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Increased circulating surfactant protein level

MedGen UID:
1700584
•Concept ID:
C5139126
•
Finding
Synonym: Increased serum surfactant protein level
 
HPO: HP:0032094

Definition

An increased concentration of a surfactant protein in the blood circulation. Pulmonary surfactant is a highly surface-active mixture of proteins and lipids that is synthesized and secreted onto the alveoli by type II epithelial cells. The protein part of surfactant constitutes of four types of surfactant proteins (SP), SP-A, SP-B, SP-C and SP-D. SP-A and SP-D are hydrophilic proteins that regulate surfactant metabolism and have immunologic functions. These two proteins are detectable in the bloodstream and an elevated level may reflect idiopathic pulmonary fibrosis. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased circulating surfactant protein level

Professional guidelines

PubMed

Fabrication and in vivo evaluation of ligand appended paclitaxel and artemether loaded lipid nanoparticulate systems for the treatment of NSCLC: A nanoparticle assisted combination oncotherapy.
Khatri H, Chokshi N, Rawal S, Patel BM, Badanthadka M, Patel MM
Int J Pharm 2020 Jun 15;583:119386. Epub 2020 May 4 doi: 10.1016/j.ijpharm.2020.119386. PMID: 32376440
Pegylated interferons for the treatment of chronic hepatitis C: pharmacological and clinical differences between peginterferon-alpha-2a and peginterferon-alpha-2b.
Foster GR
Drugs 2010;70(2):147-65. doi: 10.2165/11531990-000000000-00000. PMID: 20108989
Alveolar proteinosis syndrome: pathogenesis, diagnosis, and management.
Huizar I, Kavuru MS
Curr Opin Pulm Med 2009 Sep;15(5):491-8. doi: 10.1097/MCP.0b013e32832ea51c. PMID: 19561506

Recent clinical studies

Etiology

Luciferase Immunosorbent Assay Based on Multiple E Antigens for the Detection of Chikungunya Virus-Specific IgG Antibodies.
Li X, Wan X, Liu J, Wang H, Li A, Ke C, Tang S, Zhao W, Cai S, Wan C
Microbiol Spectr 2022 Apr 27;10(2):e0149621. Epub 2022 Mar 21 doi: 10.1128/spectrum.01496-21. PMID: 35311573Free PMC Article
Surfactant protein D is a biomarker of influenza-related pediatric lung injury.
Chakrabarti A, Nguyen A, Newhams MM, Ohlson MB, Yang X, Ulufatu S, Liu S, Park S, Xu M, Jiang J, Halpern WG, Anania VG, McBride JM, Rosenberger CM, Randolph AG; Pediatric Intensive Care Influenza (PICFLU) Investigators
Pediatr Pulmonol 2022 Feb;57(2):519-528. Epub 2021 Dec 7 doi: 10.1002/ppul.25776. PMID: 34842360Free PMC Article
Cardiogenic Pulmonary Edema.
Dobbe L, Rahman R, Elmassry M, Paz P, Nugent K
Am J Med Sci 2019 Dec;358(6):389-397. Epub 2019 Oct 1 doi: 10.1016/j.amjms.2019.09.011. PMID: 31813466
Circulating pro-surfactant protein B as a risk biomarker for lung cancer.
Taguchi A, Hanash S, Rundle A, McKeague IW, Tang D, Darakjy S, Gaziano JM, Sesso HD, Perera F
Cancer Epidemiol Biomarkers Prev 2013 Oct;22(10):1756-61. Epub 2013 Jul 29 doi: 10.1158/1055-9965.EPI-13-0251. PMID: 23897585Free PMC Article
Circulating surfactant protein -D is low and correlates negatively with systemic inflammation in early, untreated rheumatoid arthritis.
Christensen AF, Sørensen GL, Hørslev-Petersen K, Holmskov U, Lindegaard HM, Junker K, Hetland ML, Stengaard-Pedersen K, Jacobsen S, Lottenburger T, Ellingsen T, Andersen LS, Hansen I, Skjødt H, Pedersen JK, Lauridsen UB, Svendsen A, Tarp U, Pødenphant J, Vestergaard A, Jurik AG, Østergaard M, Junker P
Arthritis Res Ther 2010;12(2):R39. Epub 2010 Mar 8 doi: 10.1186/ar2948. PMID: 20211020Free PMC Article

