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Increased circulating metamyelocyte count

MedGen UID:: 1694856
•Concept ID:: C5139217
•: Finding

HPO:	HP:0032238

Definition

The number of metamyelocytes in the peripheral blood circulation is above the upper limit of normal. Metamyelocytes are immature neutrophils with a size of 10-18 micrometers, an indented or kidney-shaped nucleus, pinkish-blue staining cytoplasm with secondary granules, and a nucleus:cytoplasm ratio of 1.5:1. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVIncreased circulating metamyelocyte count

Abnormal cellular immune system morphology
- Abnormal leukocyte morphology
  - Abnormal leukocyte count
    - Abnormal granulocyte count
      - Abnormal neutrophil count
        Increased circulating immature neutrophil count
        Increased circulating metamyelocyte count

Recent clinical studies

Etiology

GLP-1RA therapy increases circulating vascular regenerative cell content in people living with type 2 diabetes.

Park B, Krishnaraj A, Teoh H, Bakbak E, Dennis F, Quan A, Hess DA, Verma S
Am J Physiol Heart Circ Physiol 2024 Aug 1;327(2):H370-H376. Epub 2024 Jun 14 doi: 10.1152/ajpheart.00257.2024. PMID: 38874618

A secondary CD34+ acute lymphoblastic leukemia unmasked and mobilized by G-CSF in an autologous stem cell donor with testicular cancer.

Cooling L, Kelley J, Sexton E, Anand S, Hoffmann S
Transfusion 2023 Apr;63(4):684-689. Epub 2023 Feb 10 doi: 10.1111/trf.17269. PMID: 36762622

Role of local eosinophilopoietic processes in the development of airway eosinophilia in prednisone-dependent severe asthma.

Sehmi R, Smith SG, Kjarsgaard M, Radford K, Boulet LP, Lemiere C, Prazma CM, Ortega H, Martin JG, Nair P
Clin Exp Allergy 2016 Jun;46(6):793-802. doi: 10.1111/cea.12695. PMID: 26685004

The diagnostic and prognostic significance of monitoring blood levels of immature neutrophils in patients with systemic inflammation.

Mare TA, Treacher DF, Shankar-Hari M, Beale R, Lewis SM, Chambers DJ, Brown KA
Crit Care 2015 Feb 25;19(1):57. doi: 10.1186/s13054-015-0778-z. PMID: 25887201 Free PMC Article

Increased promyelocytic-derived microparticles: a novel potential factor for coagulopathy in acute promyelocytic leukemia.

Ma G, Liu F, Lv L, Gao Y, Su Y
Ann Hematol 2013 May;92(5):645-52. Epub 2013 Jan 24 doi: 10.1007/s00277-013-1676-6. PMID: 23344645

See all (13)

Diagnosis

A secondary CD34+ acute lymphoblastic leukemia unmasked and mobilized by G-CSF in an autologous stem cell donor with testicular cancer.

Cooling L, Kelley J, Sexton E, Anand S, Hoffmann S
Transfusion 2023 Apr;63(4):684-689. Epub 2023 Feb 10 doi: 10.1111/trf.17269. PMID: 36762622

Role of local eosinophilopoietic processes in the development of airway eosinophilia in prednisone-dependent severe asthma.

Sehmi R, Smith SG, Kjarsgaard M, Radford K, Boulet LP, Lemiere C, Prazma CM, Ortega H, Martin JG, Nair P
Clin Exp Allergy 2016 Jun;46(6):793-802. doi: 10.1111/cea.12695. PMID: 26685004

The diagnostic and prognostic significance of monitoring blood levels of immature neutrophils in patients with systemic inflammation.

Mare TA, Treacher DF, Shankar-Hari M, Beale R, Lewis SM, Chambers DJ, Brown KA
Crit Care 2015 Feb 25;19(1):57. doi: 10.1186/s13054-015-0778-z. PMID: 25887201 Free PMC Article

Functional CXCR4-expressing microparticles and SDF-1 correlate with circulating acute myelogenous leukemia cells.

Kalinkovich A, Tavor S, Avigdor A, Kahn J, Brill A, Petit I, Goichberg P, Tesio M, Netzer N, Naparstek E, Hardan I, Nagler A, Resnick I, Tsimanis A, Lapidot T
Cancer Res 2006 Nov 15;66(22):11013-20. doi: 10.1158/0008-5472.CAN-06-2006. PMID: 17108140

Mobilization and transplantation of Philadelphia-negative peripheral-blood progenitor cells early in chronic myelogenous leukemia.

