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Podocyte hypertrophy

MedGen UID:
1695901
Concept ID:
C5209230
Finding
Synonyms: Glomerular visceral epithelial cell hypertrophy; Hypertrophy of visceral epithelial cells
 
HPO: HP:0020133

Definition

Increased visceral epithelial cell size, with or without cytoplasmic protein droplets. [from HPO]

Professional guidelines

PubMed

Atta MG, Lucas GM, Fine DM
Expert Rev Anti Infect Ther 2008 Jun;6(3):365-71. doi: 10.1586/14787210.6.3.365. PMID: 18588500

Recent clinical studies

Etiology

Bellur SS, Troyanov S, Vorobyeva O, Coppo R, Roberts ISD; Validation in IgA Nephropathy study group
Kidney Int 2024 Jun;105(6):1279-1290. Epub 2024 Mar 28 doi: 10.1016/j.kint.2024.03.011. PMID: 38554992
Terinte-Balcan G, Stefan G
Ultrastruct Pathol 2023 Nov 2;47(6):461-469. Epub 2023 Sep 12 doi: 10.1080/01913123.2023.2256836. PMID: 37700534
Trimarchi H, Coppo R
Pediatr Nephrol 2020 Nov;35(11):2043-2047. Epub 2019 Nov 26 doi: 10.1007/s00467-019-04414-4. PMID: 31773265
Bruggeman LA, Wu Z, Luo L, Madhavan S, Drawz PE, Thomas DB, Barisoni L, O'Toole JF, Sedor JR
PLoS One 2019;14(10):e0224408. Epub 2019 Oct 29 doi: 10.1371/journal.pone.0224408. PMID: 31661509Free PMC Article
Bancu I, Navarro Díaz M, Serra A, Granada M, Lopez D, Romero R, Bonet J
PLoS One 2016;11(5):e0154451. Epub 2016 May 3 doi: 10.1371/journal.pone.0154451. PMID: 27138941Free PMC Article

Diagnosis

Bellur SS, Troyanov S, Vorobyeva O, Coppo R, Roberts ISD; Validation in IgA Nephropathy study group
Kidney Int 2024 Jun;105(6):1279-1290. Epub 2024 Mar 28 doi: 10.1016/j.kint.2024.03.011. PMID: 38554992
D'Agati VD, Chagnac A, de Vries AP, Levi M, Porrini E, Herman-Edelstein M, Praga M
Nat Rev Nephrol 2016 Aug;12(8):453-71. Epub 2016 Jun 6 doi: 10.1038/nrneph.2016.75. PMID: 27263398
Huang YJ, Yang XQ, Zhai WS, Ren XQ, Guo QY, Zhang X, Yang M, Yamamoto T, Sun Y, Ding Y
World J Pediatr 2015 Nov;11(4):338-45. Epub 2014 Nov 20 doi: 10.1007/s12519-014-0527-4. PMID: 25410673
Miyauchi M, Toyoda M, Kobayashi K, Abe M, Kobayashi T, Kato M, Yamamoto N, Kimura M, Umezono T, Suzuki D
Intern Med 2009;48(18):1615-20. Epub 2009 Sep 15 doi: 10.2169/internalmedicine.48.2137. PMID: 19755763
Atta MG, Lucas GM, Fine DM
Expert Rev Anti Infect Ther 2008 Jun;6(3):365-71. doi: 10.1586/14787210.6.3.365. PMID: 18588500

