMC Article
Bax MJ, Brown MD, Rothberg PG, Laughlin TS, Scott GA
J Am Acad Dermatol 2017 Aug;77(2):328-332. Epub 2017 Apr 14 doi: 10.1016/j.jaad.2017.01.029. PMID: 28416343
Vyas R, Keller JJ, Honda K, Cooper KD, Gerstenblith MR
J Am Acad Dermatol 2015 Dec;73(6):1031-9. Epub 2015 Sep 26 doi: 10.1016/j.jaad.2015.08.016. PMID: 26412164

Clinical prediction guides

de la Fouchardiere A, Tirode F, Castillo C, Buisson A, Boivin F, Macagno N, Pissaloux D
Am J Surg Pathol 2022 Aug 1;46(8):1106-1115. Epub 2022 Mar 22 doi: 10.1097/PAS.0000000000001888. PMID: 35319526
Goto K, Pissaloux D, Paindavoine S, Tirode F, de la Fouchardière A
Am J Surg Pathol 2019 Oct;43(10):1368-1376. doi: 10.1097/PAS.0000000000001299. PMID: 31162285
Cheung WL, Smoller BR
Dermatol Clin 2012 Oct;30(4):617-22, vi. Epub 2012 Aug 3 doi: 10.1016/j.det.2012.06.014. PMID: 23021049
Mandal RV, Murali R, Lundquist KF, Ragsdale BD, Heenan P, McCarthy SW, Mihm MC Jr, Scolyer RA, Zembowicz A
Am J Surg Pathol 2009 Dec;33(12):1778-82. doi: 10.1097/PAS.0b013e3181b94f3c. PMID: 19773637
Zembowicz A, Carney JA, Mihm MC
Am J Surg Pathol 2004 Jan;28(1):31-40. doi: 10.1097/00000478-200401000-00002. PMID: 14707861

Recent systematic reviews

Pampena R, Lai M, Lombardi M, Mirra M, Raucci M, Lallas A, Apalla Z, Argenziano G, Pellacani G, Longo C
JAMA Dermatol 2020 Apr 1;156(4):430-439. doi: 10.1001/jamadermatol.2019.4912. PMID: 32101255
Vyas R, Keller JJ, Honda K, Cooper KD, Gerstenblith MR
J Am Acad Dermatol 2015 Dec;73(6):1031-9. Epub 2015 Sep 26 doi: 10.1016/j.jaad.2015.08.016. PMID: 26412164

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