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Head and Neck Large Cell Neuroendocrine Carcinoma

MedGen UID:
1698499
•Concept ID:
C5205701
•
Neoplastic Process

Definition

A large cell neuroendocrine carcinoma that arises from the head and neck. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHead and Neck Large Cell Neuroendocrine Carcinoma

Professional guidelines

PubMed

Management of olfactory neuroblastoma, neuroendocrine carcinoma, and sinonasal undifferentiated carcinoma involving the skullbase.
Mehta GU, Raza SM, Su SY, Hanna EY, DeMonte F
J Neurooncol 2020 Dec;150(3):367-375. Epub 2020 May 18 doi: 10.1007/s11060-020-03537-1. PMID: 32424573
How phenotype guides management of the neuroendocrine carcinomas of the larynx.
López F, Hunt JL, Nixon IJ, Rinaldo A, Williams MD, Cardesa A, Ferlito A
J Laryngol Otol 2018 Jul;132(7):568-574. Epub 2018 Jun 18 doi: 10.1017/S0022215118000968. PMID: 29909787
Differential Diagnosis in Neuroendocrine Neoplasms of the Larynx.
Hunt JL, Ferlito A, Hellquist H, Rinaldo A, Skálová A, Slootweg PJ, Willems SM, Cardesa A
Adv Anat Pathol 2017 May;24(3):161-168. doi: 10.1097/PAP.0000000000000147. PMID: 28338500

Recent clinical studies

Etiology

Merkel cell carcinoma of the head and neck in the south-east of England.
Bowe CM, Bean T, Loke R, Gallagher N, Rooney J, Surwald C, Dhanda J, Moody A, Bisase B, Norris P, Barrett AW, Lachanas V, Doumas S
Br J Oral Maxillofac Surg 2021 Dec;59(10):1280-1286. Epub 2021 Jun 25 doi: 10.1016/j.bjoms.2021.06.009. PMID: 34465487
Clinicopathological and genomic features in patients with head and neck neuroendocrine carcinoma.
Ohmoto A, Sato Y, Asaka R, Fukuda N, Wang X, Urasaki T, Hayashi N, Sato Y, Nakano K, Yunokawa M, Ono M, Tomomatsu J, Toshiyasu T, Mitani H, Takeuchi K, Mori S, Takahashi S
Mod Pathol 2021 Nov;34(11):1979-1989. Epub 2021 Jul 10 doi: 10.1038/s41379-021-00869-9. PMID: 34247193Free PMC Article
Lymphoepithelial-like carcinomas of the head and neck.
Wenig BM
Semin Diagn Pathol 2015 Jan;32(1):74-86. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.004. PMID: 25804344
Neuroectodermal neoplasms of the head and neck with emphasis on neuroendocrine carcinomas.
Mills SE
Mod Pathol 2002 Mar;15(3):264-78. doi: 10.1038/modpathol.3880522. PMID: 11904342
Merkel cell carcinoma arising in the head and neck: optimizing therapy.
Lawenda BD, Thiringer JK, Foss RD, Johnstone PA
Am J Clin Oncol 2001 Feb;24(1):35-42. doi: 10.1097/00000421-200102000-00006. PMID: 11232947

Diagnosis

Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Overview of the 2022 WHO Classification of Head and Neck Neuroendocrine Neoplasms.
Mete O, Wenig BM
Head Neck Pathol 2022 Mar;16(1):123-142. Epub 2022 Mar 21 doi: 10.1007/s12105-022-01435-8. PMID: 35312985Free PMC Article
SMARCA4/BRG1-Deficient Sinonasal Carcinoma.
Kakkar A, Ashraf SF, Rathor A, Adhya AK, Mani S, Sikka K, Jain D
Arch Pathol Lab Med 2022 Sep 1;146(9):1122-1130. doi: 10.5858/arpa.2021-0001-OA. PMID: 34871352
Human Papillomavirus-Related Neuroendocrine Carcinomas of the Head and Neck.
Westra WH
Head Neck Pathol 2018 Mar;12(1):9-12. Epub 2018 Mar 20 doi: 10.1007/s12105-018-0886-6. PMID: 29556964Free PMC Article
von Hippel-Lindau syndrome.
Chou A, Toon C, Pickett J, Gill AJ
Front Horm Res 2013;41:30-49. Epub 2013 Mar 19 doi: 10.1159/000345668. PMID: 23652669
Large cell neuroendocrine carcinoma of the head and neck.
Kusafuka K, Ferlito A, Lewis JS Jr, Woolgar JA, Rinaldo A, Slootweg PJ, Gnepp DR, Devaney KO, Travis WD, Barnes L
Oral Oncol 2012 Mar;48(3):211-5. Epub 2011 Oct 22 doi: 10.1016/j.oraloncology.2011.09.016. PMID: 22024350

