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Increased circulating band cell count

MedGen UID:
1704142
•Concept ID:
C4760706
•
Finding
Synonyms: Increased circulating band form neutrophils; Left shift
 
HPO: HP:0032239

Definition

The number of band cells in the peripheral blood circulation is above the upper limit of normal. Band cells are immature neutrophils with a size of 10-18 micrometers, a horseshoe-shaped nucleus with no nucleoli, light-pink staining cytoplasm with many small secondary granules, and a nucleus:cytoplasm ratio of 1:2. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased circulating band cell count

Professional guidelines

PubMed

Predictive value of pretreatment circulating inflammatory response markers in the neoadjuvant treatment of breast cancer: meta-analysis.
Dowling GP, Daly GR, Hegarty A, Hembrecht S, Bracken A, Toomey S, Hennessy BT, Hill ADK
Br J Surg 2024 May 3;111(5) doi: 10.1093/bjs/znae132. PMID: 38801441Free PMC Article
Neutrophil Count Predicts Malignant Cerebellar Edema and Poor Outcome in Acute Basilar Artery Occlusion Receiving Endovascular Treatment: A Nationwide Registry-Based Study.
Liu C, Li F, Liu S, Chen Q, Sang H, Yang Q, Zhou K, Zi W
Front Immunol 2022;13:835915. Epub 2022 May 3 doi: 10.3389/fimmu.2022.835915. PMID: 35592334Free PMC Article
CIN or not: An approach to the evaluation and management of chronic idiopathic neutrophilia.
Otieno SB, Altahan A, Karri S, Kaweeta F, Lands L, Weir A
Blood Rev 2021 Mar;46:100739. Epub 2020 Aug 5 doi: 10.1016/j.blre.2020.100739. PMID: 32811689

Recent clinical studies

Etiology

Circulating white blood cell traits and colorectal cancer risk: A Mendelian randomisation study.
Constantinescu AE, Bull CJ, Jones N, Mitchell R, Burrows K, Dimou N, Bézieau S, Brenner H, Buchanan DD, D'Amato M, Jenkins MA, Moreno V, Pai RK, Um CY, White E, Murphy N, Gunter M, Timpson NJ, Huyghe JR, Vincent EE
Int J Cancer 2024 Jan 1;154(1):94-103. Epub 2023 Aug 14 doi: 10.1002/ijc.34691. PMID: 37578112Free PMC Article
White Blood Cells and Blood Pressure: A Mendelian Randomization Study.
Siedlinski M, Jozefczuk E, Xu X, Teumer A, Evangelou E, Schnabel RB, Welsh P, Maffia P, Erdmann J, Tomaszewski M, Caulfield MJ, Sattar N, Holmes MV, Guzik TJ
Circulation 2020 Apr 21;141(16):1307-1317. Epub 2020 Mar 9 doi: 10.1161/CIRCULATIONAHA.119.045102. PMID: 32148083Free PMC Article
Recovery of the immune system after exercise.
Peake JM, Neubauer O, Walsh NP, Simpson RJ
J Appl Physiol (1985) 2017 May 1;122(5):1077-1087. Epub 2016 Dec 1 doi: 10.1152/japplphysiol.00622.2016. PMID: 27909225
Inflammatory mechanisms in patients with chronic obstructive pulmonary disease.
Barnes PJ
J Allergy Clin Immunol 2016 Jul;138(1):16-27. Epub 2016 May 27 doi: 10.1016/j.jaci.2016.05.011. PMID: 27373322
Adipokines and thrombosis.
Schäfer K, Konstantinides S
Clin Exp Pharmacol Physiol 2011 Dec;38(12):864-71. doi: 10.1111/j.1440-1681.2011.05589.x. PMID: 21848866

