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Duodenal Neuroendocrine Tumor G2

MedGen UID:
1701930
•Concept ID:
C5205253
•
Neoplastic Process
Synonym: Duodenal NET G2

Definition

A well differentiated, intermediate grade neoplasm with neuroendocrine differentiation that arises from the duodenum. The mitotic count is 2-20 per 10 HPF and/or the Ki67 index is 3 to 20 percent. [from NCI]

Professional guidelines

PubMed

Medical treatment of gastrinomas.
Auernhammer CJ, Göke B
Wien Klin Wochenschr 2007;119(19-20):609-15. doi: 10.1007/s00508-007-0877-1. PMID: 17985097

Recent clinical studies

Therapy

Evaluation of the safety, biodistribution, dosimetry of [(18)F]AlF-NOTA-LM3 and head-to-head comparison with [(68)Ga]Ga-DOTATATE in patients with well-differentiated neuroendocrine tumors: an interim analysis of a prospective trial.
Liu M, Ren C, Zhang H, Zhang Y, Huang Z, Jia R, Cheng Y, Bai C, Xu Q, Zhu W, Huo L
Eur J Nucl Med Mol Imaging 2024 Oct;51(12):3719-3730. Epub 2024 Jun 15 doi: 10.1007/s00259-024-06790-y. PMID: 38878175
Clinicopathological features and prognosis of gastroenteropancreatic neuroendocrine neoplasms in a Chinese population: a large, retrospective single-centre study.
Zhang M, Zhao P, Shi X, Zhao A, Zhang L, Zhou L
BMC Endocr Disord 2017 Jul 13;17(1):39. doi: 10.1186/s12902-017-0190-6. PMID: 28705205Free PMC Article
Evaluating lanreotide as maintenance therapy after first-line treatment in patients with non-resectable duodeno-pancreatic neuroendocrine tumours.
Lepage C, Dahan L, Bouarioua N, Toumpanakis C, Legoux JL, Le Malicot K, Guimbaud R, Smith D, Tougeron D, Lievre A, Cadiot G, Di Fiore F, Bouhier-Leporrier K, Hentic O, Faroux R, Pavel M, Borbath I, Valle JW, Rinke A, Scoazec JY, Ducreux M, Walter T
Dig Liver Dis 2017 May;49(5):568-571. Epub 2017 Mar 11 doi: 10.1016/j.dld.2017.02.004. PMID: 28292641
Lymphocytic toxicity in patients after peptide-receptor radionuclide therapy (PRRT) with 177Lu-DOTATATE and 90Y-DOTATOC.
Sierra ML, Agazzi A, Bodei L, Pacifici M, Aricò D, De Cicco C, Quarna J, Sansovini M, De Simone M, Paganelli G
Cancer Biother Radiopharm 2009 Dec;24(6):659-65. doi: 10.1089/cbr.2009.0641. PMID: 20025545
Medical treatment of gastrinomas.
Auernhammer CJ, Göke B
Wien Klin Wochenschr 2007;119(19-20):609-15. doi: 10.1007/s00508-007-0877-1. PMID: 17985097

