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Blastic Granulocytic Sarcoma

MedGen UID:
1701757
•Concept ID:
C0919896
•
Neoplastic Process
Synonym: Myeloblastoma

Definition

A granulocytic sarcoma composed primarily of myeloblasts (WHO 2001). [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBlastic Granulocytic Sarcoma

Professional guidelines

PubMed

Myeloid sarcoma: clinical and morphologic criteria useful for diagnosis.
Audouin J, Comperat E, Le Tourneau A, Camilleri-Broët S, Adida C, Molina T, Diebold J
Int J Surg Pathol 2003 Oct;11(4):271-82. doi: 10.1177/106689690301100404. PMID: 14615822

Recent clinical studies

Etiology

CD3-and CD20-negative extramedullary non-Hodgkin leukemia/lymphoma: a histopathological study of 118 cases.
Maeshima AM, Taniguchi H, Hattori D, Sasaki H, Hori Y, Makita S, Iwaki N, Fukuhara S, Munakata W, Suzuki T, Izutsu K
Hum Pathol 2022 Jun;124:14-23. Epub 2022 Mar 17 doi: 10.1016/j.humpath.2022.03.005. PMID: 35307403
Global assessment of IRF8 as a novel cancer biomarker.
McQuaid DC, Panse G, Wang WL, Pinkus GS, Katz SG, Xu ML
Hum Pathol 2022 Apr;122:1-10. Epub 2022 Jan 24 doi: 10.1016/j.humpath.2022.01.004. PMID: 35085599Free PMC Article
Extramedullary Manifestations of Myeloid Neoplasms.
Wilson CS, Medeiros LJ
Am J Clin Pathol 2015 Aug;144(2):219-39. doi: 10.1309/AJCPO58YWIBUBESX. PMID: 26185307
Blastic plasmacytoid dendritic cell neoplasm: a clinicopathologic review.
Shi Y, Wang E
Arch Pathol Lab Med 2014 Apr;138(4):564-9. doi: 10.5858/arpa.2013-0101-RS. PMID: 24678689
Myeloid sarcoma involving the breast.
Valbuena JR, Admirand JH, Gualco G, Medeiros LJ
Arch Pathol Lab Med 2005 Jan;129(1):32-8. doi: 10.5858/2005-129-32-MSITB. PMID: 15628906

Diagnosis

Top Ten Lymphoproliferative Lesions Not to Miss When Evaluating Oral Ulcer Biopsies.
Hyrcza MD, Lindenmuth TR, Auerbach A
Head Neck Pathol 2023 Mar;17(1):99-118. Epub 2023 Mar 16 doi: 10.1007/s12105-023-01532-2. PMID: 36928739Free PMC Article
Extramedullary Manifestations of Myeloid Neoplasms.
Wilson CS, Medeiros LJ
Am J Clin Pathol 2015 Aug;144(2):219-39. doi: 10.1309/AJCPO58YWIBUBESX. PMID: 26185307
Blastic plasmacytoid dendritic cell neoplasm: a clinicopathologic review.
Shi Y, Wang E
Arch Pathol Lab Med 2014 Apr;138(4):564-9. doi: 10.5858/arpa.2013-0101-RS. PMID: 24678689
State of the art in myeloid sarcoma.
Klco JM, Welch JS, Nguyen TT, Hurley MY, Kreisel FH, Hassan A, Lind AC, Frater JL
Int J Lab Hematol 2011 Dec;33(6):555-65. Epub 2011 Aug 24 doi: 10.1111/j.1751-553X.2011.01361.x. PMID: 21883967
Myeloid sarcoma: clinical and morphologic criteria useful for diagnosis.
Audouin J, Comperat E, Le Tourneau A, Camilleri-Broët S, Adida C, Molina T, Diebold J
Int J Surg Pathol 2003 Oct;11(4):271-82. doi: 10.1177/106689690301100404. PMID: 14615822

