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Duodenal Neuroendocrine Tumor G2

MedGen UID:
1701930
Concept ID:
C5205253
Neoplastic Process
Synonym: Duodenal NET G2

Definition

A well differentiated, intermediate grade neoplasm with neuroendocrine differentiation that arises from the duodenum. The mitotic count is 2-20 per 10 HPF and/or the Ki67 index is 3 to 20 percent. [from NCI]

Professional guidelines

PubMed

Auernhammer CJ, Göke B
Wien Klin Wochenschr 2007;119(19-20):609-15. doi: 10.1007/s00508-007-0877-1. PMID: 17985097

Recent clinical studies

Etiology

Ryu DG, Kim SJ, Choi CW, Kang DH, Kim HW, Park SB, Nam HS, Lee SH, Hwang SH
Medicine (Baltimore) 2022 Sep 16;101(37):e30397. doi: 10.1097/MD.0000000000030397. PMID: 36123854Free PMC Article
Matsueda K, Kanesaka T, Kitamura M, Shichijo S, Maekawa A, Yamamoto S, Takeuchi Y, Higashino K, Uedo N, Michida T, Honma K, Miyashiro I, Ishihara R
J Gastroenterol Hepatol 2021 Dec;36(12):3329-3336. Epub 2021 Jun 23 doi: 10.1111/jgh.15586. PMID: 34142385
Rossi RE, Milanetto AC, Andreasi V, Campana D, Coppa J, Nappo G, Rinzivillo M, Invernizzi P, Modica R, David A, Partelli S, Lamberti G, Mazzaferro V, Zerbi A, Panzuto F, Pasquali C, Falconi M, Massironi S; ItaNet (Italian Association for Neuroendocrine Tumours) study group
J Endocrinol Invest 2021 Oct;44(10):2227-2234. Epub 2021 Mar 2 doi: 10.1007/s40618-021-01528-1. PMID: 33651317
Zhang XF, Wu XN, Tsilimigras DI, Poultsides G, Rocha F, Abbott DE, Fields R, Idrees K, Cho C, Maithel SK, Pawlik TM; other members of the US Neuroendocrine Tumor Study Group
J Surg Oncol 2019 Dec;120(8):1302-1310. Epub 2019 Nov 3 doi: 10.1002/jso.25753. PMID: 31680243Free PMC Article
Doi R
J Hepatobiliary Pancreat Sci 2015 Aug;22(8):610-7. Epub 2015 Mar 13 doi: 10.1002/jhbp.224. PMID: 25773163

Diagnosis

Aoyama N, Wada M, Taniguchi Y, Inokuma T, Nakanishi Y, Fukuda A, Seno H
Clin J Gastroenterol 2023 Apr;16(2):171-179. Epub 2022 Dec 21 doi: 10.1007/s12328-022-01739-w. PMID: 36542298
Ryu DG, Kim SJ, Choi CW, Kang DH, Kim HW, Park SB, Nam HS, Lee SH, Hwang SH
Medicine (Baltimore) 2022 Sep 16;101(37):e30397. doi: 10.1097/MD.0000000000030397. PMID: 36123854Free PMC Article
Vanoli A, Grami O, Klersy C, Milanetto AC, Albarello L, Fassan M, Luchini C, Grillo F, Spaggiari P, Inzani F, Uccella S, Parente P, Nappo G, Mattiolo P, Milione M, Pietrabissa A, Cobianchi L, Schiavo Lena M, Partelli S, Di Sabatino A, Sempoux C, Capella C, Pasquali C, Doglioni C, Sessa F, Scarpa A, Rindi G, Paulli M, Zerbi A, Falconi M, Solcia E, La Rosa S
Endocr Pathol 2022 Jun;33(2):274-288. Epub 2022 May 13 doi: 10.1007/s12022-022-09720-6. PMID: 35553369Free PMC Article
Rindi G, Mete O, Uccella S, Basturk O, La Rosa S, Brosens LAA, Ezzat S, de Herder WW, Klimstra DS, Papotti M, Asa SL
Endocr Pathol 2022 Mar;33(1):115-154. Epub 2022 Mar 16 doi: 10.1007/s12022-022-09708-2. PMID: 35294740
Massironi S, Campana D, Partelli S, Panzuto F, Rossi RE, Faggiano A, Brighi N, Falconi M, Rinzivillo M, Delle Fave G, Colao AM, Conte D
Ann Surg Oncol 2018 Oct;25(11):3200-3206. Epub 2018 Jul 27 doi: 10.1245/s10434-018-6673-5. PMID: 30054824

