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Normal Karyotype Intermediate Risk Acute Myeloid Leukemia

MedGen UID:
1696297
Concept ID:
C5206783
Neoplastic Process

Definition

Acute myeloid leukemia with an intermediate risk of relapse or refractoriness that has a normal karyotype. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNormal Karyotype Intermediate Risk Acute Myeloid Leukemia

Professional guidelines

PubMed

Cagnetta A, Adamia S, Acharya C, Patrone F, Miglino M, Nencioni A, Gobbi M, Cea M
Leuk Res 2014 Jun;38(6):649-59. Epub 2014 Mar 18 doi: 10.1016/j.leukres.2014.03.006. PMID: 24726781
Estey EH
Am J Hematol 2013 Apr;88(4):318-27. doi: 10.1002/ajh.23404. PMID: 23526416
Prescott H, Kantarjian H, Cortes J, Ravandi F
Expert Opin Emerg Drugs 2011 Sep;16(3):407-23. Epub 2011 Mar 22 doi: 10.1517/14728214.2011.568938. PMID: 21417961Free PMC Article

Recent clinical studies

Etiology

Zotova OV, Lukianova AS, Valchuk MO, Karol YS, Shalay OO, Novak VL, Loginsky VE
Exp Oncol 2021 Sep;43(3):229-233. doi: 10.32471/exp-oncology.2312-8852.vol-43-no-3.16495. PMID: 34591430
Stölzel F, Mohr B, Kramer M, Oelschlägel U, Bochtler T, Berdel WE, Kaufmann M, Baldus CD, Schäfer-Eckart K, Stuhlmann R, Einsele H, Krause SW, Serve H, Hänel M, Herbst R, Neubauer A, Sohlbach K, Mayer J, Middeke JM, Platzbecker U, Schaich M, Krämer A, Röllig C, Schetelig J, Bornhäuser M, Ehninger G
Blood Cancer J 2016 Jan 15;6(1):e386. doi: 10.1038/bcj.2015.114. PMID: 26771812Free PMC Article
Estey EH
Am J Hematol 2013 Apr;88(4):318-27. doi: 10.1002/ajh.23404. PMID: 23526416
Estey E
Hematology Am Soc Hematol Educ Program 2010;2010:474-80. doi: 10.1182/asheducation-2010.1.474. PMID: 21239839
Ley TJ, Ding L, Walter MJ, McLellan MD, Lamprecht T, Larson DE, Kandoth C, Payton JE, Baty J, Welch J, Harris CC, Lichti CF, Townsend RR, Fulton RS, Dooling DJ, Koboldt DC, Schmidt H, Zhang Q, Osborne JR, Lin L, O'Laughlin M, McMichael JF, Delehaunty KD, McGrath SD, Fulton LA, Magrini VJ, Vickery TL, Hundal J, Cook LL, Conyers JJ, Swift GW, Reed JP, Alldredge PA, Wylie T, Walker J, Kalicki J, Watson MA, Heath S, Shannon WD, Varghese N, Nagarajan R, Westervelt P, Tomasson MH, Link DC, Graubert TA, DiPersio JF, Mardis ER, Wilson RK
N Engl J Med 2010 Dec 16;363(25):2424-33. Epub 2010 Nov 10 doi: 10.1056/NEJMoa1005143. PMID: 21067377Free PMC Article

Diagnosis

Zotova OV, Lukianova AS, Valchuk MO, Karol YS, Shalay OO, Novak VL, Loginsky VE
Exp Oncol 2021 Sep;43(3):229-233. doi: 10.32471/exp-oncology.2312-8852.vol-43-no-3.16495. PMID: 34591430
Lin Y, Wang Y, Zheng Y, Wang Z, Wang Y, Wang S
Hematology 2020 Dec;25(1):446-456. doi: 10.1080/16078454.2020.1847801. PMID: 33250015
Stölzel F, Mohr B, Kramer M, Oelschlägel U, Bochtler T, Berdel WE, Kaufmann M, Baldus CD, Schäfer-Eckart K, Stuhlmann R, Einsele H, Krause SW, Serve H, Hänel M, Herbst R, Neubauer A, Sohlbach K, Mayer J, Middeke JM, Platzbecker U, Schaich M, Krämer A, Röllig C, Schetelig J, Bornhäuser M, Ehninger G
Blood Cancer J 2016 Jan 15;6(1):e386. doi: 10.1038/bcj.2015.114. PMID: 26771812Free PMC Article
Tao H, Ma X, Su G, Yin J, Xie X, Hu C, Chen Z, Tan D, Xu Z, Zheng Y, Liu H, He C, Mao ZJ, Yin H, Wang Z, Chang W, Gale RP, Chen Z, Wu D, Yin B
Leuk Res 2016 Feb;41:71-5. Epub 2015 Dec 7 doi: 10.1016/j.leukres.2015.12.001. PMID: 26707798
Estey EH
Am J Hematol 2013 Apr;88(4):318-27. doi: 10.1002/ajh.23404. PMID: 23526416

