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Polyclonal elevation of circulating IgG

MedGen UID:
1697965
Concept ID:
C5139245
Finding
HPO: HP:0032288

Definition

An increase in polyclonal immunoglobulins resulting from many different plasma cells. On serum electrophoresis, a polyclonal gammopathy is characterized by a broad diffuse band with one or more heavy chains and kappa and lambda light chains. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPolyclonal elevation of circulating IgG

Recent clinical studies

Etiology

Braithwaite V, Bruggraber SF, Prentice A
Osteoporos Int 2013 Mar;24(3):1121-4. Epub 2012 May 31 doi: 10.1007/s00198-012-2029-3. PMID: 22648001Free PMC Article
Landgren O, Goedert JJ, Rabkin CS, Wilson WH, Dunleavy K, Kyle RA, Katzmann JA, Rajkumar SV, Engels EA
J Clin Oncol 2010 Feb 10;28(5):773-9. Epub 2010 Jan 4 doi: 10.1200/JCO.2009.25.1322. PMID: 20048176Free PMC Article
Rabassa ME, Croce MV, Pereyra A, Segal-Eiras A
BMC Cancer 2006 Oct 25;6:253. doi: 10.1186/1471-2407-6-253. PMID: 17064405Free PMC Article
Stéphan F, Cheffi MA, Kaplan C, Maillet J, Novara A, Fagon J, Bonnet F
Am J Med 2000 May;108(7):554-60. doi: 10.1016/s0002-9343(00)00332-6. PMID: 10806284
Peichl P, Pursch E, Bröll H, Lindley IJ
Rheumatol Int 1999;18(4):141-5. doi: 10.1007/s002960050073. PMID: 10220834

Diagnosis

Heaney JLJ, Faustini S, Evans L, Rapson A, Collman E, Emery A, Campbell JP, Moore S, Goodall M, Afzal Z, Chapple IL, Pratt G, Drayson MT
Eur J Haematol 2022 Jun;108(6):493-502. Epub 2022 Feb 28 doi: 10.1111/ejh.13758. PMID: 35184331Free PMC Article
Landgren O, Goedert JJ, Rabkin CS, Wilson WH, Dunleavy K, Kyle RA, Katzmann JA, Rajkumar SV, Engels EA
J Clin Oncol 2010 Feb 10;28(5):773-9. Epub 2010 Jan 4 doi: 10.1200/JCO.2009.25.1322. PMID: 20048176Free PMC Article
Jasani B, Ternynck T, Lazarus JH, Phillips DI, Avrameas S, Parkes AB
J Clin Lab Immunol 1999;51(1):9-20. PMID: 11424741
Dalakas MC
Ann Neurol 1986 Jun;19(6):545-54. doi: 10.1002/ana.410190605. PMID: 3014995
Hirohata S, Hirose S, Miyamoto T
Arch Intern Med 1985 Oct;145(10):1843-6. PMID: 3899036

Therapy

Stéphan F, Cheffi MA, Kaplan C, Maillet J, Novara A, Fagon J, Bonnet F
Am J Med 2000 May;108(7):554-60. doi: 10.1016/s0002-9343(00)00332-6. PMID: 10806284
Peichl P, Pursch E, Bröll H, Lindley IJ
Rheumatol Int 1999;18(4):141-5. doi: 10.1007/s002960050073. PMID: 10220834
Morris L, Binley JM, Clas BA, Bonhoeffer S, Astill TP, Kost R, Hurley A, Cao Y, Markowitz M, Ho DD, Moore JP
J Exp Med 1998 Jul 20;188(2):233-45. doi: 10.1084/jem.188.2.233. PMID: 9670036Free PMC Article
Traub UC, DeJager RL, Primus FJ, Losman M, Goldenberg DM
Cancer Res 1988 Jul 15;48(14):4002-6. PMID: 3289737
Hirohata S, Hirose S, Miyamoto T
Arch Intern Med 1985 Oct;145(10):1843-6. PMID: 3899036

Prognosis

Landgren O, Goedert JJ, Rabkin CS, Wilson WH, Dunleavy K, Kyle RA, Katzmann JA, Rajkumar SV, Engels EA
J Clin Oncol 2010 Feb 10;28(5):773-9. Epub 2010 Jan 4 doi: 10.1200/JCO.2009.25.1322. PMID: 20048176Free PMC Article
Hashefi M, McHugh TR, Smith GP, Elwing TJ, Burns RW, Walker SE
J Rheumatol 2000 Apr;27(4):1087-90. PMID: 10782842
Peichl P, Pursch E, Bröll H, Lindley IJ
Rheumatol Int 1999;18(4):141-5. doi: 10.1007/s002960050073. PMID: 10220834
Traub UC, DeJager RL, Primus FJ, Losman M, Goldenberg DM
Cancer Res 1988 Jul 15;48(14):4002-6. PMID: 3289737
Dalakas MC
Ann Neurol 1986 Jun;19(6):545-54. doi: 10.1002/ana.410190605. PMID: 3014995

Clinical prediction guides

Landgren O, Goedert JJ, Rabkin CS, Wilson WH, Dunleavy K, Kyle RA, Katzmann JA, Rajkumar SV, Engels EA
J Clin Oncol 2010 Feb 10;28(5):773-9. Epub 2010 Jan 4 doi: 10.1200/JCO.2009.25.1322. PMID: 20048176Free PMC Article
Kendall EA, Tarique AA, Hossain A, Alam MM, Arifuzzaman M, Akhtar N, Chowdhury F, Khan AI, Larocque RC, Harris JB, Ryan ET, Qadri F, Calderwood SB
Infect Immun 2010 Jan;78(1):253-9. Epub 2009 Oct 26 doi: 10.1128/IAI.00868-09. PMID: 19858296Free PMC Article
De Re V, Pavan A, Sansonno S, Sansonno D, Racanelli V
Ann N Y Acad Sci 2009 Sep;1173:326-33. doi: 10.1111/j.1749-6632.2009.04664.x. PMID: 19758169
Eriksson K, Kilander A, Hagberg L, Norkrans G, Holmgren J, Czerkinsky C
AIDS 1995 Jul;9(7):695-700. doi: 10.1097/00002030-199507000-00005. PMID: 7546413
Traub UC, DeJager RL, Primus FJ, Losman M, Goldenberg DM
Cancer Res 1988 Jul 15;48(14):4002-6. PMID: 3289737

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