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Nontuberculous mycobacterial pulmonary infection

MedGen UID:
1700174
Concept ID:
C5139228
Disease or Syndrome
HPO: HP:0032261

Definition

An infection of the lung caused by environmental mycobacteria. Such infections can occur in individuals with predisposing lung disease or immune disease. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNontuberculous mycobacterial pulmonary infection

Conditions with this feature

Immunodeficiency 77
MedGen UID:
1788976
Concept ID:
C5543173
Disease or Syndrome
Immunodeficiency-77 (IMD77) is an immunologic disorder characterized by recurrent and persistent polymicrobial infections with multiple unusual organisms. Skin and pulmonary infections are the most common, consistent with increased susceptibility to epithelial cell infections. The age at onset is highly variable: some patients have recurrent infections from childhood, whereas others present in late adulthood. The limited number of reported patients are all female, suggesting incomplete penetrance or a possible sex-influenced trait. Patient cells, mainly macrophages, show impaired killing of intracellular bacteria and organisms, including nontubercular mycobacteria, although there is also impaired killing of other organisms, such as Pseudomonas, Candida, and Aspergillus. Treatment with gamma-IFN (IFNG; 147570) may be a therapeutic option (summary by McCormack et al., 2017 and Merselis et al., 2020).

Professional guidelines

PubMed

Marques LRM, Ferrazoli L, Chimara É
J Bras Pneumol 2019 Apr 25;45(2):e20180278. doi: 10.1590/1806-3713/e20180278. PMID: 31038648Free PMC Article
Ikeda M, Takahashi K, Komatsu T, Tanaka T, Kato T, Fujinaga T
Gen Thorac Cardiovasc Surg 2017 Feb;65(2):117-121. Epub 2016 Dec 3 doi: 10.1007/s11748-016-0730-4. PMID: 27915421
Máiz-Carro L, Navas-Elorza E
Am J Respir Med 2002;1(2):107-17. doi: 10.1007/BF03256600. PMID: 14720065

Recent clinical studies

Etiology

Blakney RA, Ricotta EE, Frankland TB, Honda S, Zelazny A, Mayer-Barber KD, Dean SG, Follmann D, Olivier KN, Daida YG, Prevots DR
Emerg Infect Dis 2022 Aug;28(8):1543-1550. doi: 10.3201/eid2808.212375. PMID: 35876462Free PMC Article
Izhakian S, Frajman A, Mekiten O, Heching M, Pertzov B, Shtraichman O, Gershman E, Rozengarten D, Gorelik O, Kramer MR
Exp Clin Transplant 2021 Oct;19(10):1076-1081. doi: 10.6002/ect.2021.0177. PMID: 34641777
Hwang HJ, Kim MY, Shim TS, Kim DS
J Comput Assist Tomogr 2014 Nov-Dec;38(6):972-8. doi: 10.1097/RCT.0000000000000144. PMID: 25162293
Kim TS, Koh WJ, Han J, Chung MJ, Lee JH, Lee KS, Kwon OJ
AJR Am J Roentgenol 2005 Apr;184(4):1247-52. doi: 10.2214/ajr.184.4.01841247. PMID: 15788605
Jeong YJ, Lee KS, Koh WJ, Han J, Kim TS, Kwon OJ
Radiology 2004 Jun;231(3):880-6. Epub 2004 Apr 29 doi: 10.1148/radiol.2313030833. PMID: 15118112

Diagnosis

Izhakian S, Frajman A, Mekiten O, Heching M, Pertzov B, Shtraichman O, Gershman E, Rozengarten D, Gorelik O, Kramer MR
Exp Clin Transplant 2021 Oct;19(10):1076-1081. doi: 10.6002/ect.2021.0177. PMID: 34641777
Hwang HJ, Kim MY, Shim TS, Kim DS
J Comput Assist Tomogr 2014 Nov-Dec;38(6):972-8. doi: 10.1097/RCT.0000000000000144. PMID: 25162293
Ho TA, Rommelaere M, Coche E, Yombi JC, Kanaan N
Transpl Infect Dis 2010 Apr;12(2):138-42. Epub 2009 Nov 19 doi: 10.1111/j.1399-3062.2009.00473.x. PMID: 19929882
Jeong YJ, Lee KS, Koh WJ, Han J, Kim TS, Kwon OJ
Radiology 2004 Jun;231(3):880-6. Epub 2004 Apr 29 doi: 10.1148/radiol.2313030833. PMID: 15118112
Máiz-Carro L, Navas-Elorza E
Am J Respir Med 2002;1(2):107-17. doi: 10.1007/BF03256600. PMID: 14720065

Therapy

Ho TA, Rommelaere M, Coche E, Yombi JC, Kanaan N
Transpl Infect Dis 2010 Apr;12(2):138-42. Epub 2009 Nov 19 doi: 10.1111/j.1399-3062.2009.00473.x. PMID: 19929882
Murray MP, Laurenson IF, Hill AT
Clin Infect Dis 2008 Jul 15;47(2):222-4. doi: 10.1086/589250. PMID: 18532890
Davis KK, Kao PN, Jacobs SS, Ruoss SJ
BMC Pulm Med 2007 Feb 23;7:2. doi: 10.1186/1471-2466-7-2. PMID: 17319962Free PMC Article
Máiz-Carro L, Navas-Elorza E
Am J Respir Med 2002;1(2):107-17. doi: 10.1007/BF03256600. PMID: 14720065

Prognosis

Blakney RA, Ricotta EE, Frankland TB, Honda S, Zelazny A, Mayer-Barber KD, Dean SG, Follmann D, Olivier KN, Daida YG, Prevots DR
Emerg Infect Dis 2022 Aug;28(8):1543-1550. doi: 10.3201/eid2808.212375. PMID: 35876462Free PMC Article
Máiz-Carro L, Navas-Elorza E
Am J Respir Med 2002;1(2):107-17. doi: 10.1007/BF03256600. PMID: 14720065

Clinical prediction guides

Izhakian S, Frajman A, Mekiten O, Heching M, Pertzov B, Shtraichman O, Gershman E, Rozengarten D, Gorelik O, Kramer MR
Exp Clin Transplant 2021 Oct;19(10):1076-1081. doi: 10.6002/ect.2021.0177. PMID: 34641777
Davis KK, Kao PN, Jacobs SS, Ruoss SJ
BMC Pulm Med 2007 Feb 23;7:2. doi: 10.1186/1471-2466-7-2. PMID: 17319962Free PMC Article

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