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Primary Peritoneal Undifferentiated Carcinoma

MedGen UID:
1699916
Concept ID:
C5206646
Neoplastic Process

Definition

An extremely rare carcinoma arising from the peritoneum. It is characterized by the presence of a diffuse malignant infiltrate that is composed of epithelial cells without evidence of glandular or squamous differentiation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPrimary Peritoneal Undifferentiated Carcinoma

Professional guidelines

PubMed

Armstrong DK, Alvarez RD, Bakkum-Gamez JN, Barroilhet L, Behbakht K, Berchuck A, Chen LM, Cristea M, DeRosa M, Eisenhauer EL, Gershenson DM, Gray HJ, Grisham R, Hakam A, Jain A, Karam A, Konecny GE, Leath CA, Liu J, Mahdi H, Martin L, Matei D, McHale M, McLean K, Miller DS, O'Malley DM, Percac-Lima S, Ratner E, Remmenga SW, Vargas R, Werner TL, Zsiros E, Burns JL, Engh AM
J Natl Compr Canc Netw 2021 Feb 2;19(2):191-226. doi: 10.6004/jnccn.2021.0007. PMID: 33545690
Shaib WL, Assi R, Shamseddine A, Alese OB, Staley C 3rd, Memis B, Adsay V, Bekaii-Saab T, El-Rayes BF
Oncologist 2017 Sep;22(9):1107-1116. Epub 2017 Jun 29 doi: 10.1634/theoncologist.2017-0081. PMID: 28663356Free PMC Article
Gershenson DM
Best Pract Res Clin Obstet Gynaecol 2017 May;41:49-59. Epub 2016 Oct 3 doi: 10.1016/j.bpobgyn.2016.09.012. PMID: 27780698

Recent clinical studies

Etiology

Zhang D, Lu W, Cui S, Mei H, Wu X, Zhuo Z
J Ovarian Res 2022 Nov 23;15(1):123. doi: 10.1186/s13048-022-01059-0. PMID: 36424614Free PMC Article
Slomovitz B, Gourley C, Carey MS, Malpica A, Shih IM, Huntsman D, Fader AN, Grisham RN, Schlumbrecht M, Sun CC, Ludemann J, Cooney GA, Coleman R, Sood AK, Mahdi H, Wong KK, Covens A, O'Malley DM, Lecuru F, Cobb LP, Caputo TA, May T, Huang M, Siemon J, Fernández ML, Ray-Coquard I, Gershenson DM
Gynecol Oncol 2020 Mar;156(3):715-725. Epub 2020 Jan 20 doi: 10.1016/j.ygyno.2019.12.033. PMID: 31969252
Carr NJ, Bibeau F, Bradley RF, Dartigues P, Feakins RM, Geisinger KR, Gui X, Isaac S, Milione M, Misdraji J, Pai RK, Rodriguez-Justo M, Sobin LH, van Velthuysen MF, Yantiss RK
Histopathology 2017 Dec;71(6):847-858. Epub 2017 Sep 19 doi: 10.1111/his.13324. PMID: 28746986
Baratti D, Kusamura S, Guaglio M, Deraco M
Minerva Chir 2015 Jun;70(3):195-215. Epub 2015 Mar 10 PMID: 25752673
Verwaal VJ, van Ruth S, de Bree E, van Sloothen GW, van Tinteren H, Boot H, Zoetmulder FA
J Clin Oncol 2003 Oct 15;21(20):3737-43. doi: 10.1200/JCO.2003.04.187. PMID: 14551293

