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Abnormal circulating transferrin concentration

MedGen UID:
1694121
Concept ID:
C5139308
Finding
Synonym: Abnormal circulating transferrin level
 
HPO: HP:0032385

Definition

Any deviation from the normal concentration of transferrin in the blood circulation. [from HPO]

Conditions with this feature

Hemochromatosis type 5
MedGen UID:
341982
Concept ID:
C1851316
Disease or Syndrome
A rare disorder of iron metabolism and transport characterised by elevated serum ferritin levels, increased serum iron, increased transferrin saturation and heavy iron deposition in hepatocytes. Iron deposition has also been indicated in heart and bone marrow, while haematological examination of peripheral blood shows no abnormalities.

Recent clinical studies

Etiology

Higgins V, Omidi A, Tahmasebi H, Asgari S, Gordanifar K, Nieuwesteeg M, Adeli K
J Clin Endocrinol Metab 2020 Apr 1;105(4):e1781-97. doi: 10.1210/clinem/dgz161. PMID: 31845996Free PMC Article
Pluta D, Franik G, Blukacz Ł, Kowalczyk K, Witkowska A, Wysocka M, Madej P
Eur Rev Med Pharmacol Sci 2018 Nov;22(21):7379-7384. doi: 10.26355/eurrev_201811_16276. PMID: 30468484
Ostrow AM, Freeze H, Rychik J
Ann Thorac Surg 2006 Aug;82(2):695-700. doi: 10.1016/j.athoracsur.2006.02.048. PMID: 16863787
Chaturvedi RR, Shore DF, Lincoln C, Mumby S, Kemp M, Brierly J, Petros A, Gutteridge JM, Hooper J, Redington AN
Circulation 1999 Oct 5;100(14):1540-7. doi: 10.1161/01.cir.100.14.1540. PMID: 10510058
Wanachiwanawin W, Wiener E, Siripanyaphinyo U, Chinprasertsuk S, Mawas F, Fucharoen S, Wickramasinghe SN, Pootrakul P, Visudhiphan S
J Interferon Cytokine Res 1999 Feb;19(2):105-11. doi: 10.1089/107999099314243. PMID: 10090395

Diagnosis

Higgins V, Omidi A, Tahmasebi H, Asgari S, Gordanifar K, Nieuwesteeg M, Adeli K
J Clin Endocrinol Metab 2020 Apr 1;105(4):e1781-97. doi: 10.1210/clinem/dgz161. PMID: 31845996Free PMC Article
Montonen J, Boeing H, Steffen A, Lehmann R, Fritsche A, Joost HG, Schulze MB, Pischon T
Diabetologia 2012 Oct;55(10):2613-2621. Epub 2012 Jul 1 doi: 10.1007/s00125-012-2633-y. PMID: 22752055Free PMC Article
Ostrow AM, Freeze H, Rychik J
Ann Thorac Surg 2006 Aug;82(2):695-700. doi: 10.1016/j.athoracsur.2006.02.048. PMID: 16863787
Wanachiwanawin W, Wiener E, Siripanyaphinyo U, Chinprasertsuk S, Mawas F, Fucharoen S, Wickramasinghe SN, Pootrakul P, Visudhiphan S
J Interferon Cytokine Res 1999 Feb;19(2):105-11. doi: 10.1089/107999099314243. PMID: 10090395
Swaiman KF
Arch Neurol 1991 Dec;48(12):1285-93. doi: 10.1001/archneur.1991.00530240091029. PMID: 1845035

Therapy

Montonen J, Boeing H, Steffen A, Lehmann R, Fritsche A, Joost HG, Schulze MB, Pischon T
Diabetologia 2012 Oct;55(10):2613-2621. Epub 2012 Jul 1 doi: 10.1007/s00125-012-2633-y. PMID: 22752055Free PMC Article
Ostrow AM, Freeze H, Rychik J
Ann Thorac Surg 2006 Aug;82(2):695-700. doi: 10.1016/j.athoracsur.2006.02.048. PMID: 16863787
Cazzola M, Ponchio L, de Benedetti F, Ravelli A, Rosti V, Beguin Y, Invernizzi R, Barosi G, Martini A
Blood 1996 Jun 1;87(11):4824-30. PMID: 8639855
Swaiman KF
Arch Neurol 1991 Dec;48(12):1285-93. doi: 10.1001/archneur.1991.00530240091029. PMID: 1845035
Tannenbaum H, Ruddy S, Schur PH
J Allergy Clin Immunol 1975 Sep;56(3):226-34. doi: 10.1016/0091-6749(75)90094-9. PMID: 50336

Prognosis

Higgins V, Omidi A, Tahmasebi H, Asgari S, Gordanifar K, Nieuwesteeg M, Adeli K
J Clin Endocrinol Metab 2020 Apr 1;105(4):e1781-97. doi: 10.1210/clinem/dgz161. PMID: 31845996Free PMC Article
Montonen J, Boeing H, Steffen A, Lehmann R, Fritsche A, Joost HG, Schulze MB, Pischon T
Diabetologia 2012 Oct;55(10):2613-2621. Epub 2012 Jul 1 doi: 10.1007/s00125-012-2633-y. PMID: 22752055Free PMC Article
Cazzola M, Ponchio L, de Benedetti F, Ravelli A, Rosti V, Beguin Y, Invernizzi R, Barosi G, Martini A
Blood 1996 Jun 1;87(11):4824-30. PMID: 8639855

Clinical prediction guides

Higgins V, Omidi A, Tahmasebi H, Asgari S, Gordanifar K, Nieuwesteeg M, Adeli K
J Clin Endocrinol Metab 2020 Apr 1;105(4):e1781-97. doi: 10.1210/clinem/dgz161. PMID: 31845996Free PMC Article
Kovac S, Smith K, Anderson GJ, Burgess JR, Shulkes A, Baldwin GS
Am J Physiol Gastrointest Liver Physiol 2008 Oct;295(4):G855-61. Epub 2008 Aug 28 doi: 10.1152/ajpgi.90359.2008. PMID: 18755804Free PMC Article
Pesonen EJ, Peltola KI, Korpela RE, Sairanen HI, Leijala MA, Raivio KO, Andersson SH
Ann Thorac Surg 1999 Jun;67(6):1765-70. doi: 10.1016/s0003-4975(99)00320-3. PMID: 10391288
Cazzola M, Ponchio L, de Benedetti F, Ravelli A, Rosti V, Beguin Y, Invernizzi R, Barosi G, Martini A
Blood 1996 Jun 1;87(11):4824-30. PMID: 8639855
Jones PA, Miller FM, Worwood M, Jacobs A
Br J Cancer 1973 Mar;27(3):212-7. doi: 10.1038/bjc.1973.26. PMID: 4511989Free PMC Article

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