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Unresectable Colorectal Carcinoma

MedGen UID:
1700411
•Concept ID:
C5206681
•
Neoplastic Process

Definition

A colorectal carcinoma that is not amenable to surgical resection. [from NCI]

Professional guidelines

PubMed

A dose-intensive regimen of 5-fluorouracil for the treatment of metastatic colorectal carcinoma.
Poplin EA, Kraut M, Baker L, Brodfuehrer J, Vaitkevicius V
Cancer 1991 Jan 15;67(2):367-71. doi: 10.1002/1097-0142(19910115)67:2<367::aid-cncr2820670209>3.0.co;2-2. PMID: 1985732

Recent clinical studies

Etiology

Intratumoral Budding in Pretreatment Biopsies, among Tumor Microenvironmental Components, Can Predict Prognosis and Neoadjuvant Therapy Response in Colorectal Adenocarcinoma.
Yim K, Jang WM, Cho U, Sun S, Chong Y, Seo KJ
Medicina (Kaunas) 2022 Jul 12;58(7) doi: 10.3390/medicina58070926. PMID: 35888645Free PMC Article
An increase in the peripheral lymphocyte-to-monocyte ratio after primary site resection is associated with a prolonged survival in unresectable colorectal carcinoma.
Ichikawa N, Homma S, Yoshida T, Mitsuhashi T, Iijima H, Ogasawara K, Kazui K, Kamiizumi Y, Kawamata F, Taketomi A
Surg Today 2020 Jun;50(6):604-614. Epub 2019 Nov 30 doi: 10.1007/s00595-019-01927-1. PMID: 31786682
The significance of transarterial chemoembolization combined with systemic chemotherapy for patients with KRAS wild-type unresectable metachronous colorectal carcinoma with liver metastases.
Yu Q, Zhang L, Fan S, Huang L, Wang X, Xindun C
J Cancer Res Ther 2016 Dec;12(Supplement):C205-C211. doi: 10.4103/0973-1482.200603. PMID: 28230018
Sequential radiofrequency ablation and surgical debulking for unresectable colorectal carcinoma: thermo-surgical ablation.
Ripley RT, Gajdos C, Reppert AE, Macdermott T, McCarter MD, Pearlman NW
J Surg Oncol 2013 Feb;107(2):144-7. Epub 2012 Aug 23 doi: 10.1002/jso.23211. PMID: 22927225
Hepatic vascular isolation and perfusion for patients with progressive unresectable liver metastases from colorectal carcinoma refractory to previous systemic and regional chemotherapy.
Alexander HR Jr, Libutti SK, Bartlett DL, Pingpank JF, Kranda K, Helsabeck C, Beresnev T
Cancer 2002 Aug 15;95(4):730-6. doi: 10.1002/cncr.10686. PMID: 12209715

Diagnosis

The significance of transarterial chemoembolization combined with systemic chemotherapy for patients with KRAS wild-type unresectable metachronous colorectal carcinoma with liver metastases.
Yu Q, Zhang L, Fan S, Huang L, Wang X, Xindun C
J Cancer Res Ther 2016 Dec;12(Supplement):C205-C211. doi: 10.4103/0973-1482.200603. PMID: 28230018
Twelve-year experience of radioembolization for colorectal hepatic metastases in 214 patients: survival by era and chemotherapy.
Lewandowski RJ, Memon K, Mulcahy MF, Hickey R, Marshall K, Williams M, Salzig K, Gates VL, Atassi B, Vouche M, Atassi R, Desai K, Hohlastos E, Sato K, Habib A, Kircher S, Newman SB, Nimeiri H, Benson AB, Salem R
Eur J Nucl Med Mol Imaging 2014 Oct;41(10):1861-9. Epub 2014 Jun 7 doi: 10.1007/s00259-014-2799-2. PMID: 24906565
Echogenicity of liver metastases from colorectal carcinoma is an independent prognostic factor in patients treated with regional chemotherapy.
Gruenberger T, Zhao J, King J, Chung T, Clingan PR, Morris DL
Cancer 2002 Mar 15;94(6):1753-9. doi: 10.1002/cncr.10386. PMID: 11920538
Cellular immunotherapy for patients with metastatic colorectal carcinoma using lymph node lymphocytes localized in vivo by radiolabeled monoclonal antibody.
Kim JA, Bresler HS, Martin EW Jr, Aldrich W, Heffelfinger M, Triozzi PL
Cancer 1999 Jul 1;86(1):22-30. PMID: 10391559

