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Refractory Diffuse Large B-Cell Lymphoma Germinal Center B-Cell Type

MedGen UID:
1697485
•Concept ID:
C5205065
•
Neoplastic Process

Definition

Diffuse large B-cell lymphoma germinal center B-cell type that is resistant to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Diffuse Large B-Cell Lymphoma Germinal Center B-Cell Type

Professional guidelines

PubMed

Novel disease targets and management approaches for diffuse large B-cell lymphoma.
Wilson WH, Hernandez-Ilizaliturri FJ, Dunleavy K, Little RF, O'Connor OA
Leuk Lymphoma 2010 Aug;51 Suppl 1(Suppl 1):1-10. doi: 10.3109/10428194.2010.500045. PMID: 20658952Free PMC Article

Recent clinical studies

Etiology

Real life clinical outcomes of relapsed/refractory diffuse large B cell lymphoma in the rituximab era: The STRIDER study.
Dogliotti I, Peri V, Clerico M, Vassallo F, Musto D, Mercadante S, Ragaini S, Botto B, Levis M, Novo M, Ghislieri M, Molinaro L, Mortara U, Consoli C, Lonardo A, Bondielli G, Ferrero S, Freilone R, Ricardi U, Bruno B, Cavallo F
Cancer Med 2024 Jul;13(14):e7448. doi: 10.1002/cam4.7448. PMID: 39030982Free PMC Article
Longitudinal expression profiling identifies a poor risk subset of patients with ABC-type diffuse large B-cell lymphoma.
Bewicke-Copley F, Korfi K, Araf S, Hodkinson B, Kumar E, Cummin T, Ashton-Key M, Barrans S, van Hoppe S, Burton C, Elshiekh M, Rule S, Crosbie N, Clear A, Calaminici M, Runge H, Hills RK, Scott DW, Rimsza LM, Menon G, Sha C, Davies JR, Nagano A, Davies A, Painter D, Smith A, Gribben J, Naresh KN, Westhead DR, Okosun J, Steele A, Hodson DJ, Balasubramanian S, Johnson P, Wang J, Fitzgibbon J
Blood Adv 2023 Mar 14;7(5):845-855. doi: 10.1182/bloodadvances.2022007536. PMID: 35947123Free PMC Article
Clinicopathologic implication of microRNA-197 in diffuse large B cell lymphoma.
Yang JM, Jang JY, Jeon YK, Paik JH
J Transl Med 2018 Jun 11;16(1):162. doi: 10.1186/s12967-018-1537-0. PMID: 29890998Free PMC Article
Genetic Landscapes of Relapsed and Refractory Diffuse Large B-Cell Lymphomas.
Morin RD, Assouline S, Alcaide M, Mohajeri A, Johnston RL, Chong L, Grewal J, Yu S, Fornika D, Bushell K, Nielsen TH, Petrogiannis-Haliotis T, Crump M, Tosikyan A, Grande BM, MacDonald D, Rousseau C, Bayat M, Sesques P, Froment R, Albuquerque M, Monczak Y, Oros KK, Greenwood C, Riazalhosseini Y, Arseneault M, Camlioglu E, Constantin A, Pan-Hammarstrom Q, Peng R, Mann KK, Johnson NA
Clin Cancer Res 2016 May 1;22(9):2290-300. Epub 2015 Dec 8 doi: 10.1158/1078-0432.CCR-15-2123. PMID: 26647218
Double hit diffuse large B-cell lymphomas: diagnostic and therapeutic challenges.
Friedberg JW
Chin Clin Oncol 2015 Mar;4(1):9. doi: 10.3978/j.issn.2304-3865.2015.03.02. PMID: 25841716

