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Malignant Parapharyngeal Neoplasm

MedGen UID:
1701239
•Concept ID:
C5206835
•
Neoplastic Process

Definition

A primary or metastatic malignant neoplasm that affects the parapharyngeal space. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant Parapharyngeal Neoplasm

Professional guidelines

PubMed

Contemporary Management of Parapharyngeal Tumors.
Strohl MP, El-Sayed IH
Curr Oncol Rep 2019 Nov 14;21(11):103. doi: 10.1007/s11912-019-0853-8. PMID: 31728649
Contemporary management of primary parapharyngeal space tumors.
López F, Suárez C, Vander Poorten V, Mäkitie A, Nixon IJ, Strojan P, Hanna EY, Rodrigo JP, de Bree R, Quer M, Takes RP, Bradford CR, Shaha AR, Sanabria A, Rinaldo A, Ferlito A
Head Neck 2019 Feb;41(2):522-535. Epub 2018 Dec 14 doi: 10.1002/hed.25439. PMID: 30549361
Contemporary evaluation and management of parapharyngeal space neoplasms.
Eisele DW, Richmon JD
J Laryngol Otol 2013 Jun;127(6):550-5. Epub 2013 Apr 10 doi: 10.1017/S0022215113000686. PMID: 23575439

Recent clinical studies

Etiology

Transoral Approach to Parotid Tumors: A Review of the Literature.
Riva G, Lorenzi A, Borello A, Albera A, Canale A, Pecorari G
Curr Oncol 2022 Dec 1;29(12):9416-9427. doi: 10.3390/curroncol29120740. PMID: 36547154Free PMC Article
Mesenchymal neoplasms of the parotid gland and parapharyngeal space: an FNA cytologic study of 22 nonlipomatous tumors.
Wakely PE Jr
Cancer Cytopathol 2022 Jun;130(6):443-454. Epub 2022 Feb 23 doi: 10.1002/cncy.22562. PMID: 35195952
Primary neoplasms of the parapharyngeal space: diagnostic and therapeutic pearls and pitfalls.
Bulut OC, Giger R, Alwagdani A, Aldabal N, Stenzinger A, Heimgartner S, Nisa L, Borner U
Eur Arch Otorhinolaryngol 2021 Dec;278(12):4933-4941. Epub 2021 Mar 19 doi: 10.1007/s00405-021-06718-4. PMID: 33740083Free PMC Article
Transoral Parotidectomy.
Osborne RF
Oral Maxillofac Surg Clin North Am 2021 May;33(2):169-175. Epub 2021 Jan 19 doi: 10.1016/j.coms.2020.12.002. PMID: 33478916
Parapharyngeal space primary tumours.
Grilli G, Suarez V, Muñoz MG, Costales M, Llorente JL
Acta Otorrinolaringol Esp (Engl Ed) 2017 May-Jun;68(3):138-144. doi: 10.1016/j.otorri.2016.06.003. PMID: 27663220

Diagnosis

Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Hypopharynx, Larynx, Trachea and Parapharyngeal Space.
Zidar N, Gale N
Head Neck Pathol 2022 Mar;16(1):31-39. Epub 2022 Mar 21 doi: 10.1007/s12105-021-01405-6. PMID: 35312977Free PMC Article
Contemporary Management of Parapharyngeal Tumors.
Strohl MP, El-Sayed IH
Curr Oncol Rep 2019 Nov 14;21(11):103. doi: 10.1007/s11912-019-0853-8. PMID: 31728649
Contemporary management of primary parapharyngeal space tumors.
López F, Suárez C, Vander Poorten V, Mäkitie A, Nixon IJ, Strojan P, Hanna EY, Rodrigo JP, de Bree R, Quer M, Takes RP, Bradford CR, Shaha AR, Sanabria A, Rinaldo A, Ferlito A
Head Neck 2019 Feb;41(2):522-535. Epub 2018 Dec 14 doi: 10.1002/hed.25439. PMID: 30549361
Paediatric parapharyngeal ganglioneuroma.
Bach J, Azher Q, Salih A
BMJ Case Rep 2018 Aug 20;2018 doi: 10.1136/bcr-2018-225763. PMID: 30131403Free PMC Article
Parapharyngeal space primary tumours.
Grilli G, Suarez V, Muñoz MG, Costales M, Llorente JL
Acta Otorrinolaringol Esp (Engl Ed) 2017 May-Jun;68(3):138-144. doi: 10.1016/j.otorri.2016.06.003. PMID: 27663220

Therapy

A Retrospective Analysis on the Effects and Complications of Endoscope-Assisted Transoral Approach and Lateral Cervical Approach in the Resection of Parapharyngeal Space Tumors.
Guo D, Sun C, Yin X, Qu H, Dai B, Hu L, Zhou C, Du X
Comput Intell Neurosci 2022;2022:7536330. Epub 2022 Sep 23 doi: 10.1155/2022/7536330. PMID: 36188711Free PMC Article
First Bite Syndrome: What Neurologists Need to Know.
Steel SJ, Robertson CE
Curr Pain Headache Rep 2021 Mar 24;25(5):31. doi: 10.1007/s11916-021-00950-7. PMID: 33761012
Early experience in transoral robotic surgery (TORS) for non-oropharyngeal head and neck malignancies: a review of functional and oncologic outcomes.
Meulemans J, Delaere P, Vander Poorten V
B-ENT 2015;Suppl 24:21-31. PMID: 26891528
Endoscopic endonasal transpterygoid nasopharyngectomy.
Al-Sheibani S, Zanation AM, Carrau RL, Prevedello DM, Prokopakis EP, McLaughlin N, Snyderman CH, Kassam AB
Laryngoscope 2011 Oct;121(10):2081-9. Epub 2011 Sep 6 doi: 10.1002/lary.22165. PMID: 21898447
Myxofibrosarcoma of the neck.
Udaka T, Yamamoto H, Shiomori T, Fujimura T, Suzuki H
J Laryngol Otol 2006 Oct;120(10):872-4. doi: 10.1017/S0022215106001113. PMID: 17038234

