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Polyclonal elevation of circulating IgG

MedGen UID:
1697965
•Concept ID:
C5139245
•
Finding
HPO: HP:0032288

Definition

An increase in polyclonal immunoglobulins resulting from many different plasma cells. On serum electrophoresis, a polyclonal gammopathy is characterized by a broad diffuse band with one or more heavy chains and kappa and lambda light chains. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPolyclonal elevation of circulating IgG

Recent clinical studies

Etiology

Intact fibroblast growth factor 23 and fragments in plasma from Gambian children.
Braithwaite V, Bruggraber SF, Prentice A
Osteoporos Int 2013 Mar;24(3):1121-4. Epub 2012 May 31 doi: 10.1007/s00198-012-2029-3. PMID: 22648001Free PMC Article
Circulating serum free light chains as predictive markers of AIDS-related lymphoma.
Landgren O, Goedert JJ, Rabkin CS, Wilson WH, Dunleavy K, Kyle RA, Katzmann JA, Rajkumar SV, Engels EA
J Clin Oncol 2010 Feb 10;28(5):773-9. Epub 2010 Jan 4 doi: 10.1200/JCO.2009.25.1322. PMID: 20048176Free PMC Article
MUC1 expression and anti-MUC1 serum immune response in head and neck squamous cell carcinoma (HNSCC): a multivariate analysis.
Rabassa ME, Croce MV, Pereyra A, Segal-Eiras A
BMC Cancer 2006 Oct 25;6:253. doi: 10.1186/1471-2407-6-253. PMID: 17064405Free PMC Article
Autoantibodies against platelet glycoproteins in critically ill patients with thrombocytopenia.
Stéphan F, Cheffi MA, Kaplan C, Maillet J, Novara A, Fagon J, Bonnet F
Am J Med 2000 May;108(7):554-60. doi: 10.1016/s0002-9343(00)00332-6. PMID: 10806284
Anti-IL-8 autoantibodies and complexes in rheumatoid arthritis: polyclonal activation in chronic synovial tissue inflammation.
Peichl P, Pursch E, Bröll H, Lindley IJ
Rheumatol Int 1999;18(4):141-5. doi: 10.1007/s002960050073. PMID: 10220834

Diagnosis

Investigating the utility of saliva immunoglobulins for the detection of myeloma and using myeloma proteins to clarify partition between oral and systemic immunity.
Heaney JLJ, Faustini S, Evans L, Rapson A, Collman E, Emery A, Campbell JP, Moore S, Goodall M, Afzal Z, Chapple IL, Pratt G, Drayson MT
Eur J Haematol 2022 Jun;108(6):493-502. Epub 2022 Feb 28 doi: 10.1111/ejh.13758. PMID: 35184331Free PMC Article
Circulating serum free light chains as predictive markers of AIDS-related lymphoma.
Landgren O, Goedert JJ, Rabkin CS, Wilson WH, Dunleavy K, Kyle RA, Katzmann JA, Rajkumar SV, Engels EA
J Clin Oncol 2010 Feb 10;28(5):773-9. Epub 2010 Jan 4 doi: 10.1200/JCO.2009.25.1322. PMID: 20048176Free PMC Article
Natural antibody status in patients with Hashimoto's thyroiditis.
Jasani B, Ternynck T, Lazarus JH, Phillips DI, Avrameas S, Parkes AB
J Clin Lab Immunol 1999;51(1):9-20. PMID: 11424741
Anti-IL-8 autoantibodies and complexes in rheumatoid arthritis: polyclonal activation in chronic synovial tissue inflammation.
Peichl P, Pursch E, Bröll H, Lindley IJ
Rheumatol Int 1999;18(4):141-5. doi: 10.1007/s002960050073. PMID: 10220834
Chronic idiopathic ataxic neuropathy.
Dalakas MC
Ann Neurol 1986 Jun;19(6):545-54. doi: 10.1002/ana.410190605. PMID: 3014995

