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Unresectable Merkel Cell Carcinoma

MedGen UID:
1701414
Concept ID:
C5206823
Neoplastic Process

Definition

Merkel cell carcinoma that is not amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUnresectable Merkel Cell Carcinoma

Professional guidelines

PubMed

Padilla-España L, Toledo-Pastrana T, Fernández-Orland A, Ferrándiz-Pulido L
Actas Dermosifiliogr (Engl Ed) 2019 Oct;110(8):687-688. Epub 2018 Aug 17 doi: 10.1016/j.ad.2018.07.007. PMID: 30126606

Recent clinical studies

Etiology

Kim S, Wuthrick E, Blakaj D, Eroglu Z, Verschraegen C, Thapa R, Mills M, Dibs K, Liveringhouse C, Russell J, Caudell JJ, Tarhini A, Markowitz J, Kendra K, Wu R, Chen DT, Berglund A, Michael L, Aoki M, Wang MH, Hamaidi I, Cheng P, de la Iglesia J, Slebos RJ, Chung CH, Knepper TC, Moran-Segura CM, Nguyen JV, Perez BA, Rose T, Harrison L, Messina JL, Sondak VK, Tsai KY, Khushalani NI, Brohl AS
Lancet 2022 Sep 24;400(10357):1008-1019. Epub 2022 Sep 12 doi: 10.1016/S0140-6736(22)01659-2. PMID: 36108657Free PMC Article
Spassova I, Ugurel S, Kubat L, Zimmer L, Terheyden P, Mohr A, Björn Andtback H, Villabona L, Leiter U, Eigentler T, Loquai C, Hassel JC, Gambichler T, Haferkamp S, Mohr P, Pfoehler C, Heinzerling L, Gutzmer R, Utikal JS, Horny K, Schildhaus HU, Habermann D, Hoffmann D, Schadendorf D, Becker JC
J Immunother Cancer 2022 Jan;10(1) doi: 10.1136/jitc-2021-003198. PMID: 35074902Free PMC Article
In GK, Thomas JS, Silk AW
Hematol Oncol Clin North Am 2021 Oct;35(5):991-1008. Epub 2021 Jul 16 doi: 10.1016/j.hoc.2021.05.008. PMID: 34281755
Lebbe C, Becker JC, Grob JJ, Malvehy J, Del Marmol V, Pehamberger H, Peris K, Saiag P, Middleton MR, Bastholt L, Testori A, Stratigos A, Garbe C; European Dermatology Forum (EDF), the European Association of Dermato-Oncology (EADO) and the European Organization for Research and Treatment of Cancer (EORTC)
Eur J Cancer 2015 Nov;51(16):2396-403. Epub 2015 Aug 6 doi: 10.1016/j.ejca.2015.06.131. PMID: 26257075
Suárez C, Rodrigo JP, Ferlito A, Devaney KO, Rinaldo A
Oral Oncol 2004 Sep;40(8):773-9. doi: 10.1016/j.oraloncology.2003.11.005. PMID: 15288830

Diagnosis

In GK, Thomas JS, Silk AW
Hematol Oncol Clin North Am 2021 Oct;35(5):991-1008. Epub 2021 Jul 16 doi: 10.1016/j.hoc.2021.05.008. PMID: 34281755
Steven N, Lawton P, Poulsen M
Clin Oncol (R Coll Radiol) 2019 Nov;31(11):789-796. doi: 10.1016/j.clon.2019.08.012. PMID: 31594644
Bichakjian CK, Olencki T, Aasi SZ, Alam M, Andersen JS, Blitzblau R, Bowen GM, Contreras CM, Daniels GA, Decker R, Farma JM, Fisher K, Gastman B, Ghosh K, Grekin RC, Grossman K, Ho AL, Lewis KD, Loss M, Lydiatt DD, Messina J, Nehal KS, Nghiem P, Puzanov I, Schmults CD, Shaha AR, Thomas V, Xu YG, Zic JA, Hoffmann KG, Engh AM
J Natl Compr Canc Netw 2018 Jun;16(6):742-774. doi: 10.6004/jnccn.2018.0055. PMID: 29891526Free PMC Article
Lebbe C, Becker JC, Grob JJ, Malvehy J, Del Marmol V, Pehamberger H, Peris K, Saiag P, Middleton MR, Bastholt L, Testori A, Stratigos A, Garbe C; European Dermatology Forum (EDF), the European Association of Dermato-Oncology (EADO) and the European Organization for Research and Treatment of Cancer (EORTC)
Eur J Cancer 2015 Nov;51(16):2396-403. Epub 2015 Aug 6 doi: 10.1016/j.ejca.2015.06.131. PMID: 26257075
Suárez C, Rodrigo JP, Ferlito A, Devaney KO, Rinaldo A
Oral Oncol 2004 Sep;40(8):773-9. doi: 10.1016/j.oraloncology.2003.11.005. PMID: 15288830

