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Elevated circulating E selectin level

MedGen UID:
1696341
•Concept ID:
C5139218
•
Finding
HPO: HP:0032240

Definition

An increased concentration of E selectin in the blood circulation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated circulating E selectin level

Professional guidelines

PubMed

The expression of microvesicles in the blood of patients with Graves' disease and its relationship to treatment.
Mobarrez F, Abraham-Nordling M, Aguilera-Gatica K, Friberg I, Antovic A, Pisetsky DS, Jörneskog G, Wallen H
Clin Endocrinol (Oxf) 2016 May;84(5):729-35. Epub 2015 Sep 22 doi: 10.1111/cen.12872. PMID: 26252432
Circulating endothelial cell levels in psoriatic patients and their modification after an anti-TNF-alpha (Etanercept) treatment.
De Simone C, Caldarola G, Coco V, Palumbo S, Pocino K, Sgambato A, Maiorino A, Corbi M, Sandri MT, Vendittelli F, Capoluongo E
J Eur Acad Dermatol Venereol 2014 May;28(5):590-6. Epub 2013 Mar 18 doi: 10.1111/jdv.12140. PMID: 23506557
Circulating E-selectin levels in chronic hepatitis C patients with normal or elevated transaminase before and after alpha-interferon treatment.
Montalto G, Giannitrapani L, Soresi M, Virruso L, Martino DD, Gambino R, Carroccio A, Cervello M
Inflammation 2001 Apr;25(2):101-8. doi: 10.1023/a:1007118605861. PMID: 11321356

Recent clinical studies

Etiology

Expression of ICAM-1 and E-selectin in different metabolic obesity phenotypes: discrepancy for endothelial dysfunction.
Liu M, Wang P, Xie P, Xu X, He L, Chen X, Zhang S, Lin Y, Huang Y, Xia W, Wang L, Liao X, Guo Y, Zhuang X
J Endocrinol Invest 2023 Nov;46(11):2379-2389. Epub 2023 Apr 18 doi: 10.1007/s40618-023-02094-4. PMID: 37071373
Circulating hyaluronic acid signature in CAP and ARDS - the role of pneumolysin in hyaluronic acid shedding.
Sauer A, Seeliger B, Jandl K, Erfinanda L, Wilhelm J, Alexopoulos I, Baal N, Birnhuber A, David S, Welte T, Barreto G, Gaertner U, Kwapiszewska G, Seeger W, Kuebler WM, Schaefer L, Wygrecka M; members of the CAPNETZ Study Group
Matrix Biol 2022 Dec;114:67-83. Epub 2022 Nov 16 doi: 10.1016/j.matbio.2022.11.003. PMID: 36456058
Pediatric ECMO: unfavorable outcomes are associated with inflammation and endothelial activation.
Caprarola SD, Ng DK, Carroll MK, Tekes A, Felling RJ, Salorio CF, Almuqati R, Schwartz JM, Everett AD, Bembea MM
Pediatr Res 2022 Aug;92(2):549-556. Epub 2021 Nov 3 doi: 10.1038/s41390-021-01817-8. PMID: 34732815Free PMC Article
Increased fractalkine and vascular dysfunction in obesity and in type 2 diabetes. Effects of oral antidiabetic treatment.
Schinzari F, Tesauro M, Campia U, Cardillo C
Vascul Pharmacol 2020 May-Jun;128-129:106676. Epub 2020 Mar 26 doi: 10.1016/j.vph.2020.106676. PMID: 32224233
Elevated circulating E-selectin, intercellular adhesion molecule 1, and von Willebrand factor in patients with severe infection.
Kayal S, Jaïs JP, Aguini N, Chaudière J, Labrousse J
Am J Respir Crit Care Med 1998 Mar;157(3 Pt 1):776-84. doi: 10.1164/ajrccm.157.3.9705034. PMID: 9517590

