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Reduced circulating C-reactive protein concecntration

MedGen UID:
1704066
•Concept ID:
C5139347
•
Finding
Synonym: Reduced C-reactive protein level
 
HPO: HP:0032437

Definition

An abnormal decrease of the C-reactive protein level in serum. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReduced circulating C-reactive protein concecntration

Professional guidelines

PubMed

Biomarkers for Risk Assessment in Atrial Fibrillation.
Berg DD, Ruff CT, Morrow DA
Clin Chem 2021 Jan 8;67(1):87-95. doi: 10.1093/clinchem/hvaa298. PMID: 33313695
2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.
Grundy SM, Stone NJ, Bailey AL, Beam C, Birtcher KK, Blumenthal RS, Braun LT, de Ferranti S, Faiella-Tommasino J, Forman DE, Goldberg R, Heidenreich PA, Hlatky MA, Jones DW, Lloyd-Jones D, Lopez-Pajares N, Ndumele CE, Orringer CE, Peralta CA, Saseen JJ, Smith SC Jr, Sperling L, Virani SS, Yeboah J
Circulation 2019 Jun 18;139(25):e1082-e1143. Epub 2018 Nov 10 doi: 10.1161/CIR.0000000000000625. PMID: 30586774Free PMC Article
From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part I.
Naghavi M, Libby P, Falk E, Casscells SW, Litovsky S, Rumberger J, Badimon JJ, Stefanadis C, Moreno P, Pasterkamp G, Fayad Z, Stone PH, Waxman S, Raggi P, Madjid M, Zarrabi A, Burke A, Yuan C, Fitzgerald PJ, Siscovick DS, de Korte CL, Aikawa M, Juhani Airaksinen KE, Assmann G, Becker CR, Chesebro JH, Farb A, Galis ZS, Jackson C, Jang IK, Koenig W, Lodder RA, March K, Demirovic J, Navab M, Priori SG, Rekhter MD, Bahr R, Grundy SM, Mehran R, Colombo A, Boerwinkle E, Ballantyne C, Insull W Jr, Schwartz RS, Vogel R, Serruys PW, Hansson GK, Faxon DP, Kaul S, Drexler H, Greenland P, Muller JE, Virmani R, Ridker PM, Zipes DP, Shah PK, Willerson JT
Circulation 2003 Oct 7;108(14):1664-72. doi: 10.1161/01.CIR.0000087480.94275.97. PMID: 14530185

Recent clinical studies

Etiology

Effects of Randomized Treatment With Icosapent Ethyl and a Mineral Oil Comparator on Interleukin-1β, Interleukin-6, C-Reactive Protein, Oxidized Low-Density Lipoprotein Cholesterol, Homocysteine, Lipoprotein(a), and Lipoprotein-Associated Phospholipase A2: A REDUCE-IT Biomarker Substudy.
Ridker PM, Rifai N, MacFadyen J, Glynn RJ, Jiao L, Steg PG, Miller M, Brinton EA, Jacobson TA, Tardif JC, Ballantyne CM, Mason RP, Bhatt DL
Circulation 2022 Aug 2;146(5):372-379. Epub 2022 Jun 28 doi: 10.1161/CIRCULATIONAHA.122.059410. PMID: 35762321
Levels of circulating semaglutide determine reductions in HbA1c and body weight in people with type 2 diabetes.
Overgaard RV, Hertz CL, Ingwersen SH, Navarria A, Drucker DJ
Cell Rep Med 2021 Sep 21;2(9):100387. Epub 2021 Sep 3 doi: 10.1016/j.xcrm.2021.100387. PMID: 34622228Free PMC Article
Exercise training, circulating cytokine levels and immune function in cancer survivors: A meta-analysis.
Khosravi N, Stoner L, Farajivafa V, Hanson ED
Brain Behav Immun 2019 Oct;81:92-104. Epub 2019 Aug 24 doi: 10.1016/j.bbi.2019.08.187. PMID: 31454519
Effects of a Paleolithic Diet on Cardiovascular Disease Risk Factors: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Ghaedi E, Mohammadi M, Mohammadi H, Ramezani-Jolfaie N, Malekzadeh J, Hosseinzadeh M, Salehi-Abargouei A
Adv Nutr 2019 Jul 1;10(4):634-646. doi: 10.1093/advances/nmz007. PMID: 31041449Free PMC Article
Lemon detox diet reduced body fat, insulin resistance, and serum hs-CRP level without hematological changes in overweight Korean women.
Kim MJ, Hwang JH, Ko HJ, Na HB, Kim JH
Nutr Res 2015 May;35(5):409-20. Epub 2015 Apr 10 doi: 10.1016/j.nutres.2015.04.001. PMID: 25912765

