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Elevated circulating E selectin level

MedGen UID:
1696341
•Concept ID:
C5139218
•
Finding
HPO: HP:0032240

Definition

An increased concentration of E selectin in the blood circulation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated circulating E selectin level

Professional guidelines

PubMed

The expression of microvesicles in the blood of patients with Graves' disease and its relationship to treatment.
Mobarrez F, Abraham-Nordling M, Aguilera-Gatica K, Friberg I, Antovic A, Pisetsky DS, Jörneskog G, Wallen H
Clin Endocrinol (Oxf) 2016 May;84(5):729-35. Epub 2015 Sep 22 doi: 10.1111/cen.12872. PMID: 26252432
Circulating endothelial cell levels in psoriatic patients and their modification after an anti-TNF-alpha (Etanercept) treatment.
De Simone C, Caldarola G, Coco V, Palumbo S, Pocino K, Sgambato A, Maiorino A, Corbi M, Sandri MT, Vendittelli F, Capoluongo E
J Eur Acad Dermatol Venereol 2014 May;28(5):590-6. Epub 2013 Mar 18 doi: 10.1111/jdv.12140. PMID: 23506557
Circulating E-selectin levels in chronic hepatitis C patients with normal or elevated transaminase before and after alpha-interferon treatment.
Montalto G, Giannitrapani L, Soresi M, Virruso L, Martino DD, Gambino R, Carroccio A, Cervello M
Inflammation 2001 Apr;25(2):101-8. doi: 10.1023/a:1007118605861. PMID: 11321356

Recent clinical studies

Etiology

E-selectin in vascular pathophysiology.
Zhang J, Huang S, Zhu Z, Gatt A, Liu J
Front Immunol 2024;15:1401399. Epub 2024 Jul 19 doi: 10.3389/fimmu.2024.1401399. PMID: 39100681Free PMC Article
Expression of ICAM-1 and E-selectin in different metabolic obesity phenotypes: discrepancy for endothelial dysfunction.
Liu M, Wang P, Xie P, Xu X, He L, Chen X, Zhang S, Lin Y, Huang Y, Xia W, Wang L, Liao X, Guo Y, Zhuang X
J Endocrinol Invest 2023 Nov;46(11):2379-2389. Epub 2023 Apr 18 doi: 10.1007/s40618-023-02094-4. PMID: 37071373
Long-term Host Immune Response Trajectories Among Hospitalized Patients With Sepsis.
Yende S, Kellum JA, Talisa VB, Peck Palmer OM, Chang CH, Filbin MR, Shapiro NI, Hou PC, Venkat A, LoVecchio F, Hawkins K, Crouser ED, Newman AB, Angus DC
JAMA Netw Open 2019 Aug 2;2(8):e198686. doi: 10.1001/jamanetworkopen.2019.8686. PMID: 31390038Free PMC Article
Characterization of Microvesicles in Septic Shock Using High-Sensitivity Flow Cytometry.
Lehner GF, Harler U, Haller VM, Feistritzer C, Hasslacher J, Dunzendorfer S, Bellmann R, Joannidis M
Shock 2016 Oct;46(4):373-81. doi: 10.1097/SHK.0000000000000657. PMID: 27206273
Nicotine exposure alters in vivo human responses to endotoxin.
Wittebole X, Hahm S, Coyle SM, Kumar A, Calvano SE, Lowry SF
Clin Exp Immunol 2007 Jan;147(1):28-34. doi: 10.1111/j.1365-2249.2006.03248.x. PMID: 17177960Free PMC Article