Diagnosis

Real life clinical outcomes of relapsed/refractory diffuse large B cell lymphoma in the rituximab era: The STRIDER study.
Dogliotti I, Peri V, Clerico M, Vassallo F, Musto D, Mercadante S, Ragaini S, Botto B, Levis M, Novo M, Ghislieri M, Molinaro L, Mortara U, Consoli C, Lonardo A, Bondielli G, Ferrero S, Freilone R, Ricardi U, Bruno B, Cavallo F
Cancer Med 2024 Jul;13(14):e7448. doi: 10.1002/cam4.7448. PMID: 39030982Free PMC Article
Longitudinal expression profiling identifies a poor risk subset of patients with ABC-type diffuse large B-cell lymphoma.
Bewicke-Copley F, Korfi K, Araf S, Hodkinson B, Kumar E, Cummin T, Ashton-Key M, Barrans S, van Hoppe S, Burton C, Elshiekh M, Rule S, Crosbie N, Clear A, Calaminici M, Runge H, Hills RK, Scott DW, Rimsza LM, Menon G, Sha C, Davies JR, Nagano A, Davies A, Painter D, Smith A, Gribben J, Naresh KN, Westhead DR, Okosun J, Steele A, Hodson DJ, Balasubramanian S, Johnson P, Wang J, Fitzgibbon J
Blood Adv 2023 Mar 14;7(5):845-855. doi: 10.1182/bloodadvances.2022007536. PMID: 35947123Free PMC Article
Genetic Landscapes of Relapsed and Refractory Diffuse Large B-Cell Lymphomas.
Morin RD, Assouline S, Alcaide M, Mohajeri A, Johnston RL, Chong L, Grewal J, Yu S, Fornika D, Bushell K, Nielsen TH, Petrogiannis-Haliotis T, Crump M, Tosikyan A, Grande BM, MacDonald D, Rousseau C, Bayat M, Sesques P, Froment R, Albuquerque M, Monczak Y, Oros KK, Greenwood C, Riazalhosseini Y, Arseneault M, Camlioglu E, Constantin A, Pan-Hammarstrom Q, Peng R, Mann KK, Johnson NA
Clin Cancer Res 2016 May 1;22(9):2290-300. Epub 2015 Dec 8 doi: 10.1158/1078-0432.CCR-15-2123. PMID: 26647218
Double hit diffuse large B-cell lymphomas: diagnostic and therapeutic challenges.
Friedberg JW
Chin Clin Oncol 2015 Mar;4(1):9. doi: 10.3978/j.issn.2304-3865.2015.03.02. PMID: 25841716
Novel disease targets and management approaches for diffuse large B-cell lymphoma.
Wilson WH, Hernandez-Ilizaliturri FJ, Dunleavy K, Little RF, O'Connor OA
Leuk Lymphoma 2010 Aug;51 Suppl 1(Suppl 1):1-10. doi: 10.3109/10428194.2010.500045. PMID: 20658952Free PMC Article

Therapy

Real life clinical outcomes of relapsed/refractory diffuse large B cell lymphoma in the rituximab era: The STRIDER study.
Dogliotti I, Peri V, Clerico M, Vassallo F, Musto D, Mercadante S, Ragaini S, Botto B, Levis M, Novo M, Ghislieri M, Molinaro L, Mortara U, Consoli C, Lonardo A, Bondielli G, Ferrero S, Freilone R, Ricardi U, Bruno B, Cavallo F
Cancer Med 2024 Jul;13(14):e7448. doi: 10.1002/cam4.7448. PMID: 39030982Free PMC Article
Longitudinal expression profiling identifies a poor risk subset of patients with ABC-type diffuse large B-cell lymphoma.
Bewicke-Copley F, Korfi K, Araf S, Hodkinson B, Kumar E, Cummin T, Ashton-Key M, Barrans S, van Hoppe S, Burton C, Elshiekh M, Rule S, Crosbie N, Clear A, Calaminici M, Runge H, Hills RK, Scott DW, Rimsza LM, Menon G, Sha C, Davies JR, Nagano A, Davies A, Painter D, Smith A, Gribben J, Naresh KN, Westhead DR, Okosun J, Steele A, Hodson DJ, Balasubramanian S, Johnson P, Wang J, Fitzgibbon J
Blood Adv 2023 Mar 14;7(5):845-855. doi: 10.1182/bloodadvances.2022007536. PMID: 35947123Free PMC Article
Clinicopathologic implication of microRNA-197 in diffuse large B cell lymphoma.
Yang JM, Jang JY, Jeon YK, Paik JH
J Transl Med 2018 Jun 11;16(1):162. doi: 10.1186/s12967-018-1537-0. PMID: 29890998Free PMC Article
Double hit diffuse large B-cell lymphomas: diagnostic and therapeutic challenges.
Friedberg JW
Chin Clin Oncol 2015 Mar;4(1):9. doi: 10.3978/j.issn.2304-3865.2015.03.02. PMID: 25841716
Non-Hodgkin's lymphoma: the old and the new.
Cabanillas F
Clin Lymphoma Myeloma Leuk 2011 Jun;11 Suppl 1:S87-90. Epub 2011 Apr 28 doi: 10.1016/j.clml.2011.03.029. PMID: 22035756

