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Polyclonal elevation of circulating IgA

MedGen UID:
1704010
•Concept ID:
C5139275
•
Finding
HPO: HP:0032333

Definition

A heterogeneous increase in IgA mmunoglobulins characterized by a diffuse band on serum electrophoresis. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPolyclonal elevation of circulating IgA

Recent clinical studies

Etiology

Viral vector delivered immunogen focuses HIV-1 antibody specificity and increases durability of the circulating antibody recall response.
Williams LD, Shen X, Sawant SS, Akapirat S, Dahora LC, Tay MZ, Stanfield-Oakley S, Wills S, Goodman D, Tenney D, Spreng RL, Zhang L, Yates NL, Montefiori DC, Eller MA, Easterhoff D, Hope TJ, Rerks-Ngarm S, Pittisuttithum P, Nitayaphan S, Excler JL, Kim JH, Michael NL, Robb ML, O'Connell RJ, Karasavvas N, Vasan S, Ferrari G, Tomaras GD; RV305 study team
PLoS Pathog 2023 May;19(5):e1011359. Epub 2023 May 31 doi: 10.1371/journal.ppat.1011359. PMID: 37256916Free PMC Article
Circulating serum free light chains as predictive markers of AIDS-related lymphoma.
Landgren O, Goedert JJ, Rabkin CS, Wilson WH, Dunleavy K, Kyle RA, Katzmann JA, Rajkumar SV, Engels EA
J Clin Oncol 2010 Feb 10;28(5):773-9. Epub 2010 Jan 4 doi: 10.1200/JCO.2009.25.1322. PMID: 20048176Free PMC Article
Anti-IL-8 autoantibodies and complexes in rheumatoid arthritis: polyclonal activation in chronic synovial tissue inflammation.
Peichl P, Pursch E, Bröll H, Lindley IJ
Rheumatol Int 1999;18(4):141-5. doi: 10.1007/s002960050073. PMID: 10220834
Spontaneous in vitro production of rheumatoid factor during infectious exacerbations of cystic fibrosis: correlation with circulating immune complex levels.
Keogan MT, Callaghan M, Yanni G, Mulherin D, Feighery C, Brown DL, Fitzgerald MX, Bresnihan B
Clin Exp Immunol 1993 Mar;91(3):462-6. doi: 10.1111/j.1365-2249.1993.tb05925.x. PMID: 7680296Free PMC Article

Diagnosis

Investigating the utility of saliva immunoglobulins for the detection of myeloma and using myeloma proteins to clarify partition between oral and systemic immunity.
Heaney JLJ, Faustini S, Evans L, Rapson A, Collman E, Emery A, Campbell JP, Moore S, Goodall M, Afzal Z, Chapple IL, Pratt G, Drayson MT
Eur J Haematol 2022 Jun;108(6):493-502. Epub 2022 Feb 28 doi: 10.1111/ejh.13758. PMID: 35184331Free PMC Article
Circulating serum free light chains as predictive markers of AIDS-related lymphoma.
Landgren O, Goedert JJ, Rabkin CS, Wilson WH, Dunleavy K, Kyle RA, Katzmann JA, Rajkumar SV, Engels EA
J Clin Oncol 2010 Feb 10;28(5):773-9. Epub 2010 Jan 4 doi: 10.1200/JCO.2009.25.1322. PMID: 20048176Free PMC Article
Anti-IL-8 autoantibodies and complexes in rheumatoid arthritis: polyclonal activation in chronic synovial tissue inflammation.
Peichl P, Pursch E, Bröll H, Lindley IJ
Rheumatol Int 1999;18(4):141-5. doi: 10.1007/s002960050073. PMID: 10220834
Chronic idiopathic ataxic neuropathy.
Dalakas MC
Ann Neurol 1986 Jun;19(6):545-54. doi: 10.1002/ana.410190605. PMID: 3014995
Cerebrospinal fluid IgM, IgA, and IgG indexes in systemic lupus erythematosus. Their use as estimates of central nervous system disease activity.
Hirohata S, Hirose S, Miyamoto T
Arch Intern Med 1985 Oct;145(10):1843-6. PMID: 3899036

