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Elevated haptoglobin level

MedGen UID:
1698119
•Concept ID:
C5209263
•
Finding
HPO: HP:0020180

Definition

An abnormally high concentration of haptoglobin in the blood circulation. Haptoglobin is an acute-phase reactant whose levels can become elevated in the presence of infection and inflammation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated haptoglobin level

Professional guidelines

PubMed

Haptoglobin Genotype Affects Inflammation after Aneurysmal Subarachnoid Hemorrhage.
Gusdon AM, Savarraj J, Zhu L, Pandit PKT, Doré S, McBride DW, Choi HA, Blackburn SL
Curr Neurovasc Res 2020;17(5):652-659. doi: 10.2174/1567202617666201214104623. PMID: 33319684
Patient selection and vitamin E treatment in diabetes mellitus.
Goldenstein H, Levy NS, Lipener YT, Levy AP
Expert Rev Cardiovasc Ther 2013 Mar;11(3):319-26. doi: 10.1586/erc.12.187. PMID: 23469912Free PMC Article
Diagnosis, controversies, and management of the syndrome of hemolysis, elevated liver enzymes, and low platelet count.
Sibai BM
Obstet Gynecol 2004 May;103(5 Pt 1):981-91. doi: 10.1097/01.AOG.0000126245.35811.2a. PMID: 15121574

Recent clinical studies

Etiology

Elevated plasma zonulin and CAF22 are correlated with sarcopenia and functional dependency at various stages of Alzheimer's diseases.
Karim A, Iqbal MS, Muhammad T, Ahmad F, Qaisar R
Neurosci Res 2022 Nov;184:47-53. Epub 2022 Aug 5 doi: 10.1016/j.neures.2022.08.004. PMID: 35940439
IL-6 inhibition with ziltivekimab in patients at high atherosclerotic risk (RESCUE): a double-blind, randomised, placebo-controlled, phase 2 trial.
Ridker PM, Devalaraja M, Baeres FMM, Engelmann MDM, Hovingh GK, Ivkovic M, Lo L, Kling D, Pergola P, Raj D, Libby P, Davidson M; RESCUE Investigators
Lancet 2021 May 29;397(10289):2060-2069. Epub 2021 May 17 doi: 10.1016/S0140-6736(21)00520-1. PMID: 34015342
Haptoglobin-2 variant increases susceptibility to acute respiratory distress syndrome during sepsis.
Kerchberger VE, Bastarache JA, Shaver CM, Nagata H, McNeil JB, Landstreet SR, Putz ND, Yu WK, Jesse J, Wickersham NE, Sidorova TN, Janz DR, Parikh CR, Siew ED, Ware LB
JCI Insight 2019 Nov 1;4(21) doi: 10.1172/jci.insight.131206. PMID: 31573976Free PMC Article
CD163+ macrophages promote angiogenesis and vascular permeability accompanied by inflammation in atherosclerosis.
Guo L, Akahori H, Harari E, Smith SL, Polavarapu R, Karmali V, Otsuka F, Gannon RL, Braumann RE, Dickinson MH, Gupta A, Jenkins AL, Lipinski MJ, Kim J, Chhour P, de Vries PS, Jinnouchi H, Kutys R, Mori H, Kutyna MD, Torii S, Sakamoto A, Choi CU, Cheng Q, Grove ML, Sawan MA, Zhang Y, Cao Y, Kolodgie FD, Cormode DP, Arking DE, Boerwinkle E, Morrison AC, Erdmann J, Sotoodehnia N, Virmani R, Finn AV
J Clin Invest 2018 Mar 1;128(3):1106-1124. Epub 2018 Feb 19 doi: 10.1172/JCI93025. PMID: 29457790Free PMC Article
Smoking and haptoglobin phenotype modulate serum ferritin and haptoglobin levels in Parkinson disease.
Costa-Mallen P, Zabetian CP, Hu SC, Agarwal P, Yearout D, Checkoway H
J Neural Transm (Vienna) 2016 Nov;123(11):1319-1330. Epub 2016 Jun 27 doi: 10.1007/s00702-016-1590-x. PMID: 27349967Free PMC Article

