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Low anterior resection syndrome

MedGen UID:
1697708
•Concept ID:
C4524073
•
Disease or Syndrome
Synonym: Low Anterior Resection Syndrome
SNOMED CT: Low anterior resection syndrome (870625007); LARS - low anterior resection syndrome (870625007)

Definition

A collection of symptoms following removal of part or all of the rectum that may include frequency or urgency of stools, numerous bowel movements over a few hours, fecal incontinence, constipation alternating with numerous bowel movements, and/or increased intestinal gas. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLow anterior resection syndrome

Professional guidelines

PubMed

Management guidelines for low anterior resection syndrome - the MANUEL project.
Christensen P, Im Baeten C, Espín-Basany E, Martellucci J, Nugent KP, Zerbib F, Pellino G, Rosen H; MANUEL Project Working Group
Colorectal Dis 2021 Feb;23(2):461-475. Epub 2021 Jan 24 doi: 10.1111/codi.15517. PMID: 33411977Free PMC Article
Neoadjuvant radiotherapy for rectal cancer management.
Feeney G, Sehgal R, Sheehan M, Hogan A, Regan M, Joyce M, Kerin M
World J Gastroenterol 2019 Sep 7;25(33):4850-4869. doi: 10.3748/wjg.v25.i33.4850. PMID: 31543678Free PMC Article
Treatment possibilities for low anterior resection syndrome: a review of the literature.
Dulskas A, Smolskas E, Kildusiene I, Samalavicius NE
Int J Colorectal Dis 2018 Mar;33(3):251-260. Epub 2018 Jan 8 doi: 10.1007/s00384-017-2954-x. PMID: 29313107

Recent clinical studies

Etiology

Risk factors of postoperative low anterior resection syndrome for colorectal cancer: A meta-analysis.
Ye L, Huang M, Huang Y, Yu K, Wang X
Asian J Surg 2022 Jan;45(1):39-50. Epub 2021 Aug 3 doi: 10.1016/j.asjsur.2021.05.016. PMID: 34362620
Low anterior resection syndrome: can it be prevented?
Annicchiarico A, Martellucci J, Solari S, Scheiterle M, Bergamini C, Prosperi P
Int J Colorectal Dis 2021 Dec;36(12):2535-2552. Epub 2021 Aug 19 doi: 10.1007/s00384-021-04008-3. PMID: 34409501
Management guidelines for low anterior resection syndrome - the MANUEL project.
Christensen P, Im Baeten C, Espín-Basany E, Martellucci J, Nugent KP, Zerbib F, Pellino G, Rosen H; MANUEL Project Working Group
Colorectal Dis 2021 Feb;23(2):461-475. Epub 2021 Jan 24 doi: 10.1111/codi.15517. PMID: 33411977Free PMC Article
Low Anterior Resection Syndrome.
Nguyen TH, Chokshi RV
Curr Gastroenterol Rep 2020 Aug 4;22(10):48. doi: 10.1007/s11894-020-00785-z. PMID: 32749603Free PMC Article
Neoadjuvant radiotherapy for rectal cancer management.
Feeney G, Sehgal R, Sheehan M, Hogan A, Regan M, Joyce M, Kerin M
World J Gastroenterol 2019 Sep 7;25(33):4850-4869. doi: 10.3748/wjg.v25.i33.4850. PMID: 31543678Free PMC Article