Diagnosis

Pascual-Antón L, Sandoval P, González-Mateo GT, Kopytina V, Tomero-Sanz H, Arriero-País EM, Jiménez-Heffernan JA, Fabre M, Egaña I, Ferrer C, Simón L, González-Cortijo L, Sainz de la Cuesta R, López-Cabrera M
J Pathol 2023 Oct;261(2):238-251. Epub 2023 Aug 9 doi: 10.1002/path.6170. PMID: 37555348
Ritch SJ, Telleria CM
Front Endocrinol (Lausanne) 2022;13:886533. Epub 2022 Apr 28 doi: 10.3389/fendo.2022.886533. PMID: 35574025Free PMC Article
Pascual-Antón L, Cardeñes B, Sainz de la Cuesta R, González-Cortijo L, López-Cabrera M, Cabañas C, Sandoval P
Int J Mol Sci 2021 Oct 25;22(21) doi: 10.3390/ijms222111496. PMID: 34768926Free PMC Article
Carr NJ, Bibeau F, Bradley RF, Dartigues P, Feakins RM, Geisinger KR, Gui X, Isaac S, Milione M, Misdraji J, Pai RK, Rodriguez-Justo M, Sobin LH, van Velthuysen MF, Yantiss RK
Histopathology 2017 Dec;71(6):847-858. Epub 2017 Sep 19 doi: 10.1111/his.13324. PMID: 28746986
Tropé CG, Kaern J, Davidson B
Best Pract Res Clin Obstet Gynaecol 2012 Jun;26(3):325-36. Epub 2012 Feb 7 doi: 10.1016/j.bpobgyn.2011.12.006. PMID: 22321906

Therapy

Fagotti A, Ferrandina MG, Vizzielli G, Pasciuto T, Fanfani F, Gallotta V, Margariti PA, Chiantera V, Costantini B, Gueli Alletti S, Cosentino F, Scambia G
Int J Gynecol Cancer 2020 Nov;30(11):1657-1664. Epub 2020 Oct 7 doi: 10.1136/ijgc-2020-001640. PMID: 33028623
Tew WP, Lacchetti C, Ellis A, Maxian K, Banerjee S, Bookman M, Jones MB, Lee JM, Lheureux S, Liu JF, Moore KN, Muller C, Rodriguez P, Walsh C, Westin SN, Kohn EC
J Clin Oncol 2020 Oct 20;38(30):3468-3493. Epub 2020 Aug 13 doi: 10.1200/JCO.20.01924. PMID: 32790492Free PMC Article
Koole S, van Stein R, Sikorska K, Barton D, Perrin L, Brennan D, Zivanovic O, Mosgaard BJ, Fagotti A, Colombo PE, Sonke G, Driel WJV; OVHIPEC-2 Steering Committee and the Dutch OVHIPEC group
Int J Gynecol Cancer 2020 Jun;30(6):888-892. Epub 2020 Mar 23 doi: 10.1136/ijgc-2020-001231. PMID: 32205449Free PMC Article
Slomovitz B, Gourley C, Carey MS, Malpica A, Shih IM, Huntsman D, Fader AN, Grisham RN, Schlumbrecht M, Sun CC, Ludemann J, Cooney GA, Coleman R, Sood AK, Mahdi H, Wong KK, Covens A, O'Malley DM, Lecuru F, Cobb LP, Caputo TA, May T, Huang M, Siemon J, Fernández ML, Ray-Coquard I, Gershenson DM
Gynecol Oncol 2020 Mar;156(3):715-725. Epub 2020 Jan 20 doi: 10.1016/j.ygyno.2019.12.033. PMID: 31969252
Baratti D, Kusamura S, Guaglio M, Deraco M
Minerva Chir 2015 Jun;70(3):195-215. Epub 2015 Mar 10 PMID: 25752673

Prognosis

Sugarbaker PH, Chang D, Liang J
Eur J Surg Oncol 2023 May;49(5):895-901. Epub 2023 Feb 27 doi: 10.1016/j.ejso.2023.02.014. PMID: 36863914
Zhang D, Lu W, Cui S, Mei H, Wu X, Zhuo Z
J Ovarian Res 2022 Nov 23;15(1):123. doi: 10.1186/s13048-022-01059-0. PMID: 36424614Free PMC Article
Stasenko M, Fillipova O, Tew WP
J Oncol Pract 2019 Jul;15(7):375-382. Epub 2019 Jul 8 doi: 10.1200/JOP.18.00662. PMID: 31283415
Lemoine L, Sugarbaker P, Van der Speeten K
World J Gastroenterol 2016 Sep 14;22(34):7692-707. doi: 10.3748/wjg.v22.i34.7692. PMID: 27678351Free PMC Article
Casey MJ, Bewtra C
Fam Cancer 2004;3(3-4):265-81. doi: 10.1007/s10689-004-9554-y. PMID: 15516851

