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Unresectable Merkel Cell Carcinoma

MedGen UID:
1701414
•Concept ID:
C5206823
•
Neoplastic Process

Definition

Merkel cell carcinoma that is not amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUnresectable Merkel Cell Carcinoma

Professional guidelines

PubMed

Electrochemotherapy With Intravenous Bleomycin in the Treatment of Unresectable Merkel Cell Carcinoma.
Padilla-España L, Toledo-Pastrana T, Fernández-Orland A, Ferrándiz-Pulido L
Actas Dermosifiliogr (Engl Ed) 2019 Oct;110(8):687-688. Epub 2018 Aug 17 doi: 10.1016/j.ad.2018.07.007. PMID: 30126606

Recent clinical studies

Etiology

Combined nivolumab and ipilimumab with or without stereotactic body radiation therapy for advanced Merkel cell carcinoma: a randomised, open label, phase 2 trial.
Kim S, Wuthrick E, Blakaj D, Eroglu Z, Verschraegen C, Thapa R, Mills M, Dibs K, Liveringhouse C, Russell J, Caudell JJ, Tarhini A, Markowitz J, Kendra K, Wu R, Chen DT, Berglund A, Michael L, Aoki M, Wang MH, Hamaidi I, Cheng P, de la Iglesia J, Slebos RJ, Chung CH, Knepper TC, Moran-Segura CM, Nguyen JV, Perez BA, Rose T, Harrison L, Messina JL, Sondak VK, Tsai KY, Khushalani NI, Brohl AS
Lancet 2022 Sep 24;400(10357):1008-1019. Epub 2022 Sep 12 doi: 10.1016/S0140-6736(22)01659-2. PMID: 36108657Free PMC Article
Clinical and molecular characteristics associated with response to therapeutic PD-1/PD-L1 inhibition in advanced Merkel cell carcinoma.
Spassova I, Ugurel S, Kubat L, Zimmer L, Terheyden P, Mohr A, Björn Andtback H, Villabona L, Leiter U, Eigentler T, Loquai C, Hassel JC, Gambichler T, Haferkamp S, Mohr P, Pfoehler C, Heinzerling L, Gutzmer R, Utikal JS, Horny K, Schildhaus HU, Habermann D, Hoffmann D, Schadendorf D, Becker JC
J Immunother Cancer 2022 Jan;10(1) doi: 10.1136/jitc-2021-003198. PMID: 35074902Free PMC Article
Cutaneous Malignancies of the Head and Neck.
In GK, Thomas JS, Silk AW
Hematol Oncol Clin North Am 2021 Oct;35(5):991-1008. Epub 2021 Jul 16 doi: 10.1016/j.hoc.2021.05.008. PMID: 34281755
Diagnosis and treatment of Merkel Cell Carcinoma. European consensus-based interdisciplinary guideline.
Lebbe C, Becker JC, Grob JJ, Malvehy J, Del Marmol V, Pehamberger H, Peris K, Saiag P, Middleton MR, Bastholt L, Testori A, Stratigos A, Garbe C; European Dermatology Forum (EDF), the European Association of Dermato-Oncology (EADO) and the European Organization for Research and Treatment of Cancer (EORTC)
Eur J Cancer 2015 Nov;51(16):2396-403. Epub 2015 Aug 6 doi: 10.1016/j.ejca.2015.06.131. PMID: 26257075
Merkel cell carcinoma of the head and neck.
Suárez C, Rodrigo JP, Ferlito A, Devaney KO, Rinaldo A
Oral Oncol 2004 Sep;40(8):773-9. doi: 10.1016/j.oraloncology.2003.11.005. PMID: 15288830

