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Reduced circulating cholinesterase activity

MedGen UID:
1703839
•Concept ID:
C5209258
•
Finding
Synonym: Reduced cholinesterase level
 
HPO: HP:0020175

Definition

Activity or concentration of cholinesterase in the blood circulation below the lower limit of normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReduced circulating cholinesterase activity

Recent clinical studies

Etiology

Zinc improves sexual performance and erectile function by preventing penile oxidative injury and upregulating circulating testosterone in lead-exposed rats.
Besong EE, Akhigbe TM, Ashonibare PJ, Oladipo AA, Obimma JN, Hamed MA, Adeyemi DH, Akhigbe RE
Redox Rep 2023 Dec;28(1):2225675. doi: 10.1080/13510002.2023.2225675. PMID: 37345699Free PMC Article
Physical activity and all-cause mortality and mediators of the association in the very old.
Osawa Y, Abe Y, Takayama M, Oguma Y, Arai Y
Exp Gerontol 2021 Jul 15;150:111374. Epub 2021 Apr 25 doi: 10.1016/j.exger.2021.111374. PMID: 33905878
Effect of some newly synthesized xanthone and piperazine derivatives with cardiovascular activity on rheology of human erythrocytes in vitro.
Kózka M, Słoczyńska K, Szkaradek N, Waszkielewicz AM, Pękala E, Marona H
Clin Hemorheol Microcirc 2017;67(1):1-14. doi: 10.3233/CH-16001A. PMID: 27567798
Physiological roles for butyrylcholinesterase: A BChE-ghrelin axis.
Brimijoin S, Chen VP, Pang YP, Geng L, Gao Y
Chem Biol Interact 2016 Nov 25;259(Pt B):271-275. Epub 2016 Feb 23 doi: 10.1016/j.cbi.2016.02.013. PMID: 26915976Free PMC Article
Serum cholinesterase activities distinguish between stroke patients and controls and predict 12-month mortality.
Ben Assayag E, Shenhar-Tsarfaty S, Ofek K, Soreq L, Bova I, Shopin L, Berg RM, Berliner S, Shapira I, Bornstein NM, Soreq H
Mol Med 2010 Jul-Aug;16(7-8):278-86. Epub 2010 Apr 14 doi: 10.2119/molmed.2010.00015. PMID: 20464061Free PMC Article

Diagnosis

Association between serum trace element, mineral, and amino acid levels with non-alcoholic fatty liver disease (NAFLD) in adult women.
Tinkov AA, Korobeinikova TV, Morozova GD, Aschner M, Mak DV, Santamaria A, Rocha JBT, Sotnikova TI, Tazina SI, Skalny AV
J Trace Elem Med Biol 2024 May;83:127397. Epub 2024 Jan 16 doi: 10.1016/j.jtemb.2024.127397. PMID: 38290269
Contribution of Impaired Parasympathetic Activity to Right Ventricular Dysfunction and Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension.
da Silva Gonçalves Bós D, Van Der Bruggen CEE, Kurakula K, Sun XQ, Casali KR, Casali AG, Rol N, Szulcek R, Dos Remedios C, Guignabert C, Tu L, Dorfmüller P, Humbert M, Wijnker PJM, Kuster DWD, van der Velden J, Goumans MJ, Bogaard HJ, Vonk-Noordegraaf A, de Man FS, Handoko ML
Circulation 2018 Feb 27;137(9):910-924. Epub 2017 Nov 22 doi: 10.1161/CIRCULATIONAHA.117.027451. PMID: 29167228
Maternal perinatal undernutrition has long-term consequences on morphology, function and gene expression of the adrenal medulla in the adult male rat.
Laborie C, Molendi-Coste O, Breton C, Montel V, Vandenbulcke F, Grumolato L, Anouar Y, Vieau D
J Neuroendocrinol 2011 Aug;23(8):711-24. doi: 10.1111/j.1365-2826.2011.02159.x. PMID: 21564351
Elongation index of erythrocytes, study of activity of chosen erythrocyte enzymes, and the levels of glutathione, malonyldialdehyde in polycythemia vera (PV).
Dąbrowski Z, Dybowicz AJ, Marchewka A, Teległów A, Skotnicki A, Zduńczyk A, Aleksander P, Filar-Mierzwa K
Clin Hemorheol Microcirc 2011;47(3):169-76. doi: 10.3233/CH-2010-1368. PMID: 21498896
Serum cholinesterase activities distinguish between stroke patients and controls and predict 12-month mortality.
Ben Assayag E, Shenhar-Tsarfaty S, Ofek K, Soreq L, Bova I, Shopin L, Berg RM, Berliner S, Shapira I, Bornstein NM, Soreq H
Mol Med 2010 Jul-Aug;16(7-8):278-86. Epub 2010 Apr 14 doi: 10.2119/molmed.2010.00015. PMID: 20464061Free PMC Article

