U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Acute Bilineal Leukemia in Remission

MedGen UID:
1701683
•Concept ID:
C5204276
•
Neoplastic Process

Definition

A finding of acute bilineal leukemia that is not growing and responds to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcute Bilineal Leukemia in Remission

Professional guidelines

PubMed

International cooperative study identifies treatment strategy in childhood ambiguous lineage leukemia.
Hrusak O, de Haas V, Stancikova J, Vakrmanova B, Janotova I, Mejstrikova E, Capek V, Trka J, Zaliova M, Luks A, Bleckmann K, Möricke A, Irving J, Konatkowska B, Alexander TB, Inaba H, Schmiegelow K, Stokley S, Zemanova Z, Moorman AV, Rossi JG, Felice MS, Dalla-Pozza L, Morales J, Dworzak M, Buldini B, Basso G, Campbell M, Cabrera ME, Marinov N, Elitzur S, Izraeli S, Luria D, Feuerstein T, Kolenova A, Svec P, Kreminska O, Rabin KR, Polychronopoulou S, da Costa E, Marquart HV, Kattamis A, Ratei R, Reinhardt D, Choi JK, Schrappe M, Stary J
Blood 2018 Jul 19;132(3):264-276. Epub 2018 May 2 doi: 10.1182/blood-2017-12-821363. PMID: 29720486

Recent clinical studies

Etiology

Hybrid chemotherapy regimen (FLAG-IDA-vincristine-prednisone) for acute leukemia with mixed-phenotype blasts.
Reid JH, Perissinotti AJ, Benitez LL, Boyer D, Lee W, Burke PW, Pettit K, Bixby DL, Marini BL
Leuk Res 2021 Apr;103:106539. Epub 2021 Feb 19 doi: 10.1016/j.leukres.2021.106539. PMID: 33647818
International cooperative study identifies treatment strategy in childhood ambiguous lineage leukemia.
Hrusak O, de Haas V, Stancikova J, Vakrmanova B, Janotova I, Mejstrikova E, Capek V, Trka J, Zaliova M, Luks A, Bleckmann K, Möricke A, Irving J, Konatkowska B, Alexander TB, Inaba H, Schmiegelow K, Stokley S, Zemanova Z, Moorman AV, Rossi JG, Felice MS, Dalla-Pozza L, Morales J, Dworzak M, Buldini B, Basso G, Campbell M, Cabrera ME, Marinov N, Elitzur S, Izraeli S, Luria D, Feuerstein T, Kolenova A, Svec P, Kreminska O, Rabin KR, Polychronopoulou S, da Costa E, Marquart HV, Kattamis A, Ratei R, Reinhardt D, Choi JK, Schrappe M, Stary J
Blood 2018 Jul 19;132(3):264-276. Epub 2018 May 2 doi: 10.1182/blood-2017-12-821363. PMID: 29720486
Acute leukaemias of ambiguous lineage in children: characterization, prognosis and therapy recommendations.
Gerr H, Zimmermann M, Schrappe M, Dworzak M, Ludwig WD, Bradtke J, Moericke A, Schabath R, Creutzig U, Reinhardt D
Br J Haematol 2010 Apr;149(1):84-92. Epub 2010 Jan 18 doi: 10.1111/j.1365-2141.2009.08058.x. PMID: 20085575
Transformation of bilineal hybrid acute leukemia to acute lymphoid leukemia: a case report with serial analyses of cytogenetics and gene rearrangement.
Jinnai I, Kusumoto S, Shiomi Z, Bessho M, Saitoh M, Hirashima K, Minamihisamatsu M, Kamiyama T, Takase K
Am J Hematol 1990 Oct;35(2):118-24. doi: 10.1002/ajh.2830350211. PMID: 2169190

Diagnosis

Successful treatment of a child with T/myeloid acute bilineal leukemia associated with TLX3/BCL11B fusion and 9q deletion.
Oliveira JL, Kumar R, Khan SP, Law ME, Erickson-Johnson M, Oliveira AM, Ketterling RP, Dogan A
Pediatr Blood Cancer 2011 Mar;56(3):467-9. Epub 2010 Nov 11 doi: 10.1002/pbc.22850. PMID: 21225930
8p11 myeloproliferative syndrome: a review.
Jackson CC, Medeiros LJ, Miranda RN
Hum Pathol 2010 Apr;41(4):461-76. doi: 10.1016/j.humpath.2009.11.003. PMID: 20226962
Acute leukaemias of ambiguous lineage in children: characterization, prognosis and therapy recommendations.
Gerr H, Zimmermann M, Schrappe M, Dworzak M, Ludwig WD, Bradtke J, Moericke A, Schabath R, Creutzig U, Reinhardt D
Br J Haematol 2010 Apr;149(1):84-92. Epub 2010 Jan 18 doi: 10.1111/j.1365-2141.2009.08058.x. PMID: 20085575
Acute bilineal leukemia: a rare disease with poor outcome.
Weir EG, Ali Ansari-Lari M, Batista DA, Griffin CA, Fuller S, Smith BD, Borowitz MJ
Leukemia 2007 Nov;21(11):2264-70. Epub 2007 Jul 5 doi: 10.1038/sj.leu.2404848. PMID: 17611554
Bilineal acute leukemia of B and T lineage with a novel translocation t(9;17)(p11;q11).
Zomas AP, Swansbury GJ, Matutes E, Pinkerton R, Hiorns LR, Min T, Farahat N, Catovsky D
Leuk Lymphoma 1997 Mar;25(1-2):179-85. doi: 10.3109/10428199709042508. PMID: 9130626

