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Primary Peritoneal Undifferentiated Carcinoma

MedGen UID:
1699916
Concept ID:
C5206646
Neoplastic Process

Definition

An extremely rare carcinoma arising from the peritoneum. It is characterized by the presence of a diffuse malignant infiltrate that is composed of epithelial cells without evidence of glandular or squamous differentiation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPrimary Peritoneal Undifferentiated Carcinoma

Professional guidelines

PubMed

Armstrong DK, Alvarez RD, Bakkum-Gamez JN, Barroilhet L, Behbakht K, Berchuck A, Chen LM, Cristea M, DeRosa M, Eisenhauer EL, Gershenson DM, Gray HJ, Grisham R, Hakam A, Jain A, Karam A, Konecny GE, Leath CA, Liu J, Mahdi H, Martin L, Matei D, McHale M, McLean K, Miller DS, O'Malley DM, Percac-Lima S, Ratner E, Remmenga SW, Vargas R, Werner TL, Zsiros E, Burns JL, Engh AM
J Natl Compr Canc Netw 2021 Feb 2;19(2):191-226. doi: 10.6004/jnccn.2021.0007. PMID: 33545690
Shaib WL, Assi R, Shamseddine A, Alese OB, Staley C 3rd, Memis B, Adsay V, Bekaii-Saab T, El-Rayes BF
Oncologist 2017 Sep;22(9):1107-1116. Epub 2017 Jun 29 doi: 10.1634/theoncologist.2017-0081. PMID: 28663356Free PMC Article
Gershenson DM
Best Pract Res Clin Obstet Gynaecol 2017 May;41:49-59. Epub 2016 Oct 3 doi: 10.1016/j.bpobgyn.2016.09.012. PMID: 27780698

Recent clinical studies

Etiology

Sugarbaker PH, Chang D, Liang J
Eur J Surg Oncol 2023 May;49(5):895-901. Epub 2023 Feb 27 doi: 10.1016/j.ejso.2023.02.014. PMID: 36863914
Zhang D, Lu W, Cui S, Mei H, Wu X, Zhuo Z
J Ovarian Res 2022 Nov 23;15(1):123. doi: 10.1186/s13048-022-01059-0. PMID: 36424614Free PMC Article
Slomovitz B, Gourley C, Carey MS, Malpica A, Shih IM, Huntsman D, Fader AN, Grisham RN, Schlumbrecht M, Sun CC, Ludemann J, Cooney GA, Coleman R, Sood AK, Mahdi H, Wong KK, Covens A, O'Malley DM, Lecuru F, Cobb LP, Caputo TA, May T, Huang M, Siemon J, Fernández ML, Ray-Coquard I, Gershenson DM
Gynecol Oncol 2020 Mar;156(3):715-725. Epub 2020 Jan 20 doi: 10.1016/j.ygyno.2019.12.033. PMID: 31969252
Stasenko M, Fillipova O, Tew WP
J Oncol Pract 2019 Jul;15(7):375-382. Epub 2019 Jul 8 doi: 10.1200/JOP.18.00662. PMID: 31283415
Carr NJ, Bibeau F, Bradley RF, Dartigues P, Feakins RM, Geisinger KR, Gui X, Isaac S, Milione M, Misdraji J, Pai RK, Rodriguez-Justo M, Sobin LH, van Velthuysen MF, Yantiss RK
Histopathology 2017 Dec;71(6):847-858. Epub 2017 Sep 19 doi: 10.1111/his.13324. PMID: 28746986

