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Increased circulating A-type natriuretic peptide concentration

MedGen UID:
1694271
•Concept ID:
C5209266
•
Finding
Synonym: Increased circulating A-type natriuretic peptide level
 
HPO: HP:0020183

Definition

A measurable elevation in circulating levels of Atrial natriuretic peptide hormone, a protein which plays an important role in the regulation of body fluid volume and blood pressure. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased circulating A-type natriuretic peptide concentration

Professional guidelines

PubMed

Biomarkers for Risk Assessment in Atrial Fibrillation.
Berg DD, Ruff CT, Morrow DA
Clin Chem 2021 Jan 8;67(1):87-95. doi: 10.1093/clinchem/hvaa298. PMID: 33313695
Comparison of vessel dilator and long-acting natriuretic peptide in the treatment of congestive heart failure.
Vesely DL, Dietz JR, Parks JR, Antwi EA, Overton RM, McCormick MT, Cintron G, Schocken DD
Am Heart J 1999 Oct;138(4 Pt 1):625-32. doi: 10.1016/s0002-8703(99)70175-4. PMID: 10502206
The circulating renin-angiotensin system during treatment with metoprolol or captopril in patients with heart failure due to non-ischaemic dilated cardiomyopathy.
Jansson K, Dahlström U, Karlberg BE, Karlsson E, Nylander E, Nyquist O, Karlberg KE
J Intern Med 1999 May;245(5):435-43. doi: 10.1046/j.1365-2796.1999.00458.x. PMID: 10363743

Recent clinical studies

Etiology

Biomarkers for Risk Assessment in Atrial Fibrillation.
Berg DD, Ruff CT, Morrow DA
Clin Chem 2021 Jan 8;67(1):87-95. doi: 10.1093/clinchem/hvaa298. PMID: 33313695
Aberrant pro-atrial natriuretic peptide/corin/natriuretic peptide receptor signaling is present in maternal vascular endothelium in preeclampsia.
Gu Y, Thompson D, Xu J, Lewis DF, Morgan JA, Cooper DB, McCathran CE, Wang Y
Pregnancy Hypertens 2018 Jan;11:1-6. Epub 2017 Dec 7 doi: 10.1016/j.preghy.2017.12.001. PMID: 29523263Free PMC Article
Atrial natriuretic peptide and adiponectin interactions in man.
Birkenfeld AL, Boschmann M, Engeli S, Moro C, Arafat AM, Luft FC, Jordan J
PLoS One 2012;7(8):e43238. Epub 2012 Aug 16 doi: 10.1371/journal.pone.0043238. PMID: 22916229Free PMC Article
Clinical relevance of non-cardiac determinants of natriuretic peptide levels.
Passino C, Poletti R, Fontana M, Vergaro G, Prontera C, Gabutti A, Giannoni A, Emdin M, Clerico A
Clin Chem Lab Med 2008;46(11):1515-23. doi: 10.1515/CCLM.2008.293. PMID: 19012517
Atrial natriuretic peptide in diabetic and nondiabetic patients with and without heart transplantation.
Benedini S, Fiocchi R, Battezzati A, Serení Piceni L, Gamba A, Mammana C, Bevilacqua M, Perseghin G, Luzi L
Transplant Proc 2007 Jun;39(5):1580-5. doi: 10.1016/j.transproceed.2007.04.020. PMID: 17580193

Diagnosis

Natriuretic peptides in human heart: Novel insight into their molecular forms, functions, and diagnostic use.
Matsuo A, Nagai-Okatani C, Nishigori M, Kangawa K, Minamino N
Peptides 2019 Jan;111:3-17. Epub 2018 Aug 16 doi: 10.1016/j.peptides.2018.08.006. PMID: 30120963
Aberrant pro-atrial natriuretic peptide/corin/natriuretic peptide receptor signaling is present in maternal vascular endothelium in preeclampsia.
Gu Y, Thompson D, Xu J, Lewis DF, Morgan JA, Cooper DB, McCathran CE, Wang Y
Pregnancy Hypertens 2018 Jan;11:1-6. Epub 2017 Dec 7 doi: 10.1016/j.preghy.2017.12.001. PMID: 29523263Free PMC Article
BNP and Heart Failure: Preclinical and Clinical Trial Data.
Egom EE
J Cardiovasc Transl Res 2015 Apr;8(3):149-57. Epub 2015 Mar 14 doi: 10.1007/s12265-015-9619-3. PMID: 25771949
Current biochemistry, molecular biology, and clinical relevance of natriuretic peptides.
Nishikimi T, Kuwahara K, Nakao K
J Cardiol 2011 Mar;57(2):131-40. Epub 2011 Feb 5 doi: 10.1016/j.jjcc.2011.01.002. PMID: 21296556
Implications of the natriuretic peptide system in the pathogenesis of heart failure: diagnostic and therapeutic importance.
Abassi Z, Karram T, Ellaham S, Winaver J, Hoffman A
Pharmacol Ther 2004 Jun;102(3):223-41. doi: 10.1016/j.pharmthera.2004.04.004. PMID: 15246247

