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Monoclonal elevation of circulating IgA

MedGen UID:
1697825
Concept ID:
C5139277
Finding
HPO: HP:0032335

Definition

An increase in circulating IgA characterized by one predominant band in serum electrophoresis but not the broad diffuse band that characterizes a polyclonal increase in circulating immunoglobulins. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMonoclonal elevation of circulating IgA

Professional guidelines

PubMed

Cambridge G, Stohl W, Leandro MJ, Migone TS, Hilbert DM, Edwards JC
Arthritis Rheum 2006 Mar;54(3):723-32. doi: 10.1002/art.21650. PMID: 16508933

Recent clinical studies

Etiology

Zhao TX, Aetesam-Ur-Rahman M, Sage AP, Victor S, Kurian R, Fielding S, Ait-Oufella H, Chiu YD, Binder CJ, Mckie M, Hoole SP, Mallat Z
Cardiovasc Res 2022 Feb 21;118(3):872-882. doi: 10.1093/cvr/cvab113. PMID: 33783498Free PMC Article
Nishioka R, Hara S, Kawahara H, Ito K, Mizushima I, Hirata M, Nagata M, Kawano M
BMC Nephrol 2021 Mar 25;22(1):108. doi: 10.1186/s12882-021-02306-0. PMID: 33765955Free PMC Article
Kuzmina Z, Gounden V, Curtis L, Avila D, Rnp TT, Baruffaldi J, Cowen EW, Naik HB, Hasni SA, Mays JW, Mitchell S, Baird K, Steinberg SM, Pavletic SZ
Am J Hematol 2015 Feb;90(2):114-9. Epub 2014 Nov 24 doi: 10.1002/ajh.23885. PMID: 25363867Free PMC Article
Landgren O, Goedert JJ, Rabkin CS, Wilson WH, Dunleavy K, Kyle RA, Katzmann JA, Rajkumar SV, Engels EA
J Clin Oncol 2010 Feb 10;28(5):773-9. Epub 2010 Jan 4 doi: 10.1200/JCO.2009.25.1322. PMID: 20048176Free PMC Article
Yan D, Rumbeiha WK, Pestka JJ
Food Chem Toxicol 1998 Dec;36(12):1095-106. doi: 10.1016/s0278-6915(98)00072-6. PMID: 9862652

Diagnosis

Heaney JLJ, Faustini S, Evans L, Rapson A, Collman E, Emery A, Campbell JP, Moore S, Goodall M, Afzal Z, Chapple IL, Pratt G, Drayson MT
Eur J Haematol 2022 Jun;108(6):493-502. Epub 2022 Feb 28 doi: 10.1111/ejh.13758. PMID: 35184331Free PMC Article
Zhao TX, Aetesam-Ur-Rahman M, Sage AP, Victor S, Kurian R, Fielding S, Ait-Oufella H, Chiu YD, Binder CJ, Mckie M, Hoole SP, Mallat Z
Cardiovasc Res 2022 Feb 21;118(3):872-882. doi: 10.1093/cvr/cvab113. PMID: 33783498Free PMC Article
Nishioka R, Hara S, Kawahara H, Ito K, Mizushima I, Hirata M, Nagata M, Kawano M
BMC Nephrol 2021 Mar 25;22(1):108. doi: 10.1186/s12882-021-02306-0. PMID: 33765955Free PMC Article
Landgren O, Goedert JJ, Rabkin CS, Wilson WH, Dunleavy K, Kyle RA, Katzmann JA, Rajkumar SV, Engels EA
J Clin Oncol 2010 Feb 10;28(5):773-9. Epub 2010 Jan 4 doi: 10.1200/JCO.2009.25.1322. PMID: 20048176Free PMC Article
Dalakas MC
Ann Neurol 1986 Jun;19(6):545-54. doi: 10.1002/ana.410190605. PMID: 3014995

Therapy

Zhao TX, Aetesam-Ur-Rahman M, Sage AP, Victor S, Kurian R, Fielding S, Ait-Oufella H, Chiu YD, Binder CJ, Mckie M, Hoole SP, Mallat Z
Cardiovasc Res 2022 Feb 21;118(3):872-882. doi: 10.1093/cvr/cvab113. PMID: 33783498Free PMC Article
Samy E, Wax S, Huard B, Hess H, Schneider P
Int Rev Immunol 2017 Jan 2;36(1):3-19. doi: 10.1080/08830185.2016.1276903. PMID: 28215100
Kuzmina Z, Gounden V, Curtis L, Avila D, Rnp TT, Baruffaldi J, Cowen EW, Naik HB, Hasni SA, Mays JW, Mitchell S, Baird K, Steinberg SM, Pavletic SZ
Am J Hematol 2015 Feb;90(2):114-9. Epub 2014 Nov 24 doi: 10.1002/ajh.23885. PMID: 25363867Free PMC Article
Cambridge G, Stohl W, Leandro MJ, Migone TS, Hilbert DM, Edwards JC
Arthritis Rheum 2006 Mar;54(3):723-32. doi: 10.1002/art.21650. PMID: 16508933
Guerra IC, Fawcett WA 4th, Redmon AH, Lawrence EC, Rosenblatt HM, Shearer WT
J Allergy Clin Immunol 1986 Apr;77(4):603-7. doi: 10.1016/0091-6749(86)90353-2. PMID: 3082959

Prognosis

Samy E, Wax S, Huard B, Hess H, Schneider P
Int Rev Immunol 2017 Jan 2;36(1):3-19. doi: 10.1080/08830185.2016.1276903. PMID: 28215100
Landgren O, Goedert JJ, Rabkin CS, Wilson WH, Dunleavy K, Kyle RA, Katzmann JA, Rajkumar SV, Engels EA
J Clin Oncol 2010 Feb 10;28(5):773-9. Epub 2010 Jan 4 doi: 10.1200/JCO.2009.25.1322. PMID: 20048176Free PMC Article
Dalakas MC
Ann Neurol 1986 Jun;19(6):545-54. doi: 10.1002/ana.410190605. PMID: 3014995
Chatenoud L, Berrih S, Bene MC, Kreis H, Bach JF
J Clin Immunol 1982 Jul;2(3 Suppl):61S-66S. PMID: 6290529

Clinical prediction guides

Samy E, Wax S, Huard B, Hess H, Schneider P
Int Rev Immunol 2017 Jan 2;36(1):3-19. doi: 10.1080/08830185.2016.1276903. PMID: 28215100
Jones MA, DeWolf S, Vacharathit V, Yim M, Spencer S, Bamezai AK
PLoS One 2016;11(6):e0157271. Epub 2016 Jun 20 doi: 10.1371/journal.pone.0157271. PMID: 27322740Free PMC Article
Landgren O, Goedert JJ, Rabkin CS, Wilson WH, Dunleavy K, Kyle RA, Katzmann JA, Rajkumar SV, Engels EA
J Clin Oncol 2010 Feb 10;28(5):773-9. Epub 2010 Jan 4 doi: 10.1200/JCO.2009.25.1322. PMID: 20048176Free PMC Article
Yan D, Rumbeiha WK, Pestka JJ
Food Chem Toxicol 1998 Dec;36(12):1095-106. doi: 10.1016/s0278-6915(98)00072-6. PMID: 9862652
Kiefel V, Freitag E, Kroll H, Santoso S, Mueller-Eckhardt C
Ann Hematol 1996 Apr;72(4):280-5. doi: 10.1007/s002770050173. PMID: 8624385

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