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Abnormal CD4+CD25+ regulatory T cell proportion

MedGen UID:
1702842
•Concept ID:
C5139084
•
Finding
Synonym: Abnormal CD4+CD25+ Treg cell proportion
 
HPO: HP:0020111

Definition

A deviation from the normal proportion of CD4-positive, CD25-positive, alpha-beta regulatory T cells in circulation, relative to another population of cells. [from HPO]

Recent clinical studies

Etiology

Immune dysregulation in primary immune thrombocytopenia patients.
Zhang J, Zhang Q, Li Y, Tao L, Wu F, Shen Y, Tao Q, Xu X, Wu C, Ruan Y, Wang J, Wang J, Wang Y, Zhai Z
Hematology 2018 Sep;23(8):510-516. Epub 2018 Feb 6 doi: 10.1080/10245332.2018.1435021. PMID: 29409398
Abnormal phenotypic distribution of regulatory and effector T cells in octogenarian and nonagenarian women.
Cruvinel Wde M, Mesquita Júnior D, Araújo JA, Samazi KC, Kállas EG, Cendoroglo MS, Andrade LE
Rev Assoc Med Bras (1992) 2015 Aug;61(4):329-35. doi: 10.1590/1806-9282.61.04.329. PMID: 26466214
Impaired Ca²⁺ regulation of CD4⁺CD25⁺ regulatory T cells from pediatric asthma.
Yamamoto Y, Negoro T, Hoshi A, Wakagi A, Shimizu S, Banham AH, Ishii M, Akiyama H, Kiuchi Y, Sunaga S, Tobe T, Roncador G, Itabashi K, Nakano Y
Int Arch Allergy Immunol 2011;156(2):148-58. Epub 2011 May 17 doi: 10.1159/000322845. PMID: 21576985
Phenotypic characterisation of T-lymphocytes in COPD: abnormal CD4+CD25+ regulatory T-lymphocyte response to tobacco smoking.
Barceló B, Pons J, Ferrer JM, Sauleda J, Fuster A, Agustí AG
Eur Respir J 2008 Mar;31(3):555-62. Epub 2007 Dec 5 doi: 10.1183/09031936.00010407. PMID: 18057064
Evidence for extrathymic T cell maturation after thymectomy in infancy.
Torfadottir H, Freysdottir J, Skaftadottir I, Haraldsson A, Sigfusson G, Ogmundsdottir HM
Clin Exp Immunol 2006 Sep;145(3):407-12. doi: 10.1111/j.1365-2249.2006.03139.x. PMID: 16907907Free PMC Article

Diagnosis

Immune dysregulation in primary immune thrombocytopenia patients.
Zhang J, Zhang Q, Li Y, Tao L, Wu F, Shen Y, Tao Q, Xu X, Wu C, Ruan Y, Wang J, Wang J, Wang Y, Zhai Z
Hematology 2018 Sep;23(8):510-516. Epub 2018 Feb 6 doi: 10.1080/10245332.2018.1435021. PMID: 29409398

Therapy

Immune dysregulation in primary immune thrombocytopenia patients.
Zhang J, Zhang Q, Li Y, Tao L, Wu F, Shen Y, Tao Q, Xu X, Wu C, Ruan Y, Wang J, Wang J, Wang Y, Zhai Z
Hematology 2018 Sep;23(8):510-516. Epub 2018 Feb 6 doi: 10.1080/10245332.2018.1435021. PMID: 29409398
Levels and function of regulatory T cells in patients with polymorphic light eruption: relation to photohardening.
Schweintzger N, Gruber-Wackernagel A, Reginato E, Bambach I, Quehenberger F, Byrne SN, Wolf P
Br J Dermatol 2015 Aug;173(2):519-26. Epub 2015 Jul 30 doi: 10.1111/bjd.13930. PMID: 26032202Free PMC Article

Prognosis

Conjugated Bilirubin Upregulates TIM-3 Expression on CD4(+)CD25(+) T Cells: Anti-Inflammatory Implications for Hepatitis A Virus Infection.
Trujillo-Ochoa JL, Corral-Jara KF, Charles-Niño CL, Panduro A, Fierro NA
Viral Immunol 2018 Apr;31(3):223-232. Epub 2017 Nov 3 doi: 10.1089/vim.2017.0103. PMID: 29099687

Clinical prediction guides

Increased proportions of functionally impaired regulatory T cell subsets in systemic sclerosis.
Ugor E, Simon D, Almanzar G, Pap R, Najbauer J, Németh P, Balogh P, Prelog M, Czirják L, Berki T
Clin Immunol 2017 Nov;184:54-62. Epub 2017 May 15 doi: 10.1016/j.clim.2017.05.013. PMID: 28522286
Abnormal phenotypic distribution of regulatory and effector T cells in octogenarian and nonagenarian women.
Cruvinel Wde M, Mesquita Júnior D, Araújo JA, Samazi KC, Kállas EG, Cendoroglo MS, Andrade LE
Rev Assoc Med Bras (1992) 2015 Aug;61(4):329-35. doi: 10.1590/1806-9282.61.04.329. PMID: 26466214
Levels and function of regulatory T cells in patients with polymorphic light eruption: relation to photohardening.
Schweintzger N, Gruber-Wackernagel A, Reginato E, Bambach I, Quehenberger F, Byrne SN, Wolf P
Br J Dermatol 2015 Aug;173(2):519-26. Epub 2015 Jul 30 doi: 10.1111/bjd.13930. PMID: 26032202Free PMC Article
Expansion of regulatory GITR+CD25 low/-CD4+ T cells in systemic lupus erythematosus patients.
Nocentini G, Alunno A, Petrillo MG, Bistoni O, Bartoloni E, Caterbi S, Ronchetti S, Migliorati G, Riccardi C, Gerli R
Arthritis Res Ther 2014 Sep 26;16(5):444. doi: 10.1186/s13075-014-0444-x. PMID: 25256257Free PMC Article
Impaired Ca²⁺ regulation of CD4⁺CD25⁺ regulatory T cells from pediatric asthma.
Yamamoto Y, Negoro T, Hoshi A, Wakagi A, Shimizu S, Banham AH, Ishii M, Akiyama H, Kiuchi Y, Sunaga S, Tobe T, Roncador G, Itabashi K, Nakano Y
Int Arch Allergy Immunol 2011;156(2):148-58. Epub 2011 May 17 doi: 10.1159/000322845. PMID: 21576985

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