Diagnosis

Low anterior resection syndrome (LARS) after sphincter-sparing rectal cancer surgery. Incidence and risk factors.
Yazici H, Dalkilic MS, Akin MI, Yegen SC, Attaallah W
Ann Ital Chir 2022;93:566-570. PMID: 36398766
Functional anorectal studies in patients with low anterior resection syndrome.
Chen SC, Futaba K, Leung WW, Wong C, Mak T, Ng S, Gregersen H
Neurogastroenterol Motil 2022 Mar;34(3):e14208. Epub 2021 Jun 18 doi: 10.1111/nmo.14208. PMID: 34145694
Management guidelines for low anterior resection syndrome - the MANUEL project.
Christensen P, Im Baeten C, Espín-Basany E, Martellucci J, Nugent KP, Zerbib F, Pellino G, Rosen H; MANUEL Project Working Group
Colorectal Dis 2021 Feb;23(2):461-475. Epub 2021 Jan 24 doi: 10.1111/codi.15517. PMID: 33411977Free PMC Article
Defining low anterior resection syndrome: a systematic review of the literature.
Keane C, Wells C, O'Grady G, Bissett IP
Colorectal Dis 2017 Aug;19(8):713-722. doi: 10.1111/codi.13767. PMID: 28612460
Low anterior resection syndrome score: development and validation of a symptom-based scoring system for bowel dysfunction after low anterior resection for rectal cancer.
Emmertsen KJ, Laurberg S
Ann Surg 2012 May;255(5):922-8. doi: 10.1097/SLA.0b013e31824f1c21. PMID: 22504191

Therapy

The Role of Pelvic Floor Muscle Training on Low Anterior Resection Syndrome: A Multicenter Randomized Controlled Trial.
Asnong A, D'Hoore A, Van Kampen M, Wolthuis A, Van Molhem Y, Van Geluwe B, Devoogdt N, De Groef A, Guler Caamano Fajardo I, Geraerts I
Ann Surg 2022 Nov 1;276(5):761-768. Epub 2022 Jul 27 doi: 10.1097/SLA.0000000000005632. PMID: 35894434Free PMC Article
Low Anterior Resection Syndrome.
Nguyen TH, Chokshi RV
Curr Gastroenterol Rep 2020 Aug 4;22(10):48. doi: 10.1007/s11894-020-00785-z. PMID: 32749603Free PMC Article
Neoadjuvant radiotherapy for rectal cancer management.
Feeney G, Sehgal R, Sheehan M, Hogan A, Regan M, Joyce M, Kerin M
World J Gastroenterol 2019 Sep 7;25(33):4850-4869. doi: 10.3748/wjg.v25.i33.4850. PMID: 31543678Free PMC Article
A meta-analysis of the prevalence of Low Anterior Resection Syndrome and systematic review of risk factors.
Croese AD, Lonie JM, Trollope AF, Vangaveti VN, Ho YH
Int J Surg 2018 Aug;56:234-241. Epub 2018 Jun 22 doi: 10.1016/j.ijsu.2018.06.031. PMID: 29936195
Treatment possibilities for low anterior resection syndrome: a review of the literature.
Dulskas A, Smolskas E, Kildusiene I, Samalavicius NE
Int J Colorectal Dis 2018 Mar;33(3):251-260. Epub 2018 Jan 8 doi: 10.1007/s00384-017-2954-x. PMID: 29313107

Prognosis

Low anterior resection syndrome (LARS) after sphincter-sparing rectal cancer surgery. Incidence and risk factors.
Yazici H, Dalkilic MS, Akin MI, Yegen SC, Attaallah W
Ann Ital Chir 2022;93:566-570. PMID: 36398766
The incidence and risk factors of low anterior resection syndrome (LARS) after sphincter-preserving surgery of rectal cancer: a systematic review and meta-analysis.
Sun R, Dai Z, Zhang Y, Lu J, Zhang Y, Xiao Y
Support Care Cancer 2021 Dec;29(12):7249-7258. Epub 2021 Jul 23 doi: 10.1007/s00520-021-06326-2. PMID: 34296335
Transanal total mesorectal excision and low anterior resection syndrome.
van der Heijden JAG, Qaderi SM, Verhoeven R, Custers JAE, Klarenbeek BR, Maaskant-Braat AJG, de Wilt JHW; PLCRC group
Br J Surg 2021 Aug 19;108(8):991-997. doi: 10.1093/bjs/znab056. PMID: 33837383
Impact of a defunctioning ileostomy and time to stoma closure on bowel function after low anterior resection for rectal cancer: a systematic review and meta-analysis.
Vogel I, Reeves N, Tanis PJ, Bemelman WA, Torkington J, Hompes R, Cornish JA
Tech Coloproctol 2021 Jul;25(7):751-760. Epub 2021 Apr 1 doi: 10.1007/s10151-021-02436-5. PMID: 33792822Free PMC Article
The Incidence of Low Anterior Resection Syndrome as Assessed in an International Randomized Controlled Trial (MRC/NIHR ROLARR).
Bolton WS, Chapman SJ, Corrigan N, Croft J, Collinson F, Brown JM, Jayne DG
Ann Surg 2021 Dec 1;274(6):e1223-e1229. doi: 10.1097/SLA.0000000000003806. PMID: 32097165