Therapy

Viral vector delivered immunogen focuses HIV-1 antibody specificity and increases durability of the circulating antibody recall response.
Williams LD, Shen X, Sawant SS, Akapirat S, Dahora LC, Tay MZ, Stanfield-Oakley S, Wills S, Goodman D, Tenney D, Spreng RL, Zhang L, Yates NL, Montefiori DC, Eller MA, Easterhoff D, Hope TJ, Rerks-Ngarm S, Pittisuttithum P, Nitayaphan S, Excler JL, Kim JH, Michael NL, Robb ML, O'Connell RJ, Karasavvas N, Vasan S, Ferrari G, Tomaras GD; RV305 study team
PLoS Pathog 2023 May;19(5):e1011359. Epub 2023 May 31 doi: 10.1371/journal.ppat.1011359. PMID: 37256916Free PMC Article
Anti-IL-8 autoantibodies and complexes in rheumatoid arthritis: polyclonal activation in chronic synovial tissue inflammation.
Peichl P, Pursch E, Bröll H, Lindley IJ
Rheumatol Int 1999;18(4):141-5. doi: 10.1007/s002960050073. PMID: 10220834
Cerebrospinal fluid IgM, IgA, and IgG indexes in systemic lupus erythematosus. Their use as estimates of central nervous system disease activity.
Hirohata S, Hirose S, Miyamoto T
Arch Intern Med 1985 Oct;145(10):1843-6. PMID: 3899036

Prognosis

Circulating serum free light chains as predictive markers of AIDS-related lymphoma.
Landgren O, Goedert JJ, Rabkin CS, Wilson WH, Dunleavy K, Kyle RA, Katzmann JA, Rajkumar SV, Engels EA
J Clin Oncol 2010 Feb 10;28(5):773-9. Epub 2010 Jan 4 doi: 10.1200/JCO.2009.25.1322. PMID: 20048176Free PMC Article
Anti-IL-8 autoantibodies and complexes in rheumatoid arthritis: polyclonal activation in chronic synovial tissue inflammation.
Peichl P, Pursch E, Bröll H, Lindley IJ
Rheumatol Int 1999;18(4):141-5. doi: 10.1007/s002960050073. PMID: 10220834
Chronic idiopathic ataxic neuropathy.
Dalakas MC
Ann Neurol 1986 Jun;19(6):545-54. doi: 10.1002/ana.410190605. PMID: 3014995

Clinical prediction guides

Viral vector delivered immunogen focuses HIV-1 antibody specificity and increases durability of the circulating antibody recall response.
Williams LD, Shen X, Sawant SS, Akapirat S, Dahora LC, Tay MZ, Stanfield-Oakley S, Wills S, Goodman D, Tenney D, Spreng RL, Zhang L, Yates NL, Montefiori DC, Eller MA, Easterhoff D, Hope TJ, Rerks-Ngarm S, Pittisuttithum P, Nitayaphan S, Excler JL, Kim JH, Michael NL, Robb ML, O'Connell RJ, Karasavvas N, Vasan S, Ferrari G, Tomaras GD; RV305 study team
PLoS Pathog 2023 May;19(5):e1011359. Epub 2023 May 31 doi: 10.1371/journal.ppat.1011359. PMID: 37256916Free PMC Article
Circulating serum free light chains as predictive markers of AIDS-related lymphoma.
Landgren O, Goedert JJ, Rabkin CS, Wilson WH, Dunleavy K, Kyle RA, Katzmann JA, Rajkumar SV, Engels EA
J Clin Oncol 2010 Feb 10;28(5):773-9. Epub 2010 Jan 4 doi: 10.1200/JCO.2009.25.1322. PMID: 20048176Free PMC Article
Development of immunoglobulin M memory to both a T-cell-independent and a T-cell-dependent antigen following infection with Vibrio cholerae O1 in Bangladesh.
Kendall EA, Tarique AA, Hossain A, Alam MM, Arifuzzaman M, Akhtar N, Chowdhury F, Khan AI, Larocque RC, Harris JB, Ryan ET, Qadri F, Calderwood SB
Infect Immun 2010 Jan;78(1):253-9. Epub 2009 Oct 26 doi: 10.1128/IAI.00868-09. PMID: 19858296Free PMC Article
Virus-specific antibody production and polyclonal B-cell activation in the intestinal mucosa of HIV-infected individuals.
Eriksson K, Kilander A, Hagberg L, Norkrans G, Holmgren J, Czerkinsky C
AIDS 1995 Jul;9(7):695-700. doi: 10.1097/00002030-199507000-00005. PMID: 7546413
Spontaneous in vitro production of rheumatoid factor during infectious exacerbations of cystic fibrosis: correlation with circulating immune complex levels.
Keogan MT, Callaghan M, Yanni G, Mulherin D, Feighery C, Brown DL, Fitzgerald MX, Bresnihan B
Clin Exp Immunol 1993 Mar;91(3):462-6. doi: 10.1111/j.1365-2249.1993.tb05925.x. PMID: 7680296Free PMC Article

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