Clinical prediction guides

Zhang D, Lu W, Cui S, Mei H, Wu X, Zhuo Z
J Ovarian Res 2022 Nov 23;15(1):123. doi: 10.1186/s13048-022-01059-0. PMID: 36424614Free PMC Article
Kan T, Zhang S, Zhou S, Zhang Y, Zhao Y, Gao Y, Zhang T, Gao F, Wang X, Zhao L, Yang M
Oncogene 2022 Feb;41(6):895-906. Epub 2022 Jan 7 doi: 10.1038/s41388-021-02139-z. PMID: 34992217
Frenette C, Kayali Z, Mena E, Mantry PS, Lucas KJ, Neff G, Rodriguez M, Thuluvath PJ, Weinberg E, Bhandari BR, Robinson J, Wedick N, Chan JL, Hagerty DT, Kowdley KV; IDN-6556-17 Study Investigators
J Hepatol 2021 Feb;74(2):274-282. Epub 2020 Oct 8 doi: 10.1016/j.jhep.2020.09.029. PMID: 33038432
Carr NJ, Cecil TD, Mohamed F, Sobin LH, Sugarbaker PH, González-Moreno S, Taflampas P, Chapman S, Moran BJ; Peritoneal Surface Oncology Group International
Am J Surg Pathol 2016 Jan;40(1):14-26. doi: 10.1097/PAS.0000000000000535. PMID: 26492181
Pennington KP, Walsh T, Harrell MI, Lee MK, Pennil CC, Rendi MH, Thornton A, Norquist BM, Casadei S, Nord AS, Agnew KJ, Pritchard CC, Scroggins S, Garcia RL, King MC, Swisher EM
Clin Cancer Res 2014 Feb 1;20(3):764-75. Epub 2013 Nov 15 doi: 10.1158/1078-0432.CCR-13-2287. PMID: 24240112Free PMC Article

Recent systematic reviews

Matsuo K, Matsuzaki S, Maeda M, Rau AR, Yoshihara K, Tamura R, Shimada M, Machida H, Mikami M, Klar M, Roman LD, Wright JD, Sood AK, Gershenson DM
JAMA Netw Open 2023 Jun 1;6(6):e2318602. doi: 10.1001/jamanetworkopen.2023.18602. PMID: 37326992Free PMC Article
Hoegl J, Viveros-Carreño D, Palacios T, Gallego-Ardila A, Rauh-Hain JA, Estrada EE, Noll F, Krause K, Baiocchi G, Minig L, Grillo-Ardila CF, Pareja R
Int J Gynecol Cancer 2022 Dec 5;32(12):1497-1504. doi: 10.1136/ijgc-2022-003937. PMID: 36351746
Tew WP, Lacchetti C, Ellis A, Maxian K, Banerjee S, Bookman M, Jones MB, Lee JM, Lheureux S, Liu JF, Moore KN, Muller C, Rodriguez P, Walsh C, Westin SN, Kohn EC
J Clin Oncol 2020 Oct 20;38(30):3468-3493. Epub 2020 Aug 13 doi: 10.1200/JCO.20.01924. PMID: 32790492Free PMC Article
Jamel S, Markar SR, Malietzis G, Acharya A, Athanasiou T, Hanna GB
Gastric Cancer 2018 Jan;21(1):10-18. Epub 2017 Aug 4 doi: 10.1007/s10120-017-0749-y. PMID: 28779261Free PMC Article
Pentheroudakis G, Pavlidis N
Crit Rev Oncol Hematol 2010 Jul;75(1):27-42. Epub 2009 Nov 7 doi: 10.1016/j.critrevonc.2009.10.003. PMID: 19897383

Supplemental Content

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