Therapy

Zhang M, Zhao P, Shi X, Zhao A, Zhang L, Zhou L
BMC Endocr Disord 2017 Jul 13;17(1):39. doi: 10.1186/s12902-017-0190-6. PMID: 28705205Free PMC Article
Lepage C, Dahan L, Bouarioua N, Toumpanakis C, Legoux JL, Le Malicot K, Guimbaud R, Smith D, Tougeron D, Lievre A, Cadiot G, Di Fiore F, Bouhier-Leporrier K, Hentic O, Faroux R, Pavel M, Borbath I, Valle JW, Rinke A, Scoazec JY, Ducreux M, Walter T
Dig Liver Dis 2017 May;49(5):568-571. Epub 2017 Mar 11 doi: 10.1016/j.dld.2017.02.004. PMID: 28292641
Sierra ML, Agazzi A, Bodei L, Pacifici M, Aricò D, De Cicco C, Quarna J, Sansovini M, De Simone M, Paganelli G
Cancer Biother Radiopharm 2009 Dec;24(6):659-65. doi: 10.1089/cbr.2009.0641. PMID: 20025545
Auernhammer CJ, Göke B
Wien Klin Wochenschr 2007;119(19-20):609-15. doi: 10.1007/s00508-007-0877-1. PMID: 17985097

Prognosis

Aoyama N, Wada M, Taniguchi Y, Inokuma T, Nakanishi Y, Fukuda A, Seno H
Clin J Gastroenterol 2023 Apr;16(2):171-179. Epub 2022 Dec 21 doi: 10.1007/s12328-022-01739-w. PMID: 36542298
Ryu DG, Kim SJ, Choi CW, Kang DH, Kim HW, Park SB, Nam HS, Lee SH, Hwang SH
Medicine (Baltimore) 2022 Sep 16;101(37):e30397. doi: 10.1097/MD.0000000000030397. PMID: 36123854Free PMC Article
Vanoli A, Grami O, Klersy C, Milanetto AC, Albarello L, Fassan M, Luchini C, Grillo F, Spaggiari P, Inzani F, Uccella S, Parente P, Nappo G, Mattiolo P, Milione M, Pietrabissa A, Cobianchi L, Schiavo Lena M, Partelli S, Di Sabatino A, Sempoux C, Capella C, Pasquali C, Doglioni C, Sessa F, Scarpa A, Rindi G, Paulli M, Zerbi A, Falconi M, Solcia E, La Rosa S
Endocr Pathol 2022 Jun;33(2):274-288. Epub 2022 May 13 doi: 10.1007/s12022-022-09720-6. PMID: 35553369Free PMC Article
Matsueda K, Kanesaka T, Kitamura M, Shichijo S, Maekawa A, Yamamoto S, Takeuchi Y, Higashino K, Uedo N, Michida T, Honma K, Miyashiro I, Ishihara R
J Gastroenterol Hepatol 2021 Dec;36(12):3329-3336. Epub 2021 Jun 23 doi: 10.1111/jgh.15586. PMID: 34142385
Zhang XF, Wu XN, Tsilimigras DI, Poultsides G, Rocha F, Abbott DE, Fields R, Idrees K, Cho C, Maithel SK, Pawlik TM; other members of the US Neuroendocrine Tumor Study Group
J Surg Oncol 2019 Dec;120(8):1302-1310. Epub 2019 Nov 3 doi: 10.1002/jso.25753. PMID: 31680243Free PMC Article

Clinical prediction guides

Aoyama N, Wada M, Taniguchi Y, Inokuma T, Nakanishi Y, Fukuda A, Seno H
Clin J Gastroenterol 2023 Apr;16(2):171-179. Epub 2022 Dec 21 doi: 10.1007/s12328-022-01739-w. PMID: 36542298
Ryu DG, Kim SJ, Choi CW, Kang DH, Kim HW, Park SB, Nam HS, Lee SH, Hwang SH
Medicine (Baltimore) 2022 Sep 16;101(37):e30397. doi: 10.1097/MD.0000000000030397. PMID: 36123854Free PMC Article
Vanoli A, Grami O, Klersy C, Milanetto AC, Albarello L, Fassan M, Luchini C, Grillo F, Spaggiari P, Inzani F, Uccella S, Parente P, Nappo G, Mattiolo P, Milione M, Pietrabissa A, Cobianchi L, Schiavo Lena M, Partelli S, Di Sabatino A, Sempoux C, Capella C, Pasquali C, Doglioni C, Sessa F, Scarpa A, Rindi G, Paulli M, Zerbi A, Falconi M, Solcia E, La Rosa S
Endocr Pathol 2022 Jun;33(2):274-288. Epub 2022 May 13 doi: 10.1007/s12022-022-09720-6. PMID: 35553369Free PMC Article
Matsueda K, Kanesaka T, Kitamura M, Shichijo S, Maekawa A, Yamamoto S, Takeuchi Y, Higashino K, Uedo N, Michida T, Honma K, Miyashiro I, Ishihara R
J Gastroenterol Hepatol 2021 Dec;36(12):3329-3336. Epub 2021 Jun 23 doi: 10.1111/jgh.15586. PMID: 34142385
Rossi RE, Milanetto AC, Andreasi V, Campana D, Coppa J, Nappo G, Rinzivillo M, Invernizzi P, Modica R, David A, Partelli S, Lamberti G, Mazzaferro V, Zerbi A, Panzuto F, Pasquali C, Falconi M, Massironi S; ItaNet (Italian Association for Neuroendocrine Tumours) study group
J Endocrinol Invest 2021 Oct;44(10):2227-2234. Epub 2021 Mar 2 doi: 10.1007/s40618-021-01528-1. PMID: 33651317

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