U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Kidney Neuroendocrine Carcinoma

MedGen UID:
1704054
Concept ID:
C5204272
Neoplastic Process

Definition

An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the kidney. According to the size of the malignant cells, the prominence of the nucleoli, and the amount of cytoplasm, it is classified either as small or large cell neuroendocrine carcinoma. [from NCI]

Term Hierarchy

Professional guidelines

PubMed

Laks S, van Leeuwaarde R, Patel D, Keutgen XM, Hammel P, Nilubol N, Links TP, Halfdanarson TR, Daniels AB, Tirosh A; Pancreatic Manifestations Recommendations Development Subcommittee of the VHL Alliance
Cancer 2022 Feb 1;128(3):435-446. Epub 2021 Nov 4 doi: 10.1002/cncr.33978. PMID: 34735022
Chatani PD, Agarwal SK, Sadowski SM
Front Endocrinol (Lausanne) 2020;11:575620. Epub 2021 Jan 18 doi: 10.3389/fendo.2020.575620. PMID: 33537001Free PMC Article
Ito T, Hijioka S, Masui T, Kasajima A, Nakamoto Y, Kobayashi N, Komoto I, Hijioka M, Lee L, Igarashi H, Jensen RT, Imamura M
J Gastroenterol 2017 Jan;52(1):9-18. Epub 2016 Aug 18 doi: 10.1007/s00535-016-1250-9. PMID: 27539256

Recent clinical studies

Etiology

Martínez-Jiménez F, Movasati A, Brunner SR, Nguyen L, Priestley P, Cuppen E, Van Hoeck A
Nature 2023 Jun;618(7964):333-341. Epub 2023 May 10 doi: 10.1038/s41586-023-06054-z. PMID: 37165194Free PMC Article
Mohanty SK, Lobo A, Cheng L
Hum Pathol 2023 Jun;136:123-143. Epub 2022 Sep 6 doi: 10.1016/j.humpath.2022.08.006. PMID: 36084769
Moch H, Amin MB, Berney DM, Compérat EM, Gill AJ, Hartmann A, Menon S, Raspollini MR, Rubin MA, Srigley JR, Hoon Tan P, Tickoo SK, Tsuzuki T, Turajlic S, Cree I, Netto GJ
Eur Urol 2022 Nov;82(5):458-468. Epub 2022 Jul 16 doi: 10.1016/j.eururo.2022.06.016. PMID: 35853783
Louise M Binderup M, Smerdel M, Borgwadt L, Beck Nielsen SS, Madsen MG, Møller HU, Kiilgaard JF, Friis-Hansen L, Harbud V, Cortnum S, Owen H, Gimsing S, Friis Juhl HA, Munthe S, Geilswijk M, Rasmussen ÅK, Møldrup U, Graumann O, Donskov F, Grønbæk H, Stausbøl-Grøn B, Schaffalitzky de Muckadell O, Knigge U, Dam G, Wadt KA, Bøgeskov L, Bagi P, Lund L, Stochholm K, Ousager LB, Sunde L
Eur J Med Genet 2022 Aug;65(8):104538. Epub 2022 Jun 13 doi: 10.1016/j.ejmg.2022.104538. PMID: 35709961
Jonasch E, Donskov F, Iliopoulos O, Rathmell WK, Narayan VK, Maughan BL, Oudard S, Else T, Maranchie JK, Welsh SJ, Thamake S, Park EK, Perini RF, Linehan WM, Srinivasan R; MK-6482-004 Investigators
N Engl J Med 2021 Nov 25;385(22):2036-2046. doi: 10.1056/NEJMoa2103425. PMID: 34818478Free PMC Article

