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Refractory Urinary System Carcinoma

MedGen UID:
1699744
•Concept ID:
C5206768
•
Neoplastic Process

Definition

Urinary system carcinoma that does not respond to treatment. [from NCI]

Professional guidelines

PubMed

EAU guidelines on non-muscle-invasive urothelial carcinoma of the bladder: update 2013.
Babjuk M, Burger M, Zigeuner R, Shariat SF, van Rhijn BW, Compérat E, Sylvester RJ, Kaasinen E, Böhle A, Palou Redorta J, Rouprêt M; European Association of Urology
Eur Urol 2013 Oct;64(4):639-53. Epub 2013 Jun 12 doi: 10.1016/j.eururo.2013.06.003. PMID: 23827737
Recurrence and progression of disease in non-muscle-invasive bladder cancer: from epidemiology to treatment strategy.
van Rhijn BW, Burger M, Lotan Y, Solsona E, Stief CG, Sylvester RJ, Witjes JA, Zlotta AR
Eur Urol 2009 Sep;56(3):430-42. Epub 2009 Jun 26 doi: 10.1016/j.eururo.2009.06.028. PMID: 19576682
The application of epigenetic modifiers on the treatment of prostate and bladder cancer.
Zhang Z, Karam J, Frenkel E, Sagalowsky A, Hsieh JT
Urol Oncol 2006 Mar-Apr;24(2):152-60. doi: 10.1016/j.urolonc.2005.11.004. PMID: 16520279

Recent clinical studies

Etiology

Robot-assisted radical cystectomy versus open radical cystectomy in patients with bladder cancer (RAZOR): an open-label, randomised, phase 3, non-inferiority trial.
Parekh DJ, Reis IM, Castle EP, Gonzalgo ML, Woods ME, Svatek RS, Weizer AZ, Konety BR, Tollefson M, Krupski TL, Smith ND, Shabsigh A, Barocas DA, Quek ML, Dash A, Kibel AS, Shemanski L, Pruthi RS, Montgomery JS, Weight CJ, Sharp DS, Chang SS, Cookson MS, Gupta GN, Gorbonos A, Uchio EM, Skinner E, Venkatramani V, Soodana-Prakash N, Kendrick K, Smith JA Jr, Thompson IM
Lancet 2018 Jun 23;391(10139):2525-2536. doi: 10.1016/S0140-6736(18)30996-6. PMID: 29976469
EAU Guidelines on Non-Muscle-invasive Urothelial Carcinoma of the Bladder: Update 2016.
Babjuk M, Böhle A, Burger M, Capoun O, Cohen D, Compérat EM, Hernández V, Kaasinen E, Palou J, Rouprêt M, van Rhijn BWG, Shariat SF, Soukup V, Sylvester RJ, Zigeuner R
Eur Urol 2017 Mar;71(3):447-461. Epub 2016 Jun 17 doi: 10.1016/j.eururo.2016.05.041. PMID: 27324428
Mixed low- and high-grade papillary urothelial carcinoma: histopathogenetic and clinical significance.
Mai KT, Flood TA, Williams P, Kos Z, Belanger EC
Virchows Arch 2013 Oct;463(4):575-81. Epub 2013 Aug 4 doi: 10.1007/s00428-013-1456-7. PMID: 23913166
EAU guidelines on non-muscle-invasive urothelial carcinoma of the bladder: update 2013.
Babjuk M, Burger M, Zigeuner R, Shariat SF, van Rhijn BW, Compérat E, Sylvester RJ, Kaasinen E, Böhle A, Palou Redorta J, Rouprêt M; European Association of Urology
Eur Urol 2013 Oct;64(4):639-53. Epub 2013 Jun 12 doi: 10.1016/j.eururo.2013.06.003. PMID: 23827737
Recurrence and progression of disease in non-muscle-invasive bladder cancer: from epidemiology to treatment strategy.
van Rhijn BW, Burger M, Lotan Y, Solsona E, Stief CG, Sylvester RJ, Witjes JA, Zlotta AR
Eur Urol 2009 Sep;56(3):430-42. Epub 2009 Jun 26 doi: 10.1016/j.eururo.2009.06.028. PMID: 19576682

