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Abnormal pituitary glycoprotein hormone alpha subunit level

MedGen UID:
1699529
•Concept ID:
C5139372
•
Finding
HPO: HP:0032481

Definition

Any deviation from the normal concentration of circulating alpha polypeptide of glycoprotein hormones (NCBI Gene 1081). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal pituitary glycoprotein hormone alpha subunit level

Recent clinical studies

Etiology

Effect of chronic hypergastrinemia on human enterochromaffin-like cells: insights from patients with sporadic gastrinomas.
Peghini PL, Annibale B, Azzoni C, Milione M, Corleto VD, Gibril F, Venzon DJ, Delle Fave G, Bordi C, Jensen RT
Gastroenterology 2002 Jul;123(1):68-85. doi: 10.1053/gast.2002.34231. PMID: 12105835
Effect of allowing for ethnic group in prenatal screening for Down's syndrome.
Watt HC, Wald NJ, Smith D, Kennard A, Densem J
Prenat Diagn 1996 Aug;16(8):691-8. doi: 10.1002/(SICI)1097-0223(199608)16:8<691::AID-PD946>3.0.CO;2-2. PMID: 8878277
Placental expression of alpha and beta subunits of human chorionic gonadotrophin in early pregnancies with Down's syndrome.
Brizot ML, Jauniaux E, Mckie AT, Farzaneh F, Nicolaides KH
Hum Reprod 1995 Sep;10(9):2506-9. doi: 10.1093/oxfordjournals.humrep.a136331. PMID: 8530698
Histological origins of discordant chorionic gonadotropin secretion in malignancy.
Hay DL
J Clin Endocrinol Metab 1988 Mar;66(3):557-64. doi: 10.1210/jcem-66-3-557. PMID: 2450890
Abnormal maternal serum chorionic gonadotropin levels in pregnancies with fetal chromosome abnormalities.
Bogart MH, Pandian MR, Jones OW
Prenat Diagn 1987 Nov;7(9):623-30. doi: 10.1002/pd.1970070904. PMID: 2447576

Diagnosis

Thyroid hormone resistance and pituitary enlargement after thyroid ablation in a woman on levothyroxine treatment.
Marazuela M, Nattero L, Moure D, García-Polo I, Figueroa-Vega N, Guijarro C
Thyroid 2008 Oct;18(10):1119-23. doi: 10.1089/thy.2007.0375. PMID: 18816177
Effect of allowing for ethnic group in prenatal screening for Down's syndrome.
Watt HC, Wald NJ, Smith D, Kennard A, Densem J
Prenat Diagn 1996 Aug;16(8):691-8. doi: 10.1002/(SICI)1097-0223(199608)16:8<691::AID-PD946>3.0.CO;2-2. PMID: 8878277
Four-marker serum screening for Down's syndrome.
Wald NJ, Densem JW, Smith D, Klee GG
Prenat Diagn 1994 Aug;14(8):707-16. doi: 10.1002/pd.1970140810. PMID: 7527537
Chronic somatostatin analog administration in patients with alpha-subunit-secreting pituitary tumors.
Katznelson L, Oppenheim DS, Coughlin JF, Kliman B, Schoenfeld DA, Klibanski A
J Clin Endocrinol Metab 1992 Nov;75(5):1318-25. doi: 10.1210/jcem.75.5.1358910. PMID: 1358910
Pure alpha subunit-secreting pituitary tumors.
Klibanski A, Ridgway EC, Zervas NT
J Neurosurg 1983 Oct;59(4):585-9. doi: 10.3171/jns.1983.59.4.0585. PMID: 6886776