Diagnosis

White Blood Cell Count, Neutrophil-to-Lymphocyte Ratio, and Incident Cancer in the UK Biobank.
Song M, Graubard BI, Loftfield E, Rabkin CS, Engels EA
Cancer Epidemiol Biomarkers Prev 2024 Jun 3;33(6):821-829. doi: 10.1158/1055-9965.EPI-23-1145. PMID: 38568024Free PMC Article
Circulating Neutrophil Dysfunction in HBV-Related Acute-on-Chronic Liver Failure.
Wu W, Sun S, Wang Y, Zhao R, Ren H, Li Z, Zhao H, Zhang Y, Sheng J, Chen Z, Shi Y
Front Immunol 2021;12:620365. Epub 2021 Feb 25 doi: 10.3389/fimmu.2021.620365. PMID: 33717119Free PMC Article
CIN or not: An approach to the evaluation and management of chronic idiopathic neutrophilia.
Otieno SB, Altahan A, Karri S, Kaweeta F, Lands L, Weir A
Blood Rev 2021 Mar;46:100739. Epub 2020 Aug 5 doi: 10.1016/j.blre.2020.100739. PMID: 32811689
Inflammatory mechanisms in patients with chronic obstructive pulmonary disease.
Barnes PJ
J Allergy Clin Immunol 2016 Jul;138(1):16-27. Epub 2016 May 27 doi: 10.1016/j.jaci.2016.05.011. PMID: 27373322
Exercise immunology: practical applications.
Nieman DC
Int J Sports Med 1997 Mar;18 Suppl 1:S91-100. doi: 10.1055/s-2007-972705. PMID: 9129268

Therapy

Circulating white blood cell traits and colorectal cancer risk: A Mendelian randomisation study.
Constantinescu AE, Bull CJ, Jones N, Mitchell R, Burrows K, Dimou N, Bézieau S, Brenner H, Buchanan DD, D'Amato M, Jenkins MA, Moreno V, Pai RK, Um CY, White E, Murphy N, Gunter M, Timpson NJ, Huyghe JR, Vincent EE
Int J Cancer 2024 Jan 1;154(1):94-103. Epub 2023 Aug 14 doi: 10.1002/ijc.34691. PMID: 37578112Free PMC Article
Serum cytokines and neutrophil-to-lymphocyte ratio as predictive biomarkers of benefit from PD-1 inhibitors in gastric cancer.
Hou Y, Li X, Yang Y, Shi H, Wang S, Gao M
Front Immunol 2023;14:1274431. Epub 2023 Oct 31 doi: 10.3389/fimmu.2023.1274431. PMID: 38022654Free PMC Article
Peripheral blood cellular immunophenotype in depression: a systematic review and meta-analysis.
Foley ÉM, Parkinson JT, Mitchell RE, Turner L, Khandaker GM
Mol Psychiatry 2023 Mar;28(3):1004-1019. Epub 2022 Dec 28 doi: 10.1038/s41380-022-01919-7. PMID: 36577838Free PMC Article
White Blood Cells and Blood Pressure: A Mendelian Randomization Study.
Siedlinski M, Jozefczuk E, Xu X, Teumer A, Evangelou E, Schnabel RB, Welsh P, Maffia P, Erdmann J, Tomaszewski M, Caulfield MJ, Sattar N, Holmes MV, Guzik TJ
Circulation 2020 Apr 21;141(16):1307-1317. Epub 2020 Mar 9 doi: 10.1161/CIRCULATIONAHA.119.045102. PMID: 32148083Free PMC Article
A Population Pharmacokinetic-Pharmacodynamic Model of Pegfilgrastim.
Brekkan A, Lopez-Lazaro L, Yngman G, Plan EL, Acharya C, Hooker AC, Kankanwadi S, Karlsson MO
AAPS J 2018 Aug 15;20(5):91. doi: 10.1208/s12248-018-0249-y. PMID: 30112626

Prognosis

White Blood Cell Count, Neutrophil-to-Lymphocyte Ratio, and Incident Cancer in the UK Biobank.
Song M, Graubard BI, Loftfield E, Rabkin CS, Engels EA
Cancer Epidemiol Biomarkers Prev 2024 Jun 3;33(6):821-829. doi: 10.1158/1055-9965.EPI-23-1145. PMID: 38568024Free PMC Article
Systemic and local immunosuppression in glioblastoma and its prognostic significance.
Stepanenko AA, Sosnovtseva AO, Valikhov MP, Chernysheva AA, Abramova OV, Pavlov KA, Chekhonin VP
Front Immunol 2024;15:1326753. Epub 2024 Feb 28 doi: 10.3389/fimmu.2024.1326753. PMID: 38481999Free PMC Article
Serum cytokines and neutrophil-to-lymphocyte ratio as predictive biomarkers of benefit from PD-1 inhibitors in gastric cancer.
Hou Y, Li X, Yang Y, Shi H, Wang S, Gao M
Front Immunol 2023;14:1274431. Epub 2023 Oct 31 doi: 10.3389/fimmu.2023.1274431. PMID: 38022654Free PMC Article
Myeloperoxidase is a critical mediator of anthracycline-induced cardiomyopathy.
Nettersheim FS, Schlüter JD, Kreuzberg W, Mehrkens D, Grimm S, Nemade H, Braumann S, Hof A, Guthoff H, Peters V, Hoyer FF, Kargapolova Y, Lackmann JW, Müller S, Pallasch CP, Hallek M, Sachinidis A, Adam M, Winkels H, Baldus S, Geißen S, Mollenhauer M
Basic Res Cardiol 2023 Sep 1;118(1):36. doi: 10.1007/s00395-023-01006-0. PMID: 37656254Free PMC Article
The diversity of circulating neutrophils in cancer.
Mishalian I, Granot Z, Fridlender ZG
Immunobiology 2017 Jan;222(1):82-88. Epub 2016 Feb 3 doi: 10.1016/j.imbio.2016.02.001. PMID: 26874580