Diagnosis

EAU Guidelines on Non-Muscle-invasive Urothelial Carcinoma of the Bladder: Update 2016.
Babjuk M, Böhle A, Burger M, Capoun O, Cohen D, Compérat EM, Hernández V, Kaasinen E, Palou J, Rouprêt M, van Rhijn BWG, Shariat SF, Soukup V, Sylvester RJ, Zigeuner R
Eur Urol 2017 Mar;71(3):447-461. Epub 2016 Jun 17 doi: 10.1016/j.eururo.2016.05.041. PMID: 27324428
Renal cell carcinoma in pregnancy: a rare coexistence.
Boussios S, Pavlidis N
Clin Transl Oncol 2014 Feb;16(2):122-7. Epub 2013 Sep 4 doi: 10.1007/s12094-013-1105-2. PMID: 24002946
EAU guidelines on non-muscle-invasive urothelial carcinoma of the bladder: update 2013.
Babjuk M, Burger M, Zigeuner R, Shariat SF, van Rhijn BW, Compérat E, Sylvester RJ, Kaasinen E, Böhle A, Palou Redorta J, Rouprêt M; European Association of Urology
Eur Urol 2013 Oct;64(4):639-53. Epub 2013 Jun 12 doi: 10.1016/j.eururo.2013.06.003. PMID: 23827737
Recurrence and progression of disease in non-muscle-invasive bladder cancer: from epidemiology to treatment strategy.
van Rhijn BW, Burger M, Lotan Y, Solsona E, Stief CG, Sylvester RJ, Witjes JA, Zlotta AR
Eur Urol 2009 Sep;56(3):430-42. Epub 2009 Jun 26 doi: 10.1016/j.eururo.2009.06.028. PMID: 19576682
Retinoids as preventive and therapeutic anticancer agents (Part I).
Lippman SM, Kessler JF, Meyskens FL Jr
Cancer Treat Rep 1987 Apr;71(4):391-405. PMID: 3548957

Therapy

FIGHT-101, a first-in-human study of potent and selective FGFR 1-3 inhibitor pemigatinib in pan-cancer patients with FGF/FGFR alterations and advanced malignancies.
Subbiah V, Iannotti NO, Gutierrez M, Smith DC, Féliz L, Lihou CF, Tian C, Silverman IM, Ji T, Saleh M
Ann Oncol 2022 May;33(5):522-533. Epub 2022 Feb 14 doi: 10.1016/j.annonc.2022.02.001. PMID: 35176457
Robot-assisted radical cystectomy versus open radical cystectomy in patients with bladder cancer (RAZOR): an open-label, randomised, phase 3, non-inferiority trial.
Parekh DJ, Reis IM, Castle EP, Gonzalgo ML, Woods ME, Svatek RS, Weizer AZ, Konety BR, Tollefson M, Krupski TL, Smith ND, Shabsigh A, Barocas DA, Quek ML, Dash A, Kibel AS, Shemanski L, Pruthi RS, Montgomery JS, Weight CJ, Sharp DS, Chang SS, Cookson MS, Gupta GN, Gorbonos A, Uchio EM, Skinner E, Venkatramani V, Soodana-Prakash N, Kendrick K, Smith JA Jr, Thompson IM
Lancet 2018 Jun 23;391(10139):2525-2536. doi: 10.1016/S0140-6736(18)30996-6. PMID: 29976469
EAU Guidelines on Non-Muscle-invasive Urothelial Carcinoma of the Bladder: Update 2016.
Babjuk M, Böhle A, Burger M, Capoun O, Cohen D, Compérat EM, Hernández V, Kaasinen E, Palou J, Rouprêt M, van Rhijn BWG, Shariat SF, Soukup V, Sylvester RJ, Zigeuner R
Eur Urol 2017 Mar;71(3):447-461. Epub 2016 Jun 17 doi: 10.1016/j.eururo.2016.05.041. PMID: 27324428
EAU guidelines on non-muscle-invasive urothelial carcinoma of the bladder: update 2013.
Babjuk M, Burger M, Zigeuner R, Shariat SF, van Rhijn BW, Compérat E, Sylvester RJ, Kaasinen E, Böhle A, Palou Redorta J, Rouprêt M; European Association of Urology
Eur Urol 2013 Oct;64(4):639-53. Epub 2013 Jun 12 doi: 10.1016/j.eururo.2013.06.003. PMID: 23827737
Circadian chemotherapy for gynecological and genitourinary cancers.
Kobayashi M, Wood PA, Hrushesky WJ
Chronobiol Int 2002 Jan;19(1):237-51. doi: 10.1081/cbi-120002600. PMID: 11962679