Therapy

Thyroid hormone resistance and pituitary enlargement after thyroid ablation in a woman on levothyroxine treatment.
Marazuela M, Nattero L, Moure D, García-Polo I, Figueroa-Vega N, Guijarro C
Thyroid 2008 Oct;18(10):1119-23. doi: 10.1089/thy.2007.0375. PMID: 18816177
Aberrant alternative splicing of thyroid hormone receptor in a TSH-secreting pituitary tumor is a mechanism for hormone resistance.
Ando S, Sarlis NJ, Krishnan J, Feng X, Refetoff S, Zhang MQ, Oldfield EH, Yen PM
Mol Endocrinol 2001 Sep;15(9):1529-38. doi: 10.1210/mend.15.9.0687. PMID: 11518802
A pituitary tumor in a patient with thyroid hormone resistance: a diagnostic dilemma.
Safer JD, Colan SD, Fraser LM, Wondisford FE
Thyroid 2001 Mar;11(3):281-91. doi: 10.1089/105072501750159750. PMID: 11327621
Chronic somatostatin analog administration in patients with alpha-subunit-secreting pituitary tumors.
Katznelson L, Oppenheim DS, Coughlin JF, Kliman B, Schoenfeld DA, Klibanski A
J Clin Endocrinol Metab 1992 Nov;75(5):1318-25. doi: 10.1210/jcem.75.5.1358910. PMID: 1358910
Serum free thyrotropin subunit in congenital isolated thyrotropin deficiency.
Miyai K, Endo Y, Iijima Y, Kabutomori O, Hayashizaki Y
Endocrinol Jpn 1988 Jun;35(3):517-21. doi: 10.1507/endocrj1954.35.517. PMID: 2461855

Prognosis

Effect of chronic hypergastrinemia on human enterochromaffin-like cells: insights from patients with sporadic gastrinomas.
Peghini PL, Annibale B, Azzoni C, Milione M, Corleto VD, Gibril F, Venzon DJ, Delle Fave G, Bordi C, Jensen RT
Gastroenterology 2002 Jul;123(1):68-85. doi: 10.1053/gast.2002.34231. PMID: 12105835
Free alpha-subunits of human chorionic gonadotropin in preeclampsia.
Moodley D, Moodley J, Buck R, Haneef R, Payne A
Int J Gynaecol Obstet 1995 Jun;49(3):283-7. doi: 10.1016/0020-7292(95)02375-m. PMID: 9764867
Amniotic fluid levels of human chorionic gonadotropin and its alpha and beta subunits in second-trimester chromosomally abnormal pregnancies.
Wolf GC, Byrn FW, McConnell TS, Khazaeli MB
Prenat Diagn 1992 Feb;12(2):93-101. doi: 10.1002/pd.1970120204. PMID: 1372734
The luteinizing hormone-releasing hormone (LHRH) agonist [D-Trp6-Pro9-NEt]LHRH increased rather than lowered LH and alpha-subunit levels in a patient with an LH-secreting pituitary tumor.
Roman SH, Goldstein M, Kourides IA, Comite F, Bardin CW, Krieger DT
J Clin Endocrinol Metab 1984 Feb;58(2):313-9. doi: 10.1210/jcem-58-2-313. PMID: 6198331

Clinical prediction guides

Effect of chronic hypergastrinemia on human enterochromaffin-like cells: insights from patients with sporadic gastrinomas.
Peghini PL, Annibale B, Azzoni C, Milione M, Corleto VD, Gibril F, Venzon DJ, Delle Fave G, Bordi C, Jensen RT
Gastroenterology 2002 Jul;123(1):68-85. doi: 10.1053/gast.2002.34231. PMID: 12105835
Thyroid receptor alpha1 and alpha2 mutations in nonfunctioning pituitary tumors.
McCabe CJ, Gittoes NJ, Sheppard MC, Franklyn JA
J Clin Endocrinol Metab 1999 Feb;84(2):649-53. doi: 10.1210/jcem.84.2.5469. PMID: 10022432
Retinoid X receptor expression in the normal pituitary and clinically 'non-functioning' pituitary tumours.
Gittoes NJ, McCabe CJ, Verhaeg J, Sheppard MC, Franklyn JA
Clin Endocrinol (Oxf) 1998 Apr;48(4):425-33. doi: 10.1046/j.1365-2265.1998.00339.x. PMID: 9640409
Increased luteinizing hormone and alpha-subunit secretion in women with hyperandrogenic anovulation.
Berga SL, Guzick DS, Winters SJ
J Clin Endocrinol Metab 1993 Oct;77(4):895-901. doi: 10.1210/jcem.77.4.7691863. PMID: 7691863
Abnormal maternal serum chorionic gonadotropin levels in pregnancies with fetal chromosome abnormalities.
Bogart MH, Pandian MR, Jones OW
Prenat Diagn 1987 Nov;7(9):623-30. doi: 10.1002/pd.1970070904. PMID: 2447576

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