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Refractory Rectal Carcinoma

MedGen UID:
1699689
Concept ID:
C5206376
Neoplastic Process

Definition

Rectal carcinoma that is resistant to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Rectal Carcinoma

Professional guidelines

PubMed

Patell K, Mears VL, Storandt MH, Mahipal A
Expert Opin Drug Metab Toxicol 2024 Apr;20(4):197-205. Epub 2024 Mar 20 doi: 10.1080/17425255.2024.2332364. PMID: 38497279
Eng C, Messick C, Glynne-Jones R
Am Soc Clin Oncol Educ Book 2019 Jan;39:216-225. Epub 2019 May 17 doi: 10.1200/EDBK_237433. PMID: 31099616
Roccaro AM, Vacca A, Ribatti D
Recent Pat Anticancer Drug Discov 2006 Nov;1(3):397-403. doi: 10.2174/157489206778776925. PMID: 18221049

Recent clinical studies

Etiology

Dasari A, Lonardi S, Garcia-Carbonero R, Elez E, Yoshino T, Sobrero A, Yao J, García-Alfonso P, Kocsis J, Cubillo Gracian A, Sartore-Bianchi A, Satoh T, Randrian V, Tomasek J, Chong G, Paulson AS, Masuishi T, Jones J, Csőszi T, Cremolini C, Ghiringhelli F, Shergill A, Hochster HS, Krauss J, Bassam A, Ducreux M, Elme A, Faugeras L, Kasper S, Van Cutsem E, Arnold D, Nanda S, Yang Z, Schelman WR, Kania M, Tabernero J, Eng C; FRESCO-2 Study Investigators
Lancet 2023 Jul 1;402(10395):41-53. Epub 2023 Jun 15 doi: 10.1016/S0140-6736(23)00772-9. PMID: 37331369
Strickler JH, Cercek A, Siena S, André T, Ng K, Van Cutsem E, Wu C, Paulson AS, Hubbard JM, Coveler AL, Fountzilas C, Kardosh A, Kasi PM, Lenz HJ, Ciombor KK, Elez E, Bajor DL, Cremolini C, Sanchez F, Stecher M, Feng W, Bekaii-Saab TS; MOUNTAINEER investigators
Lancet Oncol 2023 May;24(5):496-508. doi: 10.1016/S1470-2045(23)00150-X. PMID: 37142372
Prager GW, Taieb J, Fakih M, Ciardiello F, Van Cutsem E, Elez E, Cruz FM, Wyrwicz L, Stroyakovskiy D, Pápai Z, Poureau PG, Liposits G, Cremolini C, Bondarenko I, Modest DP, Benhadji KA, Amellal N, Leger C, Vidot L, Tabernero J; SUNLIGHT Investigators
N Engl J Med 2023 May 4;388(18):1657-1667. doi: 10.1056/NEJMoa2214963. PMID: 37133585
Nguyen TH, Chokshi RV
Curr Gastroenterol Rep 2020 Aug 4;22(10):48. doi: 10.1007/s11894-020-00785-z. PMID: 32749603Free PMC Article
Morris VK, Salem ME, Nimeiri H, Iqbal S, Singh P, Ciombor K, Polite B, Deming D, Chan E, Wade JL, Xiao L, Bekaii-Saab T, Vence L, Blando J, Mahvash A, Foo WC, Ohaji C, Pasia M, Bland G, Ohinata A, Rogers J, Mehdizadeh A, Banks K, Lanman R, Wolff RA, Streicher H, Allison J, Sharma P, Eng C
Lancet Oncol 2017 Apr;18(4):446-453. Epub 2017 Feb 18 doi: 10.1016/S1470-2045(17)30104-3. PMID: 28223062Free PMC Article

