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Reduced circulating fibronectin level

MedGen UID:
1702486
•Concept ID:
C5139361
•
Finding
Synonym: Decreased plasma fibronectin
 
HPO: HP:0032463

Definition

A reduction below the normal concentration of fibronectin the the blood circulation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReduced circulating fibronectin level

Conditions with this feature

Plasma fibronectin deficiency
MedGen UID:
436433
•Concept ID:
C2675436
•
Finding
See: Condition Record
Plasma fibronectin deficiency

Professional guidelines

PubMed

A novel and simplified method of culture of human blood-derived early endothelial progenitor cells for the treatment of ischemic vascular disease.
Bouchentouf M, Forner K, Cuerquis J, Boulassel MR, Routy JP, Waller EK, Quyyumi AA, Paradis P, Schiffrin EL, Galipeau J
Cell Transplant 2011;20(9):1431-43. Epub 2011 Feb 3 doi: 10.3727/096368910X557164. PMID: 21294961
The significance of CD14+ monocytes in peripheral blood stem cells for the treatment of rat liver cirrhosis.
Wang J, Zhou X, Cui L, Yan L, Liang J, Cheng X, Qiao L, Shi Y, Han Z, Cao Y, Han Y, Fan D
Cytotherapy 2010 Dec;12(8):1022-34. Epub 2010 Sep 20 doi: 10.3109/14653249.2010.515578. PMID: 20849360
Effect of anti-TNFalpha treatment on circulating endothelial progenitor cells (EPCs) in rheumatoid arthritis.
Ablin JN, Boguslavski V, Aloush V, Elkayam O, Paran D, Caspi D, George J
Life Sci 2006 Nov 17;79(25):2364-9. Epub 2006 Aug 5 doi: 10.1016/j.lfs.2006.07.035. PMID: 16962143

Recent clinical studies

Etiology

Leech extract alleviates idiopathic pulmonary fibrosis by TGF-β1/Smad3 signaling pathway.
Zhang Y, Lu YB, Zhu WJ, Gong XX, Qian R, Lu YJ, Li Y, Yao WF, Bao BH, Zhang Y, Zhang L, Cheng FF
J Ethnopharmacol 2024 Apr 24;324:117737. Epub 2024 Jan 14 doi: 10.1016/j.jep.2024.117737. PMID: 38228229
Relationships between circulating irisin levels, cardiorespiratory fitness, and cardiometabolic risk: a cross-sectional study in Japanese adults.
Inoue K, Fujie S, Kurose S, Miyauchi T, Sanada K, Kimura Y, Iemitsu M
Am J Physiol Heart Circ Physiol 2023 Dec 1;325(6):H1318-H1324. Epub 2023 Oct 6 doi: 10.1152/ajpheart.00573.2023. PMID: 37801045
UPLC-Q-TOF-MS based investigation into the bioactive compounds and molecular mechanisms of Lamiophlomis Herba against hepatic fibrosis.
Chen J, Ge J, Chen W, Zhao Y, Song T, Fu K, Li X, Zheng Y
Phytomedicine 2023 Dec;121:155085. Epub 2023 Sep 16 doi: 10.1016/j.phymed.2023.155085. PMID: 37757709
Albumin Infusion in Critically Ill COVID-19 Patients: Hemodilution and Anticoagulation.
Ramadori G
Int J Mol Sci 2021 Jul 1;22(13) doi: 10.3390/ijms22137126. PMID: 34281177Free PMC Article
Association between circulating irisin levels and the promotion of insulin resistance during the weight maintenance period after a dietary weight-lowering program in obese patients.
Crujeiras AB, Zulet MA, Lopez-Legarrea P, de la Iglesia R, Pardo M, Carreira MC, Martínez JA, Casanueva FF
Metabolism 2014 Apr;63(4):520-31. Epub 2013 Dec 18 doi: 10.1016/j.metabol.2013.12.007. PMID: 24439241

