U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Oligoclonal elevation of circulating IgG

MedGen UID:
1698010
•Concept ID:
C5139246
•
Finding
HPO: HP:0032289

Definition

An increase in circulating immunoglobulins characterized by two or more bands in serum electrophoresis but not the broad diffuse band that characterizes a polyclonal increase in circulating immunoglobulins. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOligoclonal elevation of circulating IgG

Recent clinical studies

Etiology

Cerebrospinal BAFF and Epstein-Barr virus-specific oligoclonal bands in multiple sclerosis and other inflammatory demyelinating neurological diseases.
Franciotta D, Di Stefano AL, Jarius S, Zardini E, Tavazzi E, Ballerini C, Marchioni E, Bergamaschi R, Ceroni M
J Neuroimmunol 2011 Jan;230(1-2):160-3. Epub 2010 Nov 24 doi: 10.1016/j.jneuroim.2010.10.027. PMID: 21109310

Diagnosis

Tumor cell dissemination triggers an intrathecal immune response in neoplastic meningitis.
Weller M, Stevens A, Sommer N, Schabet M, Wiethölter H
Cancer 1992 Mar 15;69(6):1475-80. doi: 10.1002/1097-0142(19920315)69:6<1475::aid-cncr2820690627>3.0.co;2-d. PMID: 1371713

Therapy

Failure of intravenous and intrathecal cytarabine to modify central nervous system IgG synthesis in multiple sclerosis.
Tourtellotte WW, Potvin AR, Mendez M, Baumhefner RW, Potvin JH, Ma BI, Syndulko K
Ann Neurol 1980 Oct;8(4):402-8. doi: 10.1002/ana.410080411. PMID: 6893646

Clinical prediction guides

Intrathecal IgG synthesis and blood-brain barrier impairment in patients with systemic lupus erythematosus and central nervous system dysfunction.
Winfield JB, Shaw M, Silverman LM, Eisenberg RA, Wilson HA 3rd, Koffler D
Am J Med 1983 May;74(5):837-44. doi: 10.1016/0002-9343(83)91075-6. PMID: 6837607

Supplemental Content

Table of contents

    Clinical resources

    Consumer resources

    Reviews

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...