Diagnosis

Chen EX, Loree JM, Titmuss E, Jonker DJ, Kennecke HF, Berry S, Couture F, Ahmad CE, Goffin JR, Kavan P, Harb M, Colwell B, Samimi S, Samson B, Abbas T, Aucoin N, Aubin F, Koski S, Wei AC, Tu D, O'Callaghan CJ
JAMA Netw Open 2023 Dec 1;6(12):e2346094. doi: 10.1001/jamanetworkopen.2023.46094. PMID: 38051531Free PMC Article
Bancheno WM, Adidam SR, Melaku MA
Medicine (Baltimore) 2022 Jul 22;101(29):e29616. doi: 10.1097/MD.0000000000029616. PMID: 35866784Free PMC Article
Eng C, Messick C, Glynne-Jones R
Am Soc Clin Oncol Educ Book 2019 Jan;39:216-225. Epub 2019 May 17 doi: 10.1200/EDBK_237433. PMID: 31099616
Bracarda S, de Cobelli O, Greco C, Prayer-Galetti T, Valdagni R, Gatta G, de Braud F, Bartsch G
Crit Rev Oncol Hematol 2005 Dec;56(3):379-96. doi: 10.1016/j.critrevonc.2005.03.010. PMID: 16310371
Siafakas C, Vottler TP, Andersen JM
Clin Pediatr (Phila) 1999 Feb;38(2):63-72. doi: 10.1177/000992289903800201. PMID: 10047938

Therapy

Dasari A, Lonardi S, Garcia-Carbonero R, Elez E, Yoshino T, Sobrero A, Yao J, García-Alfonso P, Kocsis J, Cubillo Gracian A, Sartore-Bianchi A, Satoh T, Randrian V, Tomasek J, Chong G, Paulson AS, Masuishi T, Jones J, Csőszi T, Cremolini C, Ghiringhelli F, Shergill A, Hochster HS, Krauss J, Bassam A, Ducreux M, Elme A, Faugeras L, Kasper S, Van Cutsem E, Arnold D, Nanda S, Yang Z, Schelman WR, Kania M, Tabernero J, Eng C; FRESCO-2 Study Investigators
Lancet 2023 Jul 1;402(10395):41-53. Epub 2023 Jun 15 doi: 10.1016/S0140-6736(23)00772-9. PMID: 37331369
Strickler JH, Cercek A, Siena S, André T, Ng K, Van Cutsem E, Wu C, Paulson AS, Hubbard JM, Coveler AL, Fountzilas C, Kardosh A, Kasi PM, Lenz HJ, Ciombor KK, Elez E, Bajor DL, Cremolini C, Sanchez F, Stecher M, Feng W, Bekaii-Saab TS; MOUNTAINEER investigators
Lancet Oncol 2023 May;24(5):496-508. doi: 10.1016/S1470-2045(23)00150-X. PMID: 37142372
Prager GW, Taieb J, Fakih M, Ciardiello F, Van Cutsem E, Elez E, Cruz FM, Wyrwicz L, Stroyakovskiy D, Pápai Z, Poureau PG, Liposits G, Cremolini C, Bondarenko I, Modest DP, Benhadji KA, Amellal N, Leger C, Vidot L, Tabernero J; SUNLIGHT Investigators
N Engl J Med 2023 May 4;388(18):1657-1667. doi: 10.1056/NEJMoa2214963. PMID: 37133585
Kanani A, Veen T, Søreide K
Br J Surg 2021 Dec 1;108(12):1417-1425. doi: 10.1093/bjs/znab342. PMID: 34694371Free PMC Article
Nguyen TH, Chokshi RV
Curr Gastroenterol Rep 2020 Aug 4;22(10):48. doi: 10.1007/s11894-020-00785-z. PMID: 32749603Free PMC Article

