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Elevated circulating E selectin level

MedGen UID:
1696341
•Concept ID:
C5139218
•
Finding
HPO: HP:0032240

Definition

An increased concentration of E selectin in the blood circulation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated circulating E selectin level

Professional guidelines

PubMed

The expression of microvesicles in the blood of patients with Graves' disease and its relationship to treatment.
Mobarrez F, Abraham-Nordling M, Aguilera-Gatica K, Friberg I, Antovic A, Pisetsky DS, Jörneskog G, Wallen H
Clin Endocrinol (Oxf) 2016 May;84(5):729-35. Epub 2015 Sep 22 doi: 10.1111/cen.12872. PMID: 26252432
Circulating endothelial cell levels in psoriatic patients and their modification after an anti-TNF-alpha (Etanercept) treatment.
De Simone C, Caldarola G, Coco V, Palumbo S, Pocino K, Sgambato A, Maiorino A, Corbi M, Sandri MT, Vendittelli F, Capoluongo E
J Eur Acad Dermatol Venereol 2014 May;28(5):590-6. Epub 2013 Mar 18 doi: 10.1111/jdv.12140. PMID: 23506557
Circulating E-selectin levels in chronic hepatitis C patients with normal or elevated transaminase before and after alpha-interferon treatment.
Montalto G, Giannitrapani L, Soresi M, Virruso L, Martino DD, Gambino R, Carroccio A, Cervello M
Inflammation 2001 Apr;25(2):101-8. doi: 10.1023/a:1007118605861. PMID: 11321356

Recent clinical studies

Etiology

Plasma irisin is elevated in type 2 diabetes and is associated with increased E-selectin levels.
Rana KS, Pararasa C, Afzal I, Nagel DA, Hill EJ, Bailey CJ, Griffiths HR, Kyrou I, Randeva HS, Bellary S, Brown JE
Cardiovasc Diabetol 2017 Nov 9;16(1):147. doi: 10.1186/s12933-017-0627-2. PMID: 29121940Free PMC Article
Relationship between renal function and circulating microparticles, soluble P-selectin and E-selectin levels in atrial fibrillation.
Lau YC, Xiong Q, Blann AD, Lip GY
J Thromb Thrombolysis 2017 Jan;43(1):18-23. doi: 10.1007/s11239-016-1427-3. PMID: 27671694Free PMC Article
Early pregnancy soluble E-selectin concentrations and risk of preeclampsia.
Carty DM, Anderson LA, Freeman DJ, Welsh PI, Brennand JE, Dominiczak AF, Delles C
J Hypertens 2012 May;30(5):954-9. doi: 10.1097/HJH.0b013e328352573b. PMID: 22441350
Circulating intercellular adhesion molecule-1 and E-selectin levels in gastric cancer.
Benekli M, Güllü IH, Tekuzman G, Savaş MC, Hayran M, Hasçelik G, Firat D
Br J Cancer 1998 Jul;78(2):267-71. doi: 10.1038/bjc.1998.476. PMID: 9683305Free PMC Article
Circulating intercellular adhesion molecule-1 and E-selectin in patients with acute coronary syndrome.
Shyu KG, Chang H, Lin CC, Kuan P
Chest 1996 Jun;109(6):1627-30. doi: 10.1378/chest.109.6.1627. PMID: 8769521

Diagnosis

The Role of Inflammatory Biomarkers in the Detection and Therapy of Atherosclerotic Disease.
Poredos P, Jezovnik MK
Curr Vasc Pharmacol 2016;14(6):534-546. doi: 10.2174/1570161114666160625080104. PMID: 27357185
Early pregnancy soluble E-selectin concentrations and risk of preeclampsia.
Carty DM, Anderson LA, Freeman DJ, Welsh PI, Brennand JE, Dominiczak AF, Delles C
J Hypertens 2012 May;30(5):954-9. doi: 10.1097/HJH.0b013e328352573b. PMID: 22441350
Soluble adhesion molecules E-cadherin, intercellular adhesion molecule-1, and E-selectin as lung cancer biomarkers.
Gogali A, Charalabopoulos K, Zampira I, Konstantinidis AK, Tachmazoglou F, Daskalopoulos G, Constantopoulos SH, Dalavanga Y
Chest 2010 Nov;138(5):1173-9. Epub 2010 May 21 doi: 10.1378/chest.10-0157. PMID: 20495107
Elevated circulating E-selectin, intercellular adhesion molecule 1, and von Willebrand factor in patients with severe infection.
Kayal S, Jaïs JP, Aguini N, Chaudière J, Labrousse J
Am J Respir Crit Care Med 1998 Mar;157(3 Pt 1):776-84. doi: 10.1164/ajrccm.157.3.9705034. PMID: 9517590
Circulating intercellular adhesion molecule-1 and E-selectin in patients with acute coronary syndrome.
Shyu KG, Chang H, Lin CC, Kuan P
Chest 1996 Jun;109(6):1627-30. doi: 10.1378/chest.109.6.1627. PMID: 8769521

