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Increased circulating surfactant protein level

MedGen UID:
1700584
•Concept ID:
C5139126
•
Finding
Synonym: Increased serum surfactant protein level
 
HPO: HP:0032094

Definition

An increased concentration of a surfactant protein in the blood circulation. Pulmonary surfactant is a highly surface-active mixture of proteins and lipids that is synthesized and secreted onto the alveoli by type II epithelial cells. The protein part of surfactant constitutes of four types of surfactant proteins (SP), SP-A, SP-B, SP-C and SP-D. SP-A and SP-D are hydrophilic proteins that regulate surfactant metabolism and have immunologic functions. These two proteins are detectable in the bloodstream and an elevated level may reflect idiopathic pulmonary fibrosis. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased circulating surfactant protein level

Professional guidelines

PubMed

Fabrication and in vivo evaluation of ligand appended paclitaxel and artemether loaded lipid nanoparticulate systems for the treatment of NSCLC: A nanoparticle assisted combination oncotherapy.
Khatri H, Chokshi N, Rawal S, Patel BM, Badanthadka M, Patel MM
Int J Pharm 2020 Jun 15;583:119386. Epub 2020 May 4 doi: 10.1016/j.ijpharm.2020.119386. PMID: 32376440
Pegylated interferons for the treatment of chronic hepatitis C: pharmacological and clinical differences between peginterferon-alpha-2a and peginterferon-alpha-2b.
Foster GR
Drugs 2010;70(2):147-65. doi: 10.2165/11531990-000000000-00000. PMID: 20108989
Alveolar proteinosis syndrome: pathogenesis, diagnosis, and management.
Huizar I, Kavuru MS
Curr Opin Pulm Med 2009 Sep;15(5):491-8. doi: 10.1097/MCP.0b013e32832ea51c. PMID: 19561506

Recent clinical studies

Etiology

AS03 adjuvant enhances the magnitude, persistence, and clonal breadth of memory B cell responses to a plant-based COVID-19 vaccine in humans.
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Sci Immunol 2024 Apr 5;9(94):eadi8039. doi: 10.1126/sciimmunol.adi8039. PMID: 38579013
Cardiogenic Pulmonary Edema.
Dobbe L, Rahman R, Elmassry M, Paz P, Nugent K
Am J Med Sci 2019 Dec;358(6):389-397. Epub 2019 Oct 1 doi: 10.1016/j.amjms.2019.09.011. PMID: 31813466
Steady-State Plasma Concentrations of Polyethylene Glycol (PEG) are Reached in Children and Adults During Once-Weekly Prophylactic Treatment with Nonacog Beta Pegol (N9-GP).
Sternebring O, Gabel-Jensen C, Jacobsen H, Benie AJ, Bjørnsdottir I
BioDrugs 2019 Dec;33(6):673-681. doi: 10.1007/s40259-019-00380-3. PMID: 31549312Free PMC Article
Serum surfactant protein D (SP-D) is a prognostic marker of poor outcome in patients with A/H1N1 virus infection.
Delgado C, Krötzsch E, Jiménez-Alvarez LA, Ramírez-Martínez G, Márquez-García JE, Cruz-Lagunas A, Morán J, Hernández C, Sierra-Vargas P, Avila-Moreno F, Becerril C, Montaño M, Bañales-Méndez JL, Zúñiga J, Buendía-Roldán I
Lung 2015 Feb;193(1):25-30. Epub 2014 Dec 24 doi: 10.1007/s00408-014-9669-3. PMID: 25537934Free PMC Article
Use of protein A immunoadsorption as a treatment for thrombocytopenia in HIV-infected homosexual men: a retrospective evaluation of 37 cases.
Snyder HW Jr, Bertram JH, Henry DH, Kiprov DD, Benny WB, Mittelman A, Messerschmidt GL, Cochran SK, Perkins W, Balint JP Jr
AIDS 1991 Oct;5(10):1257-60. doi: 10.1097/00002030-199110000-00017. PMID: 1786153