Prognosis

Arai H, Yang Y, Baca Y, Millstein J, Denda T, Ou FS, Innocenti F, Takeda H, Kubota Y, Doi A, Horie Y, Umemoto K, Izawa N, Wang J, Battaglin F, Jayachandran P, Algaze S, Soni S, Zhang W, Goldberg RM, Hall MJ, Scott AJ, Hwang JJ, Lou E, Weinberg BA, Marshall J, Goel S, Xiu J, Michael Korn W, Venook AP, Sunakawa Y, Lenz HJ
Eur J Cancer 2024 Apr;201:113914. Epub 2024 Feb 10 doi: 10.1016/j.ejca.2024.113914. PMID: 38359495Free PMC Article
Bancheno WM, Adidam SR, Melaku MA
Medicine (Baltimore) 2022 Jul 22;101(29):e29616. doi: 10.1097/MD.0000000000029616. PMID: 35866784Free PMC Article
Sclafani F, Rao S
Curr Oncol Rep 2018 May 4;20(7):53. doi: 10.1007/s11912-018-0698-6. PMID: 29728940
Morris VK, Salem ME, Nimeiri H, Iqbal S, Singh P, Ciombor K, Polite B, Deming D, Chan E, Wade JL, Xiao L, Bekaii-Saab T, Vence L, Blando J, Mahvash A, Foo WC, Ohaji C, Pasia M, Bland G, Ohinata A, Rogers J, Mehdizadeh A, Banks K, Lanman R, Wolff RA, Streicher H, Allison J, Sharma P, Eng C
Lancet Oncol 2017 Apr;18(4):446-453. Epub 2017 Feb 18 doi: 10.1016/S1470-2045(17)30104-3. PMID: 28223062Free PMC Article
Siafakas C, Vottler TP, Andersen JM
Clin Pediatr (Phila) 1999 Feb;38(2):63-72. doi: 10.1177/000992289903800201. PMID: 10047938

Clinical prediction guides

Arai H, Yang Y, Baca Y, Millstein J, Denda T, Ou FS, Innocenti F, Takeda H, Kubota Y, Doi A, Horie Y, Umemoto K, Izawa N, Wang J, Battaglin F, Jayachandran P, Algaze S, Soni S, Zhang W, Goldberg RM, Hall MJ, Scott AJ, Hwang JJ, Lou E, Weinberg BA, Marshall J, Goel S, Xiu J, Michael Korn W, Venook AP, Sunakawa Y, Lenz HJ
Eur J Cancer 2024 Apr;201:113914. Epub 2024 Feb 10 doi: 10.1016/j.ejca.2024.113914. PMID: 38359495Free PMC Article
Pires M, Severo M, Lopes A, Neves S, Matzel K, Povo A
Int J Colorectal Dis 2023 Jul 10;38(1):189. doi: 10.1007/s00384-023-04485-8. PMID: 37428256
Prager GW, Taieb J, Fakih M, Ciardiello F, Van Cutsem E, Elez E, Cruz FM, Wyrwicz L, Stroyakovskiy D, Pápai Z, Poureau PG, Liposits G, Cremolini C, Bondarenko I, Modest DP, Benhadji KA, Amellal N, Leger C, Vidot L, Tabernero J; SUNLIGHT Investigators
N Engl J Med 2023 May 4;388(18):1657-1667. doi: 10.1056/NEJMoa2214963. PMID: 37133585
Koroulakis AI, Molitoris JK, Sullivan M, Jiang Y, Hausner PF, Hanna N, Bafford A, Miller RC, Regine WF
Pract Radiat Oncol 2022 Nov-Dec;12(6):e517-e521. Epub 2022 Jun 17 doi: 10.1016/j.prro.2022.06.002. PMID: 35718072
Nguyen TH, Chokshi RV
Curr Gastroenterol Rep 2020 Aug 4;22(10):48. doi: 10.1007/s11894-020-00785-z. PMID: 32749603Free PMC Article

Recent systematic reviews

Ciardiello D, Mauri G, Sartore-Bianchi A, Siena S, Zampino MG, Fazio N, Cervantes A
Cancer Treat Rev 2024 Mar;124:102683. Epub 2024 Jan 12 doi: 10.1016/j.ctrv.2024.102683. PMID: 38237253
Pires M, Severo M, Lopes A, Neves S, Matzel K, Povo A
Int J Colorectal Dis 2023 Jul 10;38(1):189. doi: 10.1007/s00384-023-04485-8. PMID: 37428256
Huang Y, Koh CE
Colorectal Dis 2019 Nov;21(11):1240-1248. Epub 2019 Jun 13 doi: 10.1111/codi.14690. PMID: 31081580
Matta R, Chapple CR, Fisch M, Heidenreich A, Herschorn S, Kodama RT, Koontz BF, Murphy DG, Nguyen PL, Nam RK
Eur Urol 2019 Mar;75(3):464-476. Epub 2018 Dec 17 doi: 10.1016/j.eururo.2018.12.003. PMID: 30573316

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