Therapy

Hybrid chemotherapy regimen (FLAG-IDA-vincristine-prednisone) for acute leukemia with mixed-phenotype blasts.
Reid JH, Perissinotti AJ, Benitez LL, Boyer D, Lee W, Burke PW, Pettit K, Bixby DL, Marini BL
Leuk Res 2021 Apr;103:106539. Epub 2021 Feb 19 doi: 10.1016/j.leukres.2021.106539. PMID: 33647818
Importance of Acute Lymphoblastic Leukemia-type Therapy for Bilineal Acute Leukemia.
Nakagawa S, Okamoto Y, Kodama Y, Nishikawa T, Tanabe T, Kawano Y
J Pediatr Hematol Oncol 2019 Aug;41(6):504-506. doi: 10.1097/MPH.0000000000001309. PMID: 30198961
Successful treatment of a child with T/myeloid acute bilineal leukemia associated with TLX3/BCL11B fusion and 9q deletion.
Oliveira JL, Kumar R, Khan SP, Law ME, Erickson-Johnson M, Oliveira AM, Ketterling RP, Dogan A
Pediatr Blood Cancer 2011 Mar;56(3):467-9. Epub 2010 Nov 11 doi: 10.1002/pbc.22850. PMID: 21225930
Acute leukaemias of ambiguous lineage in children: characterization, prognosis and therapy recommendations.
Gerr H, Zimmermann M, Schrappe M, Dworzak M, Ludwig WD, Bradtke J, Moericke A, Schabath R, Creutzig U, Reinhardt D
Br J Haematol 2010 Apr;149(1):84-92. Epub 2010 Jan 18 doi: 10.1111/j.1365-2141.2009.08058.x. PMID: 20085575

Prognosis

Hybrid chemotherapy regimen (FLAG-IDA-vincristine-prednisone) for acute leukemia with mixed-phenotype blasts.
Reid JH, Perissinotti AJ, Benitez LL, Boyer D, Lee W, Burke PW, Pettit K, Bixby DL, Marini BL
Leuk Res 2021 Apr;103:106539. Epub 2021 Feb 19 doi: 10.1016/j.leukres.2021.106539. PMID: 33647818
Importance of Acute Lymphoblastic Leukemia-type Therapy for Bilineal Acute Leukemia.
Nakagawa S, Okamoto Y, Kodama Y, Nishikawa T, Tanabe T, Kawano Y
J Pediatr Hematol Oncol 2019 Aug;41(6):504-506. doi: 10.1097/MPH.0000000000001309. PMID: 30198961
8p11 myeloproliferative syndrome: a review.
Jackson CC, Medeiros LJ, Miranda RN
Hum Pathol 2010 Apr;41(4):461-76. doi: 10.1016/j.humpath.2009.11.003. PMID: 20226962
Acute leukaemias of ambiguous lineage in children: characterization, prognosis and therapy recommendations.
Gerr H, Zimmermann M, Schrappe M, Dworzak M, Ludwig WD, Bradtke J, Moericke A, Schabath R, Creutzig U, Reinhardt D
Br J Haematol 2010 Apr;149(1):84-92. Epub 2010 Jan 18 doi: 10.1111/j.1365-2141.2009.08058.x. PMID: 20085575
Bilineal acute leukemia of B and T lineage with a novel translocation t(9;17)(p11;q11).
Zomas AP, Swansbury GJ, Matutes E, Pinkerton R, Hiorns LR, Min T, Farahat N, Catovsky D
Leuk Lymphoma 1997 Mar;25(1-2):179-85. doi: 10.3109/10428199709042508. PMID: 9130626

Clinical prediction guides

Mixed Phenotype Acute Leukemia, B/Myeloid (Bilineal and Biphenotypic), With t(2;22)(q35;q12);EWSR1-FEV.
Montgomery-Goecker C, Koduru P, Botten G, Xu J, Ghisoli M, Goldman SC, Krueger J, Bhushan V, Fuda F, Chen W
J Pediatr Hematol Oncol 2021 Apr 1;43(3):e388-e394. doi: 10.1097/MPH.0000000000001934. PMID: 32925408

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...