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Abnormal plasmablast proportion

MedGen UID:
1697630
Concept ID:
C5139147
Finding
HPO: HP:0032127

Definition

A deviation from the normal proportion of plasmablasts in circulation relative to total number of B cells. Plasmablasts are antibody-secreting cells that originate after infection or vaccination. [from HPO]

Recent clinical studies

Etiology

Torimoto K, Okada Y, Nakayamada S, Kubo S, Kurozumi A, Narisawa M, Tanaka Y
Sci Rep 2022 Oct 7;12(1):16880. doi: 10.1038/s41598-022-19556-z. PMID: 36207336Free PMC Article
Lu X, Zhang X, Cheung AKL, Moog C, Xia H, Li Z, Wang R, Ji Y, Xia W, Liu Z, Yuan L, Wang X, Wu H, Zhang T, Su B
Front Immunol 2022;13:837921. Epub 2022 Feb 10 doi: 10.3389/fimmu.2022.837921. PMID: 35222430Free PMC Article
Cardoso CC, Matiollo C, Pereira CHJ, Fonseca JS, Alves HEL, Silva OMD, Menegassi VS, Schiavon LL, Santos-Silva MC
Clin Res Hepatol Gastroenterol 2021 Jul;45(4):101698. Epub 2021 Apr 20 doi: 10.1016/j.clinre.2021.101698. PMID: 33852953
Kubo S, Nakayamada S, Miyazaki Y, Yoshikawa M, Yoshinari H, Satoh Y, Todoroki Y, Nakano K, Satoh M, Smith V, Cutolo M, Tanaka Y
Rheumatology (Oxford) 2019 Dec 1;58(12):2273-2283. doi: 10.1093/rheumatology/kez244. PMID: 31230071
Kubo S, Nakayamada S, Yoshikawa M, Miyazaki Y, Sakata K, Nakano K, Hanami K, Iwata S, Miyagawa I, Saito K, Tanaka Y
Arthritis Rheumatol 2017 Oct;69(10):2029-2037. Epub 2017 Aug 25 doi: 10.1002/art.40180. PMID: 28605137

Diagnosis

Baxter RM, Wang CS, Garcia-Perez JE, Kong DS, Coleman BM, Larchenko V, Schuyler RP, Jackson C, Ghosh T, Rudra P, Paul D, Claassen M, Rochford R, Cambier JC, Ghosh D, Cooper JC, Smith MJ, Hsieh EWY
Front Immunol 2023;14:1208282. Epub 2023 Oct 27 doi: 10.3389/fimmu.2023.1208282. PMID: 37965329Free PMC Article
Kubo S, Nakayamada S, Zhao J, Yoshikawa M, Miyazaki Y, Nawata A, Hirata S, Nakano K, Saito K, Tanaka Y
Rheumatology (Oxford) 2018 Mar 1;57(3):514-524. doi: 10.1093/rheumatology/kex455. PMID: 29253269
Szczawinska-Poplonyk A, Tapolska-Jozwiak K, Samara H
Ital J Pediatr 2016 Jul 26;42(1):71. doi: 10.1186/s13052-016-0279-y. PMID: 27461226Free PMC Article
Rajkumar SV, Fonseca R, Lacy MQ, Witzig TE, Therneau TM, Kyle RA, Litzow MR, Gertz MA, Greipp PR
J Clin Oncol 1999 May;17(5):1551-7. doi: 10.1200/JCO.1999.17.5.1551. PMID: 10334543

Therapy

Torimoto K, Okada Y, Nakayamada S, Kubo S, Kurozumi A, Narisawa M, Tanaka Y
Sci Rep 2022 Oct 7;12(1):16880. doi: 10.1038/s41598-022-19556-z. PMID: 36207336Free PMC Article
Lu X, Zhang X, Cheung AKL, Moog C, Xia H, Li Z, Wang R, Ji Y, Xia W, Liu Z, Yuan L, Wang X, Wu H, Zhang T, Su B
Front Immunol 2022;13:837921. Epub 2022 Feb 10 doi: 10.3389/fimmu.2022.837921. PMID: 35222430Free PMC Article
Tanko RF, Soares AP, Müller TL, Garrett NJ, Samsunder N, Abdool Karim Q, Abdool Karim SS, Riou C, Burgers WA
J Immunol 2017 Feb 1;198(3):1220-1228. Epub 2016 Dec 30 doi: 10.4049/jimmunol.1601560. PMID: 28039305Free PMC Article

Prognosis

Baxter RM, Wang CS, Garcia-Perez JE, Kong DS, Coleman BM, Larchenko V, Schuyler RP, Jackson C, Ghosh T, Rudra P, Paul D, Claassen M, Rochford R, Cambier JC, Ghosh D, Cooper JC, Smith MJ, Hsieh EWY
Front Immunol 2023;14:1208282. Epub 2023 Oct 27 doi: 10.3389/fimmu.2023.1208282. PMID: 37965329Free PMC Article
Emsen A, Uçaryılmaz H, Güler T, Artaç H
Turk J Pediatr 2022;64(2):228-238. doi: 10.24953/turkjped.2021.83. PMID: 35611411
Cardoso CC, Matiollo C, Pereira CHJ, Fonseca JS, Alves HEL, Silva OMD, Menegassi VS, Schiavon LL, Santos-Silva MC
Clin Res Hepatol Gastroenterol 2021 Jul;45(4):101698. Epub 2021 Apr 20 doi: 10.1016/j.clinre.2021.101698. PMID: 33852953
Szczawinska-Poplonyk A, Tapolska-Jozwiak K, Samara H
Ital J Pediatr 2016 Jul 26;42(1):71. doi: 10.1186/s13052-016-0279-y. PMID: 27461226Free PMC Article
Szabó K, Papp G, Szántó A, Tarr T, Zeher M
Clin Exp Immunol 2016 Jan;183(1):76-89. Epub 2015 Oct 21 doi: 10.1111/cei.12703. PMID: 26358223Free PMC Article

Clinical prediction guides

Torimoto K, Okada Y, Nakayamada S, Kubo S, Kurozumi A, Narisawa M, Tanaka Y
Sci Rep 2022 Oct 7;12(1):16880. doi: 10.1038/s41598-022-19556-z. PMID: 36207336Free PMC Article
Emsen A, Uçaryılmaz H, Güler T, Artaç H
Turk J Pediatr 2022;64(2):228-238. doi: 10.24953/turkjped.2021.83. PMID: 35611411
Yu TS, Wang HY, Zhao YJ, Yu YF, Hou Y, Liu S, Han PP, Ni XF, Ji XB, Peng J, Liu XG, Hou M
Blood Adv 2021 Oct 26;5(20):4087-4101. doi: 10.1182/bloodadvances.2020003860. PMID: 34507351Free PMC Article
Cardoso CC, Matiollo C, Pereira CHJ, Fonseca JS, Alves HEL, Silva OMD, Menegassi VS, Schiavon LL, Santos-Silva MC
Clin Res Hepatol Gastroenterol 2021 Jul;45(4):101698. Epub 2021 Apr 20 doi: 10.1016/j.clinre.2021.101698. PMID: 33852953
Kubo S, Nakayamada S, Yoshikawa M, Miyazaki Y, Sakata K, Nakano K, Hanami K, Iwata S, Miyagawa I, Saito K, Tanaka Y
Arthritis Rheumatol 2017 Oct;69(10):2029-2037. Epub 2017 Aug 25 doi: 10.1002/art.40180. PMID: 28605137

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