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Increased circulating procalcitonin concentration

MedGen UID:
1697976
•Concept ID:
C5139263
•
Finding
Synonym: Increased circulating procalcitonin level
 
HPO: HP:0032308

Definition

An elevated concentration of procalcitonin in the blood circulation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased circulating procalcitonin concentration

Recent clinical studies

Etiology

Immunomodulatory Aspects of Therapeutic Plasma Exchange in Neurological Disorders-A Pilot Study.
Foettinger F, Pilz G, Wipfler P, Harrer A, Kern JM, Trinka E, Moser T
Int J Mol Sci 2023 Mar 31;24(7) doi: 10.3390/ijms24076552. PMID: 37047524Free PMC Article
Atrial Fibrillation and the Prognostic Performance of Biomarkers in Heart Failure.
Tan ESJ, Chan SP, Liew OW, Chong JPC, Leong GKT, Yeo DPS, Ong HY, Jaufeerally F, Yap J, Sim D, Ng TP, Ling LH, Lam CSP, Richards AM
Clin Chem 2021 Jan 8;67(1):216-226. doi: 10.1093/clinchem/hvaa287. PMID: 33279970
Elevated Levels of Procalcitonin and Interleukin-6 are Linked with Postoperative Complications in Cardiac Surgery.
Brocca A, Virzì GM, de Cal M, Giavarina D, Carta M, Ronco C
Scand J Surg 2017 Dec;106(4):318-324. Epub 2017 Mar 1 doi: 10.1177/1457496916683096. PMID: 28737097
Salivary and serum procalcitonin and C-reactive protein as biomarkers of periodontitis in United States veterans with osteoarthritis or rheumatoid arthritis.
Redman RS, Kerr GS, Payne JB, Mikuls TR, Huang J, Sayles HR, Becker KL, Nylén ES
Biotech Histochem 2016;91(2):77-85. doi: 10.3109/10520295.2015.1082625. PMID: 26800284Free PMC Article
Expression and secretion of procalcitonin and calcitonin gene-related peptide by adherent monocytes and by macrophage-activated adipocytes.
Linscheid P, Seboek D, Schaer DJ, Zulewski H, Keller U, Müller B
Crit Care Med 2004 Aug;32(8):1715-21. doi: 10.1097/01.ccm.0000134404.63292.71. PMID: 15286549

Diagnosis

The shed P2X7 receptor is an index of adverse clinical outcome in COVID-19 patients.
Vultaggio-Poma V, Sanz JM, Amico A, Violi A, Ghisellini S, Pizzicotti S, Passaro A, Papi A, Libanore M, Di Virgilio F, Giuliani AL
Front Immunol 2023;14:1182454. Epub 2023 May 5 doi: 10.3389/fimmu.2023.1182454. PMID: 37215142Free PMC Article
Selective Polymyxin Hemoperfusion in Complex Therapy of Sepsis in Children after Cardiac Surgery.
Yaroustovsky M, Abramyan M, Rogalskaya E, Komardina E
Blood Purif 2021;50(2):222-229. Epub 2020 Nov 26 doi: 10.1159/000510126. PMID: 33242859
Elevated Levels of Procalcitonin and Interleukin-6 are Linked with Postoperative Complications in Cardiac Surgery.
Brocca A, Virzì GM, de Cal M, Giavarina D, Carta M, Ronco C
Scand J Surg 2017 Dec;106(4):318-324. Epub 2017 Mar 1 doi: 10.1177/1457496916683096. PMID: 28737097
Salivary and serum procalcitonin and C-reactive protein as biomarkers of periodontitis in United States veterans with osteoarthritis or rheumatoid arthritis.
Redman RS, Kerr GS, Payne JB, Mikuls TR, Huang J, Sayles HR, Becker KL, Nylén ES
Biotech Histochem 2016;91(2):77-85. doi: 10.3109/10520295.2015.1082625. PMID: 26800284Free PMC Article
Structure and diagnostic value of procalcitonin.
Floriańczyk B
Ann Univ Mariae Curie Sklodowska Med 2003;58(1):338-42. PMID: 15315011

