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Serrated intestinal polyps

MedGen UID:
1693793
Concept ID:
C5139207
Disease or Syndrome
Synonym: Serrated polyposis
 
HPO: HP:0032222

Definition

The presence of multiple serrated polyps in the intestine. Unlike conventional adenomas, which are uniformly dysplastic, the vast majority of serrated lesions contain no dysplasia. The serrated class includes the hyperplastic polyps, which are not considered precancerous; sessile serrated polyps (also called sessile serrated adenomas); and traditional serrated adenomas. Sessile serrated polyps are larger on average and more often located in the proximal colon. Sessile serrated polyps have a more irregular surface, a pattern to the surface that has been called cloudlike, and indistinct edges compared with hyperplastic polyps. Sessile serrated polyps also have large open pits on the surface (type O pits) when viewed with magnification. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSerrated intestinal polyps

Conditions with this feature

Sessile serrated polyposis cancer syndrome
MedGen UID:
934681
Concept ID:
C4310714
Neoplastic Process
Sessile serrated polyposis cancer syndrome (SSPCS) is a rare disorder characterized by the presence of multiple serrated polyps in the colon and an increased personal and familial risk of colorectal cancer. SSPCS is defined by the World Health Organization (WHO) as the presence of at least 5 sessile serrated polyps (also known as 'sessile serrated adenomas,' or SSAs) proximal to the sigmoid colon, with 2 or more that are greater than 10 mm in diameter; or any number of serrated polyps in a person with a first-degree relative with SSPCS; or more than 20 serrated polyps of any size, distributed throughout the colon. SSAs are found in 2% of average-risk individuals undergoing their first screening colonoscopy, and are estimated to be responsible for 20 to 35% of all colon cancers. SSAs exhibit somatic mutations in the BRAF gene (164757), or less commonly in the KRAS gene (190070), early in their development. Individuals with SSPCS have a lifetime risk of colon cancer as high as 54% and may have a strong personal or family history of extracolonic cancers; first-degree relatives have a 32% risk of developing multiple serrated polyps and a 5-fold increased risk of colon cancer. An increased risk of pancreatic cancer has also been observed (summary by Gala et al., 2014).

Professional guidelines

PubMed

Sung JJY, Chiu HM, Lieberman D, Kuipers EJ, Rutter MD, Macrae F, Yeoh KG, Ang TL, Chong VH, John S, Li J, Wu K, Ng SSM, Makharia GK, Abdullah M, Kobayashi N, Sekiguchi M, Byeon JS, Kim HS, Parry S, Cabral-Prodigalidad PAI, Wu DC, Khomvilai S, Lui RN, Wong S, Lin YM, Dekker E
Gut 2022 Nov;71(11):2152-2166. Epub 2022 Aug 24 doi: 10.1136/gutjnl-2022-327377. PMID: 36002247
Murakami T, Kurosawa T, Fukushima H, Shibuya T, Yao T, Nagahara A
Dig Endosc 2022 Sep;34(6):1096-1109. Epub 2022 Mar 29 doi: 10.1111/den.14273. PMID: 35352394
Crockett SD, Nagtegaal ID
Gastroenterology 2019 Oct;157(4):949-966.e4. Epub 2019 Jul 16 doi: 10.1053/j.gastro.2019.06.041. PMID: 31323292

