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Metastatic Biliary Tract Carcinoma

MedGen UID:
1693737
•Concept ID:
C5203125
•
Neoplastic Process

Definition

A biliary tract carcinoma that has spread from the original site of growth to other anatomic sites. [from NCI]

Professional guidelines

PubMed

Advances in the treatment of intrahepatic cholangiocarcinoma: An overview of the current and future therapeutic landscape for clinicians.
Moris D, Palta M, Kim C, Allen PJ, Morse MA, Lidsky ME
CA Cancer J Clin 2023 Mar;73(2):198-222. Epub 2022 Oct 19 doi: 10.3322/caac.21759. PMID: 36260350
Practical review for diagnosis and clinical management of perihilar cholangiocarcinoma.
Dondossola D, Ghidini M, Grossi F, Rossi G, Foschi D
World J Gastroenterol 2020 Jul 7;26(25):3542-3561. doi: 10.3748/wjg.v26.i25.3542. PMID: 32742125Free PMC Article
ACG clinical guideline: the diagnosis and management of focal liver lesions.
Marrero JA, Ahn J, Rajender Reddy K; Americal College of Gastroenterology
Am J Gastroenterol 2014 Sep;109(9):1328-47; quiz 1348. Epub 2014 Aug 19 doi: 10.1038/ajg.2014.213. PMID: 25135008

Recent clinical studies

Etiology

First Line Gemcitabine/Pazopanib in Locally Advanced and/or Metastatic Biliary Tract Carcinoma. A Hellenic Cooperative Oncology Group Phase II Study.
Sgouros J, Aravantinos G, Koliou GA, Pentheroudakis G, Zagouri F, Psyrri A, Lampropoulou DI, Demiri S, Pectasides D, Razis E, Fountzilas G, Samantas E
Anticancer Res 2020 Feb;40(2):929-938. doi: 10.21873/anticanres.14026. PMID: 32014937
Metastasectomy for recurrent or metastatic biliary tract cancers: A single center experience.
Park I, Kim YS, Sym SJ, Ahn HK, Kim KK, Park YH, Lee JN, Shin DB
Indian J Cancer 2017 Jan-Mar;54(1):57-62. doi: 10.4103/0019-509X.219581. PMID: 29199665
Gemcitabine and oxaliplatin combination chemotherapy in advanced biliary tract cancers.
Verderame F, Russo A, Di Leo R, Badalamenti G, Santangelo D, Cicero G, Valerio MR, Gulotta G, Tomasello G, Gebbia N, Fulfaro F
Ann Oncol 2006 Jun;17 Suppl 7:vii68-72. doi: 10.1093/annonc/mdl955. PMID: 16760298
Capecitabine combined with gemcitabine (CapGem) as first-line treatment in patients with advanced/metastatic biliary tract carcinoma.
Cho JY, Paik YH, Chang YS, Lee SJ, Lee DK, Song SY, Chung JB, Park MS, Yu JS, Yoon DS
Cancer 2005 Dec 15;104(12):2753-8. doi: 10.1002/cncr.21591. PMID: 16294346
A randomised phase II trial of weekly high-dose 5-fluorouracil with and without folinic acid and cisplatin in patients with advanced biliary tract carcinoma: results of the 40955 EORTC trial.
Ducreux M, Van Cutsem E, Van Laethem JL, Gress TM, Jeziorski K, Rougier P, Wagener T, Anak O, Baron B, Nordlinger B; EORTC Gastro Intestinal Tract Cancer Group
Eur J Cancer 2005 Feb;41(3):398-403. doi: 10.1016/j.ejca.2004.10.026. PMID: 15691639

Diagnosis

Metastasectomy for recurrent or metastatic biliary tract cancers: A single center experience.
Park I, Kim YS, Sym SJ, Ahn HK, Kim KK, Park YH, Lee JN, Shin DB
Indian J Cancer 2017 Jan-Mar;54(1):57-62. doi: 10.4103/0019-509X.219581. PMID: 29199665
Phase II trial of oxaliplatin combined with leucovorin and fluorouracil for recurrent/metastatic biliary tract carcinoma.
Lim JY, Jeung HC, Mun HS, Lee DK, Paik YH, Lee SJ, Yoon DS, Cho JY
Anticancer Drugs 2008 Jul;19(6):631-5. doi: 10.1097/CAD.0b013e3283017f94. PMID: 18525323
Gemcitabine and oxaliplatin combination chemotherapy in advanced biliary tract cancers.
Verderame F, Russo A, Di Leo R, Badalamenti G, Santangelo D, Cicero G, Valerio MR, Gulotta G, Tomasello G, Gebbia N, Fulfaro F
Ann Oncol 2006 Jun;17 Suppl 7:vii68-72. doi: 10.1093/annonc/mdl955. PMID: 16760298