Therapy

Safety and Efficacy of Trifluridine-Tipiracil Hydrochloride Oral Combination (TAS-102) in Patients with Unresectable Colorectal Cancer.
Narihiro S, Suwa K, Ushigome T, Ohtsu M, Ryu S, Shimoyama Y, Okamoto T, Yanaga K
In Vivo 2018 Nov-Dec;32(6):1643-1646. doi: 10.21873/invivo.11426. PMID: 30348728Free PMC Article
The significance of transarterial chemoembolization combined with systemic chemotherapy for patients with KRAS wild-type unresectable metachronous colorectal carcinoma with liver metastases.
Yu Q, Zhang L, Fan S, Huang L, Wang X, Xindun C
J Cancer Res Ther 2016 Dec;12(Supplement):C205-C211. doi: 10.4103/0973-1482.200603. PMID: 28230018
Chemo-diversion strategy for unresectable colorectal carcinoma: report of two cases.
Inoue Y, Miki C, Yanagi H, Noda M, Kusunoki M
Hepatogastroenterology 2009 Sep-Oct;56(94-95):1359-61. PMID: 19950791
Hepatic vascular isolation and perfusion for patients with progressive unresectable liver metastases from colorectal carcinoma refractory to previous systemic and regional chemotherapy.
Alexander HR Jr, Libutti SK, Bartlett DL, Pingpank JF, Kranda K, Helsabeck C, Beresnev T
Cancer 2002 Aug 15;95(4):730-6. doi: 10.1002/cncr.10686. PMID: 12209715
Fluorouracil and recombinant alfa-2a-interferon: an active regimen against advanced colorectal carcinoma.
Wadler S, Schwartz EL, Goldman M, Lyver A, Rader M, Zimmerman M, Itri L, Weinberg V, Wiernik PH
J Clin Oncol 1989 Dec;7(12):1769-75. doi: 10.1200/JCO.1989.7.12.1769. PMID: 2585018

Prognosis

Intratumoral Budding in Pretreatment Biopsies, among Tumor Microenvironmental Components, Can Predict Prognosis and Neoadjuvant Therapy Response in Colorectal Adenocarcinoma.
Yim K, Jang WM, Cho U, Sun S, Chong Y, Seo KJ
Medicina (Kaunas) 2022 Jul 12;58(7) doi: 10.3390/medicina58070926. PMID: 35888645Free PMC Article
An increase in the peripheral lymphocyte-to-monocyte ratio after primary site resection is associated with a prolonged survival in unresectable colorectal carcinoma.
Ichikawa N, Homma S, Yoshida T, Mitsuhashi T, Iijima H, Ogasawara K, Kazui K, Kamiizumi Y, Kawamata F, Taketomi A
Surg Today 2020 Jun;50(6):604-614. Epub 2019 Nov 30 doi: 10.1007/s00595-019-01927-1. PMID: 31786682
The significance of transarterial chemoembolization combined with systemic chemotherapy for patients with KRAS wild-type unresectable metachronous colorectal carcinoma with liver metastases.
Yu Q, Zhang L, Fan S, Huang L, Wang X, Xindun C
J Cancer Res Ther 2016 Dec;12(Supplement):C205-C211. doi: 10.4103/0973-1482.200603. PMID: 28230018
Sequential radiofrequency ablation and surgical debulking for unresectable colorectal carcinoma: thermo-surgical ablation.
Ripley RT, Gajdos C, Reppert AE, Macdermott T, McCarter MD, Pearlman NW
J Surg Oncol 2013 Feb;107(2):144-7. Epub 2012 Aug 23 doi: 10.1002/jso.23211. PMID: 22927225
Fluorouracil and recombinant alfa-2a-interferon: an active regimen against advanced colorectal carcinoma.
Wadler S, Schwartz EL, Goldman M, Lyver A, Rader M, Zimmerman M, Itri L, Weinberg V, Wiernik PH
J Clin Oncol 1989 Dec;7(12):1769-75. doi: 10.1200/JCO.1989.7.12.1769. PMID: 2585018

Clinical prediction guides

Intratumoral Budding in Pretreatment Biopsies, among Tumor Microenvironmental Components, Can Predict Prognosis and Neoadjuvant Therapy Response in Colorectal Adenocarcinoma.
Yim K, Jang WM, Cho U, Sun S, Chong Y, Seo KJ
Medicina (Kaunas) 2022 Jul 12;58(7) doi: 10.3390/medicina58070926. PMID: 35888645Free PMC Article
Safety and Efficacy of Trifluridine-Tipiracil Hydrochloride Oral Combination (TAS-102) in Patients with Unresectable Colorectal Cancer.
Narihiro S, Suwa K, Ushigome T, Ohtsu M, Ryu S, Shimoyama Y, Okamoto T, Yanaga K
In Vivo 2018 Nov-Dec;32(6):1643-1646. doi: 10.21873/invivo.11426. PMID: 30348728Free PMC Article
Echogenicity of liver metastases from colorectal carcinoma is an independent prognostic factor in patients treated with regional chemotherapy.
Gruenberger T, Zhao J, King J, Chung T, Clingan PR, Morris DL
Cancer 2002 Mar 15;94(6):1753-9. doi: 10.1002/cncr.10386. PMID: 11920538
Cellular immunotherapy for patients with metastatic colorectal carcinoma using lymph node lymphocytes localized in vivo by radiolabeled monoclonal antibody.
Kim JA, Bresler HS, Martin EW Jr, Aldrich W, Heffelfinger M, Triozzi PL
Cancer 1999 Jul 1;86(1):22-30. PMID: 10391559
The usefulness of pharmacokinetic modulating chemotherapy (UFT plus 5FU) in the treatment of unresectable colorectal carcinomas.
Kusunoki M, Yanagi H, Noda M, Yamamura T
Oncol Rep 1999 May-Jun;6(3):547-52. doi: 10.3892/or.6.3.547. PMID: 10203589

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