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Elevated haptoglobin level

MedGen UID:
1698119
•Concept ID:
C5209263
•
Finding
HPO: HP:0020180

Definition

An abnormally high concentration of haptoglobin in the blood circulation. Haptoglobin is an acute-phase reactant whose levels can become elevated in the presence of infection and inflammation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated haptoglobin level

Professional guidelines

PubMed

Haptoglobin 2-2 genotype is associated with TNF- α and IL-6 levels in subjects with obesity.
Lazalde B, Huerta-Guerrero HM, Simental-Mendía LE, Rodríguez-Morán M, Guerrero-Romero F
Dis Markers 2014;2014:912756. Epub 2014 Apr 29 doi: 10.1155/2014/912756. PMID: 24868113Free PMC Article
Patient selection and vitamin E treatment in diabetes mellitus.
Goldenstein H, Levy NS, Lipener YT, Levy AP
Expert Rev Cardiovasc Ther 2013 Mar;11(3):319-26. doi: 10.1586/erc.12.187. PMID: 23469912Free PMC Article
Diagnosis, controversies, and management of the syndrome of hemolysis, elevated liver enzymes, and low platelet count.
Sibai BM
Obstet Gynecol 2004 May;103(5 Pt 1):981-91. doi: 10.1097/01.AOG.0000126245.35811.2a. PMID: 15121574

Recent clinical studies

Etiology

Elevated Levels of Circulating Biomarkers Related to Leaky Gut Syndrome and Bacterial Translocation Are Associated With Graves' Disease.
Zheng D, Liao H, Chen S, Liu X, Mao C, Zhang C, Meng M, Wang Z, Wang Y, Jiang Q, Xue Y, Zhou L, Chen Y
Front Endocrinol (Lausanne) 2021;12:796212. Epub 2021 Dec 16 doi: 10.3389/fendo.2021.796212. PMID: 34975767Free PMC Article
Niacin Increases Atherogenic Proteins in High-Density Lipoprotein of Statin-Treated Subjects.
Ronsein GE, Vaisar T, Davidson WS, Bornfeldt KE, Probstfield JL, O'Brien KD, Zhao XQ, Heinecke JW
Arterioscler Thromb Vasc Biol 2021 Aug;41(8):2330-2341. Epub 2021 Jun 17 doi: 10.1161/ATVBAHA.121.316278. PMID: 34134520Free PMC Article
IL-6 inhibition with ziltivekimab in patients at high atherosclerotic risk (RESCUE): a double-blind, randomised, placebo-controlled, phase 2 trial.
Ridker PM, Devalaraja M, Baeres FMM, Engelmann MDM, Hovingh GK, Ivkovic M, Lo L, Kling D, Pergola P, Raj D, Libby P, Davidson M; RESCUE Investigators
Lancet 2021 May 29;397(10289):2060-2069. Epub 2021 May 17 doi: 10.1016/S0140-6736(21)00520-1. PMID: 34015342
Microbial patterns in patients with histamine intolerance.
Schink M, Konturek PC, Tietz E, Dieterich W, Pinzer TC, Wirtz S, Neurath MF, Zopf Y
J Physiol Pharmacol 2018 Aug;69(4) Epub 2018 Dec 9 doi: 10.26402/jpp.2018.4.09. PMID: 30552302
CD163+ macrophages promote angiogenesis and vascular permeability accompanied by inflammation in atherosclerosis.
Guo L, Akahori H, Harari E, Smith SL, Polavarapu R, Karmali V, Otsuka F, Gannon RL, Braumann RE, Dickinson MH, Gupta A, Jenkins AL, Lipinski MJ, Kim J, Chhour P, de Vries PS, Jinnouchi H, Kutys R, Mori H, Kutyna MD, Torii S, Sakamoto A, Choi CU, Cheng Q, Grove ML, Sawan MA, Zhang Y, Cao Y, Kolodgie FD, Cormode DP, Arking DE, Boerwinkle E, Morrison AC, Erdmann J, Sotoodehnia N, Virmani R, Finn AV
J Clin Invest 2018 Mar 1;128(3):1106-1124. Epub 2018 Feb 19 doi: 10.1172/JCI93025. PMID: 29457790Free PMC Article

