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Abnormal metabolism

MedGen UID:
1703500
Concept ID:
C5139220
Finding
HPO: HP:0032245

Definition

An abnormality in the function of the chemical reactions related to processes including conversion of food to enter, synthesis of proteins, lipids, nucleic acids, and carbohydrates, or the elimination of waste products. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal metabolism

Professional guidelines

PubMed

Zhang Y, Chen S, Yuan M, Xu Y, Xu H
Nutrients 2022 Aug 26;14(17) doi: 10.3390/nu14173525. PMID: 36079783Free PMC Article
Zhao Z, Liu W
Technol Cancer Res Treat 2020 Jan-Dec;19:1533033820962117. doi: 10.1177/1533033820962117. PMID: 33357065Free PMC Article
Crawford J
Ann Palliat Med 2019 Jan;8(1):43-49. doi: 10.21037/apm.2018.12.08. PMID: 30685983

Recent clinical studies

Etiology

Zhang Y, Chen S, Yuan M, Xu Y, Xu H
Nutrients 2022 Aug 26;14(17) doi: 10.3390/nu14173525. PMID: 36079783Free PMC Article
Zhao Z, Liu W
Technol Cancer Res Treat 2020 Jan-Dec;19:1533033820962117. doi: 10.1177/1533033820962117. PMID: 33357065Free PMC Article
Dan Z, Mao X, Liu Q, Guo M, Zhuang Y, Liu Z, Chen K, Chen J, Xu R, Tang J, Qin L, Gu B, Liu K, Su C, Zhang F, Xia Y, Hu Z, Liu X
Gut Microbes 2020 Sep 2;11(5):1246-1267. Epub 2020 Apr 21 doi: 10.1080/19490976.2020.1747329. PMID: 32312186Free PMC Article
Fearon K, Strasser F, Anker SD, Bosaeus I, Bruera E, Fainsinger RL, Jatoi A, Loprinzi C, MacDonald N, Mantovani G, Davis M, Muscaritoli M, Ottery F, Radbruch L, Ravasco P, Walsh D, Wilcock A, Kaasa S, Baracos VE
Lancet Oncol 2011 May;12(5):489-95. Epub 2011 Feb 4 doi: 10.1016/S1470-2045(10)70218-7. PMID: 21296615
Harteveld CL, Higgs DR
Orphanet J Rare Dis 2010 May 28;5:13. doi: 10.1186/1750-1172-5-13. PMID: 20507641Free PMC Article

Diagnosis

Zhao Z, Liu W
Technol Cancer Res Treat 2020 Jan-Dec;19:1533033820962117. doi: 10.1177/1533033820962117. PMID: 33357065Free PMC Article
Dunham-Snary KJ, Wu D, Sykes EA, Thakrar A, Parlow LRG, Mewburn JD, Parlow JL, Archer SL
Chest 2017 Jan;151(1):181-192. Epub 2016 Sep 16 doi: 10.1016/j.chest.2016.09.001. PMID: 27645688Free PMC Article
Chapin JC, Hajjar KA
Blood Rev 2015 Jan;29(1):17-24. Epub 2014 Sep 16 doi: 10.1016/j.blre.2014.09.003. PMID: 25294122Free PMC Article
Fearon K, Strasser F, Anker SD, Bosaeus I, Bruera E, Fainsinger RL, Jatoi A, Loprinzi C, MacDonald N, Mantovani G, Davis M, Muscaritoli M, Ottery F, Radbruch L, Ravasco P, Walsh D, Wilcock A, Kaasa S, Baracos VE
Lancet Oncol 2011 May;12(5):489-95. Epub 2011 Feb 4 doi: 10.1016/S1470-2045(10)70218-7. PMID: 21296615
Harteveld CL, Higgs DR
Orphanet J Rare Dis 2010 May 28;5:13. doi: 10.1186/1750-1172-5-13. PMID: 20507641Free PMC Article

Therapy

Lin Y, Gu Q, Lu S, Pan Z, Yang Z, Li Y, Yang S, Lv Y, Zheng Z, Sun G, Gou F, Xu C, Zhao X, Wang F, Wang C, Yuan S, Xie X, Cao Y, Liu Y, Gu W, Cheng T, Cheng H, Hu X
J Clin Invest 2023 Aug 1;133(15) doi: 10.1172/JCI162201. PMID: 37338986Free PMC Article
Yang Y, Li S, Wang Y, Zhao Y, Li Q
Signal Transduct Target Ther 2022 Sep 17;7(1):329. doi: 10.1038/s41392-022-01168-8. PMID: 36115852Free PMC Article
Piccin A, Murphy C, Eakins E, Rondinelli MB, Daves M, Vecchiato C, Wolf D, Mc Mahon C, Smith OP
Eur J Haematol 2019 Apr;102(4):319-330. Epub 2019 Feb 21 doi: 10.1111/ejh.13212. PMID: 30664257
Michaud M, Pourrat J
J Clin Rheumatol 2013 Apr;19(3):142-8. doi: 10.1097/RHU.0b013e318289e06e. PMID: 23519183
Fearon K, Strasser F, Anker SD, Bosaeus I, Bruera E, Fainsinger RL, Jatoi A, Loprinzi C, MacDonald N, Mantovani G, Davis M, Muscaritoli M, Ottery F, Radbruch L, Ravasco P, Walsh D, Wilcock A, Kaasa S, Baracos VE
Lancet Oncol 2011 May;12(5):489-95. Epub 2011 Feb 4 doi: 10.1016/S1470-2045(10)70218-7. PMID: 21296615