Therapy

First Line Gemcitabine/Pazopanib in Locally Advanced and/or Metastatic Biliary Tract Carcinoma. A Hellenic Cooperative Oncology Group Phase II Study.
Sgouros J, Aravantinos G, Koliou GA, Pentheroudakis G, Zagouri F, Psyrri A, Lampropoulou DI, Demiri S, Pectasides D, Razis E, Fountzilas G, Samantas E
Anticancer Res 2020 Feb;40(2):929-938. doi: 10.21873/anticanres.14026. PMID: 32014937
Fluoropyrimidines plus cisplatin versus gemcitabine/gemcitabine plus cisplatin in locally advanced and metastatic biliary tract carcinoma - a retrospective study.
Croitoru A, Gramaticu I, Dinu I, Gheorghe L, Alexandrescu S, Buica F, Luca I, Becheanu G, Herlea V, Simionov I, Hrehoret D, Lupescu I, Popescu I, Diculescu M
J Gastrointestin Liver Dis 2012 Sep;21(3):277-84. PMID: 23012669
Phase II trial of oxaliplatin combined with leucovorin and fluorouracil for recurrent/metastatic biliary tract carcinoma.
Lim JY, Jeung HC, Mun HS, Lee DK, Paik YH, Lee SJ, Yoon DS, Cho JY
Anticancer Drugs 2008 Jul;19(6):631-5. doi: 10.1097/CAD.0b013e3283017f94. PMID: 18525323
Gemcitabine and oxaliplatin combination chemotherapy in advanced biliary tract cancers.
Verderame F, Russo A, Di Leo R, Badalamenti G, Santangelo D, Cicero G, Valerio MR, Gulotta G, Tomasello G, Gebbia N, Fulfaro F
Ann Oncol 2006 Jun;17 Suppl 7:vii68-72. doi: 10.1093/annonc/mdl955. PMID: 16760298
First-line chemotherapy with docetaxel for unresectable or metastatic carcinoma of the biliary tract. A multicentre phase II study.
Papakostas P, Kouroussis C, Androulakis N, Samelis G, Aravantinos G, Kalbakis K, Sarra E, Souglakos J, Kakolyris S, Georgoulias V
Eur J Cancer 2001 Oct;37(15):1833-8. doi: 10.1016/s0959-8049(01)00214-3. PMID: 11576836

Prognosis

Metastasectomy for recurrent or metastatic biliary tract cancers: A single center experience.
Park I, Kim YS, Sym SJ, Ahn HK, Kim KK, Park YH, Lee JN, Shin DB
Indian J Cancer 2017 Jan-Mar;54(1):57-62. doi: 10.4103/0019-509X.219581. PMID: 29199665
Gemcitabine and oxaliplatin combination chemotherapy in advanced biliary tract cancers.
Verderame F, Russo A, Di Leo R, Badalamenti G, Santangelo D, Cicero G, Valerio MR, Gulotta G, Tomasello G, Gebbia N, Fulfaro F
Ann Oncol 2006 Jun;17 Suppl 7:vii68-72. doi: 10.1093/annonc/mdl955. PMID: 16760298
Capecitabine combined with gemcitabine (CapGem) as first-line treatment in patients with advanced/metastatic biliary tract carcinoma.
Cho JY, Paik YH, Chang YS, Lee SJ, Lee DK, Song SY, Chung JB, Park MS, Yu JS, Yoon DS
Cancer 2005 Dec 15;104(12):2753-8. doi: 10.1002/cncr.21591. PMID: 16294346
First-line chemotherapy with docetaxel for unresectable or metastatic carcinoma of the biliary tract. A multicentre phase II study.
Papakostas P, Kouroussis C, Androulakis N, Samelis G, Aravantinos G, Kalbakis K, Sarra E, Souglakos J, Kakolyris S, Georgoulias V
Eur J Cancer 2001 Oct;37(15):1833-8. doi: 10.1016/s0959-8049(01)00214-3. PMID: 11576836
Effective treatment of advanced biliary tract carcinoma using 5-fluorouracil continuous infusion with cisplatin.
Ducreux M, Rougier P, Fandi A, Clavero-Fabri MC, Villing AL, Fassone F, Fandi L, Zarba J, Armand JP
Ann Oncol 1998 Jun;9(6):653-6. doi: 10.1023/a:1008241008379. PMID: 9681080

Clinical prediction guides

Phase II trial of oxaliplatin combined with leucovorin and fluorouracil for recurrent/metastatic biliary tract carcinoma.
Lim JY, Jeung HC, Mun HS, Lee DK, Paik YH, Lee SJ, Yoon DS, Cho JY
Anticancer Drugs 2008 Jul;19(6):631-5. doi: 10.1097/CAD.0b013e3283017f94. PMID: 18525323
Gemcitabine and oxaliplatin combination chemotherapy in advanced biliary tract cancers.
Verderame F, Russo A, Di Leo R, Badalamenti G, Santangelo D, Cicero G, Valerio MR, Gulotta G, Tomasello G, Gebbia N, Fulfaro F
Ann Oncol 2006 Jun;17 Suppl 7:vii68-72. doi: 10.1093/annonc/mdl955. PMID: 16760298
A randomised phase II trial of weekly high-dose 5-fluorouracil with and without folinic acid and cisplatin in patients with advanced biliary tract carcinoma: results of the 40955 EORTC trial.
Ducreux M, Van Cutsem E, Van Laethem JL, Gress TM, Jeziorski K, Rougier P, Wagener T, Anak O, Baron B, Nordlinger B; EORTC Gastro Intestinal Tract Cancer Group
Eur J Cancer 2005 Feb;41(3):398-403. doi: 10.1016/j.ejca.2004.10.026. PMID: 15691639
First-line chemotherapy with docetaxel for unresectable or metastatic carcinoma of the biliary tract. A multicentre phase II study.
Papakostas P, Kouroussis C, Androulakis N, Samelis G, Aravantinos G, Kalbakis K, Sarra E, Souglakos J, Kakolyris S, Georgoulias V
Eur J Cancer 2001 Oct;37(15):1833-8. doi: 10.1016/s0959-8049(01)00214-3. PMID: 11576836
Effective treatment of advanced biliary tract carcinoma using 5-fluorouracil continuous infusion with cisplatin.
Ducreux M, Rougier P, Fandi A, Clavero-Fabri MC, Villing AL, Fassone F, Fandi L, Zarba J, Armand JP
Ann Oncol 1998 Jun;9(6):653-6. doi: 10.1023/a:1008241008379. PMID: 9681080

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