Clinical prediction guides

Systemic and local immunosuppression in glioblastoma and its prognostic significance.
Stepanenko AA, Sosnovtseva AO, Valikhov MP, Chernysheva AA, Abramova OV, Pavlov KA, Chekhonin VP
Front Immunol 2024;15:1326753. Epub 2024 Feb 28 doi: 10.3389/fimmu.2024.1326753. PMID: 38481999Free PMC Article
Circulating white blood cell traits and colorectal cancer risk: A Mendelian randomisation study.
Constantinescu AE, Bull CJ, Jones N, Mitchell R, Burrows K, Dimou N, Bézieau S, Brenner H, Buchanan DD, D'Amato M, Jenkins MA, Moreno V, Pai RK, Um CY, White E, Murphy N, Gunter M, Timpson NJ, Huyghe JR, Vincent EE
Int J Cancer 2024 Jan 1;154(1):94-103. Epub 2023 Aug 14 doi: 10.1002/ijc.34691. PMID: 37578112Free PMC Article
Serum cytokines and neutrophil-to-lymphocyte ratio as predictive biomarkers of benefit from PD-1 inhibitors in gastric cancer.
Hou Y, Li X, Yang Y, Shi H, Wang S, Gao M
Front Immunol 2023;14:1274431. Epub 2023 Oct 31 doi: 10.3389/fimmu.2023.1274431. PMID: 38022654Free PMC Article
Myeloperoxidase is a critical mediator of anthracycline-induced cardiomyopathy.
Nettersheim FS, Schlüter JD, Kreuzberg W, Mehrkens D, Grimm S, Nemade H, Braumann S, Hof A, Guthoff H, Peters V, Hoyer FF, Kargapolova Y, Lackmann JW, Müller S, Pallasch CP, Hallek M, Sachinidis A, Adam M, Winkels H, Baldus S, Geißen S, Mollenhauer M
Basic Res Cardiol 2023 Sep 1;118(1):36. doi: 10.1007/s00395-023-01006-0. PMID: 37656254Free PMC Article
White Blood Cells and Blood Pressure: A Mendelian Randomization Study.
Siedlinski M, Jozefczuk E, Xu X, Teumer A, Evangelou E, Schnabel RB, Welsh P, Maffia P, Erdmann J, Tomaszewski M, Caulfield MJ, Sattar N, Holmes MV, Guzik TJ
Circulation 2020 Apr 21;141(16):1307-1317. Epub 2020 Mar 9 doi: 10.1161/CIRCULATIONAHA.119.045102. PMID: 32148083Free PMC Article

Recent systematic reviews

Predictive value of pretreatment circulating inflammatory response markers in the neoadjuvant treatment of breast cancer: meta-analysis.
Dowling GP, Daly GR, Hegarty A, Hembrecht S, Bracken A, Toomey S, Hennessy BT, Hill ADK
Br J Surg 2024 May 3;111(5) doi: 10.1093/bjs/znae132. PMID: 38801441Free PMC Article
Peripheral blood cellular immunophenotype in depression: a systematic review and meta-analysis.
Foley ÉM, Parkinson JT, Mitchell RE, Turner L, Khandaker GM
Mol Psychiatry 2023 Mar;28(3):1004-1019. Epub 2022 Dec 28 doi: 10.1038/s41380-022-01919-7. PMID: 36577838Free PMC Article

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