Prognosis

Shen L, Zhang J, Zheng Z, Yang F, Liu S, Wu Y, Chen Y, Xu T, Mao S, Yan Y, Li W, Zhang W, Yao X
Int J Biol Sci 2022;18(14):5459-5474. Epub 2022 Aug 29 doi: 10.7150/ijbs.74546. PMID: 36147463Free PMC Article
Zhang Y, Chen S, Yuan M, Xu Y, Xu H
Nutrients 2022 Aug 26;14(17) doi: 10.3390/nu14173525. PMID: 36079783Free PMC Article
Zhao Z, Liu W
Technol Cancer Res Treat 2020 Jan-Dec;19:1533033820962117. doi: 10.1177/1533033820962117. PMID: 33357065Free PMC Article
Li X, Wu C, Lu J, Chen B, Li Y, Yang Y, Hu S, Li J
Lancet Public Health 2020 Dec;5(12):e672-e681. doi: 10.1016/S2468-2667(20)30191-2. PMID: 33271080
Chapin JC, Hajjar KA
Blood Rev 2015 Jan;29(1):17-24. Epub 2014 Sep 16 doi: 10.1016/j.blre.2014.09.003. PMID: 25294122Free PMC Article

Clinical prediction guides

Shen L, Zhang J, Zheng Z, Yang F, Liu S, Wu Y, Chen Y, Xu T, Mao S, Yan Y, Li W, Zhang W, Yao X
Int J Biol Sci 2022;18(14):5459-5474. Epub 2022 Aug 29 doi: 10.7150/ijbs.74546. PMID: 36147463Free PMC Article
Zhao Z, Liu W
Technol Cancer Res Treat 2020 Jan-Dec;19:1533033820962117. doi: 10.1177/1533033820962117. PMID: 33357065Free PMC Article
Dan Z, Mao X, Liu Q, Guo M, Zhuang Y, Liu Z, Chen K, Chen J, Xu R, Tang J, Qin L, Gu B, Liu K, Su C, Zhang F, Xia Y, Hu Z, Liu X
Gut Microbes 2020 Sep 2;11(5):1246-1267. Epub 2020 Apr 21 doi: 10.1080/19490976.2020.1747329. PMID: 32312186Free PMC Article
Chapin JC, Hajjar KA
Blood Rev 2015 Jan;29(1):17-24. Epub 2014 Sep 16 doi: 10.1016/j.blre.2014.09.003. PMID: 25294122Free PMC Article
Harteveld CL, Higgs DR
Orphanet J Rare Dis 2010 May 28;5:13. doi: 10.1186/1750-1172-5-13. PMID: 20507641Free PMC Article

Recent systematic reviews

Crider K, Williams J, Qi YP, Gutman J, Yeung L, Mai C, Finkelstain J, Mehta S, Pons-Duran C, Menéndez C, Moraleda C, Rogers L, Daniels K, Green P
Cochrane Database Syst Rev 2022 Feb 1;2(2022) doi: 10.1002/14651858.CD014217. PMID: 36321557Free PMC Article
Nabizadeh F, Ramezannezhad E, Sardaripour A, Seyedi SA, Salehi N, Rezaeimanesh N, Naser Moghadasi A
Neurol Sci 2022 Aug;43(8):4701-4718. Epub 2022 Apr 29 doi: 10.1007/s10072-022-06094-9. PMID: 35486333
Ahmed AI, Abebe AT, Han Y, Alnabelsi T, Agrawal T, Kassi M, Aljizeeri A, Taylor A, Tleyjeh IM, Al-Mallah MH
J Nucl Cardiol 2021 Aug;28(4):1545-1552. Epub 2021 Jul 6 doi: 10.1007/s12350-021-02681-z. PMID: 34228337
Hou YC, Lu CL, Lu KC
Nephrology (Carlton) 2018 Oct;23 Suppl 4:88-94. doi: 10.1111/nep.13457. PMID: 30298663
García-Figueiras R, Baleato-González S, Padhani AR, Oleaga L, Vilanova JC, Luna A, Cobas Gómez JC
Diagn Interv Radiol 2016 Jan-Feb;22(1):75-89. doi: 10.5152/dir.2015.15009. PMID: 26712681Free PMC Article

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