Diagnosis

Effects of Randomized Treatment With Icosapent Ethyl and a Mineral Oil Comparator on Interleukin-1β, Interleukin-6, C-Reactive Protein, Oxidized Low-Density Lipoprotein Cholesterol, Homocysteine, Lipoprotein(a), and Lipoprotein-Associated Phospholipase A2: A REDUCE-IT Biomarker Substudy.
Ridker PM, Rifai N, MacFadyen J, Glynn RJ, Jiao L, Steg PG, Miller M, Brinton EA, Jacobson TA, Tardif JC, Ballantyne CM, Mason RP, Bhatt DL
Circulation 2022 Aug 2;146(5):372-379. Epub 2022 Jun 28 doi: 10.1161/CIRCULATIONAHA.122.059410. PMID: 35762321
Inflammation in Hypertension.
Xiao L, Harrison DG
Can J Cardiol 2020 May;36(5):635-647. Epub 2020 Jan 24 doi: 10.1016/j.cjca.2020.01.013. PMID: 32389337Free PMC Article
Exercise training, circulating cytokine levels and immune function in cancer survivors: A meta-analysis.
Khosravi N, Stoner L, Farajivafa V, Hanson ED
Brain Behav Immun 2019 Oct;81:92-104. Epub 2019 Aug 24 doi: 10.1016/j.bbi.2019.08.187. PMID: 31454519
Lemon detox diet reduced body fat, insulin resistance, and serum hs-CRP level without hematological changes in overweight Korean women.
Kim MJ, Hwang JH, Ko HJ, Na HB, Kim JH
Nutr Res 2015 May;35(5):409-20. Epub 2015 Apr 10 doi: 10.1016/j.nutres.2015.04.001. PMID: 25912765
Inflammation and atherosclerosis.
Libby P, Ridker PM, Maseri A
Circulation 2002 Mar 5;105(9):1135-43. doi: 10.1161/hc0902.104353. PMID: 11877368

Therapy

Genome-wide association and Mendelian randomization study of fibroblast growth factor 21 reveals causal associations with hyperlipidemia and possibly NASH.
Larsson SC, Michaëlsson K, Mola-Caminal M, Höijer J, Mantzoros CS
Metabolism 2022 Dec;137:155329. Epub 2022 Oct 5 doi: 10.1016/j.metabol.2022.155329. PMID: 36208799
Effects of Randomized Treatment With Icosapent Ethyl and a Mineral Oil Comparator on Interleukin-1β, Interleukin-6, C-Reactive Protein, Oxidized Low-Density Lipoprotein Cholesterol, Homocysteine, Lipoprotein(a), and Lipoprotein-Associated Phospholipase A2: A REDUCE-IT Biomarker Substudy.
Ridker PM, Rifai N, MacFadyen J, Glynn RJ, Jiao L, Steg PG, Miller M, Brinton EA, Jacobson TA, Tardif JC, Ballantyne CM, Mason RP, Bhatt DL
Circulation 2022 Aug 2;146(5):372-379. Epub 2022 Jun 28 doi: 10.1161/CIRCULATIONAHA.122.059410. PMID: 35762321
Levels of circulating semaglutide determine reductions in HbA1c and body weight in people with type 2 diabetes.
Overgaard RV, Hertz CL, Ingwersen SH, Navarria A, Drucker DJ
Cell Rep Med 2021 Sep 21;2(9):100387. Epub 2021 Sep 3 doi: 10.1016/j.xcrm.2021.100387. PMID: 34622228Free PMC Article
Exercise training, circulating cytokine levels and immune function in cancer survivors: A meta-analysis.
Khosravi N, Stoner L, Farajivafa V, Hanson ED
Brain Behav Immun 2019 Oct;81:92-104. Epub 2019 Aug 24 doi: 10.1016/j.bbi.2019.08.187. PMID: 31454519
Lemon detox diet reduced body fat, insulin resistance, and serum hs-CRP level without hematological changes in overweight Korean women.
Kim MJ, Hwang JH, Ko HJ, Na HB, Kim JH
Nutr Res 2015 May;35(5):409-20. Epub 2015 Apr 10 doi: 10.1016/j.nutres.2015.04.001. PMID: 25912765

Prognosis

Diet-derived antioxidants and nonalcoholic fatty liver disease: a Mendelian randomization study.
Chen L, Fan Z, Sun X, Qiu W, Mu W, Chai K, Cao Y, Wang G, Lv G
Hepatol Int 2023 Apr;17(2):326-338. Epub 2022 Nov 10 doi: 10.1007/s12072-022-10443-3. PMID: 36352064
Soluble Urokinase Plasminogen Activator Receptor (suPAR) as a Biomarker of Systemic Chronic Inflammation.
Rasmussen LJH, Petersen JEV, Eugen-Olsen J
Front Immunol 2021;12:780641. Epub 2021 Dec 2 doi: 10.3389/fimmu.2021.780641. PMID: 34925360Free PMC Article
The impact of ageing on monocytes and macrophages.
De Maeyer RPH, Chambers ES
Immunol Lett 2021 Feb;230:1-10. Epub 2020 Dec 10 doi: 10.1016/j.imlet.2020.12.003. PMID: 33309673
2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.
Grundy SM, Stone NJ, Bailey AL, Beam C, Birtcher KK, Blumenthal RS, Braun LT, de Ferranti S, Faiella-Tommasino J, Forman DE, Goldberg R, Heidenreich PA, Hlatky MA, Jones DW, Lloyd-Jones D, Lopez-Pajares N, Ndumele CE, Orringer CE, Peralta CA, Saseen JJ, Smith SC Jr, Sperling L, Virani SS, Yeboah J
Circulation 2019 Jun 18;139(25):e1082-e1143. Epub 2018 Nov 10 doi: 10.1161/CIR.0000000000000625. PMID: 30586774Free PMC Article
Inflammation and atherosclerosis.
Libby P, Ridker PM, Maseri A
Circulation 2002 Mar 5;105(9):1135-43. doi: 10.1161/hc0902.104353. PMID: 11877368