Recent clinical studies

Etiology

Sninsky JA, Shore BM, Lupu GV, Crockett SD
Gastrointest Endosc Clin N Am 2022 Apr;32(2):195-213. Epub 2022 Feb 22 doi: 10.1016/j.giec.2021.12.008. PMID: 35361331
Sullivan BA, Noujaim M, Roper J
Gastrointest Endosc Clin N Am 2022 Apr;32(2):177-194. Epub 2022 Feb 22 doi: 10.1016/j.giec.2021.12.001. PMID: 35361330Free PMC Article
Crockett SD, Nagtegaal ID
Gastroenterology 2019 Oct;157(4):949-966.e4. Epub 2019 Jul 16 doi: 10.1053/j.gastro.2019.06.041. PMID: 31323292
Pai RK, Bettington M, Srivastava A, Rosty C
Mod Pathol 2019 Oct;32(10):1390-1415. Epub 2019 Apr 25 doi: 10.1038/s41379-019-0280-2. PMID: 31028362
Bailie L, Loughrey MB, Coleman HG
Gastroenterology 2017 Jan;152(1):92-104. Epub 2016 Sep 14 doi: 10.1053/j.gastro.2016.09.003. PMID: 27639804

Diagnosis

Dornblaser D, Young S, Shaukat A
Curr Opin Gastroenterol 2024 Jan 1;40(1):14-20. Epub 2023 Nov 1 doi: 10.1097/MOG.0000000000000988. PMID: 37909928
Sninsky JA, Shore BM, Lupu GV, Crockett SD
Gastrointest Endosc Clin N Am 2022 Apr;32(2):195-213. Epub 2022 Feb 22 doi: 10.1016/j.giec.2021.12.008. PMID: 35361331
Murakami T, Kurosawa T, Fukushima H, Shibuya T, Yao T, Nagahara A
Dig Endosc 2022 Sep;34(6):1096-1109. Epub 2022 Mar 29 doi: 10.1111/den.14273. PMID: 35352394
Sano W, Hirata D, Teramoto A, Iwatate M, Hattori S, Fujita M, Sano Y
World J Gastroenterol 2020 May 21;26(19):2276-2285. doi: 10.3748/wjg.v26.i19.2276. PMID: 32476792Free PMC Article
Pai RK, Bettington M, Srivastava A, Rosty C
Mod Pathol 2019 Oct;32(10):1390-1415. Epub 2019 Apr 25 doi: 10.1038/s41379-019-0280-2. PMID: 31028362

Therapy

Sung LB, Coleman HG, Shivappa N, Hébert JR, Murff HJ, Milne GL, Ness RM, Smalley WE, Zheng W, Shrubsole MJ
Nutr Cancer 2023;75(10):1900-1910. Epub 2023 Nov 30 doi: 10.1080/01635581.2023.2261651. PMID: 37791878Free PMC Article
Glissen Brown JR, Mansour NM, Wang P, Chuchuca MA, Minchenberg SB, Chandnani M, Liu L, Gross SA, Sengupta N, Berzin TM
Clin Gastroenterol Hepatol 2022 Jul;20(7):1499-1507.e4. Epub 2021 Sep 14 doi: 10.1016/j.cgh.2021.09.009. PMID: 34530161
Hassan C, Spadaccini M, Iannone A, Maselli R, Jovani M, Chandrasekar VT, Antonelli G, Yu H, Areia M, Dinis-Ribeiro M, Bhandari P, Sharma P, Rex DK, Rösch T, Wallace M, Repici A
Gastrointest Endosc 2021 Jan;93(1):77-85.e6. Epub 2020 Jun 26 doi: 10.1016/j.gie.2020.06.059. PMID: 32598963
Rifkin SB, Giardiello FM, Zhu X, Hylind LM, Ness RM, Drewes JL, Murff HJ, Spence EH, Smalley WE, Gills JJ, Mullin GE, Kafonek D, La Luna L, Zheng W, Sears CL, Shrubsole MJ; Biofilm Study Consortium
Br J Nutr 2020 Jul 14;124(1):80-91. Epub 2020 Feb 20 doi: 10.1017/S0007114520000550. PMID: 32077397Free PMC Article
Bailie L, Loughrey MB, Coleman HG
Gastroenterology 2017 Jan;152(1):92-104. Epub 2016 Sep 14 doi: 10.1053/j.gastro.2016.09.003. PMID: 27639804