Therapy

Utility of KI-67 as a prognostic biomarker in pulmonary neuroendocrine neoplasms: a systematic review and meta-analysis.
Naheed S, Holden C, Tanno L, Pattini L, Pearce NW, Green B, Jaynes E, Cave J, Ottensmeier CH, Pelosi G
BMJ Open 2022 Mar 3;12(3):e041961. doi: 10.1136/bmjopen-2020-041961. PMID: 35241462Free PMC Article
The Prognostic and Therapeutic Role of Genomic Subtyping by Sequencing Tumor or Cell-Free DNA in Pulmonary Large-Cell Neuroendocrine Carcinoma.
Zhuo M, Guan Y, Yang X, Hong L, Wang Y, Li Z, Chen R, Abbas HA, Chang L, Gong Y, Wu N, Zhong J, Chen W, Chen H, Dong Z, Zhu X, Li J, Wang Y, An T, Wu M, Wang Z, Wang J, Roarty EB, Rinsurongkawong W, Lewis J, Roth JA, Swisher SG, Lee JJ, Heymach JV, Wistuba II, Kalhor N, Yang L, Yi X, Futreal PA, Glisson BS, Xia X, Zhang J, Zhao J
Clin Cancer Res 2020 Feb 15;26(4):892-901. Epub 2019 Nov 6 doi: 10.1158/1078-0432.CCR-19-0556. PMID: 31694833Free PMC Article
Use of ALK Immunohistochemistry for Optimal Therapeutic Strategy of Pulmonary Large-cell Neuroendocrine Carcinoma and Identification of a Novel KIF5B-ALK Fusion Oncokinase.
Shimizu N, Akashi Y, Fujii T, Shiono H, Yane K, Kitahara T, Ohta Y, Kakudo K, Wakasa T
Anticancer Res 2019 Jan;39(1):413-420. doi: 10.21873/anticanres.13127. PMID: 30591488
Systemic therapy in non-conventional cancers of the larynx.
Tan E, Mody MD, Saba NF
Oral Oncol 2018 Jul;82:61-68. Epub 2018 May 26 doi: 10.1016/j.oraloncology.2018.05.005. PMID: 29909903
Hypopharyngeal large cell neuroendocrine carcinoma.
Lee WI, Ameratunga M, du Plessis J, Gan H
BMJ Case Rep 2015 Dec 29;2015 doi: 10.1136/bcr-2015-211908. PMID: 26715138Free PMC Article

Prognosis

How phenotype guides management of the neuroendocrine carcinomas of the larynx.
López F, Hunt JL, Nixon IJ, Rinaldo A, Williams MD, Cardesa A, Ferlito A
J Laryngol Otol 2018 Jul;132(7):568-574. Epub 2018 Jun 18 doi: 10.1017/S0022215118000968. PMID: 29909787
Human Papillomavirus-Related Neuroendocrine Carcinomas of the Head and Neck.
Westra WH
Head Neck Pathol 2018 Mar;12(1):9-12. Epub 2018 Mar 20 doi: 10.1007/s12105-018-0886-6. PMID: 29556964Free PMC Article
Differential Diagnosis in Neuroendocrine Neoplasms of the Larynx.
Hunt JL, Ferlito A, Hellquist H, Rinaldo A, Skálová A, Slootweg PJ, Willems SM, Cardesa A
Adv Anat Pathol 2017 May;24(3):161-168. doi: 10.1097/PAP.0000000000000147. PMID: 28338500
Lymphoepithelial-like carcinomas of the head and neck.
Wenig BM
Semin Diagn Pathol 2015 Jan;32(1):74-86. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.004. PMID: 25804344
Large cell neuroendocrine carcinoma of the head and neck.
Kusafuka K, Ferlito A, Lewis JS Jr, Woolgar JA, Rinaldo A, Slootweg PJ, Gnepp DR, Devaney KO, Travis WD, Barnes L
Oral Oncol 2012 Mar;48(3):211-5. Epub 2011 Oct 22 doi: 10.1016/j.oraloncology.2011.09.016. PMID: 22024350

Clinical prediction guides

Neuroendocrine Neoplasms of the Larynx: A Clinicopathologic Analysis of 27 Neuroendocrine Tumors and Neuroendocrine Carcinomas.
Bal M, Sharma A, Rane SU, Mittal N, Chaukar D, Prabhash K, Patil A
Head Neck Pathol 2022 Jun;16(2):375-387. Epub 2021 Aug 16 doi: 10.1007/s12105-021-01367-9. PMID: 34401980Free PMC Article
High-Grade Neuroendocrine Carcinoma of the Head and Neck: Human Papillomavirus Status and PD-L1 Expression.
Bahr K, Zimmer S, Springer E, Fottner C, Becker S, Ernst BP, Matthias C, Künzel J
ORL J Otorhinolaryngol Relat Spec 2019;81(5-6):309-316. Epub 2019 Sep 24 doi: 10.1159/000502325. PMID: 31550725
Human Papillomavirus-Related Neuroendocrine Carcinomas of the Head and Neck.
Westra WH
Head Neck Pathol 2018 Mar;12(1):9-12. Epub 2018 Mar 20 doi: 10.1007/s12105-018-0886-6. PMID: 29556964Free PMC Article
INSM1 is a Sensitive and Specific Marker of Neuroendocrine Differentiation in Head and Neck Tumors.
Rooper LM, Bishop JA, Westra WH
Am J Surg Pathol 2018 May;42(5):665-671. doi: 10.1097/PAS.0000000000001037. PMID: 29438167
Lymphoepithelial-like carcinomas of the head and neck.
Wenig BM
Semin Diagn Pathol 2015 Jan;32(1):74-86. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.004. PMID: 25804344

Recent systematic reviews

Utility of KI-67 as a prognostic biomarker in pulmonary neuroendocrine neoplasms: a systematic review and meta-analysis.
Naheed S, Holden C, Tanno L, Pattini L, Pearce NW, Green B, Jaynes E, Cave J, Ottensmeier CH, Pelosi G
BMJ Open 2022 Mar 3;12(3):e041961. doi: 10.1136/bmjopen-2020-041961. PMID: 35241462Free PMC Article
Small cell and large cell neuroendocrine carcinoma of the larynx: A comparative analysis.
Strojan P, Hernandez-Prera JC, Beitler JJ, Eisbruch A, Saba NF, Mendenhall WM, Nieto CS, Smee R, Rinaldo A, Ferlito A
Cancer Treat Rev 2019 Aug;78:42-51. Epub 2019 Aug 8 doi: 10.1016/j.ctrv.2019.08.002. PMID: 31437725

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