Carella AM, Cunningham I, Lerma E, Dejana A, Benvenuto F, Podestà M, Celesti L, Chimirri F, Abote M, Vassallo F, Figari O, Parodi C, Sessarego M, Valbonesi M, Carlier P, Prencipe E, Gatti AM, van den Berg D, Hoffman R, Frassoni F
J Clin Oncol 1997 Apr;15(4):1575-82. doi: 10.1200/JCO.1997.15.4.1575. PMID: 9193355

See all (6)

Therapy

GLP-1RA therapy increases circulating vascular regenerative cell content in people living with type 2 diabetes.

A secondary CD34+ acute lymphoblastic leukemia unmasked and mobilized by G-CSF in an autologous stem cell donor with testicular cancer.

Cooling L, Kelley J, Sexton E, Anand S, Hoffmann S
Transfusion 2023 Apr;63(4):684-689. Epub 2023 Feb 10 doi: 10.1111/trf.17269. PMID: 36762622

Immature cell fractions after cessation of chronic P2Y(12)-inhibition in patients with coronary artery diseases.

Jäger B, Vargas KG, Haller PM, Stojkovic S, Kaufmann CC, Freynhofer M, Quehenberger P, Wagner O, Wojta J, Huber K
Platelets 2021 Aug 18;32(6):815-820. Epub 2020 Aug 7 doi: 10.1080/09537104.2020.1803252. PMID: 32762577

Role of local eosinophilopoietic processes in the development of airway eosinophilia in prednisone-dependent severe asthma.

Sehmi R, Smith SG, Kjarsgaard M, Radford K, Boulet LP, Lemiere C, Prazma CM, Ortega H, Martin JG, Nair P
Clin Exp Allergy 2016 Jun;46(6):793-802. doi: 10.1111/cea.12695. PMID: 26685004

Effects of dietary arachidonic acid on human immune response.

Kelley DS, Taylor PC, Nelson GJ, Schmidt PC, Mackey BE, Kyle D
Lipids 1997 Apr;32(4):449-56. doi: 10.1007/s11745-997-0059-3. PMID: 9113635

See all (25)

Prognosis

Immature cell fractions after cessation of chronic P2Y(12)-inhibition in patients with coronary artery diseases.

The diagnostic and prognostic significance of monitoring blood levels of immature neutrophils in patients with systemic inflammation.

Mare TA, Treacher DF, Shankar-Hari M, Beale R, Lewis SM, Chambers DJ, Brown KA
Crit Care 2015 Feb 25;19(1):57. doi: 10.1186/s13054-015-0778-z. PMID: 25887201 Free PMC Article

Functional CXCR4-expressing microparticles and SDF-1 correlate with circulating acute myelogenous leukemia cells.

Comparison of in vivo and in vitro effects of granulocyte-macrophage colony-stimulating factor (GM-CSF) in patients with acute myeloid leukemia.

Estrov Z, Estey EH, Andreeff M, Talpaz M, Kurzrock R, Reading CL, Deisseroth AB, Gutterman JU
Exp Hematol 1992 Jun;20(5):558-64. PMID: 1587302

Neutrophil marrow profiles in patients with rheumatoid arthritis and neutropenia.

Dancey JT, Brubaker LH
Br J Haematol 1979 Dec;43(4):607-17. doi: 10.1111/j.1365-2141.1979.tb03793.x. PMID: 526442

See all (7)

Clinical prediction guides

GLP-1RA therapy increases circulating vascular regenerative cell content in people living with type 2 diabetes.

Immature cell fractions after cessation of chronic P2Y(12)-inhibition in patients with coronary artery diseases.

P-selectin glycoprotein ligand-1 deficiency augments G-CSF induced myeloid cell mobilization.

Miszti-Blasius K, Felszeghy S, Kiss C, Benkő I, Géresi K, Megyeri A, Hevessy Z, Kappelmayer J
Naunyn Schmiedebergs Arch Pharmacol 2014 Feb;387(2):109-18. Epub 2013 Oct 5 doi: 10.1007/s00210-013-0913-9. PMID: 24091681

In vitro effects and clinical evaluation of a human chorionic gonadotrophin preparation in acute leukemia.

Feldman EJ, Seiter K, Chiao JW, Halicka HD, Traganos F, Fatora SR, McMichael J, Baskind P, Goff H, Beer M, Ahmed T, Darzynkiewicz Z
Leukemia 1998 Nov;12(11):1749-55. doi: 10.1038/sj.leu.2401196. PMID: 9823950

Peripheral blood hematopoietic progenitor cells in beta-thalassemia major.

Chen JS, Lin KH, Tsao CJ
Int J Cell Cloning 1992 Nov;10(6):338-43. doi: 10.1002/stem.5530100605. PMID: 1460323

See all (19)

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Increased circulating metamyelocyte count

Definition

Term Hierarchy

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

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Practice guidelines

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