Therapy

The Role of Inflammatory Biomarkers in the Detection and Therapy of Atherosclerotic Disease.
Poredos P, Jezovnik MK
Curr Vasc Pharmacol 2016;14(6):534-546. doi: 10.2174/1570161114666160625080104. PMID: 27357185
Circulating E-selectin levels in chronic hepatitis C patients with normal or elevated transaminase before and after alpha-interferon treatment.
Montalto G, Giannitrapani L, Soresi M, Virruso L, Martino DD, Gambino R, Carroccio A, Cervello M
Inflammation 2001 Apr;25(2):101-8. doi: 10.1023/a:1007118605861. PMID: 11321356
Circulating levels of soluble E-selectin, ICAM-1 and VCAM-1 in bullous pemphigoid during low-dose methotrexate therapy. A prospective study.
Dahlman-Ghozlan K, Heilborn JD, Stephansson E
Exp Dermatol 2000 Oct;9(5):336-40. doi: 10.1034/j.1600-0625.2000.009005336.x. PMID: 11016854
Soluble E-selectin, ICAM-1 and VCAM-1 levels in systemic and coronary circulation in patients with variant angina.
Miwa K, Igawa A, Inoue H
Cardiovasc Res 1997 Oct;36(1):37-44. doi: 10.1016/s0008-6363(97)00143-0. PMID: 9415270
Increased circulating cytokines, cytokine antagonists, and E-selectin after intravenous administration of endotoxin in humans.
Kuhns DB, Alvord WG, Gallin JI
J Infect Dis 1995 Jan;171(1):145-52. doi: 10.1093/infdis/171.1.145. PMID: 7528250

Prognosis

Plasma irisin is elevated in type 2 diabetes and is associated with increased E-selectin levels.
Rana KS, Pararasa C, Afzal I, Nagel DA, Hill EJ, Bailey CJ, Griffiths HR, Kyrou I, Randeva HS, Bellary S, Brown JE
Cardiovasc Diabetol 2017 Nov 9;16(1):147. doi: 10.1186/s12933-017-0627-2. PMID: 29121940Free PMC Article
Relationship between renal function and circulating microparticles, soluble P-selectin and E-selectin levels in atrial fibrillation.
Lau YC, Xiong Q, Blann AD, Lip GY
J Thromb Thrombolysis 2017 Jan;43(1):18-23. doi: 10.1007/s11239-016-1427-3. PMID: 27671694Free PMC Article
Early pregnancy soluble E-selectin concentrations and risk of preeclampsia.
Carty DM, Anderson LA, Freeman DJ, Welsh PI, Brennand JE, Dominiczak AF, Delles C
J Hypertens 2012 May;30(5):954-9. doi: 10.1097/HJH.0b013e328352573b. PMID: 22441350
Circulating intercellular adhesion molecule-1 and E-selectin levels in gastric cancer.
Benekli M, Güllü IH, Tekuzman G, Savaş MC, Hayran M, Hasçelik G, Firat D
Br J Cancer 1998 Jul;78(2):267-71. doi: 10.1038/bjc.1998.476. PMID: 9683305Free PMC Article
Elevated circulating E-selectin, intercellular adhesion molecule 1, and von Willebrand factor in patients with severe infection.
Kayal S, Jaïs JP, Aguini N, Chaudière J, Labrousse J
Am J Respir Crit Care Med 1998 Mar;157(3 Pt 1):776-84. doi: 10.1164/ajrccm.157.3.9705034. PMID: 9517590

Clinical prediction guides

Plasma irisin is elevated in type 2 diabetes and is associated with increased E-selectin levels.
Rana KS, Pararasa C, Afzal I, Nagel DA, Hill EJ, Bailey CJ, Griffiths HR, Kyrou I, Randeva HS, Bellary S, Brown JE
Cardiovasc Diabetol 2017 Nov 9;16(1):147. doi: 10.1186/s12933-017-0627-2. PMID: 29121940Free PMC Article
Relationship between renal function and circulating microparticles, soluble P-selectin and E-selectin levels in atrial fibrillation.
Lau YC, Xiong Q, Blann AD, Lip GY
J Thromb Thrombolysis 2017 Jan;43(1):18-23. doi: 10.1007/s11239-016-1427-3. PMID: 27671694Free PMC Article
The Role of Inflammatory Biomarkers in the Detection and Therapy of Atherosclerotic Disease.
Poredos P, Jezovnik MK
Curr Vasc Pharmacol 2016;14(6):534-546. doi: 10.2174/1570161114666160625080104. PMID: 27357185
Early pregnancy soluble E-selectin concentrations and risk of preeclampsia.
Carty DM, Anderson LA, Freeman DJ, Welsh PI, Brennand JE, Dominiczak AF, Delles C
J Hypertens 2012 May;30(5):954-9. doi: 10.1097/HJH.0b013e328352573b. PMID: 22441350
Circulating intercellular adhesion molecule-1 and E-selectin levels in gastric cancer.
Benekli M, Güllü IH, Tekuzman G, Savaş MC, Hayran M, Hasçelik G, Firat D
Br J Cancer 1998 Jul;78(2):267-71. doi: 10.1038/bjc.1998.476. PMID: 9683305Free PMC Article

Recent systematic reviews

Endothelial glycocalyx-associated molecules as potential serological markers for sepsis-associated encephalopathy: A systematic review and meta-analysis.
Baby S, Reljic T, Villalba N, Kumar A, Yuan SY
PLoS One 2023;18(2):e0281941. Epub 2023 Feb 21 doi: 10.1371/journal.pone.0281941. PMID: 36802387Free PMC Article

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