Therapy

Endothelial Microparticles: Markers of Inflammatory Response After Sutureless Valve Implantation.
Oliveira JLR, Santos MAD, Timerman A
Braz J Cardiovasc Surg 2023 Oct 27;39(1):e20230111. doi: 10.21470/1678-9741-2023-0111. PMID: 37889214Free PMC Article
Atrial Fibrillation and the Prognostic Performance of Biomarkers in Heart Failure.
Tan ESJ, Chan SP, Liew OW, Chong JPC, Leong GKT, Yeo DPS, Ong HY, Jaufeerally F, Yap J, Sim D, Ng TP, Ling LH, Lam CSP, Richards AM
Clin Chem 2021 Jan 8;67(1):216-226. doi: 10.1093/clinchem/hvaa287. PMID: 33279970
Selective Polymyxin Hemoperfusion in Complex Therapy of Sepsis in Children after Cardiac Surgery.
Yaroustovsky M, Abramyan M, Rogalskaya E, Komardina E
Blood Purif 2021;50(2):222-229. Epub 2020 Nov 26 doi: 10.1159/000510126. PMID: 33242859
Procalcitonin after cardiac arrest - an indicator of severity of illness, ischemia-reperfusion injury and outcome.
Annborn M, Dankiewicz J, Erlinge D, Hertel S, Rundgren M, Smith JG, Struck J, Friberg H
Resuscitation 2013 Jun;84(6):782-7. Epub 2013 Jan 8 doi: 10.1016/j.resuscitation.2013.01.004. PMID: 23313427
Procalcitonin for reduced antibiotic exposure in ventilator-associated pneumonia: a randomised study.
Stolz D, Smyrnios N, Eggimann P, Pargger H, Thakkar N, Siegemund M, Marsch S, Azzola A, Rakic J, Mueller B, Tamm M
Eur Respir J 2009 Dec;34(6):1364-75. Epub 2009 Sep 24 doi: 10.1183/09031936.00053209. PMID: 19797133

Prognosis

The shed P2X7 receptor is an index of adverse clinical outcome in COVID-19 patients.
Vultaggio-Poma V, Sanz JM, Amico A, Violi A, Ghisellini S, Pizzicotti S, Passaro A, Papi A, Libanore M, Di Virgilio F, Giuliani AL
Front Immunol 2023;14:1182454. Epub 2023 May 5 doi: 10.3389/fimmu.2023.1182454. PMID: 37215142Free PMC Article
Atrial Fibrillation and the Prognostic Performance of Biomarkers in Heart Failure.
Tan ESJ, Chan SP, Liew OW, Chong JPC, Leong GKT, Yeo DPS, Ong HY, Jaufeerally F, Yap J, Sim D, Ng TP, Ling LH, Lam CSP, Richards AM
Clin Chem 2021 Jan 8;67(1):216-226. doi: 10.1093/clinchem/hvaa287. PMID: 33279970
Elevated Levels of Procalcitonin and Interleukin-6 are Linked with Postoperative Complications in Cardiac Surgery.
Brocca A, Virzì GM, de Cal M, Giavarina D, Carta M, Ronco C
Scand J Surg 2017 Dec;106(4):318-324. Epub 2017 Mar 1 doi: 10.1177/1457496916683096. PMID: 28737097
Increased admission serum cold-inducible RNA-binding protein concentration is associated with prognosis of severe acute pancreatitis.
Gong JD, Qi XF, Zhang Y, Li HL
Clin Chim Acta 2017 Aug;471:135-142. Epub 2017 Jun 3 doi: 10.1016/j.cca.2017.06.002. PMID: 28587954
Structure and diagnostic value of procalcitonin.
Floriańczyk B
Ann Univ Mariae Curie Sklodowska Med 2003;58(1):338-42. PMID: 15315011

Clinical prediction guides

Atrial Fibrillation and the Prognostic Performance of Biomarkers in Heart Failure.
Tan ESJ, Chan SP, Liew OW, Chong JPC, Leong GKT, Yeo DPS, Ong HY, Jaufeerally F, Yap J, Sim D, Ng TP, Ling LH, Lam CSP, Richards AM
Clin Chem 2021 Jan 8;67(1):216-226. doi: 10.1093/clinchem/hvaa287. PMID: 33279970
Interleukin-10 and interleukin-1 receptor antagonist distinguish between patients with sepsis and the systemic inflammatory response syndrome (SIRS).
Potjo M, Theron AJ, Cockeran R, Sipholi NN, Steel HC, Bale TV, Meyer PWA, Anderson R, Tintinger GR
Cytokine 2019 Aug;120:227-233. Epub 2019 May 21 doi: 10.1016/j.cyto.2019.05.015. PMID: 31125901
Elevated Levels of Procalcitonin and Interleukin-6 are Linked with Postoperative Complications in Cardiac Surgery.
Brocca A, Virzì GM, de Cal M, Giavarina D, Carta M, Ronco C
Scand J Surg 2017 Dec;106(4):318-324. Epub 2017 Mar 1 doi: 10.1177/1457496916683096. PMID: 28737097
Expression and secretion of procalcitonin and calcitonin gene-related peptide by adherent monocytes and by macrophage-activated adipocytes.
Linscheid P, Seboek D, Schaer DJ, Zulewski H, Keller U, Müller B
Crit Care Med 2004 Aug;32(8):1715-21. doi: 10.1097/01.ccm.0000134404.63292.71. PMID: 15286549
Structure and diagnostic value of procalcitonin.
Floriańczyk B
Ann Univ Mariae Curie Sklodowska Med 2003;58(1):338-42. PMID: 15315011

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