Prognosis

A case of neuroendocrine neoplasm of the minor duodenal papilla.
Aoyama N, Wada M, Taniguchi Y, Inokuma T, Nakanishi Y, Fukuda A, Seno H
Clin J Gastroenterol 2023 Apr;16(2):171-179. Epub 2022 Dec 21 doi: 10.1007/s12328-022-01739-w. PMID: 36542298
Ampullary Neuroendocrine Neoplasm: Clinicopathological Characteristics and Novel Endoscopic Entity.
Matsumoto K, Fujimori N, Hata Y, Minoda Y, Murakami M, Teramatsu K, Takamatsu Y, Takeno A, Oono T, Ihara E, Nakata K, Nakamura M, Yamamoto T, Koga Y, Oda Y, Ito T, Ogawa Y
Dig Dis 2023;41(2):316-324. Epub 2022 May 19 doi: 10.1159/000525013. PMID: 35588707
Ampullary Neuroendocrine Neoplasms: Identification of Prognostic Factors in a Multicentric Series of 119 Cases.
Vanoli A, Grami O, Klersy C, Milanetto AC, Albarello L, Fassan M, Luchini C, Grillo F, Spaggiari P, Inzani F, Uccella S, Parente P, Nappo G, Mattiolo P, Milione M, Pietrabissa A, Cobianchi L, Schiavo Lena M, Partelli S, Di Sabatino A, Sempoux C, Capella C, Pasquali C, Doglioni C, Sessa F, Scarpa A, Rindi G, Paulli M, Zerbi A, Falconi M, Solcia E, La Rosa S
Endocr Pathol 2022 Jun;33(2):274-288. Epub 2022 May 13 doi: 10.1007/s12022-022-09720-6. PMID: 35553369Free PMC Article
Favorable long-term outcomes of endoscopic resection for nonampullary duodenal neuroendocrine tumor.
Matsueda K, Kanesaka T, Kitamura M, Shichijo S, Maekawa A, Yamamoto S, Takeuchi Y, Higashino K, Uedo N, Michida T, Honma K, Miyashiro I, Ishihara R
J Gastroenterol Hepatol 2021 Dec;36(12):3329-3336. Epub 2021 Jun 23 doi: 10.1111/jgh.15586. PMID: 34142385
Duodenal neuroendocrine tumors: Impact of tumor size and total number of lymph nodes examined.
Zhang XF, Wu XN, Tsilimigras DI, Poultsides G, Rocha F, Abbott DE, Fields R, Idrees K, Cho C, Maithel SK, Pawlik TM; other members of the US Neuroendocrine Tumor Study Group
J Surg Oncol 2019 Dec;120(8):1302-1310. Epub 2019 Nov 3 doi: 10.1002/jso.25753. PMID: 31680243Free PMC Article

Clinical prediction guides

A case of neuroendocrine neoplasm of the minor duodenal papilla.
Aoyama N, Wada M, Taniguchi Y, Inokuma T, Nakanishi Y, Fukuda A, Seno H
Clin J Gastroenterol 2023 Apr;16(2):171-179. Epub 2022 Dec 21 doi: 10.1007/s12328-022-01739-w. PMID: 36542298
Clinical outcomes of gastroduodenal neuroendocrine tumors according to their WHO grade: A single-institutional retrospective analysis.
Ryu DG, Kim SJ, Choi CW, Kang DH, Kim HW, Park SB, Nam HS, Lee SH, Hwang SH
Medicine (Baltimore) 2022 Sep 16;101(37):e30397. doi: 10.1097/MD.0000000000030397. PMID: 36123854Free PMC Article
Ampullary Neuroendocrine Neoplasms: Identification of Prognostic Factors in a Multicentric Series of 119 Cases.
Vanoli A, Grami O, Klersy C, Milanetto AC, Albarello L, Fassan M, Luchini C, Grillo F, Spaggiari P, Inzani F, Uccella S, Parente P, Nappo G, Mattiolo P, Milione M, Pietrabissa A, Cobianchi L, Schiavo Lena M, Partelli S, Di Sabatino A, Sempoux C, Capella C, Pasquali C, Doglioni C, Sessa F, Scarpa A, Rindi G, Paulli M, Zerbi A, Falconi M, Solcia E, La Rosa S
Endocr Pathol 2022 Jun;33(2):274-288. Epub 2022 May 13 doi: 10.1007/s12022-022-09720-6. PMID: 35553369Free PMC Article
Favorable long-term outcomes of endoscopic resection for nonampullary duodenal neuroendocrine tumor.
Matsueda K, Kanesaka T, Kitamura M, Shichijo S, Maekawa A, Yamamoto S, Takeuchi Y, Higashino K, Uedo N, Michida T, Honma K, Miyashiro I, Ishihara R
J Gastroenterol Hepatol 2021 Dec;36(12):3329-3336. Epub 2021 Jun 23 doi: 10.1111/jgh.15586. PMID: 34142385
Heterogeneity of Duodenal Neuroendocrine Tumors: An Italian Multi-center Experience.
Massironi S, Campana D, Partelli S, Panzuto F, Rossi RE, Faggiano A, Brighi N, Falconi M, Rinzivillo M, Delle Fave G, Colao AM, Conte D
Ann Surg Oncol 2018 Oct;25(11):3200-3206. Epub 2018 Jul 27 doi: 10.1245/s10434-018-6673-5. PMID: 30054824

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