Diagnosis

Surgery in the Era of Immunotherapy for Advanced Head and Neck Non-melanoma Skin Cancer.
Lin A, Schmalbach CE
Curr Oncol Rep 2023 Jul;25(7):735-742. Epub 2023 Apr 3 doi: 10.1007/s11912-023-01391-8. PMID: 37010785
Cutaneous Malignancies of the Head and Neck.
In GK, Thomas JS, Silk AW
Hematol Oncol Clin North Am 2021 Oct;35(5):991-1008. Epub 2021 Jul 16 doi: 10.1016/j.hoc.2021.05.008. PMID: 34281755
Merkel Cell Carcinoma - Current Controversies and Future Directions.
Steven N, Lawton P, Poulsen M
Clin Oncol (R Coll Radiol) 2019 Nov;31(11):789-796. doi: 10.1016/j.clon.2019.08.012. PMID: 31594644
Diagnosis and treatment of Merkel Cell Carcinoma. European consensus-based interdisciplinary guideline.
Lebbe C, Becker JC, Grob JJ, Malvehy J, Del Marmol V, Pehamberger H, Peris K, Saiag P, Middleton MR, Bastholt L, Testori A, Stratigos A, Garbe C; European Dermatology Forum (EDF), the European Association of Dermato-Oncology (EADO) and the European Organization for Research and Treatment of Cancer (EORTC)
Eur J Cancer 2015 Nov;51(16):2396-403. Epub 2015 Aug 6 doi: 10.1016/j.ejca.2015.06.131. PMID: 26257075
Merkel cell carcinoma of the head and neck.
Suárez C, Rodrigo JP, Ferlito A, Devaney KO, Rinaldo A
Oral Oncol 2004 Sep;40(8):773-9. doi: 10.1016/j.oraloncology.2003.11.005. PMID: 15288830

Therapy

Therapeutic Cancer Vaccines for Nonmelanoma Skin Cancer.
Wu SE, Chen YH, Hung CT, Yang BH
Curr Treat Options Oncol 2023 May;24(5):496-514. Epub 2023 Mar 28 doi: 10.1007/s11864-023-01074-3. PMID: 36976454
Combined nivolumab and ipilimumab with or without stereotactic body radiation therapy for advanced Merkel cell carcinoma: a randomised, open label, phase 2 trial.
Kim S, Wuthrick E, Blakaj D, Eroglu Z, Verschraegen C, Thapa R, Mills M, Dibs K, Liveringhouse C, Russell J, Caudell JJ, Tarhini A, Markowitz J, Kendra K, Wu R, Chen DT, Berglund A, Michael L, Aoki M, Wang MH, Hamaidi I, Cheng P, de la Iglesia J, Slebos RJ, Chung CH, Knepper TC, Moran-Segura CM, Nguyen JV, Perez BA, Rose T, Harrison L, Messina JL, Sondak VK, Tsai KY, Khushalani NI, Brohl AS
Lancet 2022 Sep 24;400(10357):1008-1019. Epub 2022 Sep 12 doi: 10.1016/S0140-6736(22)01659-2. PMID: 36108657Free PMC Article
Immunotherapy for Merkel cell carcinoma.
Angeles CV, Sabel MS
J Surg Oncol 2021 Mar;123(3):775-781. doi: 10.1002/jso.26319. PMID: 33595894
The Landmark Series: Non-melanoma Skin Cancers.
Lee AY, Berman RS
Ann Surg Oncol 2020 Jan;27(1):22-27. Epub 2019 Sep 23 doi: 10.1245/s10434-019-07831-9. PMID: 31549317
Diagnosis and treatment of Merkel Cell Carcinoma. European consensus-based interdisciplinary guideline.
Lebbe C, Becker JC, Grob JJ, Malvehy J, Del Marmol V, Pehamberger H, Peris K, Saiag P, Middleton MR, Bastholt L, Testori A, Stratigos A, Garbe C; European Dermatology Forum (EDF), the European Association of Dermato-Oncology (EADO) and the European Organization for Research and Treatment of Cancer (EORTC)
Eur J Cancer 2015 Nov;51(16):2396-403. Epub 2015 Aug 6 doi: 10.1016/j.ejca.2015.06.131. PMID: 26257075