Prognosis

EAU Guidelines on Non-Muscle-invasive Urothelial Carcinoma of the Bladder: Update 2016.
Babjuk M, Böhle A, Burger M, Capoun O, Cohen D, Compérat EM, Hernández V, Kaasinen E, Palou J, Rouprêt M, van Rhijn BWG, Shariat SF, Soukup V, Sylvester RJ, Zigeuner R
Eur Urol 2017 Mar;71(3):447-461. Epub 2016 Jun 17 doi: 10.1016/j.eururo.2016.05.041. PMID: 27324428
Renal cell carcinoma in pregnancy: a rare coexistence.
Boussios S, Pavlidis N
Clin Transl Oncol 2014 Feb;16(2):122-7. Epub 2013 Sep 4 doi: 10.1007/s12094-013-1105-2. PMID: 24002946
Mixed low- and high-grade papillary urothelial carcinoma: histopathogenetic and clinical significance.
Mai KT, Flood TA, Williams P, Kos Z, Belanger EC
Virchows Arch 2013 Oct;463(4):575-81. Epub 2013 Aug 4 doi: 10.1007/s00428-013-1456-7. PMID: 23913166
EAU guidelines on non-muscle-invasive urothelial carcinoma of the bladder: update 2013.
Babjuk M, Burger M, Zigeuner R, Shariat SF, van Rhijn BW, Compérat E, Sylvester RJ, Kaasinen E, Böhle A, Palou Redorta J, Rouprêt M; European Association of Urology
Eur Urol 2013 Oct;64(4):639-53. Epub 2013 Jun 12 doi: 10.1016/j.eururo.2013.06.003. PMID: 23827737
Recurrence and progression of disease in non-muscle-invasive bladder cancer: from epidemiology to treatment strategy.
van Rhijn BW, Burger M, Lotan Y, Solsona E, Stief CG, Sylvester RJ, Witjes JA, Zlotta AR
Eur Urol 2009 Sep;56(3):430-42. Epub 2009 Jun 26 doi: 10.1016/j.eururo.2009.06.028. PMID: 19576682

Clinical prediction guides

EAU Guidelines on Non-Muscle-invasive Urothelial Carcinoma of the Bladder: Update 2016.
Babjuk M, Böhle A, Burger M, Capoun O, Cohen D, Compérat EM, Hernández V, Kaasinen E, Palou J, Rouprêt M, van Rhijn BWG, Shariat SF, Soukup V, Sylvester RJ, Zigeuner R
Eur Urol 2017 Mar;71(3):447-461. Epub 2016 Jun 17 doi: 10.1016/j.eururo.2016.05.041. PMID: 27324428
Sonic Hedgehog, VACTERL, and Fanconi anemia: Pathogenetic connections and therapeutic implications.
Lubinsky M
Am J Med Genet A 2015 Nov;167A(11):2594-8. Epub 2015 Jul 21 doi: 10.1002/ajmg.a.37257. PMID: 26198446
EAU guidelines on non-muscle-invasive urothelial carcinoma of the bladder: update 2013.
Babjuk M, Burger M, Zigeuner R, Shariat SF, van Rhijn BW, Compérat E, Sylvester RJ, Kaasinen E, Böhle A, Palou Redorta J, Rouprêt M; European Association of Urology
Eur Urol 2013 Oct;64(4):639-53. Epub 2013 Jun 12 doi: 10.1016/j.eururo.2013.06.003. PMID: 23827737
Recurrence and progression of disease in non-muscle-invasive bladder cancer: from epidemiology to treatment strategy.
van Rhijn BW, Burger M, Lotan Y, Solsona E, Stief CG, Sylvester RJ, Witjes JA, Zlotta AR
Eur Urol 2009 Sep;56(3):430-42. Epub 2009 Jun 26 doi: 10.1016/j.eururo.2009.06.028. PMID: 19576682
Anti- and proinflammatory cytokine gene polymorphism and genetic predisposition: association with smoking, tumor stage and grade, and bacillus Calmette-Guérin immunotherapy in bladder cancer.
Ahirwar D, Kesarwani P, Manchanda PK, Mandhani A, Mittal RD
Cancer Genet Cytogenet 2008 Jul;184(1):1-8. doi: 10.1016/j.cancergencyto.2008.02.015. PMID: 18558283

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