Diagnosis

Exploration of the Potential Biomarker FNDC5 for Discriminating Heart Failure in Patients with Coronary Atherosclerosis.
Zheng H, Zheng Y, Huang W, Jiang L, Liu S, Miao P, Zhu N, Cao RY
J Cardiovasc Transl Res 2024 Aug;17(4):795-802. Epub 2024 Feb 20 doi: 10.1007/s12265-024-10489-8. PMID: 38376700
Relationships between circulating irisin levels, cardiorespiratory fitness, and cardiometabolic risk: a cross-sectional study in Japanese adults.
Inoue K, Fujie S, Kurose S, Miyauchi T, Sanada K, Kimura Y, Iemitsu M
Am J Physiol Heart Circ Physiol 2023 Dec 1;325(6):H1318-H1324. Epub 2023 Oct 6 doi: 10.1152/ajpheart.00573.2023. PMID: 37801045
Changes of Circulating Irisin and High-Sensitivity C-Reactive Protein Levels in Morbidly Obese Individuals with Type 2 Diabetes After Roux-en-Y Gastric Bypass.
Shantavasinkul PC, Omotosho P, Corsino L, Muehlbauer MJ, Chattranukulchai P, Torquati A
J Laparoendosc Adv Surg Tech A 2022 Aug;32(8):817-822. Epub 2022 Feb 11 doi: 10.1089/lap.2021.0558. PMID: 35443789Free PMC Article
Fibronectin regulates anoikis resistance via cell aggregate formation.
Han HJ, Sung JY, Kim SH, Yun UJ, Kim H, Jang EJ, Yoo HE, Hong EK, Goh SH, Moon A, Lee JS, Ye SK, Shim J, Kim YN
Cancer Lett 2021 Jun 28;508:59-72. Epub 2021 Mar 23 doi: 10.1016/j.canlet.2021.03.011. PMID: 33771684
Association between circulating irisin levels and the promotion of insulin resistance during the weight maintenance period after a dietary weight-lowering program in obese patients.
Crujeiras AB, Zulet MA, Lopez-Legarrea P, de la Iglesia R, Pardo M, Carreira MC, Martínez JA, Casanueva FF
Metabolism 2014 Apr;63(4):520-31. Epub 2013 Dec 18 doi: 10.1016/j.metabol.2013.12.007. PMID: 24439241

Therapy

Circulating irisin in nonalcoholic fatty liver disease: an updated meta-analysis.
Qiu S, Wang Q, Cai X, Sun Z, Wu T
Endokrynol Pol 2023;74(1):47-54. Epub 2022 Sep 12 doi: 10.5603/EP.a2022.0067. PMID: 36094873
Changes of Circulating Irisin and High-Sensitivity C-Reactive Protein Levels in Morbidly Obese Individuals with Type 2 Diabetes After Roux-en-Y Gastric Bypass.
Shantavasinkul PC, Omotosho P, Corsino L, Muehlbauer MJ, Chattranukulchai P, Torquati A
J Laparoendosc Adv Surg Tech A 2022 Aug;32(8):817-822. Epub 2022 Feb 11 doi: 10.1089/lap.2021.0558. PMID: 35443789Free PMC Article
Albumin Infusion in Critically Ill COVID-19 Patients: Hemodilution and Anticoagulation.
Ramadori G
Int J Mol Sci 2021 Jul 1;22(13) doi: 10.3390/ijms22137126. PMID: 34281177Free PMC Article
Role of intracardiac renin-angiotensin-aldosterone system in extracellular matrix remodeling.
Lijnen PJ, Petrov VV
Methods Find Exp Clin Pharmacol 2003 Sep;25(7):541-64. doi: 10.1358/mf.2003.25.7.778094. PMID: 14571285
No effect of acenocoumarol therapy on levels of endothelial activation markers in sickle cell disease.
Schnog JB, Mac Gillavry MR, Rojer RA, Meijers JC, Fijnheer R, ten Cate H, Brandjes DP, Duits AJ
Am J Hematol 2002 Sep;71(1):53-5. doi: 10.1002/ajh.10178. PMID: 12221677