Diagnosis

Pharmacological activation of insulin-degrading enzyme improves insulin secretion and glucose tolerance in diet-induced obese mice.
Sanz-González A, Cózar-Castellano I, Broca C, Sabatier J, Acosta GA, Royo M, Hernándo-Muñoz C, Torroba T, Perdomo G, Merino B
Diabetes Obes Metab 2023 Nov;25(11):3268-3278. Epub 2023 Jul 26 doi: 10.1111/dom.15225. PMID: 37493025
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Tumor-targeting, pH-sensitive nanoparticles for docetaxel delivery to drug-resistant cancer cells.
Tran TH, Ramasamy T, Choi JY, Nguyen HT, Pham TT, Jeong JH, Ku SK, Choi HG, Yong CS, Kim JO
Int J Nanomedicine 2015;10:5249-62. Epub 2015 Aug 21 doi: 10.2147/IJN.S89584. PMID: 26346426Free PMC Article
Serum surfactant protein D (SP-D) is a prognostic marker of poor outcome in patients with A/H1N1 virus infection.
Delgado C, Krötzsch E, Jiménez-Alvarez LA, Ramírez-Martínez G, Márquez-García JE, Cruz-Lagunas A, Morán J, Hernández C, Sierra-Vargas P, Avila-Moreno F, Becerril C, Montaño M, Bañales-Méndez JL, Zúñiga J, Buendía-Roldán I
Lung 2015 Feb;193(1):25-30. Epub 2014 Dec 24 doi: 10.1007/s00408-014-9669-3. PMID: 25537934Free PMC Article
IgE-containing circulating immune complexes in Churg-Strauss vasculitis.
Manger BJ, Krapf FE, Gramatzki M, Nüsslein HG, Burmester GR, Krauledat PB, Kalden JR
Scand J Immunol 1985 Apr;21(4):369-73. doi: 10.1111/j.1365-3083.1985.tb01443.x. PMID: 3890149

Therapy

Liraglutide Improves Forced Vital Capacity in Individuals With Type 2 Diabetes: Data From the Randomized Crossover LIRALUNG Study.
López-Cano C, Ciudin A, Sánchez E, Tinahones FJ, Barbé F, Dalmases M, García-Ramírez M, Soto A, Gaeta AM, Pellitero S, Martí R, Hernández C, Simó R, Lecube A
Diabetes 2022 Feb 1;71(2):315-320. doi: 10.2337/db21-0688. PMID: 34737187
Urokinase injection-triggered clearance enhancement of a 4-arm PEG-conjugated (64)Cu-bombesin analog tetramer: A novel approach for the improvement of PET imaging contrast.
Matsumura K, Zouda M, Wada Y, Yamashita F, Hashida M, Watanabe Y, Mukai H
Int J Pharm 2018 Jul 10;545(1-2):206-214. Epub 2018 May 7 doi: 10.1016/j.ijpharm.2018.05.014. PMID: 29746998
Tumor-targeting, pH-sensitive nanoparticles for docetaxel delivery to drug-resistant cancer cells.
Tran TH, Ramasamy T, Choi JY, Nguyen HT, Pham TT, Jeong JH, Ku SK, Choi HG, Yong CS, Kim JO
Int J Nanomedicine 2015;10:5249-62. Epub 2015 Aug 21 doi: 10.2147/IJN.S89584. PMID: 26346426Free PMC Article
Significant endothelin release in patients treated with foam sclerotherapy.
Frullini A, Barsotti MC, Santoni T, Duranti E, Burchielli S, Di Stefano R
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Tullis RH, Duffin RP, Ichim TE, Joyce JA, Levin NW
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Prognosis

