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Proliferative Glomerulonephritis with Monoclonal IgG Deposits

MedGen UID:
1700425
•Concept ID:
C5204121
•
Disease or Syndrome

Definition

A sub-type of monoclonal gammopathy of renal significance, characterized by restriction to a single immunoglobulin G heavy chain subclass and a single light chain isotype. Light microscopy often shows an endocapillary proliferative or membranoproliferative glomerulopathy. Electron microscopy reveals electron-dense subendothelial and mesangial deposits. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVProliferative Glomerulonephritis with Monoclonal IgG Deposits

Professional guidelines

PubMed

Role of light and immunofluorescence microscopy to differentiate primary and secondary membranous nephropathy.
Basu K, Sengupta M, Mukherjee S, Karmakar S, Roychowdhury A, Bandopadhyay M
Indian J Pathol Microbiol 2022 Oct-Dec;65(4):821-827. doi: 10.4103/ijpm.ijpm_22_21. PMID: 36308187

Recent clinical studies

Etiology

Poor outcomes of proliferative glomerulonephritis with monoclonal IgG deposits in renal allografts: a retrospective multicenter study.
Wu Q, Liang D, Song T, Ni X, Wu X, Zhang M, Chen J, Cheng D, Xie K, Li X, Wen J
J Nephrol 2023 Jan;36(1):93-101. Epub 2022 Jul 22 doi: 10.1007/s40620-022-01385-y. PMID: 35867238
Clinicopathological analysis of proliferative glomerulonephritis with monoclonal IgG deposits in 5 renal allografts.
Wen J, Wang W, Xu F, Chen J, Zhang M, Cheng D, Ni X, Li X, Liu Z
BMC Nephrol 2018 Jul 11;19(1):173. doi: 10.1186/s12882-018-0969-3. PMID: 29996809Free PMC Article
Proliferative glomerulonephritis with monoclonal IgG deposits in children and young adults.
Xing G, Gillespie R, Bedri B, Quan A, Zhang P, Zhou XJ
Pediatr Nephrol 2018 Sep;33(9):1531-1538. Epub 2018 Apr 3 doi: 10.1007/s00467-018-3949-8. PMID: 29616329
The Scope of Kidney Affection in Monoclonal Gammopathies at All Levels of Clinical Significance.
Mehtat Ünlü Ş, Özsan H, Sarıoğlu S
Turk J Haematol 2017 Dec 1;34(4):282-288. Epub 2017 Aug 23 doi: 10.4274/tjh.2017.0197. PMID: 28832010Free PMC Article
IgG Subclass Staining in Routine Renal Biopsy Material.
Hemminger J, Nadasdy G, Satoskar A, Brodsky SV, Nadasdy T
Am J Surg Pathol 2016 May;40(5):617-26. doi: 10.1097/PAS.0000000000000605. PMID: 26848798

Diagnosis

Poor outcomes of proliferative glomerulonephritis with monoclonal IgG deposits in renal allografts: a retrospective multicenter study.
Wu Q, Liang D, Song T, Ni X, Wu X, Zhang M, Chen J, Cheng D, Xie K, Li X, Wen J
J Nephrol 2023 Jan;36(1):93-101. Epub 2022 Jul 22 doi: 10.1007/s40620-022-01385-y. PMID: 35867238
Progression of proliferative glomerulonephritis with monoclonal IgG deposits in pediatric patients.
Miller P, Xiao AY, Kung VL, Sibley RK, Higgins JP, Kambham N, Charu V, Lenihan C, Uber AM, Talley EM, Arora N, Walavalkar V, Laszik ZG, Nast CC, Troxell ML
Pediatr Nephrol 2021 Apr;36(4):927-937. Epub 2020 Oct 12 doi: 10.1007/s00467-020-04763-5. PMID: 33044675
Proliferative glomerulonephritis with monoclonal IgG deposits in children and young adults.
Xing G, Gillespie R, Bedri B, Quan A, Zhang P, Zhou XJ
Pediatr Nephrol 2018 Sep;33(9):1531-1538. Epub 2018 Apr 3 doi: 10.1007/s00467-018-3949-8. PMID: 29616329
The Scope of Kidney Affection in Monoclonal Gammopathies at All Levels of Clinical Significance.
Mehtat Ünlü Ş, Özsan H, Sarıoğlu S
Turk J Haematol 2017 Dec 1;34(4):282-288. Epub 2017 Aug 23 doi: 10.4274/tjh.2017.0197. PMID: 28832010Free PMC Article
IgG Subclass Staining in Routine Renal Biopsy Material.
Hemminger J, Nadasdy G, Satoskar A, Brodsky SV, Nadasdy T
Am J Surg Pathol 2016 May;40(5):617-26. doi: 10.1097/PAS.0000000000000605. PMID: 26848798