Diagnosis

Evaluation of urinary haptoglobin level as a biomarker of diabetic nephropathy in children with type 1 diabetes.
Bezen D, Vurgun E, Dursun H
Pediatr Nephrol 2023 Nov;38(11):3693-3698. Epub 2023 May 18 doi: 10.1007/s00467-023-06012-x. PMID: 37204490
IL-6 inhibition with ziltivekimab in patients at high atherosclerotic risk (RESCUE): a double-blind, randomised, placebo-controlled, phase 2 trial.
Ridker PM, Devalaraja M, Baeres FMM, Engelmann MDM, Hovingh GK, Ivkovic M, Lo L, Kling D, Pergola P, Raj D, Libby P, Davidson M; RESCUE Investigators
Lancet 2021 May 29;397(10289):2060-2069. Epub 2021 May 17 doi: 10.1016/S0140-6736(21)00520-1. PMID: 34015342
Zonulin-Dependent Intestinal Permeability in Children Diagnosed with Mental Disorders: A Systematic Review and Meta-Analysis.
Asbjornsdottir B, Snorradottir H, Andresdottir E, Fasano A, Lauth B, Gudmundsson LS, Gottfredsson M, Halldorsson TI, Birgisdottir BE
Nutrients 2020 Jul 3;12(7) doi: 10.3390/nu12071982. PMID: 32635367Free PMC Article
Haptoglobin testing in hemolysis: measurement and interpretation.
Shih AW, McFarlane A, Verhovsek M
Am J Hematol 2014 Apr;89(4):443-7. doi: 10.1002/ajh.23623. PMID: 24809098
Diagnosis, controversies, and management of the syndrome of hemolysis, elevated liver enzymes, and low platelet count.
Sibai BM
Obstet Gynecol 2004 May;103(5 Pt 1):981-91. doi: 10.1097/01.AOG.0000126245.35811.2a. PMID: 15121574

Therapy

Engineering Endogenous Tumor-Associated Macrophage-Targeted Biomimetic Nano-RBC to Reprogram Tumor Immunosuppressive Microenvironment for Enhanced Chemo-Immunotherapy.
Wang Y, Yu J, Luo Z, Shi Q, Liu G, Wu F, Wang Z, Huang Y, Zhou D
Adv Mater 2021 Oct;33(39):e2103497. Epub 2021 Aug 13 doi: 10.1002/adma.202103497. PMID: 34387375
Niacin Increases Atherogenic Proteins in High-Density Lipoprotein of Statin-Treated Subjects.
Ronsein GE, Vaisar T, Davidson WS, Bornfeldt KE, Probstfield JL, O'Brien KD, Zhao XQ, Heinecke JW
Arterioscler Thromb Vasc Biol 2021 Aug;41(8):2330-2341. Epub 2021 Jun 17 doi: 10.1161/ATVBAHA.121.316278. PMID: 34134520Free PMC Article
IL-6 inhibition with ziltivekimab in patients at high atherosclerotic risk (RESCUE): a double-blind, randomised, placebo-controlled, phase 2 trial.
Ridker PM, Devalaraja M, Baeres FMM, Engelmann MDM, Hovingh GK, Ivkovic M, Lo L, Kling D, Pergola P, Raj D, Libby P, Davidson M; RESCUE Investigators
Lancet 2021 May 29;397(10289):2060-2069. Epub 2021 May 17 doi: 10.1016/S0140-6736(21)00520-1. PMID: 34015342
Microbial patterns in patients with histamine intolerance.
Schink M, Konturek PC, Tietz E, Dieterich W, Pinzer TC, Wirtz S, Neurath MF, Zopf Y
J Physiol Pharmacol 2018 Aug;69(4) Epub 2018 Dec 9 doi: 10.26402/jpp.2018.4.09. PMID: 30552302
Diagnosis, controversies, and management of the syndrome of hemolysis, elevated liver enzymes, and low platelet count.
Sibai BM
Obstet Gynecol 2004 May;103(5 Pt 1):981-91. doi: 10.1097/01.AOG.0000126245.35811.2a. PMID: 15121574