Diagnosis

Toledo RA, Jimenez C, Armaiz-Pena G, Arenillas C, Capdevila J, Dahia PLM
Endocr Rev 2023 Mar 4;44(2):312-322. doi: 10.1210/endrev/bnac025. PMID: 36301191Free PMC Article
Moch H, Amin MB, Berney DM, Compérat EM, Gill AJ, Hartmann A, Menon S, Raspollini MR, Rubin MA, Srigley JR, Hoon Tan P, Tickoo SK, Tsuzuki T, Turajlic S, Cree I, Netto GJ
Eur Urol 2022 Nov;82(5):458-468. Epub 2022 Jul 16 doi: 10.1016/j.eururo.2022.06.016. PMID: 35853783
Louise M Binderup M, Smerdel M, Borgwadt L, Beck Nielsen SS, Madsen MG, Møller HU, Kiilgaard JF, Friis-Hansen L, Harbud V, Cortnum S, Owen H, Gimsing S, Friis Juhl HA, Munthe S, Geilswijk M, Rasmussen ÅK, Møldrup U, Graumann O, Donskov F, Grønbæk H, Stausbøl-Grøn B, Schaffalitzky de Muckadell O, Knigge U, Dam G, Wadt KA, Bøgeskov L, Bagi P, Lund L, Stochholm K, Ousager LB, Sunde L
Eur J Med Genet 2022 Aug;65(8):104538. Epub 2022 Jun 13 doi: 10.1016/j.ejmg.2022.104538. PMID: 35709961
Pósfai B, Kuthi L, Varga L, Laczó I, Révész J, Kránicz R, Maráz A
Anticancer Res 2018 Jun;38(6):3243-3254. doi: 10.21873/anticanres.12589. PMID: 29848671
Chou A, Toon C, Pickett J, Gill AJ
Front Horm Res 2013;41:30-49. Epub 2013 Mar 19 doi: 10.1159/000345668. PMID: 23652669

Therapy

Kaseb AO, Hasanov E, Cao HST, Xiao L, Vauthey JN, Lee SS, Yavuz BG, Mohamed YI, Qayyum A, Jindal S, Duan F, Basu S, Yadav SS, Nicholas C, Sun JJ, Singh Raghav KP, Rashid A, Carter K, Chun YS, Tzeng CD, Sakamuri D, Xu L, Sun R, Cristini V, Beretta L, Yao JC, Wolff RA, Allison JP, Sharma P
Lancet Gastroenterol Hepatol 2022 Mar;7(3):208-218. Epub 2022 Jan 20 doi: 10.1016/S2468-1253(21)00427-1. PMID: 35065057Free PMC Article
Jonasch E, Donskov F, Iliopoulos O, Rathmell WK, Narayan VK, Maughan BL, Oudard S, Else T, Maranchie JK, Welsh SJ, Thamake S, Park EK, Perini RF, Linehan WM, Srinivasan R; MK-6482-004 Investigators
N Engl J Med 2021 Nov 25;385(22):2036-2046. doi: 10.1056/NEJMoa2103425. PMID: 34818478Free PMC Article
Deeks ED
Drugs 2021 Nov;81(16):1921-1927. doi: 10.1007/s40265-021-01606-x. PMID: 34613603
Chatani PD, Agarwal SK, Sadowski SM
Front Endocrinol (Lausanne) 2020;11:575620. Epub 2021 Jan 18 doi: 10.3389/fendo.2020.575620. PMID: 33537001Free PMC Article
McGarrah PW, Westin GFM, Hobday TJ, Scales JA, Ingimarsson JP, Leibovich BC, Halfdanarson TR
Clin Genitourin Cancer 2020 Aug;18(4):e343-e349. Epub 2019 Dec 5 doi: 10.1016/j.clgc.2019.11.003. PMID: 31911122

Prognosis

Jonasch E, Donskov F, Iliopoulos O, Rathmell WK, Narayan VK, Maughan BL, Oudard S, Else T, Maranchie JK, Welsh SJ, Thamake S, Park EK, Perini RF, Linehan WM, Srinivasan R; MK-6482-004 Investigators
N Engl J Med 2021 Nov 25;385(22):2036-2046. doi: 10.1056/NEJMoa2103425. PMID: 34818478Free PMC Article
Chatani PD, Agarwal SK, Sadowski SM
Front Endocrinol (Lausanne) 2020;11:575620. Epub 2021 Jan 18 doi: 10.3389/fendo.2020.575620. PMID: 33537001Free PMC Article
Sanguedolce F, Calò B, Chirico M, Tortorella S, Carrieri G, Cormio L
Anticancer Res 2020 May;40(5):2439-2447. doi: 10.21873/anticanres.14213. PMID: 32366387
Pósfai B, Kuthi L, Varga L, Laczó I, Révész J, Kránicz R, Maráz A
Anticancer Res 2018 Jun;38(6):3243-3254. doi: 10.21873/anticanres.12589. PMID: 29848671
Cassol C, Mete O
Arch Pathol Lab Med 2015 Feb;139(2):263-8. doi: 10.5858/arpa.2013-0520-RS. PMID: 25611110