Prognosis

Longitudinal expression profiling identifies a poor risk subset of patients with ABC-type diffuse large B-cell lymphoma.
Bewicke-Copley F, Korfi K, Araf S, Hodkinson B, Kumar E, Cummin T, Ashton-Key M, Barrans S, van Hoppe S, Burton C, Elshiekh M, Rule S, Crosbie N, Clear A, Calaminici M, Runge H, Hills RK, Scott DW, Rimsza LM, Menon G, Sha C, Davies JR, Nagano A, Davies A, Painter D, Smith A, Gribben J, Naresh KN, Westhead DR, Okosun J, Steele A, Hodson DJ, Balasubramanian S, Johnson P, Wang J, Fitzgibbon J
Blood Adv 2023 Mar 14;7(5):845-855. doi: 10.1182/bloodadvances.2022007536. PMID: 35947123Free PMC Article
Exosomes and extracellular vesicles as liquid biopsy biomarkers in diffuse large B-cell lymphoma: Current state of the art and unmet clinical needs.
Ofori K, Bhagat G, Rai AJ
Br J Clin Pharmacol 2021 Feb;87(2):284-294. Epub 2020 Nov 18 doi: 10.1111/bcp.14611. PMID: 33080045
Clinicopathologic implication of microRNA-197 in diffuse large B cell lymphoma.
Yang JM, Jang JY, Jeon YK, Paik JH
J Transl Med 2018 Jun 11;16(1):162. doi: 10.1186/s12967-018-1537-0. PMID: 29890998Free PMC Article
Double hit diffuse large B-cell lymphomas: diagnostic and therapeutic challenges.
Friedberg JW
Chin Clin Oncol 2015 Mar;4(1):9. doi: 10.3978/j.issn.2304-3865.2015.03.02. PMID: 25841716
Non-Hodgkin's lymphoma: the old and the new.
Cabanillas F
Clin Lymphoma Myeloma Leuk 2011 Jun;11 Suppl 1:S87-90. Epub 2011 Apr 28 doi: 10.1016/j.clml.2011.03.029. PMID: 22035756

Clinical prediction guides

Real life clinical outcomes of relapsed/refractory diffuse large B cell lymphoma in the rituximab era: The STRIDER study.
Dogliotti I, Peri V, Clerico M, Vassallo F, Musto D, Mercadante S, Ragaini S, Botto B, Levis M, Novo M, Ghislieri M, Molinaro L, Mortara U, Consoli C, Lonardo A, Bondielli G, Ferrero S, Freilone R, Ricardi U, Bruno B, Cavallo F
Cancer Med 2024 Jul;13(14):e7448. doi: 10.1002/cam4.7448. PMID: 39030982Free PMC Article
Longitudinal expression profiling identifies a poor risk subset of patients with ABC-type diffuse large B-cell lymphoma.
Bewicke-Copley F, Korfi K, Araf S, Hodkinson B, Kumar E, Cummin T, Ashton-Key M, Barrans S, van Hoppe S, Burton C, Elshiekh M, Rule S, Crosbie N, Clear A, Calaminici M, Runge H, Hills RK, Scott DW, Rimsza LM, Menon G, Sha C, Davies JR, Nagano A, Davies A, Painter D, Smith A, Gribben J, Naresh KN, Westhead DR, Okosun J, Steele A, Hodson DJ, Balasubramanian S, Johnson P, Wang J, Fitzgibbon J
Blood Adv 2023 Mar 14;7(5):845-855. doi: 10.1182/bloodadvances.2022007536. PMID: 35947123Free PMC Article
Exosomes and extracellular vesicles as liquid biopsy biomarkers in diffuse large B-cell lymphoma: Current state of the art and unmet clinical needs.
Ofori K, Bhagat G, Rai AJ
Br J Clin Pharmacol 2021 Feb;87(2):284-294. Epub 2020 Nov 18 doi: 10.1111/bcp.14611. PMID: 33080045
Genetic Landscapes of Relapsed and Refractory Diffuse Large B-Cell Lymphomas.
Morin RD, Assouline S, Alcaide M, Mohajeri A, Johnston RL, Chong L, Grewal J, Yu S, Fornika D, Bushell K, Nielsen TH, Petrogiannis-Haliotis T, Crump M, Tosikyan A, Grande BM, MacDonald D, Rousseau C, Bayat M, Sesques P, Froment R, Albuquerque M, Monczak Y, Oros KK, Greenwood C, Riazalhosseini Y, Arseneault M, Camlioglu E, Constantin A, Pan-Hammarstrom Q, Peng R, Mann KK, Johnson NA
Clin Cancer Res 2016 May 1;22(9):2290-300. Epub 2015 Dec 8 doi: 10.1158/1078-0432.CCR-15-2123. PMID: 26647218
Double hit diffuse large B-cell lymphomas: diagnostic and therapeutic challenges.
Friedberg JW
Chin Clin Oncol 2015 Mar;4(1):9. doi: 10.3978/j.issn.2304-3865.2015.03.02. PMID: 25841716

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