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Unresectable Fibrolamellar Carcinoma

MedGen UID:
1698019
Concept ID:
C5206683
Neoplastic Process
Synonym: Unresectable Fibrolamellar Hepatocellular Carcinoma

Definition

A fibrolamellar carcinoma that is not amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUnresectable Fibrolamellar Carcinoma

Professional guidelines

PubMed

Kassahun WT
World J Surg Oncol 2016 May 23;14(1):151. doi: 10.1186/s12957-016-0903-8. PMID: 27215576Free PMC Article
Pal S, Pande GK
J Hepatobiliary Pancreat Surg 2001;8(4):323-36. doi: 10.1007/s005340170004. PMID: 11521177
Joyce AD, Howard ER
Prog Pediatr Surg 1989;22:69-93. doi: 10.1007/978-3-642-72643-9_5. PMID: 2492394

Recent clinical studies

Etiology

Short SS, Kastenberg ZJ, Wei G, Bondoc A, Dasgupta R, Tiao GM, Watters E, Heaton TE, Lotakis D, La Quaglia MP, Murphy AJ, Davidoff AM, Mansfield SA, Langham MR, Lautz TB, Superina RA, Ott KC, Malek MM, Morgan KM, Kim ES, Zamora A, Lascano D, Roach J, Murphy JT, Rothstein DH, Vasudevan SA, Whitlock R, Lal DR, Hallis B, Bütter A, Baertschiger RM, Lapidus-Krol E, Putra J, Tracy ER, Aldrink JH, Apfeld J, Le HD, Park KY, Rich BS, Glick RD, Fialkowski EA, Utria AF, Meyers RL, Riehle KJ
Cancer 2022 Jul 15;128(14):2786-2795. Epub 2022 May 13 doi: 10.1002/cncr.34256. PMID: 35561331Free PMC Article
Gottlieb S, O'Grady C, Gliksberg A, Kent P
Oncology 2021;99(5):310-317. Epub 2021 Mar 9 doi: 10.1159/000513358. PMID: 33690232
Kassahun WT
World J Surg Oncol 2016 May 23;14(1):151. doi: 10.1186/s12957-016-0903-8. PMID: 27215576Free PMC Article
Eghtesad B, Aucejo F
J Gastrointest Cancer 2014 Sep;45(3):353-62. doi: 10.1007/s12029-014-9590-2. PMID: 24604263
Sitzmann JV
World J Surg 1995 Nov-Dec;19(6):790-4. doi: 10.1007/BF00299772. PMID: 8553667

Diagnosis

Gottlieb S, O'Grady C, Gliksberg A, Kent P
Oncology 2021;99(5):310-317. Epub 2021 Mar 9 doi: 10.1159/000513358. PMID: 33690232
Ziogas IA, Ye F, Zhao Z, Matsuoka LK, Montenovo MI, Izzy M, Benedetti DJ, Lovvorn HN 3rd, Gillis LA, Alexopoulos SP
J Am Coll Surg 2020 Jun;230(6):1035-1044.e3. Epub 2020 Apr 6 doi: 10.1016/j.jamcollsurg.2020.03.024. PMID: 32272204
Kassahun WT
World J Surg Oncol 2016 May 23;14(1):151. doi: 10.1186/s12957-016-0903-8. PMID: 27215576Free PMC Article
Strong RW
Semin Surg Oncol 2000 Sep-Oct;19(2):189-99. doi: 10.1002/1098-2388(200009)19:2<189::aid-ssu10>3.0.co;2-u. PMID: 11126382
Mahfouz A, Vogl T, Hamm B
Eur Radiol 1999;9(5):841-52. doi: 10.1007/s003300050754. PMID: 10369978

Therapy

Kang S, Magliocca J, Sellers M, Roccaro G, Zheng W, Pectasides M, Draper A, Guadagno J, El-Rayes B, Akce M
Oncol Res Treat 2022;45(7-8):430-437. Epub 2022 May 10 doi: 10.1159/000524872. PMID: 35537414
Gottlieb S, O'Grady C, Gliksberg A, Kent P
Oncology 2021;99(5):310-317. Epub 2021 Mar 9 doi: 10.1159/000513358. PMID: 33690232
El Dika I, Mayer RJ, Venook AP, Capanu M, LaQuaglia MP, Kobos R, O'Neill AF, Chou JF, Ly M, Ang C, O'Reilly EM, Gordan JD, Abou-Alfa GK
Oncologist 2020 Nov;25(11):925-e1603. Epub 2020 May 26 doi: 10.1634/theoncologist.2020-0367. PMID: 32400000Free PMC Article
Eghtesad B, Aucejo F
J Gastrointest Cancer 2014 Sep;45(3):353-62. doi: 10.1007/s12029-014-9590-2. PMID: 24604263
Strong RW
Semin Surg Oncol 2000 Sep-Oct;19(2):189-99. doi: 10.1002/1098-2388(200009)19:2<189::aid-ssu10>3.0.co;2-u. PMID: 11126382