Prognosis

Evaluation of urinary haptoglobin level as a biomarker of diabetic nephropathy in children with type 1 diabetes.
Bezen D, Vurgun E, Dursun H
Pediatr Nephrol 2023 Nov;38(11):3693-3698. Epub 2023 May 18 doi: 10.1007/s00467-023-06012-x. PMID: 37204490
Elevated Levels of Circulating Biomarkers Related to Leaky Gut Syndrome and Bacterial Translocation Are Associated With Graves' Disease.
Zheng D, Liao H, Chen S, Liu X, Mao C, Zhang C, Meng M, Wang Z, Wang Y, Jiang Q, Xue Y, Zhou L, Chen Y
Front Endocrinol (Lausanne) 2021;12:796212. Epub 2021 Dec 16 doi: 10.3389/fendo.2021.796212. PMID: 34975767Free PMC Article
Elevated Plasma Haptoglobin Level as a Potential Marker for Poor Prognosis in Acute Cerebral Infarction.
Zhang T, Xiang L
Eur Neurol 2018;79(3-4):154-160. Epub 2018 Mar 8 doi: 10.1159/000487648. PMID: 29518787
High serum haptoglobin level is associated with tumor progression and predicts poor prognosis in non-small cell lung cancer.
Lu J, Wang Y, Yan M, Feng P, Yuan L, Cai Y, Xia X, Liu M, Luo J, Li L
Oncotarget 2016 Jul 5;7(27):41758-41766. doi: 10.18632/oncotarget.9676. PMID: 27248178Free PMC Article
Diagnosis, controversies, and management of the syndrome of hemolysis, elevated liver enzymes, and low platelet count.
Sibai BM
Obstet Gynecol 2004 May;103(5 Pt 1):981-91. doi: 10.1097/01.AOG.0000126245.35811.2a. PMID: 15121574

Clinical prediction guides

Elevated Levels of Circulating Biomarkers Related to Leaky Gut Syndrome and Bacterial Translocation Are Associated With Graves' Disease.
Zheng D, Liao H, Chen S, Liu X, Mao C, Zhang C, Meng M, Wang Z, Wang Y, Jiang Q, Xue Y, Zhou L, Chen Y
Front Endocrinol (Lausanne) 2021;12:796212. Epub 2021 Dec 16 doi: 10.3389/fendo.2021.796212. PMID: 34975767Free PMC Article
IL-6 inhibition with ziltivekimab in patients at high atherosclerotic risk (RESCUE): a double-blind, randomised, placebo-controlled, phase 2 trial.
Ridker PM, Devalaraja M, Baeres FMM, Engelmann MDM, Hovingh GK, Ivkovic M, Lo L, Kling D, Pergola P, Raj D, Libby P, Davidson M; RESCUE Investigators
Lancet 2021 May 29;397(10289):2060-2069. Epub 2021 May 17 doi: 10.1016/S0140-6736(21)00520-1. PMID: 34015342
Zonulin-Dependent Intestinal Permeability in Children Diagnosed with Mental Disorders: A Systematic Review and Meta-Analysis.
Asbjornsdottir B, Snorradottir H, Andresdottir E, Fasano A, Lauth B, Gudmundsson LS, Gottfredsson M, Halldorsson TI, Birgisdottir BE
Nutrients 2020 Jul 3;12(7) doi: 10.3390/nu12071982. PMID: 32635367Free PMC Article
Microbial patterns in patients with histamine intolerance.
Schink M, Konturek PC, Tietz E, Dieterich W, Pinzer TC, Wirtz S, Neurath MF, Zopf Y
J Physiol Pharmacol 2018 Aug;69(4) Epub 2018 Dec 9 doi: 10.26402/jpp.2018.4.09. PMID: 30552302
CD163+ macrophages promote angiogenesis and vascular permeability accompanied by inflammation in atherosclerosis.
Guo L, Akahori H, Harari E, Smith SL, Polavarapu R, Karmali V, Otsuka F, Gannon RL, Braumann RE, Dickinson MH, Gupta A, Jenkins AL, Lipinski MJ, Kim J, Chhour P, de Vries PS, Jinnouchi H, Kutys R, Mori H, Kutyna MD, Torii S, Sakamoto A, Choi CU, Cheng Q, Grove ML, Sawan MA, Zhang Y, Cao Y, Kolodgie FD, Cormode DP, Arking DE, Boerwinkle E, Morrison AC, Erdmann J, Sotoodehnia N, Virmani R, Finn AV
J Clin Invest 2018 Mar 1;128(3):1106-1124. Epub 2018 Feb 19 doi: 10.1172/JCI93025. PMID: 29457790Free PMC Article

Recent systematic reviews

Zonulin-Dependent Intestinal Permeability in Children Diagnosed with Mental Disorders: A Systematic Review and Meta-Analysis.
Asbjornsdottir B, Snorradottir H, Andresdottir E, Fasano A, Lauth B, Gudmundsson LS, Gottfredsson M, Halldorsson TI, Birgisdottir BE
Nutrients 2020 Jul 3;12(7) doi: 10.3390/nu12071982. PMID: 32635367Free PMC Article

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