Diagnosis

Pascual-Antón L, Sandoval P, González-Mateo GT, Kopytina V, Tomero-Sanz H, Arriero-País EM, Jiménez-Heffernan JA, Fabre M, Egaña I, Ferrer C, Simón L, González-Cortijo L, Sainz de la Cuesta R, López-Cabrera M
J Pathol 2023 Oct;261(2):238-251. Epub 2023 Aug 9 doi: 10.1002/path.6170. PMID: 37555348
Gan J, Herzog J, Smith DA, Vos D, Kikano E, Tirumani SH, Ramaiya NH
Clin Imaging 2022 Mar;83:56-64. Epub 2021 Dec 24 doi: 10.1016/j.clinimag.2021.12.007. PMID: 34974267
Elmohr MM, Elsayes KM, Pickhardt PJ
Br J Radiol 2020 Sep 1;93(1113):20200401. Epub 2020 Jul 3 doi: 10.1259/bjr.20200401. PMID: 32516560Free PMC Article
Carr NJ, Bibeau F, Bradley RF, Dartigues P, Feakins RM, Geisinger KR, Gui X, Isaac S, Milione M, Misdraji J, Pai RK, Rodriguez-Justo M, Sobin LH, van Velthuysen MF, Yantiss RK
Histopathology 2017 Dec;71(6):847-858. Epub 2017 Sep 19 doi: 10.1111/his.13324. PMID: 28746986
Raptopoulos V, Gourtsoyiannis N
Eur Radiol 2001;11(11):2195-206. doi: 10.1007/s003300100998. PMID: 11702160

Therapy

Pfisterer J, Joly F, Kristensen G, Rau J, Mahner S, Pautier P, El-Balat A, Kurtz JE, Canzler U, Sehouli J, Heubner ML, Hartkopf AD, Baumann K, Hasenburg A, Hanker LC, Belau A, Schmalfeldt B, Denschlag D, Park-Simon TW, Selle F, Jackisch C, Burges A, Lück HJ, Emons G, Meier W, Gropp-Meier M, Schröder W, de Gregorio N, Hilpert F, Harter P
J Clin Oncol 2023 Feb 1;41(4):893-902. Epub 2022 Nov 4 doi: 10.1200/JCO.22.01010. PMID: 36332161
Fagotti A, Ferrandina MG, Vizzielli G, Pasciuto T, Fanfani F, Gallotta V, Margariti PA, Chiantera V, Costantini B, Gueli Alletti S, Cosentino F, Scambia G
Int J Gynecol Cancer 2020 Nov;30(11):1657-1664. Epub 2020 Oct 7 doi: 10.1136/ijgc-2020-001640. PMID: 33028623
Tew WP, Lacchetti C, Ellis A, Maxian K, Banerjee S, Bookman M, Jones MB, Lee JM, Lheureux S, Liu JF, Moore KN, Muller C, Rodriguez P, Walsh C, Westin SN, Kohn EC
J Clin Oncol 2020 Oct 20;38(30):3468-3493. Epub 2020 Aug 13 doi: 10.1200/JCO.20.01924. PMID: 32790492Free PMC Article
Koole S, van Stein R, Sikorska K, Barton D, Perrin L, Brennan D, Zivanovic O, Mosgaard BJ, Fagotti A, Colombo PE, Sonke G, Driel WJV; OVHIPEC-2 Steering Committee and the Dutch OVHIPEC group
Int J Gynecol Cancer 2020 Jun;30(6):888-892. Epub 2020 Mar 23 doi: 10.1136/ijgc-2020-001231. PMID: 32205449Free PMC Article
Slomovitz B, Gourley C, Carey MS, Malpica A, Shih IM, Huntsman D, Fader AN, Grisham RN, Schlumbrecht M, Sun CC, Ludemann J, Cooney GA, Coleman R, Sood AK, Mahdi H, Wong KK, Covens A, O'Malley DM, Lecuru F, Cobb LP, Caputo TA, May T, Huang M, Siemon J, Fernández ML, Ray-Coquard I, Gershenson DM
Gynecol Oncol 2020 Mar;156(3):715-725. Epub 2020 Jan 20 doi: 10.1016/j.ygyno.2019.12.033. PMID: 31969252

Prognosis

Zhang D, Lu W, Cui S, Mei H, Wu X, Zhuo Z
J Ovarian Res 2022 Nov 23;15(1):123. doi: 10.1186/s13048-022-01059-0. PMID: 36424614Free PMC Article
Gan J, Herzog J, Smith DA, Vos D, Kikano E, Tirumani SH, Ramaiya NH
Clin Imaging 2022 Mar;83:56-64. Epub 2021 Dec 24 doi: 10.1016/j.clinimag.2021.12.007. PMID: 34974267
Stasenko M, Fillipova O, Tew WP
J Oncol Pract 2019 Jul;15(7):375-382. Epub 2019 Jul 8 doi: 10.1200/JOP.18.00662. PMID: 31283415
Raptopoulos V, Gourtsoyiannis N
Eur Radiol 2001;11(11):2195-206. doi: 10.1007/s003300100998. PMID: 11702160
Hinson FL, Ambrose NS
Br J Surg 1998 Oct;85(10):1332-9. doi: 10.1046/j.1365-2168.1998.00882.x. PMID: 9782010