Prognosis

Melehy A, Agopian V
Curr Opin Organ Transplant 2024 Feb 1;29(1):30-36. Epub 2023 Oct 18 doi: 10.1097/MOT.0000000000001118. PMID: 37851086
Short SS, Kastenberg ZJ, Wei G, Bondoc A, Dasgupta R, Tiao GM, Watters E, Heaton TE, Lotakis D, La Quaglia MP, Murphy AJ, Davidoff AM, Mansfield SA, Langham MR, Lautz TB, Superina RA, Ott KC, Malek MM, Morgan KM, Kim ES, Zamora A, Lascano D, Roach J, Murphy JT, Rothstein DH, Vasudevan SA, Whitlock R, Lal DR, Hallis B, Bütter A, Baertschiger RM, Lapidus-Krol E, Putra J, Tracy ER, Aldrink JH, Apfeld J, Le HD, Park KY, Rich BS, Glick RD, Fialkowski EA, Utria AF, Meyers RL, Riehle KJ
Cancer 2022 Jul 15;128(14):2786-2795. Epub 2022 May 13 doi: 10.1002/cncr.34256. PMID: 35561331Free PMC Article
Gottlieb S, O'Grady C, Gliksberg A, Kent P
Oncology 2021;99(5):310-317. Epub 2021 Mar 9 doi: 10.1159/000513358. PMID: 33690232
Kassahun WT
World J Surg Oncol 2016 May 23;14(1):151. doi: 10.1186/s12957-016-0903-8. PMID: 27215576Free PMC Article
Mahfouz A, Vogl T, Hamm B
Eur Radiol 1999;9(5):841-52. doi: 10.1007/s003300050754. PMID: 10369978

Clinical prediction guides

Melehy A, Agopian V
Curr Opin Organ Transplant 2024 Feb 1;29(1):30-36. Epub 2023 Oct 18 doi: 10.1097/MOT.0000000000001118. PMID: 37851086
Short SS, Kastenberg ZJ, Wei G, Bondoc A, Dasgupta R, Tiao GM, Watters E, Heaton TE, Lotakis D, La Quaglia MP, Murphy AJ, Davidoff AM, Mansfield SA, Langham MR, Lautz TB, Superina RA, Ott KC, Malek MM, Morgan KM, Kim ES, Zamora A, Lascano D, Roach J, Murphy JT, Rothstein DH, Vasudevan SA, Whitlock R, Lal DR, Hallis B, Bütter A, Baertschiger RM, Lapidus-Krol E, Putra J, Tracy ER, Aldrink JH, Apfeld J, Le HD, Park KY, Rich BS, Glick RD, Fialkowski EA, Utria AF, Meyers RL, Riehle KJ
Cancer 2022 Jul 15;128(14):2786-2795. Epub 2022 May 13 doi: 10.1002/cncr.34256. PMID: 35561331Free PMC Article
El Dika I, Mayer RJ, Venook AP, Capanu M, LaQuaglia MP, Kobos R, O'Neill AF, Chou JF, Ly M, Ang C, O'Reilly EM, Gordan JD, Abou-Alfa GK
Oncologist 2020 Nov;25(11):925-e1603. Epub 2020 May 26 doi: 10.1634/theoncologist.2020-0367. PMID: 32400000Free PMC Article
Kassahun WT
World J Surg Oncol 2016 May 23;14(1):151. doi: 10.1186/s12957-016-0903-8. PMID: 27215576Free PMC Article
Riehle KJ, Yeh MM, Yu JJ, Kenerson HL, Harris WP, Park JO, Yeung RS
Mod Pathol 2015 Jan;28(1):103-10. Epub 2014 Jun 13 doi: 10.1038/modpathol.2014.78. PMID: 24925055

Recent systematic reviews

Houben KW, McCall JL
Liver Transpl Surg 1999 Mar;5(2):91-5. doi: 10.1002/lt.500050201. PMID: 10071346

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