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Refractory High Grade B-Cell Lymphoma with MYC, BCL2, and BCL6 Rearrangements

MedGen UID:
1700179
Concept ID:
C5206566
Neoplastic Process
Synonym: Refractory High-Grade B-Cell Lymphoma with MYC, BCL2, and BCL6 Rearrangements

Definition

High grade B-cell lymphoma with MYC, BCL2, and BCL6 rearrangements that is resistant to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory High Grade B-Cell Lymphoma with MYC, BCL2, and BCL6 Rearrangements

Professional guidelines

PubMed

Witte HM, Riedl J, Künstner A, Fähnrich A, Ketzer J, Fliedner SMJ, Reimer N, Bernard V, von Bubnoff N, Merz H, Busch H, Feller A, Gebauer N
Target Oncol 2023 Sep;18(5):749-765. Epub 2023 Jul 24 doi: 10.1007/s11523-023-00983-5. PMID: 37488307Free PMC Article
Alderuccio JP, Sharman JP
Blood Rev 2022 Nov;56:100967. Epub 2022 Apr 22 doi: 10.1016/j.blre.2022.100967. PMID: 35489963

Recent clinical studies

Etiology

Dunleavy K
Hematology Am Soc Hematol Educ Program 2021 Dec 10;2021(1):157-163. doi: 10.1182/hematology.2021000247. PMID: 34889402Free PMC Article
Abramson JS, Palomba ML, Gordon LI, Lunning MA, Wang M, Arnason J, Mehta A, Purev E, Maloney DG, Andreadis C, Sehgal A, Solomon SR, Ghosh N, Albertson TM, Garcia J, Kostic A, Mallaney M, Ogasawara K, Newhall K, Kim Y, Li D, Siddiqi T
Lancet 2020 Sep 19;396(10254):839-852. Epub 2020 Sep 1 doi: 10.1016/S0140-6736(20)31366-0. PMID: 32888407
Kim A, Stevenson P, Cassaday RD, Soma L, Fromm JR, Gopal AK, Smith SD, Till B, Lynch RC, Ujjani C, Shadman M, Warren EH, Menon M, Russell K, Tseng YD
Pract Radiat Oncol 2020 Jan-Feb;10(1):44-52. Epub 2019 Oct 1 doi: 10.1016/j.prro.2019.09.013. PMID: 31585205
Rosenthal A, Younes A
Blood Rev 2017 Mar;31(2):37-42. Epub 2016 Sep 30 doi: 10.1016/j.blre.2016.09.004. PMID: 27717585Free PMC Article

Diagnosis

Mitobe M, Kawamoto K, Suzuki T, Suwabe T, Shibasaki Y, Masuko M, Inoue K, Miyoshi H, Ohshima K, Sone H, Takizawa J
J Clin Exp Hematop 2021 Mar 18;61(1):42-47. Epub 2021 Feb 6 doi: 10.3960/jslrt.20043. PMID: 33551436Free PMC Article
Dheur MS, Poirel HA, Ameye G, Tilman G, Saussoy P, Defour JP, Camboni A, Van Den Neste E, Coulie PG, van Baren N
Leuk Lymphoma 2019 Apr;60(4):1043-1052. Epub 2018 Oct 2 doi: 10.1080/10428194.2018.1508663. PMID: 30277098
Li S, Lin P, Medeiros LJ
Expert Rev Hematol 2018 Aug;11(8):637-648. Epub 2018 Jul 10 doi: 10.1080/17474086.2018.1494567. PMID: 29989509

Therapy

Alderuccio JP, Sharman JP
Blood Rev 2022 Nov;56:100967. Epub 2022 Apr 22 doi: 10.1016/j.blre.2022.100967. PMID: 35489963
Dunleavy K
Hematology Am Soc Hematol Educ Program 2021 Dec 10;2021(1):157-163. doi: 10.1182/hematology.2021000247. PMID: 34889402Free PMC Article
Mitobe M, Kawamoto K, Suzuki T, Suwabe T, Shibasaki Y, Masuko M, Inoue K, Miyoshi H, Ohshima K, Sone H, Takizawa J
J Clin Exp Hematop 2021 Mar 18;61(1):42-47. Epub 2021 Feb 6 doi: 10.3960/jslrt.20043. PMID: 33551436Free PMC Article
Abramson JS, Palomba ML, Gordon LI, Lunning MA, Wang M, Arnason J, Mehta A, Purev E, Maloney DG, Andreadis C, Sehgal A, Solomon SR, Ghosh N, Albertson TM, Garcia J, Kostic A, Mallaney M, Ogasawara K, Newhall K, Kim Y, Li D, Siddiqi T
Lancet 2020 Sep 19;396(10254):839-852. Epub 2020 Sep 1 doi: 10.1016/S0140-6736(20)31366-0. PMID: 32888407
Rosenthal A, Younes A
Blood Rev 2017 Mar;31(2):37-42. Epub 2016 Sep 30 doi: 10.1016/j.blre.2016.09.004. PMID: 27717585Free PMC Article

Prognosis

Kim A, Stevenson P, Cassaday RD, Soma L, Fromm JR, Gopal AK, Smith SD, Till B, Lynch RC, Ujjani C, Shadman M, Warren EH, Menon M, Russell K, Tseng YD
Pract Radiat Oncol 2020 Jan-Feb;10(1):44-52. Epub 2019 Oct 1 doi: 10.1016/j.prro.2019.09.013. PMID: 31585205
Dheur MS, Poirel HA, Ameye G, Tilman G, Saussoy P, Defour JP, Camboni A, Van Den Neste E, Coulie PG, van Baren N
Leuk Lymphoma 2019 Apr;60(4):1043-1052. Epub 2018 Oct 2 doi: 10.1080/10428194.2018.1508663. PMID: 30277098
Zeng D, Desai A, Yan F, Gong T, Ye H, Ahmed M, Nomie K, Romaguera J, Champlin R, Li S, Wang M
Am J Clin Oncol 2019 Mar;42(3):304-316. doi: 10.1097/COC.0000000000000427. PMID: 29419530
Li S, Lin P, Medeiros LJ
Expert Rev Hematol 2018 Aug;11(8):637-648. Epub 2018 Jul 10 doi: 10.1080/17474086.2018.1494567. PMID: 29989509
Rosenthal A, Younes A
Blood Rev 2017 Mar;31(2):37-42. Epub 2016 Sep 30 doi: 10.1016/j.blre.2016.09.004. PMID: 27717585Free PMC Article

Clinical prediction guides

Kim A, Stevenson P, Cassaday RD, Soma L, Fromm JR, Gopal AK, Smith SD, Till B, Lynch RC, Ujjani C, Shadman M, Warren EH, Menon M, Russell K, Tseng YD
Pract Radiat Oncol 2020 Jan-Feb;10(1):44-52. Epub 2019 Oct 1 doi: 10.1016/j.prro.2019.09.013. PMID: 31585205

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