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Increased proportion of unswitched memory B cells

MedGen UID:
1697224
•Concept ID:
C5139145
•
Finding
Synonyms: Elevated proportion of unswitched memory B cells; Increased proportion of non-class-switched memory B cells
 
HPO: HP:0032125

Definition

An increase above the normal proportion of non-class-switched memory B cells relative to the total number of B cells. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased proportion of unswitched memory B cells

Recent clinical studies

Etiology

Unswitched memory B cell deficiency in children with sickle cell disease and response to pneumococcal polysaccharide vaccine.
Tubman VN, Maysonet D, Estrada N, Halder T, Ramos L, Bhamidipati S, Carisey AF, Minard CG, Allen CE
Am J Hematol 2024 Jun;99(6):1084-1094. Epub 2024 May 6 doi: 10.1002/ajh.27319. PMID: 38708915

Diagnosis

Integrating single-cell RNA sequencing with spatial transcriptomics reveals immune landscape for interstitial cystitis.
Peng L, Jin X, Li BY, Zeng X, Liao BH, Jin T, Chen JW, Gao XS, Wang W, He Q, Chen G, Gong LN, Shen H, Wang KJ, Li H, Luo DY
Signal Transduct Target Ther 2022 May 20;7(1):161. doi: 10.1038/s41392-022-00962-8. PMID: 35589692Free PMC Article

Therapy

Unswitched memory B cell deficiency in children with sickle cell disease and response to pneumococcal polysaccharide vaccine.
Tubman VN, Maysonet D, Estrada N, Halder T, Ramos L, Bhamidipati S, Carisey AF, Minard CG, Allen CE
Am J Hematol 2024 Jun;99(6):1084-1094. Epub 2024 May 6 doi: 10.1002/ajh.27319. PMID: 38708915

Clinical prediction guides

Effect of climatic environment on immunological features of rheumatoid arthritis.
Kondo Y, Abe S, Toko H, Hirota T, Takahashi H, Shimizu M, Noma H, Tsuboi H, Matsumoto I, Inaba T, Sumida T
Sci Rep 2023 Jan 24;13(1):1304. doi: 10.1038/s41598-022-27153-3. PMID: 36693893Free PMC Article
HIV-Exposed Uninfected Infants Show Robust Memory B-Cell Responses in Spite of a Delayed Accumulation of Memory B Cells: an Observational Study in the First 2 Years of Life.
Nduati EW, Nkumama IN, Gambo FK, Muema DM, Knight MG, Hassan AS, Jahangir MN, Etyang TJ, Berkley JA, Urban BC
Clin Vaccine Immunol 2016 Jul;23(7):576-85. Epub 2016 Jul 5 doi: 10.1128/CVI.00149-16. PMID: 27170641Free PMC Article

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