Diagnosis

Dysregulated serum and seminal plasma levels of surfactant protein D and MCP-1 in men with genital tract infection/inflammation.
Subedi R, Rokade S, Surve S, Patil A, Kulkarni V, Gajbhiye RK, Madan T
Am J Reprod Immunol 2023 Feb;89(2):e13588. Epub 2022 Jul 8 doi: 10.1111/aji.13588. PMID: 35771685
Luciferase Immunosorbent Assay Based on Multiple E Antigens for the Detection of Chikungunya Virus-Specific IgG Antibodies.
Li X, Wan X, Liu J, Wang H, Li A, Ke C, Tang S, Zhao W, Cai S, Wan C
Microbiol Spectr 2022 Apr 27;10(2):e0149621. Epub 2022 Mar 21 doi: 10.1128/spectrum.01496-21. PMID: 35311573Free PMC Article
Surfactant protein D is a biomarker of influenza-related pediatric lung injury.
Chakrabarti A, Nguyen A, Newhams MM, Ohlson MB, Yang X, Ulufatu S, Liu S, Park S, Xu M, Jiang J, Halpern WG, Anania VG, McBride JM, Rosenberger CM, Randolph AG; Pediatric Intensive Care Influenza (PICFLU) Investigators
Pediatr Pulmonol 2022 Feb;57(2):519-528. Epub 2021 Dec 7 doi: 10.1002/ppul.25776. PMID: 34842360Free PMC Article
Alveolar proteinosis syndrome: pathogenesis, diagnosis, and management.
Huizar I, Kavuru MS
Curr Opin Pulm Med 2009 Sep;15(5):491-8. doi: 10.1097/MCP.0b013e32832ea51c. PMID: 19561506
Partitioning lung and plasma proteins: circulating surfactant proteins as biomarkers of alveolocapillary permeability.
Doyle IR, Nicholas TE, Bersten AD
Clin Exp Pharmacol Physiol 1999 Mar;26(3):185-97. doi: 10.1046/j.1440-1681.1999.03015.x. PMID: 10081613

Therapy

Challenges and advancements in the pharmacokinetic enhancement of therapeutic proteins.
Khodabakhsh F, Salimian M, Hedayati MH, Ahangari Cohan R, Norouzian D
Prep Biochem Biotechnol 2021;51(6):519-529. Epub 2021 Jan 18 doi: 10.1080/10826068.2020.1839907. PMID: 33459157
Surfactant protein D multimerization and gene polymorphism in COPD and asthma.
Fakih D, Akiki Z, Junker K, Medlej-Hashim M, Waked M, Salameh P, Holmskov U, Bouharoun-Tayoun H, Chamat S, Sorensen GL, Jounblat R
Respirology 2018 Mar;23(3):298-305. Epub 2017 Sep 28 doi: 10.1111/resp.13193. PMID: 28960651
Circulating pro-surfactant protein B as a risk biomarker for lung cancer.
Taguchi A, Hanash S, Rundle A, McKeague IW, Tang D, Darakjy S, Gaziano JM, Sesso HD, Perera F
Cancer Epidemiol Biomarkers Prev 2013 Oct;22(10):1756-61. Epub 2013 Jul 29 doi: 10.1158/1055-9965.EPI-13-0251. PMID: 23897585Free PMC Article
Circulating surfactant protein -D is low and correlates negatively with systemic inflammation in early, untreated rheumatoid arthritis.
Christensen AF, Sørensen GL, Hørslev-Petersen K, Holmskov U, Lindegaard HM, Junker K, Hetland ML, Stengaard-Pedersen K, Jacobsen S, Lottenburger T, Ellingsen T, Andersen LS, Hansen I, Skjødt H, Pedersen JK, Lauridsen UB, Svendsen A, Tarp U, Pødenphant J, Vestergaard A, Jurik AG, Østergaard M, Junker P
Arthritis Res Ther 2010;12(2):R39. Epub 2010 Mar 8 doi: 10.1186/ar2948. PMID: 20211020Free PMC Article
Alveolar proteinosis syndrome: pathogenesis, diagnosis, and management.
Huizar I, Kavuru MS
Curr Opin Pulm Med 2009 Sep;15(5):491-8. doi: 10.1097/MCP.0b013e32832ea51c. PMID: 19561506