Diagnosis

Soluble adhesion molecules and functional outcome after ischemic stroke: A Mendelian randomization study.
Wang M, Zhang Z, Liu D, Karhunen V, Georgakis MK, Ren Y, Ye D, Gill D, Liu M
J Stroke Cerebrovasc Dis 2023 Jun;32(6):107136. Epub 2023 Apr 15 doi: 10.1016/j.jstrokecerebrovasdis.2023.107136. PMID: 37068323
Endothelial glycocalyx-associated molecules as potential serological markers for sepsis-associated encephalopathy: A systematic review and meta-analysis.
Baby S, Reljic T, Villalba N, Kumar A, Yuan SY
PLoS One 2023;18(2):e0281941. Epub 2023 Feb 21 doi: 10.1371/journal.pone.0281941. PMID: 36802387Free PMC Article
Increased fractalkine and vascular dysfunction in obesity and in type 2 diabetes. Effects of oral antidiabetic treatment.
Schinzari F, Tesauro M, Campia U, Cardillo C
Vascul Pharmacol 2020 May-Jun;128-129:106676. Epub 2020 Mar 26 doi: 10.1016/j.vph.2020.106676. PMID: 32224233
The Role of Inflammatory Biomarkers in the Detection and Therapy of Atherosclerotic Disease.
Poredos P, Jezovnik MK
Curr Vasc Pharmacol 2016;14(6):534-546. doi: 10.2174/1570161114666160625080104. PMID: 27357185
Elevated circulating E-selectin, intercellular adhesion molecule 1, and von Willebrand factor in patients with severe infection.
Kayal S, Jaïs JP, Aguini N, Chaudière J, Labrousse J
Am J Respir Crit Care Med 1998 Mar;157(3 Pt 1):776-84. doi: 10.1164/ajrccm.157.3.9705034. PMID: 9517590

Therapy

Soluble adhesion molecules and functional outcome after ischemic stroke: A Mendelian randomization study.
Wang M, Zhang Z, Liu D, Karhunen V, Georgakis MK, Ren Y, Ye D, Gill D, Liu M
J Stroke Cerebrovasc Dis 2023 Jun;32(6):107136. Epub 2023 Apr 15 doi: 10.1016/j.jstrokecerebrovasdis.2023.107136. PMID: 37068323
Etiology of Myocardial Injury in Critically Ill Patients with Sepsis: A Cohort Study.
Frencken JF, van Smeden M, van de Groep K, Ong DSY, Klein Klouwenberg PMC, Juffermans N, Bonten MJM, van der Poll T, Cremer OL; MARS Consortium
Ann Am Thorac Soc 2022 May;19(5):773-780. doi: 10.1513/AnnalsATS.202106-689OC. PMID: 34784496
Increased fractalkine and vascular dysfunction in obesity and in type 2 diabetes. Effects of oral antidiabetic treatment.
Schinzari F, Tesauro M, Campia U, Cardillo C
Vascul Pharmacol 2020 May-Jun;128-129:106676. Epub 2020 Mar 26 doi: 10.1016/j.vph.2020.106676. PMID: 32224233
The Role of Inflammatory Biomarkers in the Detection and Therapy of Atherosclerotic Disease.
Poredos P, Jezovnik MK
Curr Vasc Pharmacol 2016;14(6):534-546. doi: 10.2174/1570161114666160625080104. PMID: 27357185
Increased circulating cytokines, cytokine antagonists, and E-selectin after intravenous administration of endotoxin in humans.
Kuhns DB, Alvord WG, Gallin JI
J Infect Dis 1995 Jan;171(1):145-52. doi: 10.1093/infdis/171.1.145. PMID: 7528250