Clinical prediction guides

Effects of Randomized Treatment With Icosapent Ethyl and a Mineral Oil Comparator on Interleukin-1β, Interleukin-6, C-Reactive Protein, Oxidized Low-Density Lipoprotein Cholesterol, Homocysteine, Lipoprotein(a), and Lipoprotein-Associated Phospholipase A2: A REDUCE-IT Biomarker Substudy.
Ridker PM, Rifai N, MacFadyen J, Glynn RJ, Jiao L, Steg PG, Miller M, Brinton EA, Jacobson TA, Tardif JC, Ballantyne CM, Mason RP, Bhatt DL
Circulation 2022 Aug 2;146(5):372-379. Epub 2022 Jun 28 doi: 10.1161/CIRCULATIONAHA.122.059410. PMID: 35762321
The impact of ageing on monocytes and macrophages.
De Maeyer RPH, Chambers ES
Immunol Lett 2021 Feb;230:1-10. Epub 2020 Dec 10 doi: 10.1016/j.imlet.2020.12.003. PMID: 33309673
Inflammation in Hypertension.
Xiao L, Harrison DG
Can J Cardiol 2020 May;36(5):635-647. Epub 2020 Jan 24 doi: 10.1016/j.cjca.2020.01.013. PMID: 32389337Free PMC Article
Lemon detox diet reduced body fat, insulin resistance, and serum hs-CRP level without hematological changes in overweight Korean women.
Kim MJ, Hwang JH, Ko HJ, Na HB, Kim JH
Nutr Res 2015 May;35(5):409-20. Epub 2015 Apr 10 doi: 10.1016/j.nutres.2015.04.001. PMID: 25912765
Inflammation and atherosclerosis.
Libby P, Ridker PM, Maseri A
Circulation 2002 Mar 5;105(9):1135-43. doi: 10.1161/hc0902.104353. PMID: 11877368

Recent systematic reviews

The effects of probiotic and synbiotic supplementation on inflammation, oxidative stress, and circulating adiponectin and leptin concentration in subjects with prediabetes and type 2 diabetes mellitus: a GRADE-assessed systematic review, meta-analysis, and meta-regression of randomized clinical trials.
Naseri K, Saadati S, Ghaemi F, Ashtary-Larky D, Asbaghi O, Sadeghi A, Afrisham R, de Courten B
Eur J Nutr 2023 Mar;62(2):543-561. Epub 2022 Oct 14 doi: 10.1007/s00394-022-03012-9. PMID: 36239789Free PMC Article
Effects of whey and soy protein supplementation on inflammatory cytokines in older adults: a systematic review and meta-analysis.
Prokopidis K, Mazidi M, Sankaranarayanan R, Tajik B, McArdle A, Isanejad M
Br J Nutr 2023 Mar 14;129(5):759-770. Epub 2022 Jun 16 doi: 10.1017/S0007114522001787. PMID: 35706399Free PMC Article
Probiotics, prebiotics, and synbiotics for the improvement of metabolic profiles in patients with chronic kidney disease: A systematic review and meta-analysis of randomized controlled trials.
Zheng HJ, Guo J, Wang Q, Wang L, Wang Y, Zhang F, Huang WJ, Zhang W, Liu WJ, Wang Y
Crit Rev Food Sci Nutr 2021;61(4):577-598. Epub 2020 Apr 24 doi: 10.1080/10408398.2020.1740645. PMID: 32329633
Effects of a Paleolithic Diet on Cardiovascular Disease Risk Factors: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Ghaedi E, Mohammadi M, Mohammadi H, Ramezani-Jolfaie N, Malekzadeh J, Hosseinzadeh M, Salehi-Abargouei A
Adv Nutr 2019 Jul 1;10(4):634-646. doi: 10.1093/advances/nmz007. PMID: 31041449Free PMC Article
2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.
Grundy SM, Stone NJ, Bailey AL, Beam C, Birtcher KK, Blumenthal RS, Braun LT, de Ferranti S, Faiella-Tommasino J, Forman DE, Goldberg R, Heidenreich PA, Hlatky MA, Jones DW, Lloyd-Jones D, Lopez-Pajares N, Ndumele CE, Orringer CE, Peralta CA, Saseen JJ, Smith SC Jr, Sperling L, Virani SS, Yeboah J
Circulation 2019 Jun 18;139(25):e1082-e1143. Epub 2018 Nov 10 doi: 10.1161/CIR.0000000000000625. PMID: 30586774Free PMC Article

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