Prognosis

Dysregulated serum and seminal plasma levels of surfactant protein D and MCP-1 in men with genital tract infection/inflammation.
Subedi R, Rokade S, Surve S, Patil A, Kulkarni V, Gajbhiye RK, Madan T
Am J Reprod Immunol 2023 Feb;89(2):e13588. Epub 2022 Jul 8 doi: 10.1111/aji.13588. PMID: 35771685
A Potential Biomarker for Predicting the Risk of Radiation-Induced Fibrosis in the Lung.
Groves AM, Williams JP, Hernady E, Reed C, Fenton B, Love T, Finkelstein JN, Johnston CJ
Radiat Res 2018 Nov;190(5):513-525. Epub 2018 Aug 17 doi: 10.1667/RR15122.1. PMID: 30117783
Circulating pro-surfactant protein B as a risk biomarker for lung cancer.
Taguchi A, Hanash S, Rundle A, McKeague IW, Tang D, Darakjy S, Gaziano JM, Sesso HD, Perera F
Cancer Epidemiol Biomarkers Prev 2013 Oct;22(10):1756-61. Epub 2013 Jul 29 doi: 10.1158/1055-9965.EPI-13-0251. PMID: 23897585Free PMC Article
Circulating surfactant protein D is decreased in early rheumatoid arthritis: a 1-year prospective study.
Hoegh SV, Lindegaard HM, Sorensen GL, Høj A, Bendixen C, Junker P, Holmskov U
Scand J Immunol 2008 Jan;67(1):71-6. doi: 10.1111/j.1365-3083.2007.02039.x. PMID: 18052966
Surfactant proteins A and D: disease markers.
Kuroki Y, Takahashi H, Chiba H, Akino T
Biochim Biophys Acta 1998 Nov 19;1408(2-3):334-45. doi: 10.1016/s0925-4439(98)00079-9. PMID: 9813383

Clinical prediction guides

Dysregulated serum and seminal plasma levels of surfactant protein D and MCP-1 in men with genital tract infection/inflammation.
Subedi R, Rokade S, Surve S, Patil A, Kulkarni V, Gajbhiye RK, Madan T
Am J Reprod Immunol 2023 Feb;89(2):e13588. Epub 2022 Jul 8 doi: 10.1111/aji.13588. PMID: 35771685
Challenges and advancements in the pharmacokinetic enhancement of therapeutic proteins.
Khodabakhsh F, Salimian M, Hedayati MH, Ahangari Cohan R, Norouzian D
Prep Biochem Biotechnol 2021;51(6):519-529. Epub 2021 Jan 18 doi: 10.1080/10826068.2020.1839907. PMID: 33459157
Circulating surfactant protein -D is low and correlates negatively with systemic inflammation in early, untreated rheumatoid arthritis.
Christensen AF, Sørensen GL, Hørslev-Petersen K, Holmskov U, Lindegaard HM, Junker K, Hetland ML, Stengaard-Pedersen K, Jacobsen S, Lottenburger T, Ellingsen T, Andersen LS, Hansen I, Skjødt H, Pedersen JK, Lauridsen UB, Svendsen A, Tarp U, Pødenphant J, Vestergaard A, Jurik AG, Østergaard M, Junker P
Arthritis Res Ther 2010;12(2):R39. Epub 2010 Mar 8 doi: 10.1186/ar2948. PMID: 20211020Free PMC Article
Partitioning lung and plasma proteins: circulating surfactant proteins as biomarkers of alveolocapillary permeability.
Doyle IR, Nicholas TE, Bersten AD
Clin Exp Pharmacol Physiol 1999 Mar;26(3):185-97. doi: 10.1046/j.1440-1681.1999.03015.x. PMID: 10081613
Surfactant proteins A and D: disease markers.
Kuroki Y, Takahashi H, Chiba H, Akino T
Biochim Biophys Acta 1998 Nov 19;1408(2-3):334-45. doi: 10.1016/s0925-4439(98)00079-9. PMID: 9813383

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