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Infectious posterior uveitis

MedGen UID:
1701702
Concept ID:
C5230265
Disease or Syndrome
Synonyms: infectious posterior uveitis; Posterior uveitis due to infectious disease
SNOMED CT: Infectious posterior uveitis (789008006); Posterior uveitis due to infectious disease (789008006)
 
Monarch Initiative: MONDO:0017209
Orphanet: ORPHA279919

Definition

A rare ophthalmic disorder characterized by inflammation of the posterior uveal tract (retina and choroid), due to an infectious etiology. Presenting symptoms are decreased visual acuity, visual field defects, floaters, photopsia, photophobia, and occasionally pain. Signs on examination include conjunctival injection, keratic precipitates, retrolental cells, inflammatory infiltrates on the retina, macular edema, and peripheral retinal neovascularization, among others. Complications (such as cataracts, band keratopathy, glaucoma, cystoid macula edema, and retinal detachment) may lead to permanent vision loss. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVInfectious posterior uveitis

Professional guidelines

PubMed

Papasavvas I, Herbort CP Jr
Medicina (Kaunas) 2022 Jan 21;58(2) doi: 10.3390/medicina58020165. PMID: 35208488Free PMC Article
Standardization of Uveitis Nomenclature (SUN) Working Group
Am J Ophthalmol 2021 Aug;228:142-151. Epub 2021 May 11 doi: 10.1016/j.ajo.2021.03.040. PMID: 33845014Free PMC Article
Singh RB, Sinha S, Saini C, Elbasiony E, Thakur S, Agarwal A
Int Ophthalmol 2020 Nov;40(11):3187-3207. Epub 2020 Jul 2 doi: 10.1007/s10792-020-01496-0. PMID: 32617804

Recent clinical studies

Etiology

Reddy A, Liu SH, Brady CJ, Sieving PC, Palestine AG
Cochrane Database Syst Rev 2023 Aug 29;8(8):CD010469. doi: 10.1002/14651858.CD010469.pub4. PMID: 37642198Free PMC Article
Reddy A, Liu SH, Brady CJ, Sieving PC, Palestine AG
Cochrane Database Syst Rev 2023 Jan 16;1(1):CD010469. doi: 10.1002/14651858.CD010469.pub3. PMID: 36645716Free PMC Article
Hermann L, Falcão-Reis F, Figueira L
Semin Ophthalmol 2021 Feb 17;36(1-2):51-57. doi: 10.1080/08820538.2021.1885721. PMID: 33593242
Waizel M, Todorova MG, Terrada C, LeHoang P, Massamba N, Bodaghi B
Graefes Arch Clin Exp Ophthalmol 2018 Oct;256(10):1977-1984. Epub 2018 Jul 6 doi: 10.1007/s00417-018-4057-y. PMID: 29980918
Garweg JG
Klin Monbl Augenheilkd 2016 Apr;233(4):534-9. Epub 2016 Apr 26 doi: 10.1055/s-0041-111821. PMID: 27116531

Diagnosis

Curi ALL, de-la-Torre A, Schlaen A, Mahendradas P, Biswas J
Ocul Immunol Inflamm 2023 Dec;31(10):1944-1954. Epub 2023 Dec 14 doi: 10.1080/09273948.2023.2284990. PMID: 38096404
Pichi F, Curi ALL, Vasconcelos-Santos DV, Marchese A, Cicinelli MV, Miserocchi E, Schlaen A
Ocul Immunol Inflamm 2022 Apr 3;30(3):652-663. Epub 2022 Feb 28 doi: 10.1080/09273948.2022.2032197. PMID: 35226572
Agarwal A, Mahajan S, Khairallah M, Mahendradas P, Gupta A, Gupta V
Ocul Immunol Inflamm 2017 Feb;25(1):134-145. Epub 2016 Oct 11 doi: 10.1080/09273948.2016.1231332. PMID: 27726520
Garweg JG
Klin Monbl Augenheilkd 2016 Apr;233(4):534-9. Epub 2016 Apr 26 doi: 10.1055/s-0041-111821. PMID: 27116531
Dhoot DS, Martin DF, Srivastava SK
Int Ophthalmol Clin 2011 Winter;51(1):113-28. doi: 10.1097/IIO.0b013e318200e0ed. PMID: 21139480