Therapy

Ph-negative isolated myeloid sarcoma with NPM1 gene mutation in adolescent with Ph-positive chronic myeloid leukemia in remission after treatment with allogeneic bone marrow transplantation and imatinib mesylate.
Skalska-Sadowska J, Januszkiewicz-Lewandowska D, Derwich K, Pieczonka A, Samborska M, Wachowiak J
Pediatr Blood Cancer 2015 Jun;62(6):1070-1. Epub 2015 Jan 28 doi: 10.1002/pbc.25428. PMID: 25631405
Safety of imatinib in chronic myeloid leukemia in blastic crisis presenting as cholestatic jaundice.
Ramamoorthy SK, Pandita R, Prakash A, Ramaswamy NV, Al Bahar S
Acta Haematol 2007;118(3):141-5. Epub 2007 Sep 5 doi: 10.1159/000107925. PMID: 17804901
Central nervous system blastic crisis in chronic myeloid leukemia on imatinib mesylate therapy: a case report.
Altintas A, Cil T, Kilinc I, Kaplan MA, Ayyildiz O
J Neurooncol 2007 Aug;84(1):103-5. Epub 2007 Feb 23 doi: 10.1007/s11060-007-9352-0. PMID: 17318411
Idiopathic myelofibrosis developing isolated granulocytic sarcoma with der (1;7)(q10; p10) after splenectomy and finally transforming to acute myelogenous leukemia.
Kasahara S, Tsurumi H, Hara T, Goto H, Moriwaki H
Leuk Lymphoma 2000 Oct;39(3-4):427-33. doi: 10.3109/10428190009065844. PMID: 11342325
Granulocytic sarcoma presented as a reactivation of chronic myeloid leukemia after allogenic marrow transplantation.
de Oliveira JS, Chauffaille Mde L, Colleoni GW, Morelli VM, Hauache OM, Alberti VN, Kerbauy J
Sao Paulo Med J 1998 Mar-Apr;116(2):1689-91. doi: 10.1590/s1516-31801998000200009. PMID: 9778890

Prognosis

Infiltration of thyroid papillary cancer tissue with myeloid leukemic cells: a case report.
Sözen M, Vural Ç, Selek A, Kiraz U, Cantürk Z, Çetinarslan B, Gezer E, Köksalan D
World J Surg Oncol 2021 Jul 29;19(1):225. doi: 10.1186/s12957-021-02341-z. PMID: 34325712Free PMC Article
Granulocytic sarcoma: 32 cases and review of the literature.
Paydas S, Zorludemir S, Ergin M
Leuk Lymphoma 2006 Dec;47(12):2527-41. doi: 10.1080/10428190600967196. PMID: 17169797
Myeloid sarcoma involving the breast.
Valbuena JR, Admirand JH, Gualco G, Medeiros LJ
Arch Pathol Lab Med 2005 Jan;129(1):32-8. doi: 10.5858/2005-129-32-MSITB. PMID: 15628906
Granulocytic sarcoma of the ovotestis: an association of myelodysplastic syndrome and hermaphroditism.
Bolaman Z, Kadikoylu G, Kafkas S, Kacar F
Leuk Lymphoma 2004 Jun;45(6):1285-7. doi: 10.1080/1042819032000159906. PMID: 15360014
Myeloid sarcoma: clinical and morphologic criteria useful for diagnosis.
Audouin J, Comperat E, Le Tourneau A, Camilleri-Broët S, Adida C, Molina T, Diebold J
Int J Surg Pathol 2003 Oct;11(4):271-82. doi: 10.1177/106689690301100404. PMID: 14615822

Clinical prediction guides

ERG Immunoreactivity in Blastic Hematolymphoid Neoplasms: Diagnostic Pitfall in the Workup of Undifferentiated Malignant Neoplasms.
Koo M, Natkunam Y
Appl Immunohistochem Mol Morphol 2022 Jan 1;30(1):42-48. doi: 10.1097/PAI.0000000000000958. PMID: 34261976
Infiltration of thyroid papillary cancer tissue with myeloid leukemic cells: a case report.
Sözen M, Vural Ç, Selek A, Kiraz U, Cantürk Z, Çetinarslan B, Gezer E, Köksalan D
World J Surg Oncol 2021 Jul 29;19(1):225. doi: 10.1186/s12957-021-02341-z. PMID: 34325712Free PMC Article
Optimized immunohistochemical panel to differentiate myeloid sarcoma from blastic plasmacytoid dendritic cell neoplasm.
Sangle NA, Schmidt RL, Patel JL, Medeiros LJ, Agarwal AM, Perkins SL, Salama ME
Mod Pathol 2014 Aug;27(8):1137-43. Epub 2014 Jan 3 doi: 10.1038/modpathol.2013.238. PMID: 24390220
ERG transcription factor as an immunohistochemical marker for vascular endothelial tumors and prostatic carcinoma.
Miettinen M, Wang ZF, Paetau A, Tan SH, Dobi A, Srivastava S, Sesterhenn I
Am J Surg Pathol 2011 Mar;35(3):432-41. doi: 10.1097/PAS.0b013e318206b67b. PMID: 21317715Free PMC Article
Myeloid sarcoma: clinico-pathologic, phenotypic and cytogenetic analysis of 92 adult patients.
Pileri SA, Ascani S, Cox MC, Campidelli C, Bacci F, Piccioli M, Piccaluga PP, Agostinelli C, Asioli S, Novero D, Bisceglia M, Ponzoni M, Gentile A, Rinaldi P, Franco V, Vincelli D, Pileri A Jr, Gasbarra R, Falini B, Zinzani PL, Baccarani M
Leukemia 2007 Feb;21(2):340-50. Epub 2006 Dec 14 doi: 10.1038/sj.leu.2404491. PMID: 17170724

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