Therapy

Acute effects of insulin on circulating natriuretic peptide levels in humans.
Bachmann KN, Deger SM, Alsouqi A, Huang S, Xu M, Ferguson JF, Su YR, Niswender KD, Ikizler TA, Wang TJ
PLoS One 2018;13(5):e0196869. Epub 2018 May 14 doi: 10.1371/journal.pone.0196869. PMID: 29758041Free PMC Article
Chronic heart failure as a state of reduced effectiveness of the natriuretic peptide system: implications for therapy.
Díez J
Eur J Heart Fail 2017 Feb;19(2):167-176. Epub 2016 Oct 21 doi: 10.1002/ejhf.656. PMID: 27766748Free PMC Article
BNP and Heart Failure: Preclinical and Clinical Trial Data.
Egom EE
J Cardiovasc Transl Res 2015 Apr;8(3):149-57. Epub 2015 Mar 14 doi: 10.1007/s12265-015-9619-3. PMID: 25771949
Endogenous and exogenous cardiac glycosides and their mechanisms of action.
Schoner W, Scheiner-Bobis G
Am J Cardiovasc Drugs 2007;7(3):173-89. doi: 10.2165/00129784-200707030-00004. PMID: 17610345
Implications of the natriuretic peptide system in the pathogenesis of heart failure: diagnostic and therapeutic importance.
Abassi Z, Karram T, Ellaham S, Winaver J, Hoffman A
Pharmacol Ther 2004 Jun;102(3):223-41. doi: 10.1016/j.pharmthera.2004.04.004. PMID: 15246247

Prognosis

Biomarkers for Risk Assessment in Atrial Fibrillation.
Berg DD, Ruff CT, Morrow DA
Clin Chem 2021 Jan 8;67(1):87-95. doi: 10.1093/clinchem/hvaa298. PMID: 33313695
BNP and Heart Failure: Preclinical and Clinical Trial Data.
Egom EE
J Cardiovasc Transl Res 2015 Apr;8(3):149-57. Epub 2015 Mar 14 doi: 10.1007/s12265-015-9619-3. PMID: 25771949
Clinical relevance of non-cardiac determinants of natriuretic peptide levels.
Passino C, Poletti R, Fontana M, Vergaro G, Prontera C, Gabutti A, Giannoni A, Emdin M, Clerico A
Clin Chem Lab Med 2008;46(11):1515-23. doi: 10.1515/CCLM.2008.293. PMID: 19012517
The kidney in heart failure.
De Santo NG, Cirillo M, Perna A, Pollastro RM, Frangiosa A, Di Stazio E, Iorio L, Andrea Di Leo V, Anastasio P
Semin Nephrol 2005 Nov;25(6):404-7. doi: 10.1016/j.semnephrol.2005.05.010. PMID: 16298263
Implications of the natriuretic peptide system in the pathogenesis of heart failure: diagnostic and therapeutic importance.
Abassi Z, Karram T, Ellaham S, Winaver J, Hoffman A
Pharmacol Ther 2004 Jun;102(3):223-41. doi: 10.1016/j.pharmthera.2004.04.004. PMID: 15246247

Clinical prediction guides

Biomarkers for Risk Assessment in Atrial Fibrillation.
Berg DD, Ruff CT, Morrow DA
Clin Chem 2021 Jan 8;67(1):87-95. doi: 10.1093/clinchem/hvaa298. PMID: 33313695
Acute effects of insulin on circulating natriuretic peptide levels in humans.
Bachmann KN, Deger SM, Alsouqi A, Huang S, Xu M, Ferguson JF, Su YR, Niswender KD, Ikizler TA, Wang TJ
PLoS One 2018;13(5):e0196869. Epub 2018 May 14 doi: 10.1371/journal.pone.0196869. PMID: 29758041Free PMC Article
BNP and Heart Failure: Preclinical and Clinical Trial Data.
Egom EE
J Cardiovasc Transl Res 2015 Apr;8(3):149-57. Epub 2015 Mar 14 doi: 10.1007/s12265-015-9619-3. PMID: 25771949
Atrial natriuretic peptide and adiponectin interactions in man.
Birkenfeld AL, Boschmann M, Engeli S, Moro C, Arafat AM, Luft FC, Jordan J
PLoS One 2012;7(8):e43238. Epub 2012 Aug 16 doi: 10.1371/journal.pone.0043238. PMID: 22916229Free PMC Article
Guanylin peptide family: history, interactions with ANP, and new pharmacological perspectives.
Fonteles MC, do Nascimento NR
Can J Physiol Pharmacol 2011 Aug;89(8):575-85. Epub 2011 Aug 4 doi: 10.1139/y11-050. PMID: 21815750

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