Therapy

Reddy A, Liu SH, Brady CJ, Sieving PC, Palestine AG
Cochrane Database Syst Rev 2023 Jan 16;1(1):CD010469. doi: 10.1002/14651858.CD010469.pub3. PMID: 36645716Free PMC Article
Singh RB, Sinha S, Saini C, Elbasiony E, Thakur S, Agarwal A
Int Ophthalmol 2020 Nov;40(11):3187-3207. Epub 2020 Jul 2 doi: 10.1007/s10792-020-01496-0. PMID: 32617804
Agarwal A, Mahajan S, Khairallah M, Mahendradas P, Gupta A, Gupta V
Ocul Immunol Inflamm 2017 Feb;25(1):134-145. Epub 2016 Oct 11 doi: 10.1080/09273948.2016.1231332. PMID: 27726520
Garweg JG
Klin Monbl Augenheilkd 2016 Apr;233(4):534-9. Epub 2016 Apr 26 doi: 10.1055/s-0041-111821. PMID: 27116531
Dhoot DS, Martin DF, Srivastava SK
Int Ophthalmol Clin 2011 Winter;51(1):113-28. doi: 10.1097/IIO.0b013e318200e0ed. PMID: 21139480

Prognosis

Hermann L, Falcão-Reis F, Figueira L
Semin Ophthalmol 2021 Feb 17;36(1-2):51-57. doi: 10.1080/08820538.2021.1885721. PMID: 33593242
Elyashiv SM, Samson CM, Jabs DA
Retina 2020 Mar;40(3):567-571. doi: 10.1097/IAE.0000000000002423. PMID: 30601389
Waizel M, Todorova MG, Terrada C, LeHoang P, Massamba N, Bodaghi B
Graefes Arch Clin Exp Ophthalmol 2018 Oct;256(10):1977-1984. Epub 2018 Jul 6 doi: 10.1007/s00417-018-4057-y. PMID: 29980918
Maenz M, Schlüter D, Liesenfeld O, Schares G, Gross U, Pleyer U
Prog Retin Eye Res 2014 Mar;39:77-106. Epub 2014 Jan 9 doi: 10.1016/j.preteyeres.2013.12.005. PMID: 24412517
Dhoot DS, Martin DF, Srivastava SK
Int Ophthalmol Clin 2011 Winter;51(1):113-28. doi: 10.1097/IIO.0b013e318200e0ed. PMID: 21139480

Clinical prediction guides

Melo LA, Paiva MRB, Fernandes-Cunha GM, Silva-Cunha A, Mol MPG, Fialho SL
Rev Soc Bras Med Trop 2023;56:e05522022. Epub 2023 May 22 doi: 10.1590/0037-8682-0552-2022. PMID: 37222350Free PMC Article
Papasavvas I, Herbort CP Jr
Medicina (Kaunas) 2022 Jan 21;58(2) doi: 10.3390/medicina58020165. PMID: 35208488Free PMC Article
Hermann L, Falcão-Reis F, Figueira L
Semin Ophthalmol 2021 Feb 17;36(1-2):51-57. doi: 10.1080/08820538.2021.1885721. PMID: 33593242
Singh A, Behera UC, Agrawal H
Eur J Ophthalmol 2021 Mar;31(2):NP109-NP111. Epub 2019 Jul 8 doi: 10.1177/1120672119858899. PMID: 31282202
Elyashiv SM, Samson CM, Jabs DA
Retina 2020 Mar;40(3):567-571. doi: 10.1097/IAE.0000000000002423. PMID: 30601389

Recent systematic reviews

Reddy A, Liu SH, Brady CJ, Sieving PC, Palestine AG
Cochrane Database Syst Rev 2023 Aug 29;8(8):CD010469. doi: 10.1002/14651858.CD010469.pub4. PMID: 37642198Free PMC Article
Melo LA, Paiva MRB, Fernandes-Cunha GM, Silva-Cunha A, Mol MPG, Fialho SL
Rev Soc Bras Med Trop 2023;56:e05522022. Epub 2023 May 22 doi: 10.1590/0037-8682-0552-2022. PMID: 37222350Free PMC Article
Reddy A, Liu SH, Brady CJ, Sieving PC, Palestine AG
Cochrane Database Syst Rev 2023 Jan 16;1(1):CD010469. doi: 10.1002/14651858.CD010469.pub3. PMID: 36645716Free PMC Article
Brady CJ, Villanti AC, Law HA, Rahimy E, Reddy R, Sieving PC, Garg SJ, Tang J
Cochrane Database Syst Rev 2016 Feb 12;2(2):CD010469. doi: 10.1002/14651858.CD010469.pub2. PMID: 26866343Free PMC Article

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