Clinical prediction guides

Low anterior resection syndrome: can it be prevented?
Annicchiarico A, Martellucci J, Solari S, Scheiterle M, Bergamini C, Prosperi P
Int J Colorectal Dis 2021 Dec;36(12):2535-2552. Epub 2021 Aug 19 doi: 10.1007/s00384-021-04008-3. PMID: 34409501
Low Anterior Resection Syndrome.
Nguyen TH, Chokshi RV
Curr Gastroenterol Rep 2020 Aug 4;22(10):48. doi: 10.1007/s11894-020-00785-z. PMID: 32749603Free PMC Article
A meta-analysis of the prevalence of Low Anterior Resection Syndrome and systematic review of risk factors.
Croese AD, Lonie JM, Trollope AF, Vangaveti VN, Ho YH
Int J Surg 2018 Aug;56:234-241. Epub 2018 Jun 22 doi: 10.1016/j.ijsu.2018.06.031. PMID: 29936195
Treatment possibilities for low anterior resection syndrome: a review of the literature.
Dulskas A, Smolskas E, Kildusiene I, Samalavicius NE
Int J Colorectal Dis 2018 Mar;33(3):251-260. Epub 2018 Jan 8 doi: 10.1007/s00384-017-2954-x. PMID: 29313107
Low anterior resection syndrome score: development and validation of a symptom-based scoring system for bowel dysfunction after low anterior resection for rectal cancer.
Emmertsen KJ, Laurberg S
Ann Surg 2012 May;255(5):922-8. doi: 10.1097/SLA.0b013e31824f1c21. PMID: 22504191

Recent systematic reviews

The incidence and risk factors of low anterior resection syndrome (LARS) after sphincter-preserving surgery of rectal cancer: a systematic review and meta-analysis.
Sun R, Dai Z, Zhang Y, Lu J, Zhang Y, Xiao Y
Support Care Cancer 2021 Dec;29(12):7249-7258. Epub 2021 Jul 23 doi: 10.1007/s00520-021-06326-2. PMID: 34296335
Impact of a defunctioning ileostomy and time to stoma closure on bowel function after low anterior resection for rectal cancer: a systematic review and meta-analysis.
Vogel I, Reeves N, Tanis PJ, Bemelman WA, Torkington J, Hompes R, Cornish JA
Tech Coloproctol 2021 Jul;25(7):751-760. Epub 2021 Apr 1 doi: 10.1007/s10151-021-02436-5. PMID: 33792822Free PMC Article
Functional outcomes of surgery for colon cancer: A systematic review and meta-analysis.
Verkuijl SJ, Jonker JE, Trzpis M, Burgerhof JGM, Broens PMA, Furnée EJB
Eur J Surg Oncol 2021 May;47(5):960-969. Epub 2020 Nov 26 doi: 10.1016/j.ejso.2020.11.136. PMID: 33277056
A meta-analysis of the prevalence of Low Anterior Resection Syndrome and systematic review of risk factors.
Croese AD, Lonie JM, Trollope AF, Vangaveti VN, Ho YH
Int J Surg 2018 Aug;56:234-241. Epub 2018 Jun 22 doi: 10.1016/j.ijsu.2018.06.031. PMID: 29936195
Defining low anterior resection syndrome: a systematic review of the literature.
Keane C, Wells C, O'Grady G, Bissett IP
Colorectal Dis 2017 Aug;19(8):713-722. doi: 10.1111/codi.13767. PMID: 28612460

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