Prognosis

Exploration of the Potential Biomarker FNDC5 for Discriminating Heart Failure in Patients with Coronary Atherosclerosis.
Zheng H, Zheng Y, Huang W, Jiang L, Liu S, Miao P, Zhu N, Cao RY
J Cardiovasc Transl Res 2024 Aug;17(4):795-802. Epub 2024 Feb 20 doi: 10.1007/s12265-024-10489-8. PMID: 38376700
Albumin Infusion in Critically Ill COVID-19 Patients: Hemodilution and Anticoagulation.
Ramadori G
Int J Mol Sci 2021 Jul 1;22(13) doi: 10.3390/ijms22137126. PMID: 34281177Free PMC Article
Circulating irisin levels in heart failure with preserved or reduced ejection fraction: A pilot study.
Silvestrini A, Bruno C, Vergani E, Venuti A, Favuzzi AMR, Guidi F, Nicolotti N, Meucci E, Mordente A, Mancini A
PLoS One 2019;14(1):e0210320. Epub 2019 Jan 18 doi: 10.1371/journal.pone.0210320. PMID: 30657767Free PMC Article
Association between irisin and major chronic diseases: a review.
Gouveia MC, Vella JP, Cafeo FR, Affonso Fonseca FL, Bacci MR
Eur Rev Med Pharmacol Sci 2016 Oct;20(19):4072-4077. PMID: 27775791
Association between circulating irisin levels and the promotion of insulin resistance during the weight maintenance period after a dietary weight-lowering program in obese patients.
Crujeiras AB, Zulet MA, Lopez-Legarrea P, de la Iglesia R, Pardo M, Carreira MC, Martínez JA, Casanueva FF
Metabolism 2014 Apr;63(4):520-31. Epub 2013 Dec 18 doi: 10.1016/j.metabol.2013.12.007. PMID: 24439241

Clinical prediction guides

Exploration of the Potential Biomarker FNDC5 for Discriminating Heart Failure in Patients with Coronary Atherosclerosis.
Zheng H, Zheng Y, Huang W, Jiang L, Liu S, Miao P, Zhu N, Cao RY
J Cardiovasc Transl Res 2024 Aug;17(4):795-802. Epub 2024 Feb 20 doi: 10.1007/s12265-024-10489-8. PMID: 38376700
Leech extract alleviates idiopathic pulmonary fibrosis by TGF-β1/Smad3 signaling pathway.
Zhang Y, Lu YB, Zhu WJ, Gong XX, Qian R, Lu YJ, Li Y, Yao WF, Bao BH, Zhang Y, Zhang L, Cheng FF
J Ethnopharmacol 2024 Apr 24;324:117737. Epub 2024 Jan 14 doi: 10.1016/j.jep.2024.117737. PMID: 38228229
Relationships between circulating irisin levels, cardiorespiratory fitness, and cardiometabolic risk: a cross-sectional study in Japanese adults.
Inoue K, Fujie S, Kurose S, Miyauchi T, Sanada K, Kimura Y, Iemitsu M
Am J Physiol Heart Circ Physiol 2023 Dec 1;325(6):H1318-H1324. Epub 2023 Oct 6 doi: 10.1152/ajpheart.00573.2023. PMID: 37801045
Association between circulating irisin levels and the promotion of insulin resistance during the weight maintenance period after a dietary weight-lowering program in obese patients.
Crujeiras AB, Zulet MA, Lopez-Legarrea P, de la Iglesia R, Pardo M, Carreira MC, Martínez JA, Casanueva FF
Metabolism 2014 Apr;63(4):520-31. Epub 2013 Dec 18 doi: 10.1016/j.metabol.2013.12.007. PMID: 24439241
No effect of acenocoumarol therapy on levels of endothelial activation markers in sickle cell disease.
Schnog JB, Mac Gillavry MR, Rojer RA, Meijers JC, Fijnheer R, ten Cate H, Brandjes DP, Duits AJ
Am J Hematol 2002 Sep;71(1):53-5. doi: 10.1002/ajh.10178. PMID: 12221677

Recent systematic reviews

Association between irisin and major chronic diseases: a review.
Gouveia MC, Vella JP, Cafeo FR, Affonso Fonseca FL, Bacci MR
Eur Rev Med Pharmacol Sci 2016 Oct;20(19):4072-4077. PMID: 27775791

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