Prognosis

Gorji L, Albrecht P
World J Gastroenterol 2023 Feb 28;29(8):1304-1314. doi: 10.3748/wjg.v29.i8.1304. PMID: 36925460Free PMC Article
Sninsky JA, Shore BM, Lupu GV, Crockett SD
Gastrointest Endosc Clin N Am 2022 Apr;32(2):195-213. Epub 2022 Feb 22 doi: 10.1016/j.giec.2021.12.008. PMID: 35361331
Bell PD, Anderson JC, Srivastava A
Am J Surg Pathol 2022 Jan 1;46(1):e64-e70. doi: 10.1097/PAS.0000000000001806. PMID: 34545859
Crockett SD, Nagtegaal ID
Gastroenterology 2019 Oct;157(4):949-966.e4. Epub 2019 Jul 16 doi: 10.1053/j.gastro.2019.06.041. PMID: 31323292
Bettington ML, Chetty R
Hum Pathol 2015 Jul;46(7):933-8. Epub 2015 Apr 20 doi: 10.1016/j.humpath.2015.04.002. PMID: 26001333

Clinical prediction guides

Zhou YJ, Lu XF, Chen H, Wang XY, Cheng W, Zhang QW, Chen JN, Wang XY, Jin JZ, Yan FR, Chen H, Li XB
Cell Mol Gastroenterol Hepatol 2023;15(2):393-424. Epub 2022 Oct 8 doi: 10.1016/j.jcmgh.2022.10.001. PMID: 36216310Free PMC Article
Bell PD, Anderson JC, Srivastava A
Am J Surg Pathol 2022 Jan 1;46(1):e64-e70. doi: 10.1097/PAS.0000000000001806. PMID: 34545859
Rashtak S, Rego R, Sweetser SR, Sinicrope FA
Cancer Prev Res (Phila) 2017 May;10(5):270-278. Epub 2017 Mar 21 doi: 10.1158/1940-6207.CAPR-16-0264. PMID: 28325827
Bailie L, Loughrey MB, Coleman HG
Gastroenterology 2017 Jan;152(1):92-104. Epub 2016 Sep 14 doi: 10.1053/j.gastro.2016.09.003. PMID: 27639804
Bettington ML, Chetty R
Hum Pathol 2015 Jul;46(7):933-8. Epub 2015 Apr 20 doi: 10.1016/j.humpath.2015.04.002. PMID: 26001333

Recent systematic reviews

Abdallah M, Ahmed K, Abbas D, Mohamed MFH, Suryawanshi G, McDonald N, Wilson N, Umar S, Shaukat A, Bilal M
Endoscopy 2023 Dec;55(12):1083-1094. Epub 2023 Jul 14 doi: 10.1055/a-2129-5752. PMID: 37451284
Jung YS, Park JH, Park CH
Clin Gastroenterol Hepatol 2022 Jan;20(1):31-43.e1. Epub 2020 Sep 30 doi: 10.1016/j.cgh.2020.09.051. PMID: 33007512
Hassan C, Spadaccini M, Iannone A, Maselli R, Jovani M, Chandrasekar VT, Antonelli G, Yu H, Areia M, Dinis-Ribeiro M, Bhandari P, Sharma P, Rex DK, Rösch T, Wallace M, Repici A
Gastrointest Endosc 2021 Jan;93(1):77-85.e6. Epub 2020 Jun 26 doi: 10.1016/j.gie.2020.06.059. PMID: 32598963
Bailie L, Loughrey MB, Coleman HG
Gastroenterology 2017 Jan;152(1):92-104. Epub 2016 Sep 14 doi: 10.1053/j.gastro.2016.09.003. PMID: 27639804
Gao Q, Tsoi KK, Hirai HW, Wong MC, Chan FK, Wu JC, Lau JY, Sung JJ, Ng SC
Am J Gastroenterol 2015 Apr;110(4):501-9; quiz 510. Epub 2015 Mar 10 doi: 10.1038/ajg.2015.49. PMID: 25756237

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