Liraglutide Improves Forced Vital Capacity in Individuals With Type 2 Diabetes: Data From the Randomized Crossover LIRALUNG Study.
López-Cano C, Ciudin A, Sánchez E, Tinahones FJ, Barbé F, Dalmases M, García-Ramírez M, Soto A, Gaeta AM, Pellitero S, Martí R, Hernández C, Simó R, Lecube A
Diabetes 2022 Feb 1;71(2):315-320. doi: 10.2337/db21-0688. PMID: 34737187
Urokinase injection-triggered clearance enhancement of a 4-arm PEG-conjugated (64)Cu-bombesin analog tetramer: A novel approach for the improvement of PET imaging contrast.
Matsumura K, Zouda M, Wada Y, Yamashita F, Hashida M, Watanabe Y, Mukai H
Int J Pharm 2018 Jul 10;545(1-2):206-214. Epub 2018 May 7 doi: 10.1016/j.ijpharm.2018.05.014. PMID: 29746998
Serum surfactant protein D (SP-D) is a prognostic marker of poor outcome in patients with A/H1N1 virus infection.
Delgado C, Krötzsch E, Jiménez-Alvarez LA, Ramírez-Martínez G, Márquez-García JE, Cruz-Lagunas A, Morán J, Hernández C, Sierra-Vargas P, Avila-Moreno F, Becerril C, Montaño M, Bañales-Méndez JL, Zúñiga J, Buendía-Roldán I
Lung 2015 Feb;193(1):25-30. Epub 2014 Dec 24 doi: 10.1007/s00408-014-9669-3. PMID: 25537934Free PMC Article
Modeling hepatitis C virus therapies combining drugs and lectin affinity plasmapheresis.
Tullis RH, Duffin RP, Ichim TE, Joyce JA, Levin NW
Blood Purif 2010;29(2):210-5. Epub 2010 Jan 8 doi: 10.1159/000245649. PMID: 20093829
Pharmacodynamic enhancement of the anti-platelet antibody fab abciximab by site-specific pegylation.
Knight DM, Jordan RE, Kruszynski M, Tam SH, Giles-Komar J, Treacy G, Heavner GA
Platelets 2004 Nov;15(7):409-18. doi: 10.1080/09537100410001723135. PMID: 15745312

Clinical prediction guides

Liraglutide Improves Forced Vital Capacity in Individuals With Type 2 Diabetes: Data From the Randomized Crossover LIRALUNG Study.
López-Cano C, Ciudin A, Sánchez E, Tinahones FJ, Barbé F, Dalmases M, García-Ramírez M, Soto A, Gaeta AM, Pellitero S, Martí R, Hernández C, Simó R, Lecube A
Diabetes 2022 Feb 1;71(2):315-320. doi: 10.2337/db21-0688. PMID: 34737187
Urokinase injection-triggered clearance enhancement of a 4-arm PEG-conjugated (64)Cu-bombesin analog tetramer: A novel approach for the improvement of PET imaging contrast.
Matsumura K, Zouda M, Wada Y, Yamashita F, Hashida M, Watanabe Y, Mukai H
Int J Pharm 2018 Jul 10;545(1-2):206-214. Epub 2018 May 7 doi: 10.1016/j.ijpharm.2018.05.014. PMID: 29746998
Serum surfactant protein D (SP-D) is a prognostic marker of poor outcome in patients with A/H1N1 virus infection.
Delgado C, Krötzsch E, Jiménez-Alvarez LA, Ramírez-Martínez G, Márquez-García JE, Cruz-Lagunas A, Morán J, Hernández C, Sierra-Vargas P, Avila-Moreno F, Becerril C, Montaño M, Bañales-Méndez JL, Zúñiga J, Buendía-Roldán I
Lung 2015 Feb;193(1):25-30. Epub 2014 Dec 24 doi: 10.1007/s00408-014-9669-3. PMID: 25537934Free PMC Article
Modeling hepatitis C virus therapies combining drugs and lectin affinity plasmapheresis.
Tullis RH, Duffin RP, Ichim TE, Joyce JA, Levin NW
Blood Purif 2010;29(2):210-5. Epub 2010 Jan 8 doi: 10.1159/000245649. PMID: 20093829
Surfactant protein D (SP-D) serum levels in patients with community-acquired pneumonia.
Leth-Larsen R, Nordenbaek C, Tornoe I, Moeller V, Schlosser A, Koch C, Teisner B, Junker P, Holmskov U
Clin Immunol 2003 Jul;108(1):29-37. doi: 10.1016/s1521-6616(03)00042-1. PMID: 12865068

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