Diagnosis

A Case Report of Leukocytoclastic Vasculitis: Diagnostic Approach and Treatment.
Strubchevska K, Kozyk M, Balanescu DV
Am J Case Rep 2023 May 30;24:e939541. doi: 10.12659/AJCR.939541. PMID: 37248678Free PMC Article
IL-6 inhibition with ziltivekimab in patients at high atherosclerotic risk (RESCUE): a double-blind, randomised, placebo-controlled, phase 2 trial.
Ridker PM, Devalaraja M, Baeres FMM, Engelmann MDM, Hovingh GK, Ivkovic M, Lo L, Kling D, Pergola P, Raj D, Libby P, Davidson M; RESCUE Investigators
Lancet 2021 May 29;397(10289):2060-2069. Epub 2021 May 17 doi: 10.1016/S0140-6736(21)00520-1. PMID: 34015342
Serum zonulin level is not elevated in patients with polycystic ovary syndrome without metabolic syndrome.
Cetin Z, Kosem A, Can B, Baser O, Catak M, Turhan T, Berker D
Arch Gynecol Obstet 2019 Dec;300(6):1785-1790. Epub 2019 Oct 30 doi: 10.1007/s00404-019-05345-z. PMID: 31667610
Haptoglobin testing in hemolysis: measurement and interpretation.
Shih AW, McFarlane A, Verhovsek M
Am J Hematol 2014 Apr;89(4):443-7. doi: 10.1002/ajh.23623. PMID: 24809098
Diagnosis, controversies, and management of the syndrome of hemolysis, elevated liver enzymes, and low platelet count.
Sibai BM
Obstet Gynecol 2004 May;103(5 Pt 1):981-91. doi: 10.1097/01.AOG.0000126245.35811.2a. PMID: 15121574

Therapy

Effects of Iron Supplements on Heme Scavengers in Pregnancy.
Nti AM, Botchway F, Salifu H, Cespedes JC, Harbuzariu A, Onyekaba J, Chambliss C, Liu M, Adjei A, Jolly P, Stiles JK
Am J Trop Med Hyg 2021 Sep 27;105(5):1163-1172. doi: 10.4269/ajtmh.20-0413. PMID: 34583348Free PMC Article
Niacin Increases Atherogenic Proteins in High-Density Lipoprotein of Statin-Treated Subjects.
Ronsein GE, Vaisar T, Davidson WS, Bornfeldt KE, Probstfield JL, O'Brien KD, Zhao XQ, Heinecke JW
Arterioscler Thromb Vasc Biol 2021 Aug;41(8):2330-2341. Epub 2021 Jun 17 doi: 10.1161/ATVBAHA.121.316278. PMID: 34134520Free PMC Article
IL-6 inhibition with ziltivekimab in patients at high atherosclerotic risk (RESCUE): a double-blind, randomised, placebo-controlled, phase 2 trial.
Ridker PM, Devalaraja M, Baeres FMM, Engelmann MDM, Hovingh GK, Ivkovic M, Lo L, Kling D, Pergola P, Raj D, Libby P, Davidson M; RESCUE Investigators
Lancet 2021 May 29;397(10289):2060-2069. Epub 2021 May 17 doi: 10.1016/S0140-6736(21)00520-1. PMID: 34015342
Haptoglobin improves shock, lung injury, and survival in canine pneumonia.
Remy KE, Cortés-Puch I, Solomon SB, Sun J, Pockros BM, Feng J, Lertora JJ, Hantgan RR, Liu X, Perlegas A, Warren HS, Gladwin MT, Kim-Shapiro DB, Klein HG, Natanson C
JCI Insight 2018 Sep 20;3(18) doi: 10.1172/jci.insight.123013. PMID: 30232287Free PMC Article
Diagnosis, controversies, and management of the syndrome of hemolysis, elevated liver enzymes, and low platelet count.
Sibai BM
Obstet Gynecol 2004 May;103(5 Pt 1):981-91. doi: 10.1097/01.AOG.0000126245.35811.2a. PMID: 15121574