Diagnosis

Soluble adhesion molecules and functional outcome after ischemic stroke: A Mendelian randomization study.
Wang M, Zhang Z, Liu D, Karhunen V, Georgakis MK, Ren Y, Ye D, Gill D, Liu M
J Stroke Cerebrovasc Dis 2023 Jun;32(6):107136. Epub 2023 Apr 15 doi: 10.1016/j.jstrokecerebrovasdis.2023.107136. PMID: 37068323
Endothelial glycocalyx-associated molecules as potential serological markers for sepsis-associated encephalopathy: A systematic review and meta-analysis.
Baby S, Reljic T, Villalba N, Kumar A, Yuan SY
PLoS One 2023;18(2):e0281941. Epub 2023 Feb 21 doi: 10.1371/journal.pone.0281941. PMID: 36802387Free PMC Article
Long-term Host Immune Response Trajectories Among Hospitalized Patients With Sepsis.
Yende S, Kellum JA, Talisa VB, Peck Palmer OM, Chang CH, Filbin MR, Shapiro NI, Hou PC, Venkat A, LoVecchio F, Hawkins K, Crouser ED, Newman AB, Angus DC
JAMA Netw Open 2019 Aug 2;2(8):e198686. doi: 10.1001/jamanetworkopen.2019.8686. PMID: 31390038Free PMC Article
Characterization of Microvesicles in Septic Shock Using High-Sensitivity Flow Cytometry.
Lehner GF, Harler U, Haller VM, Feistritzer C, Hasslacher J, Dunzendorfer S, Bellmann R, Joannidis M
Shock 2016 Oct;46(4):373-81. doi: 10.1097/SHK.0000000000000657. PMID: 27206273
Elevated circulating E-selectin, intercellular adhesion molecule 1, and von Willebrand factor in patients with severe infection.
Kayal S, Jaïs JP, Aguini N, Chaudière J, Labrousse J
Am J Respir Crit Care Med 1998 Mar;157(3 Pt 1):776-84. doi: 10.1164/ajrccm.157.3.9705034. PMID: 9517590

Therapy

Soluble adhesion molecules and functional outcome after ischemic stroke: A Mendelian randomization study.
Wang M, Zhang Z, Liu D, Karhunen V, Georgakis MK, Ren Y, Ye D, Gill D, Liu M
J Stroke Cerebrovasc Dis 2023 Jun;32(6):107136. Epub 2023 Apr 15 doi: 10.1016/j.jstrokecerebrovasdis.2023.107136. PMID: 37068323
The Role of Inflammatory Biomarkers in the Detection and Therapy of Atherosclerotic Disease.
Poredos P, Jezovnik MK
Curr Vasc Pharmacol 2016;14(6):534-546. doi: 10.2174/1570161114666160625080104. PMID: 27357185
Increased circulating PEDF and low sICAM-1 are associated with sickle cell retinopathy.
Cruz PR, Lira RP, Pereira Filho SA, Souza BB, Mitsuushi FN, Menaa F, Fertrin KY, Vasconcellos JP, Conran N, Costa FF, Melo MB
Blood Cells Mol Dis 2015 Jan;54(1):33-7. Epub 2014 Aug 29 doi: 10.1016/j.bcmd.2014.08.003. PMID: 25172543
Nicotine exposure alters in vivo human responses to endotoxin.
Wittebole X, Hahm S, Coyle SM, Kumar A, Calvano SE, Lowry SF
Clin Exp Immunol 2007 Jan;147(1):28-34. doi: 10.1111/j.1365-2249.2006.03248.x. PMID: 17177960Free PMC Article
Increased circulating cytokines, cytokine antagonists, and E-selectin after intravenous administration of endotoxin in humans.
Kuhns DB, Alvord WG, Gallin JI
J Infect Dis 1995 Jan;171(1):145-52. doi: 10.1093/infdis/171.1.145. PMID: 7528250