Clinical prediction guides

Chen TY, Mihalopoulos M, Zuluaga L, Rich J, Ganta T, Mehrazin R, Tsao CK, Tewari A, Gonzalez-Kozlova E, Badani K, Dogra N, Kyprianou N
Int J Mol Sci 2023 Sep 28;24(19) doi: 10.3390/ijms241914713. PMID: 37834162Free PMC Article
Toledo RA, Jimenez C, Armaiz-Pena G, Arenillas C, Capdevila J, Dahia PLM
Endocr Rev 2023 Mar 4;44(2):312-322. doi: 10.1210/endrev/bnac025. PMID: 36301191Free PMC Article
Fallah J, Brave MH, Weinstock C, Mehta GU, Bradford D, Gittleman H, Bloomquist EW, Charlab R, Hamed SS, Miller CP, Dorff SE, Chambers WA, Mixter BD, Dinin J, Pierce WF, Ricks TK, Tang S, Donoghue M, Pazdur R, Amiri-Kordestani L, Ibrahim A, Beaver JA
Clin Cancer Res 2022 Nov 14;28(22):4843-4848. doi: 10.1158/1078-0432.CCR-22-1054. PMID: 35727604Free PMC Article
Visweswaran V, Pavithran K
Curr Drug Res Rev 2022;14(2):88-95. doi: 10.2174/2589977514666220401094724. PMID: 35366789
Jonasch E, Donskov F, Iliopoulos O, Rathmell WK, Narayan VK, Maughan BL, Oudard S, Else T, Maranchie JK, Welsh SJ, Thamake S, Park EK, Perini RF, Linehan WM, Srinivasan R; MK-6482-004 Investigators
N Engl J Med 2021 Nov 25;385(22):2036-2046. doi: 10.1056/NEJMoa2103425. PMID: 34818478Free PMC Article

Recent systematic reviews

Persano I, Parlagreco E, La Salvia A, Audisio M, Volante M, Buttigliero C, Scagliotti GV, Brizzi MP
Semin Oncol 2022 Dec;49(6):476-481. Epub 2023 Feb 2 doi: 10.1053/j.seminoncol.2023.01.007. PMID: 36759234
Eccher A, Girolami I, Motter JD, Marletta S, Gambaro G, Momo REN, Nacchia F, Donato P, Boschiero L, Boggi U, Lombardini L, Cardillo M, D'Errico A, Neil D, Segev DL, Zaza G
J Nephrol 2020 Dec;33(6):1321-1332. Epub 2020 Jun 13 doi: 10.1007/s40620-020-00775-4. PMID: 32535833Free PMC Article
Nakasato T, Hiramatsu A, Matsui Y, Unoki T, Shimoyama H, Oshinomi K, Morita J, Maeda Y, Naoe M, Fuji K, Ogura H, Homma M, Yamochi T, Takimoto M, Ogawa Y
Cancer Treat Res Commun 2018;17:23-30. Epub 2018 Oct 9 doi: 10.1016/j.ctarc.2018.10.003. PMID: 30326420
Alvarez O, Rodriguez MM, Jordan L, Sarnaik S
Pediatr Blood Cancer 2015 Oct;62(10):1694-9. Epub 2015 Jun 5 doi: 10.1002/pbc.25592. PMID: 26053587
Shuch B, Amin A, Armstrong AJ, Eble JN, Ficarra V, Lopez-Beltran A, Martignoni G, Rini BI, Kutikov A
Eur Urol 2015 Jan;67(1):85-97. Epub 2014 May 21 doi: 10.1016/j.eururo.2014.04.029. PMID: 24857407

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...