Therapy

Kim S, Wuthrick E, Blakaj D, Eroglu Z, Verschraegen C, Thapa R, Mills M, Dibs K, Liveringhouse C, Russell J, Caudell JJ, Tarhini A, Markowitz J, Kendra K, Wu R, Chen DT, Berglund A, Michael L, Aoki M, Wang MH, Hamaidi I, Cheng P, de la Iglesia J, Slebos RJ, Chung CH, Knepper TC, Moran-Segura CM, Nguyen JV, Perez BA, Rose T, Harrison L, Messina JL, Sondak VK, Tsai KY, Khushalani NI, Brohl AS
Lancet 2022 Sep 24;400(10357):1008-1019. Epub 2022 Sep 12 doi: 10.1016/S0140-6736(22)01659-2. PMID: 36108657Free PMC Article
Angeles CV, Sabel MS
J Surg Oncol 2021 Mar;123(3):775-781. doi: 10.1002/jso.26319. PMID: 33595894
Lee AY, Berman RS
Ann Surg Oncol 2020 Jan;27(1):22-27. Epub 2019 Sep 23 doi: 10.1245/s10434-019-07831-9. PMID: 31549317
Lebbe C, Becker JC, Grob JJ, Malvehy J, Del Marmol V, Pehamberger H, Peris K, Saiag P, Middleton MR, Bastholt L, Testori A, Stratigos A, Garbe C; European Dermatology Forum (EDF), the European Association of Dermato-Oncology (EADO) and the European Organization for Research and Treatment of Cancer (EORTC)
Eur J Cancer 2015 Nov;51(16):2396-403. Epub 2015 Aug 6 doi: 10.1016/j.ejca.2015.06.131. PMID: 26257075
Feun LG, Savaraj N, Legha SS, Silva EG, Benjamin RS, Burgess MA
Cancer 1988 Aug 15;62(4):683-5. doi: 10.1002/1097-0142(19880815)62:4<683::aid-cncr2820620406>3.0.co;2-j. PMID: 3293760

Prognosis

Patrinely JR Jr, Dewan AK, Johnson DB
BioDrugs 2020 Aug;34(4):495-503. doi: 10.1007/s40259-020-00428-9. PMID: 32447657Free PMC Article
Steven N, Lawton P, Poulsen M
Clin Oncol (R Coll Radiol) 2019 Nov;31(11):789-796. doi: 10.1016/j.clon.2019.08.012. PMID: 31594644
Lebbe C, Becker JC, Grob JJ, Malvehy J, Del Marmol V, Pehamberger H, Peris K, Saiag P, Middleton MR, Bastholt L, Testori A, Stratigos A, Garbe C; European Dermatology Forum (EDF), the European Association of Dermato-Oncology (EADO) and the European Organization for Research and Treatment of Cancer (EORTC)
Eur J Cancer 2015 Nov;51(16):2396-403. Epub 2015 Aug 6 doi: 10.1016/j.ejca.2015.06.131. PMID: 26257075
Suárez C, Rodrigo JP, Ferlito A, Devaney KO, Rinaldo A
Oral Oncol 2004 Sep;40(8):773-9. doi: 10.1016/j.oraloncology.2003.11.005. PMID: 15288830
Feun LG, Savaraj N, Legha SS, Silva EG, Benjamin RS, Burgess MA
Cancer 1988 Aug 15;62(4):683-5. doi: 10.1002/1097-0142(19880815)62:4<683::aid-cncr2820620406>3.0.co;2-j. PMID: 3293760

Clinical prediction guides

Kim S, Wuthrick E, Blakaj D, Eroglu Z, Verschraegen C, Thapa R, Mills M, Dibs K, Liveringhouse C, Russell J, Caudell JJ, Tarhini A, Markowitz J, Kendra K, Wu R, Chen DT, Berglund A, Michael L, Aoki M, Wang MH, Hamaidi I, Cheng P, de la Iglesia J, Slebos RJ, Chung CH, Knepper TC, Moran-Segura CM, Nguyen JV, Perez BA, Rose T, Harrison L, Messina JL, Sondak VK, Tsai KY, Khushalani NI, Brohl AS
Lancet 2022 Sep 24;400(10357):1008-1019. Epub 2022 Sep 12 doi: 10.1016/S0140-6736(22)01659-2. PMID: 36108657Free PMC Article
Spassova I, Ugurel S, Kubat L, Zimmer L, Terheyden P, Mohr A, Björn Andtback H, Villabona L, Leiter U, Eigentler T, Loquai C, Hassel JC, Gambichler T, Haferkamp S, Mohr P, Pfoehler C, Heinzerling L, Gutzmer R, Utikal JS, Horny K, Schildhaus HU, Habermann D, Hoffmann D, Schadendorf D, Becker JC
J Immunother Cancer 2022 Jan;10(1) doi: 10.1136/jitc-2021-003198. PMID: 35074902Free PMC Article
Steven N, Lawton P, Poulsen M
Clin Oncol (R Coll Radiol) 2019 Nov;31(11):789-796. doi: 10.1016/j.clon.2019.08.012. PMID: 31594644
Lebbe C, Becker JC, Grob JJ, Malvehy J, Del Marmol V, Pehamberger H, Peris K, Saiag P, Middleton MR, Bastholt L, Testori A, Stratigos A, Garbe C; European Dermatology Forum (EDF), the European Association of Dermato-Oncology (EADO) and the European Organization for Research and Treatment of Cancer (EORTC)
Eur J Cancer 2015 Nov;51(16):2396-403. Epub 2015 Aug 6 doi: 10.1016/j.ejca.2015.06.131. PMID: 26257075
Suárez C, Rodrigo JP, Ferlito A, Devaney KO, Rinaldo A
Oral Oncol 2004 Sep;40(8):773-9. doi: 10.1016/j.oraloncology.2003.11.005. PMID: 15288830

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