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Borderline Ovarian Mixed Epithelial Tumor/Atypical Proliferative Ovarian Mixed Epithelial Tumor

MedGen UID:
1699016
•Concept ID:
C5203818
•
Neoplastic Process

Definition

A low grade, non-invasive mixed epithelial proliferative neoplasm that arises from the ovary. In most cases is composed of serous and endocervical-type mucinous cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBorderline Ovarian Mixed Epithelial Tumor/Atypical Proliferative Ovarian Mixed Epithelial Tumor

Professional guidelines

PubMed

Diagnostic criteria and behavior of ovarian seromucinous (endocervical-type mucinous and mixed cell-type) tumors: atypical proliferative (borderline) tumors, intraepithelial, microinvasive, and invasive carcinomas.
Shappell HW, Riopel MA, Smith Sehdev AE, Ronnett BM, Kurman RJ
Am J Surg Pathol 2002 Dec;26(12):1529-41. doi: 10.1097/00000478-200212000-00001. PMID: 12459620

Recent clinical studies

Etiology

Endocervical-type mucinous borderline tumors are related to endometrioid tumors based on mutation and loss of expression of ARID1A.
Wu CH, Mao TL, Vang R, Ayhan A, Wang TL, Kurman RJ, Shih IeM
Int J Gynecol Pathol 2012 Jul;31(4):297-303. doi: 10.1097/PGP.0b013e31823f8482. PMID: 22653341Free PMC Article
p16 expression in primary ovarian mucinous and endometrioid tumors and metastatic adenocarcinomas in the ovary: utility for identification of metastatic HPV-related endocervical adenocarcinomas.
Vang R, Gown AM, Farinola M, Barry TS, Wheeler DT, Yemelyanova A, Seidman JD, Judson K, Ronnett BM
Am J Surg Pathol 2007 May;31(5):653-63. doi: 10.1097/01.pas.0000213369.71676.25. PMID: 17460447
Diagnostic criteria and behavior of ovarian seromucinous (endocervical-type mucinous and mixed cell-type) tumors: atypical proliferative (borderline) tumors, intraepithelial, microinvasive, and invasive carcinomas.
Shappell HW, Riopel MA, Smith Sehdev AE, Ronnett BM, Kurman RJ
Am J Surg Pathol 2002 Dec;26(12):1529-41. doi: 10.1097/00000478-200212000-00001. PMID: 12459620

Diagnosis

Borderline Brenner Tumor of the Ovary Coexisting With an Ovarian Mucinous Cystadenoma With Focal Atypical Epithelial Proliferation: A Rare Case With Review of the Literature.
Salibay CJ, Zanfagnin V, Miller H, Walia S, Brunette LL, Wang T
Int J Surg Pathol 2021 Oct;29(7):788-793. Epub 2021 Feb 26 doi: 10.1177/1066896921999459. PMID: 33635096
p16 expression in primary ovarian mucinous and endometrioid tumors and metastatic adenocarcinomas in the ovary: utility for identification of metastatic HPV-related endocervical adenocarcinomas.
Vang R, Gown AM, Farinola M, Barry TS, Wheeler DT, Yemelyanova A, Seidman JD, Judson K, Ronnett BM
Am J Surg Pathol 2007 May;31(5):653-63. doi: 10.1097/01.pas.0000213369.71676.25. PMID: 17460447
Diagnostic criteria and behavior of ovarian seromucinous (endocervical-type mucinous and mixed cell-type) tumors: atypical proliferative (borderline) tumors, intraepithelial, microinvasive, and invasive carcinomas.
Shappell HW, Riopel MA, Smith Sehdev AE, Ronnett BM, Kurman RJ
Am J Surg Pathol 2002 Dec;26(12):1529-41. doi: 10.1097/00000478-200212000-00001. PMID: 12459620

Prognosis

Borderline Brenner Tumor of the Ovary Coexisting With an Ovarian Mucinous Cystadenoma With Focal Atypical Epithelial Proliferation: A Rare Case With Review of the Literature.
Salibay CJ, Zanfagnin V, Miller H, Walia S, Brunette LL, Wang T
Int J Surg Pathol 2021 Oct;29(7):788-793. Epub 2021 Feb 26 doi: 10.1177/1066896921999459. PMID: 33635096
Diagnostic criteria and behavior of ovarian seromucinous (endocervical-type mucinous and mixed cell-type) tumors: atypical proliferative (borderline) tumors, intraepithelial, microinvasive, and invasive carcinomas.
Shappell HW, Riopel MA, Smith Sehdev AE, Ronnett BM, Kurman RJ
Am J Surg Pathol 2002 Dec;26(12):1529-41. doi: 10.1097/00000478-200212000-00001. PMID: 12459620

Clinical prediction guides

Endocervical-type mucinous borderline tumors are related to endometrioid tumors based on mutation and loss of expression of ARID1A.
Wu CH, Mao TL, Vang R, Ayhan A, Wang TL, Kurman RJ, Shih IeM
Int J Gynecol Pathol 2012 Jul;31(4):297-303. doi: 10.1097/PGP.0b013e31823f8482. PMID: 22653341Free PMC Article
The development of high-grade serous carcinoma from atypical proliferative (borderline) serous tumors and low-grade micropapillary serous carcinoma: a morphologic and molecular genetic analysis.
Dehari R, Kurman RJ, Logani S, Shih IeM
Am J Surg Pathol 2007 Jul;31(7):1007-12. doi: 10.1097/PAS.0b013e31802cbbe9. PMID: 17592266

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