Therapy

Proliferative glomerulonephritis with monoclonal IgG deposits triggered by Filgrastim in a patient with multiple myeloma.
Villegas-Gamas JM, Márquez-Macedo SE, Jiménez-Franco B, Fonseca-Correa JI, Mejía-Vilet JM
J Nephrol 2023 May;36(4):1209-1212. Epub 2023 Jan 18 doi: 10.1007/s40620-022-01555-y. PMID: 36652170
Poor outcomes of proliferative glomerulonephritis with monoclonal IgG deposits in renal allografts: a retrospective multicenter study.
Wu Q, Liang D, Song T, Ni X, Wu X, Zhang M, Chen J, Cheng D, Xie K, Li X, Wen J
J Nephrol 2023 Jan;36(1):93-101. Epub 2022 Jul 22 doi: 10.1007/s40620-022-01385-y. PMID: 35867238
Proliferative Glomerulonephritis with Monoclonal IgG Deposits and Refractory Ascites: Successful Treatment with Rituximab and Cell-free and Concentrated Ascites Reinfusion Therapy.
Takami N, Inoue M, Kobayashi Y, Sugiyama Y
Intern Med 2022 Aug 15;61(16):2497-2502. Epub 2022 Feb 1 doi: 10.2169/internalmedicine.8799-21. PMID: 35110486Free PMC Article
Clinicopathological analysis of proliferative glomerulonephritis with monoclonal IgG deposits in 5 renal allografts.
Wen J, Wang W, Xu F, Chen J, Zhang M, Cheng D, Ni X, Li X, Liu Z
BMC Nephrol 2018 Jul 11;19(1):173. doi: 10.1186/s12882-018-0969-3. PMID: 29996809Free PMC Article
Proliferative glomerulonephritis with monoclonal IgG deposits in children and young adults.
Xing G, Gillespie R, Bedri B, Quan A, Zhang P, Zhou XJ
Pediatr Nephrol 2018 Sep;33(9):1531-1538. Epub 2018 Apr 3 doi: 10.1007/s00467-018-3949-8. PMID: 29616329

Prognosis

Poor outcomes of proliferative glomerulonephritis with monoclonal IgG deposits in renal allografts: a retrospective multicenter study.
Wu Q, Liang D, Song T, Ni X, Wu X, Zhang M, Chen J, Cheng D, Xie K, Li X, Wen J
J Nephrol 2023 Jan;36(1):93-101. Epub 2022 Jul 22 doi: 10.1007/s40620-022-01385-y. PMID: 35867238
Progression of proliferative glomerulonephritis with monoclonal IgG deposits in pediatric patients.
Miller P, Xiao AY, Kung VL, Sibley RK, Higgins JP, Kambham N, Charu V, Lenihan C, Uber AM, Talley EM, Arora N, Walavalkar V, Laszik ZG, Nast CC, Troxell ML
Pediatr Nephrol 2021 Apr;36(4):927-937. Epub 2020 Oct 12 doi: 10.1007/s00467-020-04763-5. PMID: 33044675
Proliferative glomerulonephritis with monoclonal IgG deposits in children and young adults.
Xing G, Gillespie R, Bedri B, Quan A, Zhang P, Zhou XJ
Pediatr Nephrol 2018 Sep;33(9):1531-1538. Epub 2018 Apr 3 doi: 10.1007/s00467-018-3949-8. PMID: 29616329
The Scope of Kidney Affection in Monoclonal Gammopathies at All Levels of Clinical Significance.
Mehtat Ünlü Ş, Özsan H, Sarıoğlu S
Turk J Haematol 2017 Dec 1;34(4):282-288. Epub 2017 Aug 23 doi: 10.4274/tjh.2017.0197. PMID: 28832010Free PMC Article
IgG Subclass Staining in Routine Renal Biopsy Material.
Hemminger J, Nadasdy G, Satoskar A, Brodsky SV, Nadasdy T
Am J Surg Pathol 2016 May;40(5):617-26. doi: 10.1097/PAS.0000000000000605. PMID: 26848798

Clinical prediction guides

Poor outcomes of proliferative glomerulonephritis with monoclonal IgG deposits in renal allografts: a retrospective multicenter study.
Wu Q, Liang D, Song T, Ni X, Wu X, Zhang M, Chen J, Cheng D, Xie K, Li X, Wen J
J Nephrol 2023 Jan;36(1):93-101. Epub 2022 Jul 22 doi: 10.1007/s40620-022-01385-y. PMID: 35867238
Steroid-sensitive recurrent mesangial proliferative glomerulonephritis with monoclonal IgG deposits.
Nomura K, Miyatake N, Okada K, Hayashi N, Fujimoto K, Adachi H, Furuichi K, Shimizu A, Yokoyama H
CEN Case Rep 2021 May;10(2):308-313. Epub 2021 Jan 4 doi: 10.1007/s13730-020-00562-x. PMID: 33398782Free PMC Article
Clinicopathological analysis of proliferative glomerulonephritis with monoclonal IgG deposits in 5 renal allografts.
Wen J, Wang W, Xu F, Chen J, Zhang M, Cheng D, Ni X, Li X, Liu Z
BMC Nephrol 2018 Jul 11;19(1):173. doi: 10.1186/s12882-018-0969-3. PMID: 29996809Free PMC Article
IgG Subclass Staining in Routine Renal Biopsy Material.
Hemminger J, Nadasdy G, Satoskar A, Brodsky SV, Nadasdy T
Am J Surg Pathol 2016 May;40(5):617-26. doi: 10.1097/PAS.0000000000000605. PMID: 26848798
Proliferative glomerulonephritis with monoclonal IgG deposits.
Nasr SH, Satoskar A, Markowitz GS, Valeri AM, Appel GB, Stokes MB, Nadasdy T, D'Agati VD
J Am Soc Nephrol 2009 Sep;20(9):2055-64. Epub 2009 May 21 doi: 10.1681/ASN.2009010110. PMID: 19470674Free PMC Article

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