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Refractory EBV-Related Lymphoma

MedGen UID:
1700005
•Concept ID:
C5204983
•
Neoplastic Process
Synonym: Refractory EBV-Associated Lymphoma

Definition

EBV-related lymphoma that is resistant to treatment. [from NCI]

Professional guidelines

PubMed

Current Treatment Options for Older Patients with Hodgkin Lymphoma.
Carter J, David KA, Kritharis A, Evens AM
Curr Treat Options Oncol 2020 Apr 23;21(5):42. doi: 10.1007/s11864-020-00745-9. PMID: 32328822

Recent clinical studies

Etiology

Epstein-Barr Virus-Positive Mucocutaneous Ulcers Complicate Colitis Caused by Immune Checkpoint Regulator Therapy and Associate With Colon Perforation.
Pugh MR, Leopold GD, Morgan M, Christian AD, Hewett R, Durai D, Wagstaff J, Harris D, Dojcinov SD
Clin Gastroenterol Hepatol 2020 Jul;18(8):1785-1795.e3. Epub 2019 Oct 11 doi: 10.1016/j.cgh.2019.09.031. PMID: 31610336
Umbilical cord blood transplantation in adults with advanced hodgkin's disease: high incidence of post-transplant lymphoproliferative disease.
Piñana JL, Sanz J, Esquirol A, Martino R, Picardi A, Barba P, Parody R, Gayoso J, Montesinos P, Guidi S, Terol MJ, Moscardó F, Solano C, Arcese W, Sanz MA, Sierra J, Sanz G; GETH GITMO groups
Eur J Haematol 2016 Feb;96(2):128-35. Epub 2015 Apr 18 doi: 10.1111/ejh.12557. PMID: 25845981
B-cell lymphoma in a patient with complete interferon gamma receptor 1 deficiency.
Bax HI, Freeman AF, Anderson VL, Vesterhus P, Laerum D, Pittaluga S, Wilson WH, Holland SM
J Clin Immunol 2013 Aug;33(6):1062-6. Epub 2013 Jun 26 doi: 10.1007/s10875-013-9907-0. PMID: 23800860Free PMC Article
Safety of allogeneic Epstein-Barr virus (EBV)-specific cytotoxic T lymphocytes for patients with refractory EBV-related lymphoma.
Sun Q, Burton R, Reddy V, Lucas KG
Br J Haematol 2002 Sep;118(3):799-808. doi: 10.1046/j.1365-2141.2002.03683.x. PMID: 12181048
Treatment of posttransplant lymphoproliferative disease in the central nervous system of a lung transplant recipient using allogeneic leukocytes.
Emanuel DJ, Lucas KG, Mallory GB Jr, Edwards-Brown MK, Pollok KE, Conrad PD, Robertson KA, Smith FO
Transplantation 1997 Jun 15;63(11):1691-4. doi: 10.1097/00007890-199706150-00027. PMID: 9197369

Diagnosis

Current Treatment Options for Older Patients with Hodgkin Lymphoma.
Carter J, David KA, Kritharis A, Evens AM
Curr Treat Options Oncol 2020 Apr 23;21(5):42. doi: 10.1007/s11864-020-00745-9. PMID: 32328822
Successful treatment of a child with late-onset T-cell post-transplant lymphoproliferative disorder/lymphoma.
Williams KM, Higman MA, Chen AR, Schwartz CL, Wharam M, Colombani P, Arceci RJ
Pediatr Blood Cancer 2008 Mar;50(3):667-70. doi: 10.1002/pbc.21171. PMID: 17318876
Successful unrelated cord blood transplantation for Epstein-Barr virus-associated lymphoproliferative disease with hemophagocytic syndrome.
Toubo T, Suga N, Ohga S, Nomura A, Onoe Y, Takada H, Hara T
Int J Hematol 2004 Dec;80(5):458-62. doi: 10.1532/ijh97.04081. PMID: 15646660

Therapy

Umbilical cord blood transplantation in adults with advanced hodgkin's disease: high incidence of post-transplant lymphoproliferative disease.
Piñana JL, Sanz J, Esquirol A, Martino R, Picardi A, Barba P, Parody R, Gayoso J, Montesinos P, Guidi S, Terol MJ, Moscardó F, Solano C, Arcese W, Sanz MA, Sierra J, Sanz G; GETH GITMO groups
Eur J Haematol 2016 Feb;96(2):128-35. Epub 2015 Apr 18 doi: 10.1111/ejh.12557. PMID: 25845981
Successful treatment of a child with late-onset T-cell post-transplant lymphoproliferative disorder/lymphoma.
Williams KM, Higman MA, Chen AR, Schwartz CL, Wharam M, Colombani P, Arceci RJ
Pediatr Blood Cancer 2008 Mar;50(3):667-70. doi: 10.1002/pbc.21171. PMID: 17318876
Safety of allogeneic Epstein-Barr virus (EBV)-specific cytotoxic T lymphocytes for patients with refractory EBV-related lymphoma.
Sun Q, Burton R, Reddy V, Lucas KG
Br J Haematol 2002 Sep;118(3):799-808. doi: 10.1046/j.1365-2141.2002.03683.x. PMID: 12181048
Efficient gene delivery into epstein-barr virus (EBV)-transformed human B cells mediated by replication-defective herpes simplex virus-1 (HSV-1): A gene therapy model for EBV-related B cell malignancy.
Suzuki T, Piche A, Kasono K, Xiang J, Gomez-Navarro J, Moriuchi S, Krisky DM, Oligino T, Glorioso JC, Curiel TJ, Curiel DT
Biochem Biophys Res Commun 1998 Nov 27;252(3):686-90. doi: 10.1006/bbrc.1998.9685. PMID: 9837767
Treatment of posttransplant lymphoproliferative disease in the central nervous system of a lung transplant recipient using allogeneic leukocytes.
Emanuel DJ, Lucas KG, Mallory GB Jr, Edwards-Brown MK, Pollok KE, Conrad PD, Robertson KA, Smith FO
Transplantation 1997 Jun 15;63(11):1691-4. doi: 10.1097/00007890-199706150-00027. PMID: 9197369

Prognosis

Successful treatment of a child with late-onset T-cell post-transplant lymphoproliferative disorder/lymphoma.
Williams KM, Higman MA, Chen AR, Schwartz CL, Wharam M, Colombani P, Arceci RJ
Pediatr Blood Cancer 2008 Mar;50(3):667-70. doi: 10.1002/pbc.21171. PMID: 17318876
Successful unrelated cord blood transplantation for Epstein-Barr virus-associated lymphoproliferative disease with hemophagocytic syndrome.
Toubo T, Suga N, Ohga S, Nomura A, Onoe Y, Takada H, Hara T
Int J Hematol 2004 Dec;80(5):458-62. doi: 10.1532/ijh97.04081. PMID: 15646660
Safety of allogeneic Epstein-Barr virus (EBV)-specific cytotoxic T lymphocytes for patients with refractory EBV-related lymphoma.
Sun Q, Burton R, Reddy V, Lucas KG
Br J Haematol 2002 Sep;118(3):799-808. doi: 10.1046/j.1365-2141.2002.03683.x. PMID: 12181048

Clinical prediction guides

Safety of allogeneic Epstein-Barr virus (EBV)-specific cytotoxic T lymphocytes for patients with refractory EBV-related lymphoma.
Sun Q, Burton R, Reddy V, Lucas KG
Br J Haematol 2002 Sep;118(3):799-808. doi: 10.1046/j.1365-2141.2002.03683.x. PMID: 12181048

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