Clinical prediction guides

Zhang D, Lu W, Cui S, Mei H, Wu X, Zhuo Z
J Ovarian Res 2022 Nov 23;15(1):123. doi: 10.1186/s13048-022-01059-0. PMID: 36424614Free PMC Article
Kan T, Zhang S, Zhou S, Zhang Y, Zhao Y, Gao Y, Zhang T, Gao F, Wang X, Zhao L, Yang M
Oncogene 2022 Feb;41(6):895-906. Epub 2022 Jan 7 doi: 10.1038/s41388-021-02139-z. PMID: 34992217
Bochtler T, Löffler H, Krämer A
Semin Diagn Pathol 2018 May;35(3):199-206. Epub 2017 Nov 26 doi: 10.1053/j.semdp.2017.11.013. PMID: 29203116
Carr NJ, Cecil TD, Mohamed F, Sobin LH, Sugarbaker PH, González-Moreno S, Taflampas P, Chapman S, Moran BJ; Peritoneal Surface Oncology Group International
Am J Surg Pathol 2016 Jan;40(1):14-26. doi: 10.1097/PAS.0000000000000535. PMID: 26492181
Pennington KP, Walsh T, Harrell MI, Lee MK, Pennil CC, Rendi MH, Thornton A, Norquist BM, Casadei S, Nord AS, Agnew KJ, Pritchard CC, Scroggins S, Garcia RL, King MC, Swisher EM
Clin Cancer Res 2014 Feb 1;20(3):764-75. Epub 2013 Nov 15 doi: 10.1158/1078-0432.CCR-13-2287. PMID: 24240112Free PMC Article

Recent systematic reviews

Matsuo K, Matsuzaki S, Maeda M, Rau AR, Yoshihara K, Tamura R, Shimada M, Machida H, Mikami M, Klar M, Roman LD, Wright JD, Sood AK, Gershenson DM
JAMA Netw Open 2023 Jun 1;6(6):e2318602. doi: 10.1001/jamanetworkopen.2023.18602. PMID: 37326992Free PMC Article
Wang Y, Luo W, Li Y
Eur J Med Res 2023 Jan 18;28(1):34. doi: 10.1186/s40001-023-00997-9. PMID: 36653862Free PMC Article
Steenbeek MP, van Bommel MHD, Bulten J, Hulsmann JA, Bogaerts J, Garcia C, Cun HT, Lu KH, van Beekhuizen HJ, Minig L, Gaarenstroom KN, Nobbenhuis M, Krajc M, Rudaitis V, Norquist BM, Swisher EM, Mourits MJE, Massuger LFAG, Hoogerbrugge N, Hermens RPMG, IntHout J, de Hullu JA
J Clin Oncol 2022 Jun 10;40(17):1879-1891. Epub 2022 Mar 18 doi: 10.1200/JCO.21.02016. PMID: 35302882Free PMC Article
Lionetti R, DE Luca M, Raffone A, Travaglino A, Coppellotti A, Peltrini R, Bracale U, D'Ambra M, Insabato L, Zullo F, D'Armiento M, Corcione F
Minerva Obstet Gynecol 2022 Aug;74(4):356-363. Epub 2021 May 4 doi: 10.23736/S2724-606X.21.04797-7. PMID: 33944524
Tew WP, Lacchetti C, Ellis A, Maxian K, Banerjee S, Bookman M, Jones MB, Lee JM, Lheureux S, Liu JF, Moore KN, Muller C, Rodriguez P, Walsh C, Westin SN, Kohn EC
J Clin Oncol 2020 Oct 20;38(30):3468-3493. Epub 2020 Aug 13 doi: 10.1200/JCO.20.01924. PMID: 32790492Free PMC Article

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