Prognosis

Soluble adhesion molecules and functional outcome after ischemic stroke: A Mendelian randomization study.
Wang M, Zhang Z, Liu D, Karhunen V, Georgakis MK, Ren Y, Ye D, Gill D, Liu M
J Stroke Cerebrovasc Dis 2023 Jun;32(6):107136. Epub 2023 Apr 15 doi: 10.1016/j.jstrokecerebrovasdis.2023.107136. PMID: 37068323
Pediatric ECMO: unfavorable outcomes are associated with inflammation and endothelial activation.
Caprarola SD, Ng DK, Carroll MK, Tekes A, Felling RJ, Salorio CF, Almuqati R, Schwartz JM, Everett AD, Bembea MM
Pediatr Res 2022 Aug;92(2):549-556. Epub 2021 Nov 3 doi: 10.1038/s41390-021-01817-8. PMID: 34732815Free PMC Article
Plasma irisin is elevated in type 2 diabetes and is associated with increased E-selectin levels.
Rana KS, Pararasa C, Afzal I, Nagel DA, Hill EJ, Bailey CJ, Griffiths HR, Kyrou I, Randeva HS, Bellary S, Brown JE
Cardiovasc Diabetol 2017 Nov 9;16(1):147. doi: 10.1186/s12933-017-0627-2. PMID: 29121940Free PMC Article
Relationship between renal function and circulating microparticles, soluble P-selectin and E-selectin levels in atrial fibrillation.
Lau YC, Xiong Q, Blann AD, Lip GY
J Thromb Thrombolysis 2017 Jan;43(1):18-23. doi: 10.1007/s11239-016-1427-3. PMID: 27671694Free PMC Article
Elevated circulating E-selectin, intercellular adhesion molecule 1, and von Willebrand factor in patients with severe infection.
Kayal S, Jaïs JP, Aguini N, Chaudière J, Labrousse J
Am J Respir Crit Care Med 1998 Mar;157(3 Pt 1):776-84. doi: 10.1164/ajrccm.157.3.9705034. PMID: 9517590

Clinical prediction guides

Soluble adhesion molecules and functional outcome after ischemic stroke: A Mendelian randomization study.
Wang M, Zhang Z, Liu D, Karhunen V, Georgakis MK, Ren Y, Ye D, Gill D, Liu M
J Stroke Cerebrovasc Dis 2023 Jun;32(6):107136. Epub 2023 Apr 15 doi: 10.1016/j.jstrokecerebrovasdis.2023.107136. PMID: 37068323
Circulating hyaluronic acid signature in CAP and ARDS - the role of pneumolysin in hyaluronic acid shedding.
Sauer A, Seeliger B, Jandl K, Erfinanda L, Wilhelm J, Alexopoulos I, Baal N, Birnhuber A, David S, Welte T, Barreto G, Gaertner U, Kwapiszewska G, Seeger W, Kuebler WM, Schaefer L, Wygrecka M; members of the CAPNETZ Study Group
Matrix Biol 2022 Dec;114:67-83. Epub 2022 Nov 16 doi: 10.1016/j.matbio.2022.11.003. PMID: 36456058
Corneal nerve loss in patients with TIA and acute ischemic stroke in relation to circulating markers of inflammation and vascular integrity.
Khan A, Parray A, Akhtar N, Agouni A, Kamran S, Pananchikkal SV, Priyanka R, Gad H, Ponirakis G, Petropoulos IN, Chen KH, Tayyab K, Saqqur M, Shuaib A, Malik RA
Sci Rep 2022 Feb 28;12(1):3332. doi: 10.1038/s41598-022-07353-7. PMID: 35228650Free PMC Article
Pediatric ECMO: unfavorable outcomes are associated with inflammation and endothelial activation.
Caprarola SD, Ng DK, Carroll MK, Tekes A, Felling RJ, Salorio CF, Almuqati R, Schwartz JM, Everett AD, Bembea MM
Pediatr Res 2022 Aug;92(2):549-556. Epub 2021 Nov 3 doi: 10.1038/s41390-021-01817-8. PMID: 34732815Free PMC Article
Elevated circulating E-selectin, intercellular adhesion molecule 1, and von Willebrand factor in patients with severe infection.
Kayal S, Jaïs JP, Aguini N, Chaudière J, Labrousse J
Am J Respir Crit Care Med 1998 Mar;157(3 Pt 1):776-84. doi: 10.1164/ajrccm.157.3.9705034. PMID: 9517590

Recent systematic reviews

Endothelial glycocalyx-associated molecules as potential serological markers for sepsis-associated encephalopathy: A systematic review and meta-analysis.
Baby S, Reljic T, Villalba N, Kumar A, Yuan SY
PLoS One 2023;18(2):e0281941. Epub 2023 Feb 21 doi: 10.1371/journal.pone.0281941. PMID: 36802387Free PMC Article

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