Prognosis

Soluble adhesion molecules and functional outcome after ischemic stroke: A Mendelian randomization study.
Wang M, Zhang Z, Liu D, Karhunen V, Georgakis MK, Ren Y, Ye D, Gill D, Liu M
J Stroke Cerebrovasc Dis 2023 Jun;32(6):107136. Epub 2023 Apr 15 doi: 10.1016/j.jstrokecerebrovasdis.2023.107136. PMID: 37068323
Pediatric ECMO: unfavorable outcomes are associated with inflammation and endothelial activation.
Caprarola SD, Ng DK, Carroll MK, Tekes A, Felling RJ, Salorio CF, Almuqati R, Schwartz JM, Everett AD, Bembea MM
Pediatr Res 2022 Aug;92(2):549-556. Epub 2021 Nov 3 doi: 10.1038/s41390-021-01817-8. PMID: 34732815Free PMC Article
Long-term Host Immune Response Trajectories Among Hospitalized Patients With Sepsis.
Yende S, Kellum JA, Talisa VB, Peck Palmer OM, Chang CH, Filbin MR, Shapiro NI, Hou PC, Venkat A, LoVecchio F, Hawkins K, Crouser ED, Newman AB, Angus DC
JAMA Netw Open 2019 Aug 2;2(8):e198686. doi: 10.1001/jamanetworkopen.2019.8686. PMID: 31390038Free PMC Article
Plasma irisin is elevated in type 2 diabetes and is associated with increased E-selectin levels.
Rana KS, Pararasa C, Afzal I, Nagel DA, Hill EJ, Bailey CJ, Griffiths HR, Kyrou I, Randeva HS, Bellary S, Brown JE
Cardiovasc Diabetol 2017 Nov 9;16(1):147. doi: 10.1186/s12933-017-0627-2. PMID: 29121940Free PMC Article
Circulating receptors implicated in the cyto-adherence occurring in severe Plasmodium falciparum malaria in Thailand.
Muanza K, Traoré B, Gay F, Krudsood S, Danis M, Looareesuwan S
Ann Trop Med Parasitol 1999 Jul;93(5):449-55. doi: 10.1080/00034989958186. PMID: 10690240

Clinical prediction guides

Soluble adhesion molecules and functional outcome after ischemic stroke: A Mendelian randomization study.
Wang M, Zhang Z, Liu D, Karhunen V, Georgakis MK, Ren Y, Ye D, Gill D, Liu M
J Stroke Cerebrovasc Dis 2023 Jun;32(6):107136. Epub 2023 Apr 15 doi: 10.1016/j.jstrokecerebrovasdis.2023.107136. PMID: 37068323
Endothelial glycocalyx-associated molecules as potential serological markers for sepsis-associated encephalopathy: A systematic review and meta-analysis.
Baby S, Reljic T, Villalba N, Kumar A, Yuan SY
PLoS One 2023;18(2):e0281941. Epub 2023 Feb 21 doi: 10.1371/journal.pone.0281941. PMID: 36802387Free PMC Article
Long-term Host Immune Response Trajectories Among Hospitalized Patients With Sepsis.
Yende S, Kellum JA, Talisa VB, Peck Palmer OM, Chang CH, Filbin MR, Shapiro NI, Hou PC, Venkat A, LoVecchio F, Hawkins K, Crouser ED, Newman AB, Angus DC
JAMA Netw Open 2019 Aug 2;2(8):e198686. doi: 10.1001/jamanetworkopen.2019.8686. PMID: 31390038Free PMC Article
Plasma irisin is elevated in type 2 diabetes and is associated with increased E-selectin levels.
Rana KS, Pararasa C, Afzal I, Nagel DA, Hill EJ, Bailey CJ, Griffiths HR, Kyrou I, Randeva HS, Bellary S, Brown JE
Cardiovasc Diabetol 2017 Nov 9;16(1):147. doi: 10.1186/s12933-017-0627-2. PMID: 29121940Free PMC Article
Circulating receptors implicated in the cyto-adherence occurring in severe Plasmodium falciparum malaria in Thailand.
Muanza K, Traoré B, Gay F, Krudsood S, Danis M, Looareesuwan S
Ann Trop Med Parasitol 1999 Jul;93(5):449-55. doi: 10.1080/00034989958186. PMID: 10690240

Recent systematic reviews

Endothelial glycocalyx-associated molecules as potential serological markers for sepsis-associated encephalopathy: A systematic review and meta-analysis.
Baby S, Reljic T, Villalba N, Kumar A, Yuan SY
PLoS One 2023;18(2):e0281941. Epub 2023 Feb 21 doi: 10.1371/journal.pone.0281941. PMID: 36802387Free PMC Article

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