Therapy

Autoantibodies against platelet glycoproteins in critically ill patients with thrombocytopenia.
Stéphan F, Cheffi MA, Kaplan C, Maillet J, Novara A, Fagon J, Bonnet F
Am J Med 2000 May;108(7):554-60. doi: 10.1016/s0002-9343(00)00332-6. PMID: 10806284
Anti-IL-8 autoantibodies and complexes in rheumatoid arthritis: polyclonal activation in chronic synovial tissue inflammation.
Peichl P, Pursch E, Bröll H, Lindley IJ
Rheumatol Int 1999;18(4):141-5. doi: 10.1007/s002960050073. PMID: 10220834
HIV-1 antigen-specific and -nonspecific B cell responses are sensitive to combination antiretroviral therapy.
Morris L, Binley JM, Clas BA, Bonhoeffer S, Astill TP, Kost R, Hurley A, Cao Y, Markowitz M, Ho DD, Moore JP
J Exp Med 1998 Jul 20;188(2):233-45. doi: 10.1084/jem.188.2.233. PMID: 9670036Free PMC Article
Antiidiotype antibodies in cancer patients receiving monoclonal antibody to carcinoembryonic antigen.
Traub UC, DeJager RL, Primus FJ, Losman M, Goldenberg DM
Cancer Res 1988 Jul 15;48(14):4002-6. PMID: 3289737
Cerebrospinal fluid IgM, IgA, and IgG indexes in systemic lupus erythematosus. Their use as estimates of central nervous system disease activity.
Hirohata S, Hirose S, Miyamoto T
Arch Intern Med 1985 Oct;145(10):1843-6. PMID: 3899036

Prognosis

Circulating serum free light chains as predictive markers of AIDS-related lymphoma.
Landgren O, Goedert JJ, Rabkin CS, Wilson WH, Dunleavy K, Kyle RA, Katzmann JA, Rajkumar SV, Engels EA
J Clin Oncol 2010 Feb 10;28(5):773-9. Epub 2010 Jan 4 doi: 10.1200/JCO.2009.25.1322. PMID: 20048176Free PMC Article
Seropositive rheumatoid arthritis with dermatomyositis sine myositis, angioimmunoblastic lymphadenopathy with dysproteinemia-type T cell lymphoma, and B cell lymphoma of the oropharynx.
Hashefi M, McHugh TR, Smith GP, Elwing TJ, Burns RW, Walker SE
J Rheumatol 2000 Apr;27(4):1087-90. PMID: 10782842
Anti-IL-8 autoantibodies and complexes in rheumatoid arthritis: polyclonal activation in chronic synovial tissue inflammation.
Peichl P, Pursch E, Bröll H, Lindley IJ
Rheumatol Int 1999;18(4):141-5. doi: 10.1007/s002960050073. PMID: 10220834
Antiidiotype antibodies in cancer patients receiving monoclonal antibody to carcinoembryonic antigen.
Traub UC, DeJager RL, Primus FJ, Losman M, Goldenberg DM
Cancer Res 1988 Jul 15;48(14):4002-6. PMID: 3289737
Chronic idiopathic ataxic neuropathy.
Dalakas MC
Ann Neurol 1986 Jun;19(6):545-54. doi: 10.1002/ana.410190605. PMID: 3014995

Clinical prediction guides

Circulating serum free light chains as predictive markers of AIDS-related lymphoma.
Landgren O, Goedert JJ, Rabkin CS, Wilson WH, Dunleavy K, Kyle RA, Katzmann JA, Rajkumar SV, Engels EA
J Clin Oncol 2010 Feb 10;28(5):773-9. Epub 2010 Jan 4 doi: 10.1200/JCO.2009.25.1322. PMID: 20048176Free PMC Article
Development of immunoglobulin M memory to both a T-cell-independent and a T-cell-dependent antigen following infection with Vibrio cholerae O1 in Bangladesh.
Kendall EA, Tarique AA, Hossain A, Alam MM, Arifuzzaman M, Akhtar N, Chowdhury F, Khan AI, Larocque RC, Harris JB, Ryan ET, Qadri F, Calderwood SB
Infect Immun 2010 Jan;78(1):253-9. Epub 2009 Oct 26 doi: 10.1128/IAI.00868-09. PMID: 19858296Free PMC Article
Virus-specific antibody production and polyclonal B-cell activation in the intestinal mucosa of HIV-infected individuals.
Eriksson K, Kilander A, Hagberg L, Norkrans G, Holmgren J, Czerkinsky C
AIDS 1995 Jul;9(7):695-700. doi: 10.1097/00002030-199507000-00005. PMID: 7546413
Polyclonal B cell activation in paracoccidioidomycosis. Polyclonal activation in paracoccidioidomycosis.
Chequer-Bou-Habib D, Daniel-Ribeiro C, Banic DM, do Valle AC, Galvao-Castro B
Mycopathologia 1989 Nov;108(2):89-93. doi: 10.1007/BF00436058. PMID: 2594051
Antiidiotype antibodies in cancer patients receiving monoclonal antibody to carcinoembryonic antigen.
Traub UC, DeJager RL, Primus FJ, Losman M, Goldenberg DM
Cancer Res 1988 Jul 15;48(14):4002-6. PMID: 3289737

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