Prognosis

Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Hypopharynx, Larynx, Trachea and Parapharyngeal Space.
Zidar N, Gale N
Head Neck Pathol 2022 Mar;16(1):31-39. Epub 2022 Mar 21 doi: 10.1007/s12105-021-01405-6. PMID: 35312977Free PMC Article
Contemporary Management of Parapharyngeal Tumors.
Strohl MP, El-Sayed IH
Curr Oncol Rep 2019 Nov 14;21(11):103. doi: 10.1007/s11912-019-0853-8. PMID: 31728649
Comprehensive Analyses of Intraoral Benign and Malignant Nerve Sheath Tumors: The Rare Disease Entities Revisited.
Song Y, Hu J, Wu Y, Wang D, Wang Y, Zhang P, Jiang H, Yang J, Cheng J
J Craniofac Surg 2019 Jun;30(4):e317-e327. doi: 10.1097/SCS.0000000000005231. PMID: 30845091
Parapharyngeal space neoplasms.
Hughes KV 3rd, Olsen KD, McCaffrey TV
Head Neck 1995 Mar-Apr;17(2):124-30. doi: 10.1002/hed.2880170209. PMID: 7558809
Tumors and surgery of the parapharyngeal space.
Olsen KD
Laryngoscope 1994 May;104(5 Pt 2 Suppl 63):1-28. doi: 10.1288/00005537-199405000-00001. PMID: 8189998

Clinical prediction guides

Management of Parapharyngeal Space Tumors: Clinical Experience with a Large Sample and Review of the Literature.
Jiang C, Wang W, Chen S, Liu Y
Curr Oncol 2023 Jan 11;30(1):1020-1031. doi: 10.3390/curroncol30010078. PMID: 36661727Free PMC Article
Pre-styloid parapharyngeal space masses-Tumor margins as a predictor of benign versus malignant histology on pre-operative CT or MRI.
Vargas N, Assadsangabi R, Birkeland A, Bewley A, Broadhead K, Morisada M, Ivanovic V
Neuroradiol J 2022 Dec;35(6):701-705. Epub 2022 May 31 doi: 10.1177/19714009221089027. PMID: 35640057Free PMC Article
Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Hypopharynx, Larynx, Trachea and Parapharyngeal Space.
Zidar N, Gale N
Head Neck Pathol 2022 Mar;16(1):31-39. Epub 2022 Mar 21 doi: 10.1007/s12105-021-01405-6. PMID: 35312977Free PMC Article
Contemporary Management of Parapharyngeal Tumors.
Strohl MP, El-Sayed IH
Curr Oncol Rep 2019 Nov 14;21(11):103. doi: 10.1007/s11912-019-0853-8. PMID: 31728649
Contemporary evaluation and management of parapharyngeal space neoplasms.
Eisele DW, Richmon JD
J Laryngol Otol 2013 Jun;127(6):550-5. Epub 2013 Apr 10 doi: 10.1017/S0022215113000686. PMID: 23575439

Recent systematic reviews

Head and neck lipoblastoma in children: A case report and systematic review.
Tyra J, Mierzwińska-Dolny P, Fishman AJ, Mierzwiński J
Int J Pediatr Otorhinolaryngol 2023 Oct;173:111699. Epub 2023 Aug 16 doi: 10.1016/j.ijporl.2023.111699. PMID: 37597314
The development of a clinical algorithm for the diagnosis of tumours in the parapharyngeal space. A systematic review.
Limardo A, Blanco L, Menendez J, García L, Ortega A
Acta Otorrinolaringol Esp (Engl Ed) 2022 May-Jun;73(3):141-150. doi: 10.1016/j.otoeng.2020.11.007. PMID: 35577429
Histopathologic classification of parapharyngeal space tumors: a case series and review of the literature.
Locketz GD, Horowitz G, Abu-Ghanem S, Wasserzug O, Abergel A, Yehuda M, Fliss DM
Eur Arch Otorhinolaryngol 2016 Mar;273(3):727-34. Epub 2015 Feb 24 doi: 10.1007/s00405-015-3545-5. PMID: 25708410
Management of tumors arising from the parapharyngeal space: A systematic review of 1,293 cases reported over 25 years.
Kuet ML, Kasbekar AV, Masterson L, Jani P
Laryngoscope 2015 Jun;125(6):1372-81. Epub 2014 Dec 2 doi: 10.1002/lary.25077. PMID: 25448637
A systematic review of 1143 parapharyngeal space tumors reported over 20 years.
Riffat F, Dwivedi RC, Palme C, Fish B, Jani P
Oral Oncol 2014 May;50(5):421-30. Epub 2014 Feb 28 doi: 10.1016/j.oraloncology.2014.02.007. PMID: 24589290

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