Prognosis

Clinical and molecular characteristics associated with response to therapeutic PD-1/PD-L1 inhibition in advanced Merkel cell carcinoma.
Spassova I, Ugurel S, Kubat L, Zimmer L, Terheyden P, Mohr A, Björn Andtback H, Villabona L, Leiter U, Eigentler T, Loquai C, Hassel JC, Gambichler T, Haferkamp S, Mohr P, Pfoehler C, Heinzerling L, Gutzmer R, Utikal JS, Horny K, Schildhaus HU, Habermann D, Hoffmann D, Schadendorf D, Becker JC
J Immunother Cancer 2022 Jan;10(1) doi: 10.1136/jitc-2021-003198. PMID: 35074902Free PMC Article
The Role of Anti-PD-1/PD-L1 in the Treatment of Skin Cancer.
Patrinely JR Jr, Dewan AK, Johnson DB
BioDrugs 2020 Aug;34(4):495-503. doi: 10.1007/s40259-020-00428-9. PMID: 32447657Free PMC Article
Merkel Cell Carcinoma - Current Controversies and Future Directions.
Steven N, Lawton P, Poulsen M
Clin Oncol (R Coll Radiol) 2019 Nov;31(11):789-796. doi: 10.1016/j.clon.2019.08.012. PMID: 31594644
Diagnosis and treatment of Merkel Cell Carcinoma. European consensus-based interdisciplinary guideline.
Lebbe C, Becker JC, Grob JJ, Malvehy J, Del Marmol V, Pehamberger H, Peris K, Saiag P, Middleton MR, Bastholt L, Testori A, Stratigos A, Garbe C; European Dermatology Forum (EDF), the European Association of Dermato-Oncology (EADO) and the European Organization for Research and Treatment of Cancer (EORTC)
Eur J Cancer 2015 Nov;51(16):2396-403. Epub 2015 Aug 6 doi: 10.1016/j.ejca.2015.06.131. PMID: 26257075
Merkel cell carcinoma of the head and neck.
Suárez C, Rodrigo JP, Ferlito A, Devaney KO, Rinaldo A
Oral Oncol 2004 Sep;40(8):773-9. doi: 10.1016/j.oraloncology.2003.11.005. PMID: 15288830

Clinical prediction guides

Combined nivolumab and ipilimumab with or without stereotactic body radiation therapy for advanced Merkel cell carcinoma: a randomised, open label, phase 2 trial.
Kim S, Wuthrick E, Blakaj D, Eroglu Z, Verschraegen C, Thapa R, Mills M, Dibs K, Liveringhouse C, Russell J, Caudell JJ, Tarhini A, Markowitz J, Kendra K, Wu R, Chen DT, Berglund A, Michael L, Aoki M, Wang MH, Hamaidi I, Cheng P, de la Iglesia J, Slebos RJ, Chung CH, Knepper TC, Moran-Segura CM, Nguyen JV, Perez BA, Rose T, Harrison L, Messina JL, Sondak VK, Tsai KY, Khushalani NI, Brohl AS
Lancet 2022 Sep 24;400(10357):1008-1019. Epub 2022 Sep 12 doi: 10.1016/S0140-6736(22)01659-2. PMID: 36108657Free PMC Article
The Role of Anti-PD-1/PD-L1 in the Treatment of Skin Cancer.
Patrinely JR Jr, Dewan AK, Johnson DB
BioDrugs 2020 Aug;34(4):495-503. doi: 10.1007/s40259-020-00428-9. PMID: 32447657Free PMC Article
Merkel Cell Carcinoma - Current Controversies and Future Directions.
Steven N, Lawton P, Poulsen M
Clin Oncol (R Coll Radiol) 2019 Nov;31(11):789-796. doi: 10.1016/j.clon.2019.08.012. PMID: 31594644
Diagnosis and treatment of Merkel Cell Carcinoma. European consensus-based interdisciplinary guideline.
Lebbe C, Becker JC, Grob JJ, Malvehy J, Del Marmol V, Pehamberger H, Peris K, Saiag P, Middleton MR, Bastholt L, Testori A, Stratigos A, Garbe C; European Dermatology Forum (EDF), the European Association of Dermato-Oncology (EADO) and the European Organization for Research and Treatment of Cancer (EORTC)
Eur J Cancer 2015 Nov;51(16):2396-403. Epub 2015 Aug 6 doi: 10.1016/j.ejca.2015.06.131. PMID: 26257075
Merkel cell carcinoma of the head and neck.
Suárez C, Rodrigo JP, Ferlito A, Devaney KO, Rinaldo A
Oral Oncol 2004 Sep;40(8):773-9. doi: 10.1016/j.oraloncology.2003.11.005. PMID: 15288830

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