Therapy

A study of once-a-week donepezil transdermal system's bioequivalence to oral donepezil in healthy volunteers: a plain language summary.
Braeckman R, Oh C
Neurodegener Dis Manag 2023 Dec;13(6):303-313. Epub 2023 Sep 6 doi: 10.2217/nmt-2023-0012. PMID: 37671720
Zinc improves sexual performance and erectile function by preventing penile oxidative injury and upregulating circulating testosterone in lead-exposed rats.
Besong EE, Akhigbe TM, Ashonibare PJ, Oladipo AA, Obimma JN, Hamed MA, Adeyemi DH, Akhigbe RE
Redox Rep 2023 Dec;28(1):2225675. doi: 10.1080/13510002.2023.2225675. PMID: 37345699Free PMC Article
Contribution of Impaired Parasympathetic Activity to Right Ventricular Dysfunction and Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension.
da Silva Gonçalves Bós D, Van Der Bruggen CEE, Kurakula K, Sun XQ, Casali KR, Casali AG, Rol N, Szulcek R, Dos Remedios C, Guignabert C, Tu L, Dorfmüller P, Humbert M, Wijnker PJM, Kuster DWD, van der Velden J, Goumans MJ, Bogaard HJ, Vonk-Noordegraaf A, de Man FS, Handoko ML
Circulation 2018 Feb 27;137(9):910-924. Epub 2017 Nov 22 doi: 10.1161/CIRCULATIONAHA.117.027451. PMID: 29167228
Cholinergic modulation of visual working memory during aging: a parametric PET study.
Ricciardi E, Pietrini P, Schapiro MB, Rapoport SI, Furey ML
Brain Res Bull 2009 Jun 30;79(5):322-32. Epub 2009 Feb 7 doi: 10.1016/j.brainresbull.2009.01.013. PMID: 19480991Free PMC Article
Acetylcholine regulates ghrelin secretion in humans.
Broglio F, Gottero C, Van Koetsveld P, Prodam F, Destefanis S, Benso A, Gauna C, Hofland L, Arvat E, van der Lely AJ, Ghigo E
J Clin Endocrinol Metab 2004 May;89(5):2429-33. doi: 10.1210/jc.2003-031517. PMID: 15126574

Prognosis

Physical activity and all-cause mortality and mediators of the association in the very old.
Osawa Y, Abe Y, Takayama M, Oguma Y, Arai Y
Exp Gerontol 2021 Jul 15;150:111374. Epub 2021 Apr 25 doi: 10.1016/j.exger.2021.111374. PMID: 33905878
Gut feeling: MicroRNA discriminators of the intestinal TLR9-cholinergic links.
Nadorp B, Soreq H
Int Immunopharmacol 2015 Nov;29(1):8-14. Epub 2015 May 20 doi: 10.1016/j.intimp.2015.04.058. PMID: 26003847Free PMC Article
Serum cholinesterase activities distinguish between stroke patients and controls and predict 12-month mortality.
Ben Assayag E, Shenhar-Tsarfaty S, Ofek K, Soreq L, Bova I, Shopin L, Berg RM, Berliner S, Shapira I, Bornstein NM, Soreq H
Mol Med 2010 Jul-Aug;16(7-8):278-86. Epub 2010 Apr 14 doi: 10.2119/molmed.2010.00015. PMID: 20464061Free PMC Article
Gene transfer of cocaine hydrolase suppresses cardiovascular responses to cocaine in rats.
Gao Y, Atanasova E, Sui N, Pancook JD, Watkins JD, Brimijoin S
Mol Pharmacol 2005 Jan;67(1):204-11. Epub 2004 Oct 1 doi: 10.1124/mol.104.006924. PMID: 15465921

Clinical prediction guides

Physical activity and all-cause mortality and mediators of the association in the very old.
Osawa Y, Abe Y, Takayama M, Oguma Y, Arai Y
Exp Gerontol 2021 Jul 15;150:111374. Epub 2021 Apr 25 doi: 10.1016/j.exger.2021.111374. PMID: 33905878
Contribution of Impaired Parasympathetic Activity to Right Ventricular Dysfunction and Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension.
da Silva Gonçalves Bós D, Van Der Bruggen CEE, Kurakula K, Sun XQ, Casali KR, Casali AG, Rol N, Szulcek R, Dos Remedios C, Guignabert C, Tu L, Dorfmüller P, Humbert M, Wijnker PJM, Kuster DWD, van der Velden J, Goumans MJ, Bogaard HJ, Vonk-Noordegraaf A, de Man FS, Handoko ML
Circulation 2018 Feb 27;137(9):910-924. Epub 2017 Nov 22 doi: 10.1161/CIRCULATIONAHA.117.027451. PMID: 29167228
Gut feeling: MicroRNA discriminators of the intestinal TLR9-cholinergic links.
Nadorp B, Soreq H
Int Immunopharmacol 2015 Nov;29(1):8-14. Epub 2015 May 20 doi: 10.1016/j.intimp.2015.04.058. PMID: 26003847Free PMC Article
Apolipoprotein ε4 modulates phenotype of butyrylcholinesterase in CSF of patients with Alzheimer's disease.
Darreh-Shori T, Siawesh M, Mousavi M, Andreasen N, Nordberg A
J Alzheimers Dis 2012;28(2):443-58. doi: 10.3233/JAD-2011-111088. PMID: 22012848
Serum cholinesterase activities distinguish between stroke patients and controls and predict 12-month mortality.
Ben Assayag E, Shenhar-Tsarfaty S, Ofek K, Soreq L, Bova I, Shopin L, Berg RM, Berliner S, Shapira I, Bornstein NM, Soreq H
Mol Med 2010 Jul-Aug;16(7-8):278-86. Epub 2010 Apr 14 doi: 10.2119/molmed.2010.00015. PMID: 20464061Free PMC Article

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