Therapy

Bellur SS, Troyanov S, Vorobyeva O, Coppo R, Roberts ISD; Validation in IgA Nephropathy study group
Kidney Int 2024 Jun;105(6):1279-1290. Epub 2024 Mar 28 doi: 10.1016/j.kint.2024.03.011. PMID: 38554992
Puelles VG, van der Wolde JW, Wanner N, Scheppach MW, Cullen-McEwen LA, Bork T, Lindenmeyer MT, Gernhold L, Wong MN, Braun F, Cohen CD, Kett MM, Kuppe C, Kramann R, Saritas T, van Roeyen CR, Moeller MJ, Tribolet L, Rebello R, Sun YB, Li J, Müller-Newen G, Hughson MD, Hoy WE, Person F, Wiech T, Ricardo SD, Kerr PG, Denton KM, Furic L, Huber TB, Nikolic-Paterson DJ, Bertram JF
JCI Insight 2019 Sep 19;4(18) doi: 10.1172/jci.insight.99271. PMID: 31534053Free PMC Article
Anguiano Gómez L, Lei Y, Kumar Devarapu S, Anders HJ
Nephrol Dial Transplant 2018 Aug 1;33(8):1292-1304. doi: 10.1093/ndt/gfx219. PMID: 28992221
Schmitt R, Melk A
Kidney Int 2017 Sep;92(3):569-579. Epub 2017 Jul 18 doi: 10.1016/j.kint.2017.02.036. PMID: 28729036
Mesquita FF, Gontijo JA, Boer PA
Braz J Med Biol Res 2010 Nov;43(11):1010-8. Epub 2010 Oct 29 doi: 10.1590/s0100-879x2010007500113. PMID: 21049242

Prognosis

Trimarchi H, Coppo R
Pediatr Nephrol 2020 Nov;35(11):2043-2047. Epub 2019 Nov 26 doi: 10.1007/s00467-019-04414-4. PMID: 31773265
Anguiano Gómez L, Lei Y, Kumar Devarapu S, Anders HJ
Nephrol Dial Transplant 2018 Aug 1;33(8):1292-1304. doi: 10.1093/ndt/gfx219. PMID: 28992221
Dai H, Liu Q, Liu B
J Diabetes Res 2017;2017:2615286. Epub 2017 Jul 16 doi: 10.1155/2017/2615286. PMID: 28791309Free PMC Article
Huang YJ, Yang XQ, Zhai WS, Ren XQ, Guo QY, Zhang X, Yang M, Yamamoto T, Sun Y, Ding Y
World J Pediatr 2015 Nov;11(4):338-45. Epub 2014 Nov 20 doi: 10.1007/s12519-014-0527-4. PMID: 25410673
Lohmann F, Sachs M, Meyer TN, Sievert H, Lindenmeyer MT, Wiech T, Cohen CD, Balabanov S, Stahl RA, Meyer-Schwesinger C
Biochim Biophys Acta 2014 Jul;1842(7):945-58. Epub 2014 Feb 28 doi: 10.1016/j.bbadis.2014.02.011. PMID: 24583340

Clinical prediction guides

Shirai Y, Miura K, Yokoyama T, Horita S, Nakayama H, Seino H, Ando T, Shiratori A, Yabuuchi T, Kaneko N, Ishiwa S, Ishizuka K, Hara M, Hattori M
Kidney360 2021 Mar 25;2(3):477-486. Epub 2020 Dec 1 doi: 10.34067/KID.0005612020. PMID: 35369007Free PMC Article
Trimarchi H, Coppo R
Pediatr Nephrol 2020 Nov;35(11):2043-2047. Epub 2019 Nov 26 doi: 10.1007/s00467-019-04414-4. PMID: 31773265
Anguiano Gómez L, Lei Y, Kumar Devarapu S, Anders HJ
Nephrol Dial Transplant 2018 Aug 1;33(8):1292-1304. doi: 10.1093/ndt/gfx219. PMID: 28992221
Miyauchi M, Toyoda M, Kobayashi K, Abe M, Kobayashi T, Kato M, Yamamoto N, Kimura M, Umezono T, Suzuki D
Intern Med 2009;48(18):1615-20. Epub 2009 Sep 15 doi: 10.2169/internalmedicine.48.2137. PMID: 19755763
Kim NH
Nephrology (Carlton) 2005 Oct;10 Suppl:S14-6. doi: 10.1111/j.1440-1797.2005.00450.x. PMID: 16174280

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