Therapy

Lin Y, Wang Y, Zheng Y, Wang Z, Wang Y, Wang S
Hematology 2020 Dec;25(1):446-456. doi: 10.1080/16078454.2020.1847801. PMID: 33250015
Gerber JM, Zeidner JF, Morse S, Blackford AL, Perkins B, Yanagisawa B, Zhang H, Morsberger L, Karp J, Ning Y, Gocke CD, Rosner GL, Smith BD, Jones RJ
Haematologica 2016 May;101(5):607-16. Epub 2016 Jan 27 doi: 10.3324/haematol.2015.135194. PMID: 26819054Free PMC Article
Stölzel F, Mohr B, Kramer M, Oelschlägel U, Bochtler T, Berdel WE, Kaufmann M, Baldus CD, Schäfer-Eckart K, Stuhlmann R, Einsele H, Krause SW, Serve H, Hänel M, Herbst R, Neubauer A, Sohlbach K, Mayer J, Middeke JM, Platzbecker U, Schaich M, Krämer A, Röllig C, Schetelig J, Bornhäuser M, Ehninger G
Blood Cancer J 2016 Jan 15;6(1):e386. doi: 10.1038/bcj.2015.114. PMID: 26771812Free PMC Article
Estey EH
Am J Hematol 2013 Apr;88(4):318-27. doi: 10.1002/ajh.23404. PMID: 23526416
Estey E
Hematology Am Soc Hematol Educ Program 2010;2010:474-80. doi: 10.1182/asheducation-2010.1.474. PMID: 21239839

Prognosis

Zotova OV, Lukianova AS, Valchuk MO, Karol YS, Shalay OO, Novak VL, Loginsky VE
Exp Oncol 2021 Sep;43(3):229-233. doi: 10.32471/exp-oncology.2312-8852.vol-43-no-3.16495. PMID: 34591430
Stölzel F, Mohr B, Kramer M, Oelschlägel U, Bochtler T, Berdel WE, Kaufmann M, Baldus CD, Schäfer-Eckart K, Stuhlmann R, Einsele H, Krause SW, Serve H, Hänel M, Herbst R, Neubauer A, Sohlbach K, Mayer J, Middeke JM, Platzbecker U, Schaich M, Krämer A, Röllig C, Schetelig J, Bornhäuser M, Ehninger G
Blood Cancer J 2016 Jan 15;6(1):e386. doi: 10.1038/bcj.2015.114. PMID: 26771812Free PMC Article
Estey EH
Am J Hematol 2013 Apr;88(4):318-27. doi: 10.1002/ajh.23404. PMID: 23526416
Estey E
Hematology Am Soc Hematol Educ Program 2010;2010:474-80. doi: 10.1182/asheducation-2010.1.474. PMID: 21239839
Ley TJ, Ding L, Walter MJ, McLellan MD, Lamprecht T, Larson DE, Kandoth C, Payton JE, Baty J, Welch J, Harris CC, Lichti CF, Townsend RR, Fulton RS, Dooling DJ, Koboldt DC, Schmidt H, Zhang Q, Osborne JR, Lin L, O'Laughlin M, McMichael JF, Delehaunty KD, McGrath SD, Fulton LA, Magrini VJ, Vickery TL, Hundal J, Cook LL, Conyers JJ, Swift GW, Reed JP, Alldredge PA, Wylie T, Walker J, Kalicki J, Watson MA, Heath S, Shannon WD, Varghese N, Nagarajan R, Westervelt P, Tomasson MH, Link DC, Graubert TA, DiPersio JF, Mardis ER, Wilson RK
N Engl J Med 2010 Dec 16;363(25):2424-33. Epub 2010 Nov 10 doi: 10.1056/NEJMoa1005143. PMID: 21067377Free PMC Article

Clinical prediction guides

Han L, Wu J, Lyu X, Yu J, Han X, Zhao H, Bian Z, Li W, Fan W, He C, Wang W, Zhang M, Li Y, Liu C, Sun H, Cao H, Sang L, Zhang J, Jiang Z, Peng J
Exp Hematol 2023 Dec;128:67-76. Epub 2023 Sep 20 doi: 10.1016/j.exphem.2023.09.004. PMID: 37739208
Khasawneh MK, Abdel-Wahab O
Curr Hematol Malig Rep 2014 Jun;9(2):93-9. doi: 10.1007/s11899-014-0200-y. PMID: 24609756
Estey EH
Am J Hematol 2013 Apr;88(4):318-27. doi: 10.1002/ajh.23404. PMID: 23526416
Estey E
Hematology Am Soc Hematol Educ Program 2010;2010:474-80. doi: 10.1182/asheducation-2010.1.474. PMID: 21239839
Ley TJ, Ding L, Walter MJ, McLellan MD, Lamprecht T, Larson DE, Kandoth C, Payton JE, Baty J, Welch J, Harris CC, Lichti CF, Townsend RR, Fulton RS, Dooling DJ, Koboldt DC, Schmidt H, Zhang Q, Osborne JR, Lin L, O'Laughlin M, McMichael JF, Delehaunty KD, McGrath SD, Fulton LA, Magrini VJ, Vickery TL, Hundal J, Cook LL, Conyers JJ, Swift GW, Reed JP, Alldredge PA, Wylie T, Walker J, Kalicki J, Watson MA, Heath S, Shannon WD, Varghese N, Nagarajan R, Westervelt P, Tomasson MH, Link DC, Graubert TA, DiPersio JF, Mardis ER, Wilson RK
N Engl J Med 2010 Dec 16;363(25):2424-33. Epub 2010 Nov 10 doi: 10.1056/NEJMoa1005143. PMID: 21067377Free PMC Article

Recent systematic reviews

Xu Q, Li Y, Lv N, Jing Y, Xu Y, Li Y, Li W, Yao Z, Chen X, Huang S, Wang L, Li Y, Yu L
Clin Cancer Res 2017 Aug 1;23(15):4511-4522. Epub 2017 Feb 28 doi: 10.1158/1078-0432.CCR-16-2628. PMID: 28246275

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