Prognosis

Evaluation of urinary haptoglobin level as a biomarker of diabetic nephropathy in children with type 1 diabetes.
Bezen D, Vurgun E, Dursun H
Pediatr Nephrol 2023 Nov;38(11):3693-3698. Epub 2023 May 18 doi: 10.1007/s00467-023-06012-x. PMID: 37204490
Haptoglobin-2 variant increases susceptibility to acute respiratory distress syndrome during sepsis.
Kerchberger VE, Bastarache JA, Shaver CM, Nagata H, McNeil JB, Landstreet SR, Putz ND, Yu WK, Jesse J, Wickersham NE, Sidorova TN, Janz DR, Parikh CR, Siew ED, Ware LB
JCI Insight 2019 Nov 1;4(21) doi: 10.1172/jci.insight.131206. PMID: 31573976Free PMC Article
The Compensatory Immune-Regulatory Reflex System (CIRS) in Depression and Bipolar Disorder.
Maes M, Carvalho AF
Mol Neurobiol 2018 Dec;55(12):8885-8903. Epub 2018 Apr 2 doi: 10.1007/s12035-018-1016-x. PMID: 29611101
Elevated Plasma Haptoglobin Level as a Potential Marker for Poor Prognosis in Acute Cerebral Infarction.
Zhang T, Xiang L
Eur Neurol 2018;79(3-4):154-160. Epub 2018 Mar 8 doi: 10.1159/000487648. PMID: 29518787
Diagnosis, controversies, and management of the syndrome of hemolysis, elevated liver enzymes, and low platelet count.
Sibai BM
Obstet Gynecol 2004 May;103(5 Pt 1):981-91. doi: 10.1097/01.AOG.0000126245.35811.2a. PMID: 15121574

Clinical prediction guides

Elevated plasma zonulin and CAF22 are correlated with sarcopenia and functional dependency at various stages of Alzheimer's diseases.
Karim A, Iqbal MS, Muhammad T, Ahmad F, Qaisar R
Neurosci Res 2022 Nov;184:47-53. Epub 2022 Aug 5 doi: 10.1016/j.neures.2022.08.004. PMID: 35940439
IL-6 inhibition with ziltivekimab in patients at high atherosclerotic risk (RESCUE): a double-blind, randomised, placebo-controlled, phase 2 trial.
Ridker PM, Devalaraja M, Baeres FMM, Engelmann MDM, Hovingh GK, Ivkovic M, Lo L, Kling D, Pergola P, Raj D, Libby P, Davidson M; RESCUE Investigators
Lancet 2021 May 29;397(10289):2060-2069. Epub 2021 May 17 doi: 10.1016/S0140-6736(21)00520-1. PMID: 34015342
Haptoglobin-2 variant increases susceptibility to acute respiratory distress syndrome during sepsis.
Kerchberger VE, Bastarache JA, Shaver CM, Nagata H, McNeil JB, Landstreet SR, Putz ND, Yu WK, Jesse J, Wickersham NE, Sidorova TN, Janz DR, Parikh CR, Siew ED, Ware LB
JCI Insight 2019 Nov 1;4(21) doi: 10.1172/jci.insight.131206. PMID: 31573976Free PMC Article
CD163+ macrophages promote angiogenesis and vascular permeability accompanied by inflammation in atherosclerosis.
Guo L, Akahori H, Harari E, Smith SL, Polavarapu R, Karmali V, Otsuka F, Gannon RL, Braumann RE, Dickinson MH, Gupta A, Jenkins AL, Lipinski MJ, Kim J, Chhour P, de Vries PS, Jinnouchi H, Kutys R, Mori H, Kutyna MD, Torii S, Sakamoto A, Choi CU, Cheng Q, Grove ML, Sawan MA, Zhang Y, Cao Y, Kolodgie FD, Cormode DP, Arking DE, Boerwinkle E, Morrison AC, Erdmann J, Sotoodehnia N, Virmani R, Finn AV
J Clin Invest 2018 Mar 1;128(3):1106-1124. Epub 2018 Feb 19 doi: 10.1172/JCI93025. PMID: 29457790Free PMC Article
Smoking and haptoglobin phenotype modulate serum ferritin and haptoglobin levels in Parkinson disease.
Costa-Mallen P, Zabetian CP, Hu SC, Agarwal P, Yearout D, Checkoway H
J Neural Transm (Vienna) 2016 Nov;123(11):1319-1330. Epub 2016 Jun 27 doi: 10.1007/s00702-016-1590-x. PMID: 27349967Free PMC Article

Recent systematic reviews

Zonulin-Dependent Intestinal Permeability in Children Diagnosed with Mental Disorders: A Systematic Review and Meta-Analysis.
Asbjornsdottir B, Snorradottir H, Andresdottir E, Fasano A, Lauth B, Gudmundsson LS, Gottfredsson M, Halldorsson TI, Birgisdottir BE
Nutrients 2020 Jul 3;12(7) doi: 10.3390/nu12071982. PMID: 32635367Free PMC Article

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